JP2003503019A - プレプチン機能を有するペプチド - Google Patents
プレプチン機能を有するペプチドInfo
- Publication number
- JP2003503019A JP2003503019A JP2001505563A JP2001505563A JP2003503019A JP 2003503019 A JP2003503019 A JP 2003503019A JP 2001505563 A JP2001505563 A JP 2001505563A JP 2001505563 A JP2001505563 A JP 2001505563A JP 2003503019 A JP2003503019 A JP 2003503019A
- Authority
- JP
- Japan
- Prior art keywords
- pro
- preptin
- asp
- thr
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101800001717 Preptin Proteins 0.000 title claims abstract description 222
- 102100025947 Insulin-like growth factor II Human genes 0.000 title claims abstract description 221
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 51
- 230000003914 insulin secretion Effects 0.000 claims abstract description 51
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 87
- 229940125396 insulin Drugs 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 45
- 108090001061 Insulin Proteins 0.000 claims description 44
- 102000004877 Insulin Human genes 0.000 claims description 43
- QOJJMJKTMKNFEF-ZKWXMUAHSA-N Asp-Val-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CC(O)=O QOJJMJKTMKNFEF-ZKWXMUAHSA-N 0.000 claims description 40
- 210000004027 cell Anatomy 0.000 claims description 38
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 34
- 239000008103 glucose Substances 0.000 claims description 34
- MROIJTGJGIDEEJ-RCWTZXSCSA-N Thr-Pro-Pro Chemical compound C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 MROIJTGJGIDEEJ-RCWTZXSCSA-N 0.000 claims description 32
- 108010089198 phenylalanyl-prolyl-arginine Proteins 0.000 claims description 31
- BKVICMPZWRNWOC-RHYQMDGZSA-N Thr-Val-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)[C@@H](C)O BKVICMPZWRNWOC-RHYQMDGZSA-N 0.000 claims description 29
- 150000001413 amino acids Chemical group 0.000 claims description 28
- 108010057821 leucylproline Proteins 0.000 claims description 28
- CJZTUKSFZUSNCC-FXQIFTODSA-N Pro-Asp-Asn Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1 CJZTUKSFZUSNCC-FXQIFTODSA-N 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 26
- NTUPOKHATNSWCY-PMPSAXMXSA-N (2s)-2-[[(2s)-1-[(2r)-2-amino-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C([C@@H](N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O)C1=CC=CC=C1 NTUPOKHATNSWCY-PMPSAXMXSA-N 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 23
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical class CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- 101500026260 Rattus norvegicus Preptin Proteins 0.000 claims description 18
- 108091033319 polynucleotide Proteins 0.000 claims description 18
- 102000040430 polynucleotide Human genes 0.000 claims description 18
- 239000002157 polynucleotide Substances 0.000 claims description 18
- 101500026336 Homo sapiens Preptin Proteins 0.000 claims description 14
- 101500026263 Mus musculus Preptin Proteins 0.000 claims description 14
- MHZXESQPPXOING-KBPBESRZSA-N Gly-Lys-Phe Chemical compound [H]NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O MHZXESQPPXOING-KBPBESRZSA-N 0.000 claims description 13
- RGYCVIZZTUBSSG-JYJNAYRXSA-N Tyr-Pro-Val Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(O)=O RGYCVIZZTUBSSG-JYJNAYRXSA-N 0.000 claims description 13
- 238000009472 formulation Methods 0.000 claims description 13
- 239000005557 antagonist Substances 0.000 claims description 12
- 230000001404 mediated effect Effects 0.000 claims description 12
- 108010073025 phenylalanylphenylalanine Proteins 0.000 claims description 12
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- 241000282414 Homo sapiens Species 0.000 claims description 11
- 239000000556 agonist Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 238000012360 testing method Methods 0.000 claims description 11
- KCOPOPKJRHVGPE-AQZXSJQPSA-N Asp-Thr-Trp Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O KCOPOPKJRHVGPE-AQZXSJQPSA-N 0.000 claims description 10
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- ABQFNJAFONNUTH-FHWLQOOXSA-N Phe-Gln-Tyr Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O)N ABQFNJAFONNUTH-FHWLQOOXSA-N 0.000 claims description 8
- ZHQWPWQNVRCXAX-XQQFMLRXSA-N Val-Leu-Pro Chemical compound CC(C)C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](C(C)C)N ZHQWPWQNVRCXAX-XQQFMLRXSA-N 0.000 claims description 8
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 108010020532 tyrosyl-proline Proteins 0.000 claims description 7
- SVFOIXMRMLROHO-SRVKXCTJSA-N Asp-Asp-Phe Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 SVFOIXMRMLROHO-SRVKXCTJSA-N 0.000 claims description 6
- OYEUSRAZOGIDBY-JYJNAYRXSA-N Pro-Arg-Tyr Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O OYEUSRAZOGIDBY-JYJNAYRXSA-N 0.000 claims description 6
- DOBIBIXIHJKVJF-XKBZYTNZSA-N Thr-Ser-Gln Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCC(N)=O DOBIBIXIHJKVJF-XKBZYTNZSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- NNCDAORZCMPZPX-GUBZILKMSA-N Lys-Gln-Ser Chemical compound C(CCN)C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)O)N NNCDAORZCMPZPX-GUBZILKMSA-N 0.000 claims description 5
- 108010015792 glycyllysine Proteins 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 5
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- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical class OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims description 4
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical class CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- KUBFPYIMAGXGBT-ACZMJKKPSA-N Gln-Ser-Ala Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O KUBFPYIMAGXGBT-ACZMJKKPSA-N 0.000 claims description 4
- OVSKVOOUFAKODB-UWVGGRQHSA-N Gly-Arg-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CCCN=C(N)N OVSKVOOUFAKODB-UWVGGRQHSA-N 0.000 claims description 4
- PMGDADKJMCOXHX-UHFFFAOYSA-N L-Arginyl-L-glutamin-acetat Natural products NC(=N)NCCCC(N)C(=O)NC(CCC(N)=O)C(O)=O PMGDADKJMCOXHX-UHFFFAOYSA-N 0.000 claims description 4
- IPTUBUUIFRZMJK-ACRUOGEOSA-N Lys-Phe-Phe Chemical compound C([C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 IPTUBUUIFRZMJK-ACRUOGEOSA-N 0.000 claims description 4
- FUOGXAQMNJMBFG-WPRPVWTQSA-N Pro-Val-Gly Chemical compound OC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1 FUOGXAQMNJMBFG-WPRPVWTQSA-N 0.000 claims description 4
- QILPDQCTQZDHFM-HJGDQZAQSA-N Thr-Gln-Arg Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O QILPDQCTQZDHFM-HJGDQZAQSA-N 0.000 claims description 4
- ZOCJFNXUVSGBQI-HSHDSVGOSA-N Thr-Trp-Arg Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N)O ZOCJFNXUVSGBQI-HSHDSVGOSA-N 0.000 claims description 4
- 108010047495 alanylglycine Proteins 0.000 claims description 4
- 108010008355 arginyl-glutamine Proteins 0.000 claims description 4
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- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical class OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
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- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ336359 | 1999-06-18 | ||
| NZ33635999 | 1999-06-18 | ||
| PCT/NZ2000/000102 WO2000078805A1 (fr) | 1999-06-18 | 2000-06-19 | Peptide ayant une fonctionnalite preptine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2003503019A true JP2003503019A (ja) | 2003-01-28 |
