JP2003512036A5 - - Google Patents
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- Publication number
- JP2003512036A5 JP2003512036A5 JP2001531854A JP2001531854A JP2003512036A5 JP 2003512036 A5 JP2003512036 A5 JP 2003512036A5 JP 2001531854 A JP2001531854 A JP 2001531854A JP 2001531854 A JP2001531854 A JP 2001531854A JP 2003512036 A5 JP2003512036 A5 JP 2003512036A5
- Authority
- JP
- Japan
- Prior art keywords
- tadg
- fragment
- protein
- cancer
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 31
- 239000012634 fragment Substances 0.000 description 27
- 102000004169 proteins and genes Human genes 0.000 description 23
- 108090000623 proteins and genes Proteins 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 18
- 206010028980 Neoplasm Diseases 0.000 description 16
- 239000000203 mixture Substances 0.000 description 15
- 108020004414 DNA Proteins 0.000 description 14
- 239000000523 sample Substances 0.000 description 13
- 201000011510 cancer Diseases 0.000 description 12
- 239000012472 biological sample Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 108091005804 Peptidases Proteins 0.000 description 5
- 239000004365 Protease Substances 0.000 description 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 230000002163 immunogen Effects 0.000 description 4
- 230000003308 immunostimulating effect Effects 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 210000004443 dendritic cell Anatomy 0.000 description 3
- 108020005544 Antisense RNA Proteins 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000001613 neoplastic effect Effects 0.000 description 2
- 230000002611 ovarian Effects 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 108091081021 Sense strand Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- -1 chemotherapeutics Substances 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 108020001756 ligand binding domains Proteins 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/421,213 | 1999-10-20 | ||
| US09/421,213 US7022821B1 (en) | 1998-02-20 | 1999-10-20 | Antibody kit for the detection of TADG-15 protein |
| PCT/US2000/029095 WO2001029056A1 (en) | 1999-10-20 | 2000-10-20 | Tadg-15: an extracellular serine protease overexpressed in carcinomas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003512036A JP2003512036A (ja) | 2003-04-02 |
| JP2003512036A5 true JP2003512036A5 (enExample) | 2007-12-20 |
Family
ID=23669632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001531854A Pending JP2003512036A (ja) | 1999-10-20 | 2000-10-20 | Ｔａｄｇ−１５：癌において過剰発現されている細胞外セリンプロテアーゼ |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1226150A4 (enExample) |
| JP (1) | JP2003512036A (enExample) |
| AU (1) | AU774106B2 (enExample) |
| CA (1) | CA2388450C (enExample) |
| MX (1) | MXPA02004046A (enExample) |
| WO (1) | WO2001029056A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795211B2 (en) * | 2000-02-22 | 2010-09-14 | Board Of Trustees Of The University Of Arkansas | Methods for the early diagnosis of ovarian cancer |
| US7157596B2 (en) | 2000-09-08 | 2007-01-02 | Dendreon Corporation | Inhibitors of serine protease activity of matriptase or MTSP1 |
| US7019019B2 (en) | 2002-12-23 | 2006-03-28 | Dendreon Corporation | Matriptase inhibitors and methods of use |
| ATE504602T1 (de) | 2004-12-20 | 2011-04-15 | Amgen Fremont Inc | Für humane matriptase spezifische bindungsproteine |
| GB0611116D0 (en) * | 2006-06-06 | 2006-07-19 | Oxford Genome Sciences Uk Ltd | Proteins |
| DK2185933T3 (en) * | 2007-08-07 | 2015-10-26 | Oxford Biotherapeutics Ltd | MATRIPTASE PROTEIN AND APPLICATIONS THEREOF |
| US9309325B2 (en) | 2009-05-07 | 2016-04-12 | The Regents Of The University Of California | Antibodies and methods of use thereof |
| US8455200B2 (en) | 2009-10-15 | 2013-06-04 | Traxxsson, Llc | Measurement of PKA for cancer detection |
| EP3211421A1 (en) | 2010-09-09 | 2017-08-30 | Traxxsson, LLC | Combination methods of diagnosing cancer in a patient |
| WO2014120555A1 (en) | 2013-01-31 | 2014-08-07 | The Regents Of The University Of California | Antibodies specific for urokinase-type plasminogen activator and methods of use thereof |
| KR20160079818A (ko) | 2013-11-25 | 2016-07-06 | 옥스포드 바이오테라퓨틱스 리미티드 | 암 치료용 항-매트립타제 항체 |
| US9272027B1 (en) | 2014-09-08 | 2016-03-01 | The United States Of America As Represented By The Secretary Of The Air Force | Francisella tularensis live vaccine strains and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09149790A (ja) * | 1995-09-29 | 1997-06-10 | Suntory Ltd | 新規セリンプロテアーゼ |
| WO1998041656A1 (en) * | 1997-03-19 | 1998-09-24 | The Board Of Trustees Of The University Of Arkansas | Compositions and method for the early diagnosis of ovarian cancer |
| US6203979B1 (en) * | 1998-01-16 | 2001-03-20 | Incyte Pharmaceuticals, Inc. | Human protease molecules |
| US5972616A (en) * | 1998-02-20 | 1999-10-26 | The Board Of Trustees Of The University Of Arkansas | TADG-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas |
| AU2501200A (en) * | 1999-01-11 | 2000-08-01 | Incyte Pharmaceuticals, Inc. | Human peptidases |
| CA2362670A1 (en) * | 1999-03-12 | 2000-09-14 | Georgetown University | Matriptase, a serine protease and its applications |
-
2000
- 2000-10-20 MX MXPA02004046A patent/MXPA02004046A/es active IP Right Grant
- 2000-10-20 CA CA2388450A patent/CA2388450C/en not_active Expired - Fee Related
- 2000-10-20 JP JP2001531854A patent/JP2003512036A/ja active Pending
- 2000-10-20 EP EP00973739A patent/EP1226150A4/en not_active Withdrawn
- 2000-10-20 EP EP07118615A patent/EP1887082A3/en not_active Withdrawn
- 2000-10-20 WO PCT/US2000/029095 patent/WO2001029056A1/en not_active Ceased
- 2000-10-20 AU AU12215/01A patent/AU774106B2/en not_active Ceased
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