JP2003506077A - 組換え安定細胞クローン、その産生およびその使用 - Google Patents

組換え安定細胞クローン、その産生およびその使用

Info

Publication number
JP2003506077A
JP2003506077A JP2001515808A JP2001515808A JP2003506077A JP 2003506077 A JP2003506077 A JP 2003506077A JP 2001515808 A JP2001515808 A JP 2001515808A JP 2001515808 A JP2001515808 A JP 2001515808A JP 2003506077 A JP2003506077 A JP 2003506077A
Authority
JP
Japan
Prior art keywords
protein
cell
recombinant
serum
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001515808A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003506077A5 (https=
Inventor
マンフレッド ライター，
ヴォルフガング ムント，
フリードリッヒ ドルナー，
Original Assignee
バクスター アクチェンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3683861&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2003506077(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by バクスター アクチェンゲゼルシャフト filed Critical バクスター アクチェンゲゼルシャフト
Publication of JP2003506077A publication Critical patent/JP2003506077A/ja
Publication of JP2003506077A5 publication Critical patent/JP2003506077A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/005—Protein-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/76—Undefined extracts from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2001515808A 1999-08-05 1999-08-05 組換え安定細胞クローン、その産生およびその使用 Withdrawn JP2003506077A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/AT1999/000197 WO2001011021A1 (de) 1999-08-05 1999-08-05 Rekombinanter stabiler zellklon, seine herstellung und verwendung

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2010024874A Division JP2010099093A (ja) 2010-02-05 2010-02-05 組換え安定細胞クローン、その産生およびその使用
JP2010176423A Division JP2011004754A (ja) 2010-08-05 2010-08-05 組換え安定細胞クローン、その産生およびその使用

Publications (2)

Publication Number Publication Date
JP2003506077A true JP2003506077A (ja) 2003-02-18
JP2003506077A5 JP2003506077A5 (https=) 2010-09-30

Family

ID=3683861

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001515808A Withdrawn JP2003506077A (ja) 1999-08-05 1999-08-05 組換え安定細胞クローン、その産生およびその使用

Country Status (11)

Country Link
EP (1) EP1200561B1 (https=)
JP (1) JP2003506077A (https=)
AT (1) ATE330003T1 (https=)
AU (1) AU780810B2 (https=)
CA (1) CA2381173A1 (https=)
CY (1) CY1106111T1 (https=)
DE (1) DE59913565D1 (https=)
DK (1) DK1200561T3 (https=)
ES (1) ES2267280T3 (https=)
PT (1) PT1200561E (https=)
WO (1) WO2001011021A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004510439A (ja) * 2000-10-02 2004-04-08 ノボ　ノルディスク　アクティーゼルスカブ 哺乳動物細胞における組換えタンパク質の工業的規模の無血清製造法
JP2007502608A (ja) * 2003-08-19 2007-02-15 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 生産細胞の再クローン化方法
JP2012508562A (ja) * 2008-11-12 2012-04-12 バクスター・インターナショナル・インコーポレイテッド 血清不含インスリン不含で第ｖｉｉ因子を産生する方法
JP2012107042A (ja) * 2003-12-31 2012-06-07 Merck Patent Gmbh 改良された薬物動態を有するＦｃ−エリスロポエチン融合タンパク質
US8669109B2 (en) 2003-08-19 2014-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methods of producing proteins in Chinese hamster ovary (CHO) cells
WO2024024671A1 (ja) * 2022-07-27 2024-02-01 不二製油グループ本社株式会社 動物細胞増殖促進剤

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1482031B1 (en) 1996-08-30 2015-10-28 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
EP1434857B1 (en) 2001-10-02 2007-08-01 Novo Nordisk Health Care AG Method for production of recombinant proteins in eukaryote cells
HUP0402226A2 (hu) * 2001-11-28 2005-02-28 Sandoz Ag. Eljárás sejttenyésztésre
WO2003048357A1 (fr) * 2001-12-04 2003-06-12 Mitsubishi Pharma Corporation Procede d'activation de proteine
PT2287288E (pt) 2002-07-09 2012-12-10 Baxter Int Meio isento de proteína animal para cultura de células
US20060094104A1 (en) * 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
AU2011221414B2 (en) * 2004-10-29 2012-09-20 Takeda Pharmaceutical Company Limited Animal Protein-Free Media for Cultivation of Cells
ATE541919T1 (de) 2005-02-11 2012-02-15 Novo Nordisk Healthcare Ag Herstellung eines proteins in serumfreier zellkultur, die ein proteinhydrolysat aus pflanzen enthält
EP3653699A1 (en) 2006-01-04 2020-05-20 Baxalta Incorporated Oligopeptide-free cell culture media