Family
ID=19927343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001505563A Pending JP2003503019A (ja) | 1999-06-18 | 2000-06-19 | プレプチン機能を有するペプチド |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1185558A4 (fr) |
| JP (1) | JP2003503019A (fr) |
| CN (1) | CN1296384C (fr) |
| AU (1) | AU759203B2 (fr) |
| CA (1) | CA2375207A1 (fr) |
| HK (1) | HK1042307A1 (fr) |
| WO (1) | WO2000078805A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000018392A1 (fr) | 1998-09-25 | 2000-04-06 | Glycox Corporation Limited | Fructosamine-oxydase: antagonistes et inhibiteurs |
| EP1487431B1 (fr) | 2002-03-08 | 2012-05-02 | PhilERA New Zealand Limited | Prevention et/ou traitement de maladie cardio-vasculaire et/ou d'insuffisance cardiaque connexe |
| WO2004012760A1 (fr) * | 2002-08-01 | 2004-02-12 | Auckland Uniservices Limited | Procedes d'utilisation de la preptine |
| EP1534321A1 (fr) * | 2002-08-01 | 2005-06-01 | Protemix Corporation Limited | Methodes d'utilisation de composes avec une fonction preptine |
| CA3011023A1 (fr) | 2002-08-20 | 2004-03-04 | Philera New Zealand Limited | Composition renfermant des sels de triethylenetetramine pour traiter lesdeteriorations de tissu |
| DK1778618T3 (da) | 2004-07-19 | 2014-03-10 | Philera New Zealand Ltd | Syntese af triethylentetraminer |
| WO2006112737A1 (fr) | 2005-04-20 | 2006-10-26 | Protemix Discovery Limited | Vesiculines |
| CN102369015A (zh) * | 2009-02-02 | 2012-03-07 | 雷蒙特亚特特拉维夫大学有限公司 | 肽、包含该肽的药物组合物及其用途 |
| EP2600885A2 (fr) | 2010-08-04 | 2013-06-12 | Ramot at Tel Aviv University, Ltd. | Procédés de traitement de maladies auto-immunes du système nerveux central (snc) et de maladies neurodégénératives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986000619A1 (fr) * | 1984-07-13 | 1986-01-30 | Chiron Corporation | Facteurs de croissance prepro i et ii analogues a l'insuline |
| GB8720115D0 (en) * | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
| DE68924372T2 (de) * | 1988-01-11 | 1996-05-09 | Amylin Pharmaceuticals Inc | Behandlung von diabetes mellitus typ 2. |
| JPH04500688A (ja) * | 1989-07-10 | 1992-02-06 | アミリン・コーポレイション | 肥満および本態性高血圧および関連疾患の治療 |
| US5234906A (en) * | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
-
2000
- 2000-06-19 EP EP00942575A patent/EP1185558A4/fr not_active Withdrawn
- 2000-06-19 CA CA002375207A patent/CA2375207A1/fr not_active Abandoned
- 2000-06-19 WO PCT/NZ2000/000102 patent/WO2000078805A1/fr active Application Filing
- 2000-06-19 CN CNB008087857A patent/CN1296384C/zh not_active Expired - Fee Related
- 2000-06-19 JP JP2001505563A patent/JP2003503019A/ja active Pending
- 2000-06-19 AU AU57178/00A patent/AU759203B2/en not_active Ceased
-
2002
- 2002-05-11 HK HK02103568.4A patent/HK1042307A1/zh unknown
Non-Patent Citations (5)
| Title |
|---|
| JPN6010018480, Ｊ． Ｃｌｉｎ． Ｅｎｄｏｃｒｉｎｏｌ． Ｍｅｔａｂ．, 1993, Ｖｏｌ． ７６， Ｎｏ． ５, ｐｐ．１０９５−１１００ * |
| JPN6010018482, Ｎａｔｕｒｅ, 1984, Ｖｏｌ． ３１０, ｐｐ．７７７−７８１ * |
| JPN6010018484, ＤＮＡ, 1986, Ｖｏｌ． ５， Ｎｏ． ５, ｐｐ．３５７−３６１ * |
| JPN6010018486, Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ, 1985, Ｖｏｌ． ８２, ｐｐ．３１６９−３１７２ * |
| JPN6010018491, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．, 1985, Ｖｏｌ． ２６０， Ｎｏ． ２７, ｐｐ．１４４１７−１４４２０ * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1185558A1 (fr) | 2002-03-13 |
| CA2375207A1 (fr) | 2000-12-28 |
| AU759203B2 (en) | 2003-04-10 |
| WO2000078805A1 (fr) | 2000-12-28 |
| AU5717800A (en) | 2001-01-09 |
| HK1042307A1 (zh) | 2002-08-09 |
| EP1185558A4 (fr) | 2006-02-15 |
| CN1355813A (zh) | 2002-06-26 |
| CN1296384C (zh) | 2007-01-24 |
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