JP2003506438A5 - - Google Patents
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- Publication number
- JP2003506438A5 JP2003506438A5 JP2001515301A JP2001515301A JP2003506438A5 JP 2003506438 A5 JP2003506438 A5 JP 2003506438A5 JP 2001515301 A JP2001515301 A JP 2001515301A JP 2001515301 A JP2001515301 A JP 2001515301A JP 2003506438 A5 JP2003506438 A5 JP 2003506438A5
- Authority
- JP
- Japan
- Prior art keywords
- butyl
- benzyl
- formula
- group
- cyclopentylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 hydrogen Chemical class 0.000 description 17
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 1
- 125000004511 1,2,3-thiadiazolyl group Chemical group 0.000 description 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000005059 halophenyl group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9918869.0A GB9918869D0 (en) | 1999-08-10 | 1999-08-10 | Antibacterial agents |
| GB9918869.0 | 1999-08-10 | ||
| GBGB9927093.6A GB9927093D0 (en) | 1999-11-16 | 1999-11-16 | Antibacterial agents |
| GB9927093.6 | 1999-11-16 | ||
| PCT/GB2000/003078 WO2001010834A2 (en) | 1999-08-10 | 2000-08-10 | Antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003506438A JP2003506438A (ja) | 2003-02-18 |
| JP2003506438A5 true JP2003506438A5 (enExample) | 2007-09-27 |
Family
ID=26315838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001515301A Withdrawn JP2003506438A (ja) | 1999-08-10 | 2000-08-10 | 抗菌剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6846825B1 (enExample) |
| EP (1) | EP1202968A2 (enExample) |
| JP (1) | JP2003506438A (enExample) |
| KR (1) | KR100710596B1 (enExample) |
| CN (1) | CN1217932C (enExample) |
| AU (1) | AU766881B2 (enExample) |
| BR (1) | BR0013112A (enExample) |
| CA (1) | CA2379061C (enExample) |
| CZ (1) | CZ2002498A3 (enExample) |
| HU (1) | HUP0202514A3 (enExample) |
| IL (1) | IL148015A0 (enExample) |
| MX (1) | MXPA02001394A (enExample) |
| NO (1) | NO20020621L (enExample) |
| NZ (1) | NZ517239A (enExample) |
| PL (1) | PL353745A1 (enExample) |
| TR (1) | TR200200360T2 (enExample) |
| WO (1) | WO2001010834A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2268401A (en) * | 1999-12-17 | 2001-06-25 | Versicor Inc | Novel succinate compounds, compositions and methods of use and preparation |
| AU2002255634A1 (en) * | 2001-03-01 | 2002-09-19 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
| EP1492534B1 (en) | 2002-04-03 | 2008-06-25 | TopoTarget UK Limited | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors |
| GB0208579D0 (en) * | 2002-04-13 | 2002-05-22 | British Biotech Pharm | Antibacterial agents |
| UY27813A1 (es) * | 2002-05-31 | 2003-12-31 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
| GB0223532D0 (en) * | 2002-10-09 | 2002-11-13 | British Biotech Pharm | Antibacterial agents |
| AU2004205372B2 (en) | 2003-01-17 | 2011-02-24 | Topotarget Uk Limited | Hydroxamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors |
| WO2005028467A1 (en) * | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds |
| KR100648133B1 (ko) * | 2005-04-25 | 2006-11-23 | 일동제약주식회사 | 펩티드 데포르밀라제 저해제로서 신규의 히드록사믹 산유도체 및 그 제조방법 |
| CA2630551C (en) | 2005-11-24 | 2014-08-05 | Laboratoires Serono S.A. | N-hydroxyamide derivatives and use thereof |
| KR100774728B1 (ko) | 2006-05-25 | 2007-11-08 | 일동제약주식회사 | 펩티드 데포르밀라제 저해제로서 신규의 엔-포르밀히드록실아민 유도체 및 그 제조방법 |
| KR100753796B1 (ko) * | 2006-07-28 | 2007-08-31 | 주식회사 프로메디텍 | 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물 |
| EP2234608A2 (en) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
| JP5038509B2 (ja) | 2008-01-18 | 2012-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | β−ラクタマーゼ阻害剤 |
| CN112521369A (zh) | 2013-03-13 | 2021-03-19 | 福马治疗股份有限公司 | 用于抑制fasn的化合物及组合物 |
| WO2020092395A1 (en) | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
| CN116763804A (zh) * | 2023-07-10 | 2023-09-19 | 徐州工程学院 | 胡椒基哌嗪联合奈替米星在制备抗荧光假单胞菌感染药物中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8919251D0 (en) * | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
| GB9412350D0 (en) | 1994-06-20 | 1994-08-10 | Fujisawa Pharmaceutical Co | New compound and its preparation |
| US6281245B1 (en) | 1996-10-28 | 2001-08-28 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof |
| EP1052984B1 (en) * | 1998-02-07 | 2004-05-12 | Vernalis (Oxford) Ltd | Antibacterial agents |
-
2000
- 2000-08-10 BR BR0013112-1A patent/BR0013112A/pt not_active Application Discontinuation
- 2000-08-10 NZ NZ517239A patent/NZ517239A/en unknown
- 2000-08-10 WO PCT/GB2000/003078 patent/WO2001010834A2/en not_active Ceased
- 2000-08-10 KR KR1020027001841A patent/KR100710596B1/ko not_active Expired - Fee Related
- 2000-08-10 AU AU63080/00A patent/AU766881B2/en not_active Ceased
- 2000-08-10 IL IL14801500A patent/IL148015A0/xx unknown
- 2000-08-10 HU HU0202514A patent/HUP0202514A3/hu unknown
- 2000-08-10 TR TR2002/00360T patent/TR200200360T2/xx unknown
- 2000-08-10 CZ CZ2002498A patent/CZ2002498A3/cs unknown
- 2000-08-10 JP JP2001515301A patent/JP2003506438A/ja not_active Withdrawn
- 2000-08-10 CA CA002379061A patent/CA2379061C/en not_active Expired - Fee Related
- 2000-08-10 EP EP00949820A patent/EP1202968A2/en not_active Withdrawn
- 2000-08-10 CN CN00812860XA patent/CN1217932C/zh not_active Expired - Fee Related
- 2000-08-10 PL PL00353745A patent/PL353745A1/xx unknown
- 2000-08-10 MX MXPA02001394A patent/MXPA02001394A/es active IP Right Grant
- 2000-08-10 US US10/049,131 patent/US6846825B1/en not_active Expired - Fee Related
-
2002
- 2002-02-08 NO NO20020621A patent/NO20020621L/no not_active Application Discontinuation
-
2004
- 2004-09-30 US US10/953,788 patent/US7186719B2/en not_active Expired - Fee Related
-
2006
- 2006-12-14 US US11/638,704 patent/US20100125075A1/en not_active Abandoned
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