JP2003511550A - 生物学的に活性な分解産物を有するポリ酸無水物 - Google Patents

生物学的に活性な分解産物を有するポリ酸無水物

Info

Publication number
JP2003511550A
JP2003511550A JP2001531088A JP2001531088A JP2003511550A JP 2003511550 A JP2003511550 A JP 2003511550A JP 2001531088 A JP2001531088 A JP 2001531088A JP 2001531088 A JP2001531088 A JP 2001531088A JP 2003511550 A JP2003511550 A JP 2003511550A
Authority
JP
Japan
Prior art keywords
composition
polyanhydride
polyanhydrides
administered
host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001531088A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003511550A5 (enExample
Inventor
キャスリン イー. アーリッヒ,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Publication of JP2003511550A publication Critical patent/JP2003511550A/ja
Publication of JP2003511550A5 publication Critical patent/JP2003511550A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85Polyesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/18Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G67/00Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
    • C08G67/04Polyanhydrides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L73/00Compositions of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08L59/00 - C08L71/00; Compositions of derivatives of such polymers
    • C08L73/02Polyanhydrides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/006Antidandruff preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
JP2001531088A 1999-10-21 2000-10-11 生物学的に活性な分解産物を有するポリ酸無水物 Pending JP2003511550A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/422,294 1999-10-21
US09/422,294 US6468519B1 (en) 1997-09-10 1999-10-21 Polyanhydrides with biologically active degradation products
PCT/US2000/027962 WO2001028492A2 (en) 1999-10-21 2000-10-11 Polyanhydrides with biologically active degradation products

Publications (2)

Publication Number Publication Date
JP2003511550A true JP2003511550A (ja) 2003-03-25
JP2003511550A5 JP2003511550A5 (enExample) 2007-11-29

Family

ID=23674230

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001531088A Pending JP2003511550A (ja) 1999-10-21 2000-10-11 生物学的に活性な分解産物を有するポリ酸無水物

Country Status (9)

Country Link
US (2) US6468519B1 (enExample)
EP (2) EP1246627B1 (enExample)
JP (1) JP2003511550A (enExample)
AT (1) ATE314078T1 (enExample)
AU (1) AU7877100A (enExample)
CA (1) CA2387558A1 (enExample)
DE (1) DE60025272D1 (enExample)
MX (1) MXPA02003890A (enExample)
WO (1) WO2001028492A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003528044A (ja) * 1999-12-07 2003-09-24 ラトガーズ, ザ ステイト ユニバーシティ オブ ニュー ジャージー 治療組成物および治療方法
JP2022539168A (ja) * 2019-07-05 2022-09-07 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 好中球損傷用ポリマー粒子

