JP2003113027A5 - - Google Patents
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- Publication number
- JP2003113027A5 JP2003113027A5 JP2001311182A JP2001311182A JP2003113027A5 JP 2003113027 A5 JP2003113027 A5 JP 2003113027A5 JP 2001311182 A JP2001311182 A JP 2001311182A JP 2001311182 A JP2001311182 A JP 2001311182A JP 2003113027 A5 JP2003113027 A5 JP 2003113027A5
- Authority
- JP
- Japan
- Prior art keywords
- ophiopogon
- extract
- plant
- liliaceae
- melanocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930195210 Ophiopogon Natural products 0.000 claims description 56
- 210000002752 melanocyte Anatomy 0.000 claims description 37
- 239000000284 extract Substances 0.000 claims description 35
- 210000001787 dendrite Anatomy 0.000 claims description 25
- 239000003112 inhibitor Substances 0.000 claims description 19
- 241000234280 Liliaceae Species 0.000 claims description 13
- 241000196324 Embryophyta Species 0.000 claims description 11
- 239000002798 polar solvent Substances 0.000 claims description 9
- 239000002537 cosmetic Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 230000002087 whitening effect Effects 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 4
- 239000003708 ampul Substances 0.000 claims description 3
- 241001448424 Ophiopogon Species 0.000 claims 8
- 244000248557 Ophiopogon japonicus Species 0.000 description 58
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 12
- 240000002948 Ophiopogon intermedius Species 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 12
- 241001448355 Ophiopogon planiscapus Species 0.000 description 11
- 210000002540 macrophage Anatomy 0.000 description 11
- 239000000049 pigment Substances 0.000 description 10
- 230000005856 abnormality Effects 0.000 description 9
- 230000002401 inhibitory effect Effects 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 241000219051 Fagopyrum Species 0.000 description 6
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000008187 granular material Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000953634 Ophiopogon platyphyllus Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 241000659286 Ophiopogon chingii Species 0.000 description 2
- 241001520971 Ophiopogon clarkei Species 0.000 description 2
- 241001525476 Ophiopogon grandis Species 0.000 description 2
- 241000953633 Ophiopogon latifolius Species 0.000 description 2
- 241001525459 Ophiopogon tonkinensis Species 0.000 description 2
- 102000002508 Peptide Elongation Factors Human genes 0.000 description 2
- 108010068204 Peptide Elongation Factors Proteins 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 2
- 235000003385 Diospyros ebenum Nutrition 0.000 description 1
- 241000792913 Ebenaceae Species 0.000 description 1
- 241000237537 Ensis Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001448421 Ophiopogon jaburan Species 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- -1 acetonitrile Chemical compound 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000000622 liquid--liquid extraction Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001311182A JP3709363B2 (ja) | 2001-10-09 | 2001-10-09 | メラノサイトのデンドライトの伸長抑制剤及びそれを含有する化粧料 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001311182A JP3709363B2 (ja) | 2001-10-09 | 2001-10-09 | メラノサイトのデンドライトの伸長抑制剤及びそれを含有する化粧料 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003113027A JP2003113027A (ja) | 2003-04-18 |
| JP2003113027A5 true JP2003113027A5 (https=) | 2005-05-19 |
| JP3709363B2 JP3709363B2 (ja) | 2005-10-26 |
Family
ID=19130045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001311182A Expired - Fee Related JP3709363B2 (ja) | 2001-10-09 | 2001-10-09 | メラノサイトのデンドライトの伸長抑制剤及びそれを含有する化粧料 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3709363B2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1570837B1 (en) * | 2002-12-02 | 2013-09-11 | Pola Chemical Industries, Inc. | Dendrite elongation inhibitor for melanocyte and skin preparation for external use containing the same |
| US7795300B2 (en) | 2003-12-15 | 2010-09-14 | Kuraray Co., Ltd. | External preparation for skin |
| JP4250071B2 (ja) * | 2003-12-15 | 2009-04-08 | 株式会社クラレ | 皮膚外用剤 |
| EP2165694B8 (en) | 2007-05-29 | 2017-11-08 | Pola Chemical Industries Inc. | Vesicle useful for external preparation for skin, and external preparation for skin comprising the vesicle |
| MX339842B (es) * | 2009-12-22 | 2016-06-14 | Avon Prod Inc | Composiciones estimuladoras de paxilina y usos cosmeticos de las mismas. |
| US20110159125A1 (en) | 2009-12-29 | 2011-06-30 | Avon Products, Inc. | CGRP Compositions and Uses Thereof |
| KR101978145B1 (ko) * | 2011-11-25 | 2019-05-15 | (주)아모레퍼시픽 | 황금 추출물, 맥문동 추출물 및 차전자 추출물이 함유된 화장료 조성물 |
| JP5953108B2 (ja) * | 2012-05-14 | 2016-07-20 | ポーラ化成工業株式会社 | スクリーニング方法 |
| FR3158236A1 (fr) * | 2024-01-11 | 2025-07-18 | Mavilef Holdings Pte Ltd | Composition cosmétique pour éclaircir ou blanchir la peau |
-
2001
- 2001-10-09 JP JP2001311182A patent/JP3709363B2/ja not_active Expired - Fee Related
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