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025599A1 (de) * 1993-04-26 1994-11-10 Biotechnolog Forschung Gmbh Säugerzellinien und verfahren zur glykoproteingewinnung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
EP0666312A1 (en) * 1994-02-08 1995-08-09 Wolfgang A. Renner Process for the improvement of mammalian cell growth
ES2378409T3 (es) * 1994-11-10 2012-04-12 Baxter Healthcare S.A. Método para producir sustancias biológicas en cultivo sin proteínas
EP0799310A1 (en) * 1994-12-16 1997-10-08 Novartis AG Production of recombinant secretory component
AUPN442295A0 (en) * 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
US5851800A (en) * 1996-05-14 1998-12-22 Pharmacia & Upjohn Ab Process for producing a protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025599A1 (de) * 1993-04-26 1994-11-10 Biotechnolog Forschung Gmbh Säugerzellinien und verfahren zur glykoproteingewinnung

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004510439A (ja) * 2000-10-02 2004-04-08 ノボ　ノルディスク　アクティーゼルスカブ 哺乳動物細胞における組換えタンパク質の工業的規模の無血清製造法
JP2004512835A (ja) * 2000-10-02 2004-04-30 ノボ　ノルディスク　アクティーゼルスカブ 哺乳動物細胞における組換えｆｖｉｉの工業的規模の無血清製造法
JP2007502608A (ja) * 2003-08-19 2007-02-15 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 生産細胞の再クローン化方法
US8669109B2 (en) 2003-08-19 2014-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methods of producing proteins in Chinese hamster ovary (CHO) cells
JP2012107042A (ja) * 2003-12-31 2012-06-07 Merck Patent Gmbh 改良された薬物動態を有するＦｃ−エリスロポエチン融合タンパク質
JP2012508562A (ja) * 2008-11-12 2012-04-12 バクスター・インターナショナル・インコーポレイテッド 血清不含インスリン不含で第ｖｉｉ因子を産生する方法
WO2024024671A1 (ja) * 2022-07-27 2024-02-01 不二製油グループ本社株式会社 動物細胞増殖促進剤

Also Published As

Publication number Publication date
DE59913565D1 (de) 2006-07-27
CY1106111T1 (el) 2011-06-08
WO2001011021A1 (de) 2001-02-15
ES2267280T3 (es) 2007-03-01
DK1200561T3 (da) 2006-10-16
AU5363699A (en) 2001-03-05
CA2381173A1 (en) 2001-02-15
ATE330003T1 (de) 2006-07-15
PT1200561E (pt) 2006-09-29
EP1200561B1 (de) 2006-06-14
AU780810B2 (en) 2005-04-21
EP1200561A1 (de) 2002-05-02

Similar Documents

Publication Publication Date Title
US6100061A (en) Recombinant cell clone having increased stability in serum- and protein-free medium and a method of recovering the stable cell clone and the production of recombinant proteins by using a stable cell clone
US7094574B2 (en) Recombinant cell clones having increased stability and methods of making and using the same
JP2003506077A (ja) 組換え安定細胞クローン、その産生およびその使用
JP5441288B2 (ja) 細胞の無タンパク質かつ無血清の培養のための培地
JP2003506077A5 (https=)
CA2316739C (en) Preparation of cells for production of biologicals
JP6245299B2 (ja) 組換え安定細胞クローン、その産生およびその使用
JP2011004754A (ja) 組換え安定細胞クローン、その産生およびその使用
JP6097725B2 (ja) 組換え安定細胞クローン、その産生およびその使用
JP2010099093A (ja) 組換え安定細胞クローン、その産生およびその使用
AT409493B (de) Stabiler rekombinanter zellklon
HK1030628B (en) Preparation of cells for production of biologicals
HK1030628C (en) Preparation of cells for production of biologicals

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060614

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090806

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091023

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091030

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091130

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100205

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100407

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20100727

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20100805

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20100811

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20100727

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20100921