JP2003206243A5 - - Google Patents
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- Publication number
- JP2003206243A5 JP2003206243A5 JP2002189244A JP2002189244A JP2003206243A5 JP 2003206243 A5 JP2003206243 A5 JP 2003206243A5 JP 2002189244 A JP2002189244 A JP 2002189244A JP 2002189244 A JP2002189244 A JP 2002189244A JP 2003206243 A5 JP2003206243 A5 JP 2003206243A5
- Authority
- JP
- Japan
- Prior art keywords
- release composition
- molecular weight
- composition according
- average molecular
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 22
- 238000013268 sustained release Methods 0.000 claims 22
- 239000012730 sustained-release form Substances 0.000 claims 22
- 229920000642 polymer Polymers 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 claims 10
- 239000013543 active substance Substances 0.000 claims 9
- 239000003960 organic solvent Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 4
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical class C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 201000010260 leiomyoma Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010057654 Breast cancer female Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 125000000030 D-alanine group Chemical group [H]N([H])[C@](C([H])([H])[H])(C(=O)[*])[H] 0.000 claims 1
- 125000002437 D-histidyl group Chemical group N[C@@H](C(=O)*)CC=1N=CNC1 0.000 claims 1
- 125000003301 D-leucyl group Chemical group N[C@@H](C(=O)*)CC(C)C 0.000 claims 1
- 125000000734 D-serino group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000002254 contraceptive effect Effects 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- 208000006155 precocious puberty Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 201000004240 prostatic hypertrophy Diseases 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 claims 1
- 201000007954 uterine fibroid Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002189244A JP3902518B2 (ja) | 2001-06-29 | 2002-06-28 | 徐放性組成物用乳酸−グリコール酸重合体の製造法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001199462 | 2001-06-29 | ||
| JP2001-199462 | 2001-06-29 | ||
| JP2001340980 | 2001-11-06 | ||
| JP2001-340980 | 2001-11-06 | ||
| JP2002189244A JP3902518B2 (ja) | 2001-06-29 | 2002-06-28 | 徐放性組成物用乳酸−グリコール酸重合体の製造法 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004004122A Division JP2004155792A (ja) | 2001-06-29 | 2004-01-09 | 徐放性組成物およびその製造法 |
| JP2004110135A Division JP5188670B2 (ja) | 2001-06-29 | 2004-04-02 | 徐放性組成物およびその製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003206243A JP2003206243A (ja) | 2003-07-22 |
| JP2003206243A5 true JP2003206243A5 (enExample) | 2004-12-16 |
| JP3902518B2 JP3902518B2 (ja) | 2007-04-11 |
Family
ID=27670190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002189244A Expired - Lifetime JP3902518B2 (ja) | 2001-06-29 | 2002-06-28 | 徐放性組成物用乳酸−グリコール酸重合体の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3902518B2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5188670B2 (ja) * | 2001-06-29 | 2013-04-24 | 武田薬品工業株式会社 | 徐放性組成物およびその製造法 |
| TW200613012A (en) * | 2004-07-02 | 2006-05-01 | Takeda Pharmaceuticals Co | Sustained-release composition, process for producing the same and use of the same |
| EP1716847B1 (en) | 2005-04-28 | 2008-01-02 | Nipro Corporation | Bioabsorbable pharmaceutical formulation comprising a PLGA copolymer |
| CA2750815C (en) * | 2009-02-09 | 2018-03-13 | Swetree Technologies Ab | Polymer shells |
| EP2985304B1 (en) | 2013-04-11 | 2024-08-14 | Mitsui Chemicals, Inc. | Method for manufacturing lactic acid-glycolic acid copolymer and method for manufacturing salt thereof |
-
2002
- 2002-06-28 JP JP2002189244A patent/JP3902518B2/ja not_active Expired - Lifetime
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