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122615B1 (en) * 1998-09-10 2006-10-17 Rutgers, The State University Of New Jersey Polyanhydrides with therapeutically useful degradation products
US7985415B2 (en) * 1997-09-10 2011-07-26 Rutgers, The State University Of New Jersey Medical devices employing novel polymers
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
US6527801B1 (en) 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
CA2417389C (en) * 2000-07-27 2012-05-29 Rutgers, The State University Therapeutic polyesters and polyamides
AU2001279064A1 (en) 2000-07-27 2002-02-13 Rutgers, The State University Therapeutic azo-compounds for drug delivery
ATE424722T1 (de) * 2001-11-23 2009-03-15 Univ Rutgers Verbesserte synthese von polyanhydriden
AU2003251992A1 (en) * 2002-07-17 2004-02-02 Rutgers, The State University Therapeutic devices for patterned cell growth
US7285287B2 (en) 2002-11-14 2007-10-23 Synecor, Llc Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses
US6932930B2 (en) * 2003-03-10 2005-08-23 Synecor, Llc Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same
US9445901B2 (en) * 2003-03-12 2016-09-20 Deger C. Tunc Prosthesis with sustained release analgesic
WO2004100926A2 (en) * 2003-05-13 2004-11-25 Medtronic, Inc. Delivery of agents using hydrolyzable leaving groups
US20050249697A1 (en) * 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
US8352712B2 (en) * 2004-05-06 2013-01-08 International Business Machines Corporation Method and system for specualtively sending processor-issued store operations to a store queue with full signal asserted
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
EP1744787A4 (en) * 2004-05-14 2011-04-06 Interface Biologics Inc POLYMER COUPLING AGENTS AND PHARMACEUTICALLY ACTIVE POLYMERS MANUFACTURED THEREOF
US7691364B2 (en) 2005-01-28 2010-04-06 Bezwada Biomedical, Llc Functionalized drugs and polymers derived therefrom
US7858077B2 (en) * 2005-01-28 2010-12-28 Bezwada Biomedical Llc Functionalized phenolic esters and amides and polymers therefrom
US20060193891A1 (en) * 2005-02-25 2006-08-31 Robert Richard Medical devices and therapeutic delivery devices composed of bioabsorbable polymers produced at room temperature, method of making the devices, and a system for making the devices
WO2006127667A1 (en) * 2005-05-23 2006-11-30 Rutgers, The State University Of New Jersey Fast degrading polymers
EP1951260A4 (en) * 2005-10-21 2009-11-11 Bezwada Biomedical Llc FUNCTIONALIZED PHENOLIC COMPOUNDS AND POURABLE ARTICLES THEREOF
US8007526B2 (en) 2005-12-01 2011-08-30 Bezwada Biomedical, Llc Difunctionalized aromatic compounds and polymers therefrom
US7935843B2 (en) * 2005-12-09 2011-05-03 Bezwada Biomedical, Llc Functionalized diphenolics and absorbable polymers therefrom
US9603941B2 (en) * 2006-01-24 2017-03-28 Minghui Chai Method of preparing dendritic drugs
US20070225472A1 (en) * 2006-03-23 2007-09-27 Varshney Sunil K Polyanhydride polymers and their uses in biomedical devices
EP2032614A2 (en) * 2006-06-06 2009-03-11 Rutgers, The State University Of New Jersey Iodinated polymers
EP2102144A4 (en) 2006-09-13 2011-03-23 Univ Rutgers ACTIVE SUBSTANCES AND THEIR OLIGOMERS AND POLYMERS
US20110223232A1 (en) * 2006-10-23 2011-09-15 Olexander Hnojewyj drug-release composition having a therapeutic carrier
US9457047B2 (en) 2006-11-06 2016-10-04 Whitehead Institute Immunomodulating compositions and methods of use thereof
ES2397186T3 (es) * 2006-11-06 2013-03-05 Whitehead Institute Composiciones inmunomoduladoras y métodos para su uso
US8747832B2 (en) * 2007-04-12 2014-06-10 Rutgers, The State University Of New Jersey Biodegradable polyanhydrides with natural bioactive molecules
US8217134B2 (en) * 2007-08-30 2012-07-10 Bezwada Biomedical, Llc Controlled release of biologically active compounds
US8026285B2 (en) * 2007-09-04 2011-09-27 Bezwada Biomedical, Llc Control release of biologically active compounds from multi-armed oligomers
US8048980B2 (en) 2007-09-17 2011-11-01 Bezwada Biomedical, Llc Hydrolysable linkers and cross-linkers for absorbable polymers
WO2010148104A2 (en) * 2009-06-16 2010-12-23 L'oreal S.A. Topical compositions containing a polymer for releasing at least one salicylic acid compound
WO2010148101A2 (en) * 2009-06-16 2010-12-23 L'oreal S.A. Topical compositions containing a polymer for releasing at least one salicylic acid compound
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
WO2014194055A1 (en) 2013-05-29 2014-12-04 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
WO2015191742A1 (en) 2014-06-13 2015-12-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
JP6930918B6 (ja) 2015-04-10 2021-12-15 ラトガーズ, ザ ステイト ユニバーシティ オブ ニュー ジャージー コウジ酸ポリマー
US11612567B2 (en) 2018-02-02 2023-03-28 Ripple Therapeutics Corporation Ocular inserts comprising a covalently linked steroid dimer
WO2020154815A1 (en) 2019-02-01 2020-08-06 Ripple Therapeutics Corporation Crystalline forms of dexamethasone dimers and uses thereof
EP4146664A4 (en) 2020-05-01 2024-11-13 Ripple Therapeutics Corporation HETERODIMER COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES
WO2025115004A1 (en) * 2023-11-29 2025-06-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Biodegradable agricultural pesticides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002517606A (ja) * 1998-06-11 2002-06-18 クラリアント・インターナシヨナル・リミテッド 193nmポジ型フォトレジスト組成物

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE288311C (enExample) 1915-10-27
DE288387C (enExample)
US4062855A (en) 1971-09-27 1977-12-13 University Of Washington Synthetic polymers furnishing controlled release of a biologically active component during degradation
US4363815A (en) * 1975-07-23 1982-12-14 Yu Ruey J Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions
US4287174A (en) * 1978-03-31 1981-09-01 The Proctor & Gamble Company Anti-ulcer composition
US4298595A (en) * 1978-12-20 1981-11-03 Dynapol Pharmaceutical preparations containing a polymeric agent for releasing 5-aminosalicylic acid or its salts into the gastrointestinal tract
US4888176A (en) 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4757128A (en) 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4483854A (en) * 1983-04-12 1984-11-20 Key Pharmaceuticals, Inc. Systemic treatment of psoriasis using certain salicylates
IL68965A (en) * 1983-06-13 1987-02-27 Rafa Labor Ltd Topical pharmaceutical preparation comprising acetylsalicylic acid for the treatment of dermatological disorders
US4612302A (en) 1983-11-14 1986-09-16 Brigham And Women's Hospital Clinical use of somatostatin analogues
US4891225A (en) 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4886870A (en) * 1984-05-21 1989-12-12 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4684620A (en) 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
CH666185A5 (en) * 1985-09-16 1988-07-15 Dieter Dr Russmann Salicylic acid or sodium salt - used for treating inflammatory intestinal disorders
CH671402A5 (enExample) 1985-10-02 1989-08-31 Sandoz Ag
DE246341T1 (de) 1986-05-20 1989-03-30 Massachusetts Institute Of Technology, Cambridge, Mass. Bioerodierbare erzeugnisse zur verwendung als implantate oder prothese mit einem voraussehbaren resorbierungsgrad.
US6024983A (en) 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US5055524A (en) * 1987-07-16 1991-10-08 Ppg Industries, Inc. Polyol-modified polyanhydride curing agent for polyepoxide powder coatings
US4916204A (en) * 1987-07-31 1990-04-10 Massachusetts Institute Of Technology Pure polyanhydride from dicarboxylic acid and coupling agent
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US5259968A (en) 1988-02-29 1993-11-09 Exxon Chemical Patents Inc. Dispersant additive comprising the reaction product of a polyanhydride and a mannich condensation product
US4868274A (en) 1988-05-23 1989-09-19 Hoechst Celanese Corp. Polyanhydride from carboxy aryloxy alkanoic acid
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
WO1990009779A1 (en) 1989-02-28 1990-09-07 Benhuri Marc N Method and composition for treatment of periodontal disease
US4999417A (en) 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
DK339289D0 (da) * 1989-07-07 1989-07-07 Dak Lab As Farmaceutisk praeparat
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US4997904A (en) 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
JPH06501448A (ja) 1989-12-26 1994-02-17 ノバ ファーマシューティカル コーポレイション 無水物プロドラッグ組成物
US5660851A (en) * 1989-12-26 1997-08-26 Yissum Research Development Company Of The Hebrew Univ. Of Jerusalem Ocular inserts
US5175235A (en) 1990-06-04 1992-12-29 Nova Pharmaceutical Corporation Branched polyanhydrides
US5317079A (en) * 1990-01-19 1994-05-31 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydride
NL9000237A (nl) 1990-01-31 1991-08-16 Re Novative Drugs For Dermatol Topicale farmaceutische composities voor de mondholte en vagina.
US5082925A (en) 1990-08-16 1992-01-21 Ethicon, Inc. Homopolymers and copolymers of salicylate lactones
EP0558556B1 (en) 1990-11-19 1997-04-23 Cornell Research Foundation, Inc. Hyperbranched polyesters
US5198572A (en) * 1991-02-04 1993-03-30 General Electric Company Copolymers of dicarboxylic acids and salicylic acids
US5151415A (en) * 1991-05-23 1992-09-29 Dallas Sirany Method of treating a papova-type viral infection
US5264540A (en) 1992-07-20 1993-11-23 Ethicon, Inc. Aromatic polyanhydrides
US5516793A (en) * 1993-04-26 1996-05-14 Avon Products, Inc. Use of ascorbic acid to reduce irritation of topically applied active ingredients
GB9400163D0 (en) 1994-01-06 1994-03-02 Geistlich Soehne Ag Membrane
EP0804148B1 (fr) * 1994-07-22 2006-03-08 Engelhard Lyon Acide hydroxyle lipophile, son utilisation en cosmetique et en pharmacie, et son procede de preparation
US5902110A (en) 1995-12-18 1999-05-11 The Block Drug Company Bone regeneration
CA2243649C (en) * 1996-02-15 2009-08-04 J. Paul Santerre Bioresponsive pharmacologically-active polymers and articles made therefrom
US5837680A (en) * 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
US5902599A (en) 1996-02-20 1999-05-11 Massachusetts Institute Of Technology Biodegradable polymer networks for use in orthopedic and dental applications
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
AU729552B2 (en) 1997-02-18 2001-02-01 Rutgers, The State University Monomers derived from hydroxy acids and polymers prepared therefrom
EP1005347A4 (en) * 1997-08-06 2002-08-28 Smithkline Beecham Corp ANTAGONISTS OF THE RECEPTORS OF THE MONOCYTE MACROPHAGE FOR USE IN TREATING CARDIOVASCULAR DISEASES
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
ATE378364T1 (de) 1997-09-10 2007-11-15 Univ Rutgers Polyamhydride mit therapeutisch verwendbaren abbauprodukten
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US5882665A (en) * 1997-11-18 1999-03-16 Elizabeth Arden Co., Division Of Conopco, Inc. Phytosphingosine salicylates in cosmetic compositions
DE19754063A1 (de) 1997-12-05 1999-06-10 Bayer Ag Abbau von biologisch abbaubaren Polymeren
US6153212A (en) * 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6685928B2 (en) * 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
US20040038948A1 (en) * 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
CA2417389C (en) * 2000-07-27 2012-05-29 Rutgers, The State University Therapeutic polyesters and polyamides
AU2001279064A1 (en) * 2000-07-27 2002-02-13 Rutgers, The State University Therapeutic azo-compounds for drug delivery
AU2003251992A1 (en) * 2002-07-17 2004-02-02 Rutgers, The State University Therapeutic devices for patterned cell growth

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002517606A (ja) * 1998-06-11 2002-06-18 クラリアント・インターナシヨナル・リミテッド 193nmポジ型フォトレジスト組成物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003528044A (ja) * 1999-12-07 2003-09-24 ラトガーズ, ザ ステイト ユニバーシティ オブ ニュー ジャージー 治療組成物および治療方法
JP2022539168A (ja) * 2019-07-05 2022-09-07 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 好中球損傷用ポリマー粒子
JP7591831B2 (ja) 2019-07-05 2024-11-29 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 好中球損傷用ポリマー粒子
US12296048B2 (en) 2019-07-05 2025-05-13 The Regents Of The University Of Michigan Polymer particles for neutrophil injury

Also Published As

Publication number Publication date
EP1246627B1 (en) 2005-12-28
AU7877100A (en) 2001-04-30
MXPA02003890A (es) 2002-12-13
ATE314078T1 (de) 2006-01-15
EP1464673A3 (en) 2007-12-19
EP1464673A2 (en) 2004-10-06
CA2387558A1 (en) 2001-04-26
US20030035787A1 (en) 2003-02-20
EP1246627A4 (en) 2003-04-02
DE60025272D1 (de) 2006-02-02
US6468519B1 (en) 2002-10-22
WO2001028492A2 (en) 2001-04-26
EP1246627A2 (en) 2002-10-09
WO2001028492A3 (en) 2001-09-13

Similar Documents

Publication Publication Date Title
US6468519B1 (en) Polyanhydrides with biologically active degradation products
US8017714B2 (en) Polyanhydrides with therapeutically useful degradation products
AU750424B2 (en) Polyanhydrides with therapeutically useful degradation products
US7666398B2 (en) Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US7411031B2 (en) Synthesis of polyanhydrides
HK1070088A (en) Polyanhydrides with biologically active degradation products
AU2005248970A1 (en) Polyanhydrides with biologically active degradation products
AU2002301261B2 (en) Polyanhydrides with therapeutically useful degradation products
AU2006202416A1 (en) Polyanhydrides with therapeutically useful degradation products
MXPA00002494A (en) Polyanhydrides with therapeutically useful degradation products
HK1069285B (en) Improved synthesis of polyanhyrides

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071010

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071010

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20100728

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100730

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110105