JP2003505694A5 - - Google Patents
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- JP2003505694A5 JP2003505694A5 JP2001512292A JP2001512292A JP2003505694A5 JP 2003505694 A5 JP2003505694 A5 JP 2003505694A5 JP 2001512292 A JP2001512292 A JP 2001512292A JP 2001512292 A JP2001512292 A JP 2001512292A JP 2003505694 A5 JP2003505694 A5 JP 2003505694A5
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- 210000004027 cell Anatomy 0.000 description 56
- 238000000034 method Methods 0.000 description 54
- 239000000758 substrate Substances 0.000 description 42
- 239000000523 sample Substances 0.000 description 20
- 239000011159 matrix material Substances 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 206010028980 Neoplasm Diseases 0.000 description 9
- 239000000499 gel Substances 0.000 description 7
- 238000000926 separation method Methods 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 206010061309 Neoplasm progression Diseases 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 239000011543 agarose gel Substances 0.000 description 2
- 210000003850 cellular structure Anatomy 0.000 description 2
- 238000004581 coalescence Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 230000001293 nucleolytic effect Effects 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000002797 proteolythic effect Effects 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 230000005751 tumor progression Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000000370 laser capture micro-dissection Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000007479 molecular analysis Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14561399P | 1999-07-26 | 1999-07-26 | |
| US60/145,613 | 1999-07-26 | ||
| PCT/US2000/020354 WO2001007915A2 (en) | 1999-07-26 | 2000-07-26 | Layered device with capture regions for cellular analysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003505694A JP2003505694A (ja) | 2003-02-12 |
| JP2003505694A5 true JP2003505694A5 (enExample) | 2007-09-13 |
| JP4137444B2 JP4137444B2 (ja) | 2008-08-20 |
Family
ID=22513857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512292A Expired - Lifetime JP4137444B2 (ja) | 1999-07-26 | 2000-07-26 | 細胞分析用の捕捉領域を有する層状装置 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6602661B1 (enExample) |
| EP (1) | EP1218743B1 (enExample) |
| JP (1) | JP4137444B2 (enExample) |
| AT (1) | ATE328277T1 (enExample) |
| AU (1) | AU771499B2 (enExample) |
| CA (1) | CA2375034C (enExample) |
| DE (1) | DE60028393T2 (enExample) |
| ES (1) | ES2269171T3 (enExample) |
| WO (1) | WO2001007915A2 (enExample) |
Families Citing this family (74)
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| US7214477B1 (en) * | 1999-07-26 | 2007-05-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Layered device with capture regions for cellular analysis |
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| US20060275851A1 (en) * | 2000-07-26 | 2006-12-07 | Emmert-Buck Michael R | Layered peptide/antigen arrays - for high-throughput antibody screening of clinical samples |
| US20040053326A1 (en) * | 2001-03-14 | 2004-03-18 | Emmert-Buck Michael R. | Transfer microdessection |
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| JP4915527B2 (ja) * | 2007-09-27 | 2012-04-11 | 凸版印刷株式会社 | 電気泳動兼転写用積層体、電気泳動兼転写用チップ、電気泳動兼転写装置、電気泳動兼転写方法、電気泳動兼転写用積層体の製造方法 |
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| EP3236264A3 (en) | 2009-10-13 | 2017-11-08 | Nanostring Technologies, Inc | Protein detection via nanoreporters |
| JP5415560B2 (ja) * | 2009-12-04 | 2014-02-12 | 株式会社日立製作所 | ２次元ｃＤＮＡライブラリを用いた遺伝子発現解析方法 |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| RS54482B1 (sr) | 2010-04-05 | 2016-06-30 | Prognosys Biosciences, Inc. | Biološka testiranja sa prostornim kodiranjem |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| JP2013178140A (ja) * | 2012-02-28 | 2013-09-09 | Sharp Corp | 核酸−タンパク質複合体の単離装置 |
| USRE50065E1 (en) | 2012-10-17 | 2024-07-30 | 10X Genomics Sweden Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
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| CN109254346B (zh) * | 2018-07-16 | 2020-09-11 | 哈尔滨工程大学 | 一种基于波分复用技术的单光纤光镊 |
| CN109556939B (zh) * | 2018-12-03 | 2021-05-11 | 中国科学院青藏高原研究所 | 样品裂变径迹原位蚀刻观测方法及设备 |
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| US20220160692A1 (en) | 2019-04-09 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer |
| AU2020288603A1 (en) | 2019-06-03 | 2021-12-16 | Assistance Publique - Hôpitaux De Paris | Methods for modulating a treatment regimen |
| US20240301497A1 (en) | 2019-10-17 | 2024-09-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing nasal intestinal type adenocarcinomas |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
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| WO2021170777A1 (en) | 2020-02-28 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, prognosing and managing treatment of breast cancer |
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| EP4472740A1 (en) | 2022-01-31 | 2024-12-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd38 as a biomarker and biotarget in t-cell lymphomas |
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| DE60011390T2 (de) | 1999-01-28 | 2004-10-14 | Université De Genève | Verfahren und vorrichtung zur identifikation oder karakterisierung von polypeptiden |
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| US6969615B2 (en) * | 1999-07-26 | 2005-11-29 | 20/20 Genesystems, Inc. | Methods, devices, arrays and kits for detecting and analyzing biomolecules |
-
2000
- 2000-07-26 JP JP2001512292A patent/JP4137444B2/ja not_active Expired - Lifetime
- 2000-07-26 ES ES00953685T patent/ES2269171T3/es not_active Expired - Lifetime
- 2000-07-26 CA CA2375034A patent/CA2375034C/en not_active Expired - Lifetime
- 2000-07-26 AU AU66091/00A patent/AU771499B2/en not_active Expired
- 2000-07-26 EP EP00953685A patent/EP1218743B1/en not_active Expired - Lifetime
- 2000-07-26 AT AT00953685T patent/ATE328277T1/de not_active IP Right Cessation
- 2000-07-26 WO PCT/US2000/020354 patent/WO2001007915A2/en not_active Ceased
- 2000-07-26 DE DE60028393T patent/DE60028393T2/de not_active Expired - Lifetime
- 2000-11-20 US US09/718,990 patent/US6602661B1/en not_active Expired - Lifetime
-
2003
- 2003-07-25 US US10/627,352 patent/US20040081987A1/en not_active Abandoned
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