AU759203B2 - Peptide having preptin functionality - Google Patents
Peptide having preptin functionality Download PDFInfo
- Publication number
- AU759203B2 AU759203B2 AU57178/00A AU5717800A AU759203B2 AU 759203 B2 AU759203 B2 AU 759203B2 AU 57178/00 A AU57178/00 A AU 57178/00A AU 5717800 A AU5717800 A AU 5717800A AU 759203 B2 AU759203 B2 AU 759203B2
- Authority
- AU
- Australia
- Prior art keywords
- preptin
- pro
- asp
- analog
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 238000002390 rotary evaporation Methods 0.000 description 1
- 238000003345 scintillation counting Methods 0.000 description 1
- 230000000580 secretagogue effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 108010026668 snake venom protein C activator Proteins 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-N sodium;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O QGMRQYFBGABWDR-UHFFFAOYSA-N 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ33635999 | 1999-06-18 | ||
| NZ336359 | 1999-06-18 | ||
| PCT/NZ2000/000102 WO2000078805A1 (fr) | 1999-06-18 | 2000-06-19 | Peptide ayant une fonctionnalite preptine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5717800A AU5717800A (en) | 2001-01-09 |
| AU759203B2 true AU759203B2 (en) | 2003-04-10 |
Family
ID=19927343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU57178/00A Ceased AU759203B2 (en) | 1999-06-18 | 2000-06-19 | Peptide having preptin functionality |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1185558A4 (fr) |
| JP (1) | JP2003503019A (fr) |
| CN (1) | CN1296384C (fr) |
| AU (1) | AU759203B2 (fr) |
| CA (1) | CA2375207A1 (fr) |
| HK (1) | HK1042307A1 (fr) |
| WO (1) | WO2000078805A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1324234A (zh) | 1998-09-25 | 2001-11-28 | 格利科克斯有限公司 | 果糖胺氧化酶,拮抗剂和抑制剂 |
| EP1487431B1 (fr) | 2002-03-08 | 2012-05-02 | PhilERA New Zealand Limited | Prevention et/ou traitement de maladie cardio-vasculaire et/ou d'insuffisance cardiaque connexe |
| EP1534321A1 (fr) * | 2002-08-01 | 2005-06-01 | Protemix Corporation Limited | Methodes d'utilisation de composes avec une fonction preptine |
| CA2494305A1 (fr) * | 2002-08-01 | 2004-02-12 | Auckland Uniservices Limited | Procedes d'utilisation de la preptine |
| JP2006503014A (ja) | 2002-08-20 | 2006-01-26 | プロテミックス コーポレイション リミティド | 剤形及び関連する治療法 |
| CA3050047A1 (fr) | 2004-07-19 | 2006-03-16 | Philera New Zealand Limited | Synthese de triethylenetetramines |
| US20090054320A1 (en) * | 2005-04-20 | 2009-02-26 | Protemix Discovery Limited | Vesiculins |
| US8691760B2 (en) | 2009-02-02 | 2014-04-08 | Ramot At Tel-Aviv University | Peptides, pharmaceutical compositions comprising same and uses thereof |
| WO2012017439A2 (fr) | 2010-08-04 | 2012-02-09 | Ramot At Tel-Aviv University Ltd. | Procédés de traitement de maladies auto-immunes du système nerveux central (snc) et de maladies neurodégénératives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986000619A1 (fr) * | 1984-07-13 | 1986-01-30 | Chiron Corporation | Facteurs de croissance prepro i et ii analogues a l'insuline |
| GB8720115D0 (en) * | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
| ATE128359T1 (de) * | 1988-01-11 | 1995-10-15 | Amylin Pharmaceuticals Inc | Behandlung von diabetes mellitus typ 2. |
| ATE128032T1 (de) * | 1989-07-10 | 1995-10-15 | Amylin Pharmaceuticals Inc | Verwendung eines amylinantagonisten zur herstellung eines artzneimittels zur behandlung von fettsucht und essentieller hypertonie und damit zusammenhängenden krankheiten. |
| US5234906A (en) * | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
-
2000
- 2000-06-19 WO PCT/NZ2000/000102 patent/WO2000078805A1/fr active Application Filing
- 2000-06-19 CA CA002375207A patent/CA2375207A1/fr not_active Abandoned
- 2000-06-19 CN CNB008087857A patent/CN1296384C/zh not_active Expired - Fee Related
- 2000-06-19 AU AU57178/00A patent/AU759203B2/en not_active Ceased
- 2000-06-19 JP JP2001505563A patent/JP2003503019A/ja active Pending
- 2000-06-19 EP EP00942575A patent/EP1185558A4/fr not_active Withdrawn
-
2002
- 2002-05-11 HK HK02103568.4A patent/HK1042307A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1355813A (zh) | 2002-06-26 |
| WO2000078805A1 (fr) | 2000-12-28 |
| AU5717800A (en) | 2001-01-09 |
| EP1185558A1 (fr) | 2002-03-13 |
| JP2003503019A (ja) | 2003-01-28 |
| CA2375207A1 (fr) | 2000-12-28 |
| HK1042307A1 (zh) | 2002-08-09 |
| EP1185558A4 (fr) | 2006-02-15 |
| CN1296384C (zh) | 2007-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |