JP2003512471A - 窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物 - Google Patents

窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物

Info

Publication number
JP2003512471A
JP2003512471A JP2001533142A JP2001533142A JP2003512471A JP 2003512471 A JP2003512471 A JP 2003512471A JP 2001533142 A JP2001533142 A JP 2001533142A JP 2001533142 A JP2001533142 A JP 2001533142A JP 2003512471 A JP2003512471 A JP 2003512471A
Authority
JP
Japan
Prior art keywords
compound according
compound
alkyl
aryl
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001533142A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003512471A5 (enExample
Inventor
ロバート エドワード モリス，
ピーター ジョン サドラー，
ハイメイ チェン，
ダンカン ジョドゥレル，
Original Assignee
ユニバーシティ コート， エディンバラ大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9925274.4A external-priority patent/GB9925274D0/en
Priority claimed from GB0016054A external-priority patent/GB0016054D0/en
Application filed by ユニバーシティ コート， エディンバラ大学 filed Critical ユニバーシティ コート， エディンバラ大学
Publication of JP2003512471A publication Critical patent/JP2003512471A/ja
Publication of JP2003512471A5 publication Critical patent/JP2003512471A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001533142A 1999-10-27 2000-10-26 窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物 Pending JP2003512471A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9925274.4 1999-10-27
GBGB9925274.4A GB9925274D0 (en) 1999-10-27 1999-10-27 Ruthenium (II) compounds
GB0016054A GB0016054D0 (en) 2000-06-30 2000-06-30 Ruthenium (II) compounds
GB0016054.9 2000-06-30
PCT/GB2000/004144 WO2001030790A1 (en) 1999-10-27 2000-10-26 Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer

Publications (2)

Publication Number Publication Date
JP2003512471A true JP2003512471A (ja) 2003-04-02
JP2003512471A5 JP2003512471A5 (enExample) 2007-12-20

Family

ID=26244569

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001533142A Pending JP2003512471A (ja) 1999-10-27 2000-10-26 窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物

Country Status (8)

Country Link
US (3) US6750251B2 (enExample)
EP (1) EP1224192B1 (enExample)
JP (1) JP2003512471A (enExample)
AT (1) ATE303393T1 (enExample)
DE (1) DE60022372T2 (enExample)
DK (1) DK1224192T3 (enExample)
ES (1) ES2248136T3 (enExample)
WO (1) WO2001030790A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013507386A (ja) * 2009-10-08 2013-03-04 アンガス ケミカル カンパニー 低ｖｏｃポリアミン

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1224192T3 (da) * 1999-10-27 2006-01-02 Univ Court The University Of E Halvsandwich-ruthenium (II)-forbindelser omfattende nitrogenholdige ligander til behandling af cancer
GB0215526D0 (en) * 2002-07-05 2002-08-14 Univ Edinburgh Anticancer compounds
DE602004014125D1 (de) * 2003-04-30 2008-07-10 Univ Edinburgh Ruthenium(ii)-komplexe zur behandlung von tumoren
GB0418643D0 (en) * 2004-08-20 2004-09-22 Univ Edinburgh Ruthenium (II) compounds
GB0604602D0 (en) * 2006-03-07 2006-04-19 Univ Edinburgh Ruthenium (II) compounds
EP2016085B9 (en) 2006-05-09 2015-12-30 Ecole Polytechnique Fédérale de Lausanne (EPFL) Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis
GB0610062D0 (en) * 2006-05-19 2006-06-28 Univ Edinburgh Ruthenium (ll) compounds
US8383673B2 (en) * 2010-03-19 2013-02-26 City University Of Hong Kong Nitridoosmium(VI) complexes for treatment of cancer
WO2013038395A1 (en) 2011-09-16 2013-03-21 Universidade De Lisboa Transition metal complexes for pharmaceutical applications
WO2013136296A2 (en) 2012-03-14 2013-09-19 Universidade De Lisboa Water-soluble organometallic ruthenium and iron compunds presenting heteroaromatic ligands
US9290528B1 (en) 2013-03-15 2016-03-22 University Of Kentucky Research Foundation Light-activated compounds
US9751081B2 (en) 2014-12-01 2017-09-05 Clemson University Self-regenerating antioxidant catalysts and methods of using the same
US10053480B1 (en) 2017-10-11 2018-08-21 King Saud University Anti-quorum and DNA cleaving agent

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980472A (en) 1983-06-23 1990-12-25 American Cyanamid Company Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones
US4843069A (en) 1984-07-24 1989-06-27 Asta Pharma Ag Medicament formulations containing ruthenium compounds with an antitumoral action
WO1986000804A1 (fr) 1984-07-24 1986-02-13 Byk Gulden Lomberg Chemische Fabrik Gesellschaft M Compositions de ruthenium a effet inhibiteur de tumeurs
US4699978A (en) 1985-01-18 1987-10-13 The Trustees Of Columbia University In The City Of New York Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US5225556A (en) 1985-01-18 1993-07-06 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers
US4980473A (en) * 1985-01-18 1990-12-25 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
US5386044A (en) 1993-11-30 1995-01-31 E. I. Du Pont De Nemours And Company Polyhaloaromatic ruthenium complexes and reactions thereof
WO1996013510A1 (en) 1994-10-28 1996-05-09 Procept, Inc. Ruthenium complexes and their use as immunosuppressive agents
US5708022A (en) 1994-10-28 1998-01-13 Procept, Inc. Method for inhibiting immune response
JPH11209314A (ja) * 1997-09-30 1999-08-03 Takasago Internatl Corp シクロオクタジエン類の製造方法
DK1224192T3 (da) * 1999-10-27 2006-01-02 Univ Court The University Of E Halvsandwich-ruthenium (II)-forbindelser omfattende nitrogenholdige ligander til behandling af cancer
GB0016052D0 (en) * 2000-06-30 2000-08-23 Univ Edinburgh Ruthenium (II) compounds
GB0028025D0 (en) 2000-11-17 2001-01-03 Univ York Compounds
GB0215526D0 (en) * 2002-07-05 2002-08-14 Univ Edinburgh Anticancer compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013507386A (ja) * 2009-10-08 2013-03-04 アンガス ケミカル カンパニー 低ｖｏｃポリアミン

Also Published As

Publication number Publication date
US20040220166A1 (en) 2004-11-04
EP1224192A1 (en) 2002-07-24
EP1224192B1 (en) 2005-08-31
DK1224192T3 (da) 2006-01-02
US6979681B2 (en) 2005-12-27
DE60022372D1 (de) 2005-10-06
DE60022372T2 (de) 2006-06-08
US20050239765A1 (en) 2005-10-27
ATE303393T1 (de) 2005-09-15
WO2001030790A1 (en) 2001-05-03
US6750251B2 (en) 2004-06-15
US20030023088A1 (en) 2003-01-30
ES2248136T3 (es) 2006-03-16

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