JP2003095961A - Skin beautifying promoter - Google Patents
Skin beautifying promoterInfo
- Publication number
- JP2003095961A JP2003095961A JP2001297314A JP2001297314A JP2003095961A JP 2003095961 A JP2003095961 A JP 2003095961A JP 2001297314 A JP2001297314 A JP 2001297314A JP 2001297314 A JP2001297314 A JP 2001297314A JP 2003095961 A JP2003095961 A JP 2003095961A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- skin beautifying
- decomposition product
- beautifying agent
- swallow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、経口摂取すること
により、肌の潤いを向上し、キメの細かな肌を得ること
ができる美肌促進剤に関する。TECHNICAL FIELD The present invention relates to a skin beautifying agent capable of improving moisturization of the skin and obtaining finely textured skin by ingestion.
【0002】[0002]
【従来の技術】肌荒れや小じわ等の肌のトラブルは、特
に女性にとって重大な問題である。皮膚組織において、
その保水性や弾力性に大きく関与している成分として、
ヒアルロン酸やコンドロイチン硫酸等の酸性ムコ多糖類
やコラーゲンが知られている。2. Description of the Related Art Skin troubles such as rough skin and fine wrinkles are serious problems especially for women. In skin tissue,
As a component that is greatly involved in its water retention and elasticity,
Known are acidic mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, and collagen.
【0003】上記酸性ムコ多糖類は高い保水性を有し、
細胞間物質マトリックスの支柱の役目を果たしているコ
ラーゲンと結合して、結合組織、軟骨組織や皮膚組織等
に多く分布し、細胞の機能や形態を維持するのに役立っ
ている。The above-mentioned acidic mucopolysaccharide has a high water retention property,
It binds to collagen, which functions as a pillar of the intercellular matrix, and is distributed in a large amount in connective tissue, cartilage tissue, skin tissue, etc., and serves to maintain the function and morphology of cells.
【0004】そして、加齢等により、これらの量が減少
すると皮膚の保水性や弾力性が失われてしまい、肌荒れ
や小じわ等の原因となる。When the amount of these decreases due to aging or the like, the water retention and elasticity of the skin are lost, causing rough skin and fine wrinkles.
【0005】したがって、肌荒れや小じわ等を予防・改
善するためには肌の潤いと張りを保持することが重要で
ある。Therefore, in order to prevent and improve skin roughness and fine wrinkles, it is important to maintain the moisture and tension of the skin.
【0006】従来、肌の保湿性や弾力性の維持効果を有
する様々な成分を配合した化粧品や美容健康食品が市販
されている。このような成分としては、例えば、上述し
たヒアルロン酸、コンドロイチン硫酸等のムコ多糖類
や、コラーゲン等のタンパク質、トレハロース、ソルビ
トール等の低分子糖類、ビタミン類、アミノ酸誘導体、
セラミド、α−オリザノール、精製ツバキ油等の油脂類
などが挙げられ、特に最近は安全性の高い天然由来の成
分が尊重される傾向がある。[0006] Conventionally, cosmetics and beauty health foods containing various components having a skin moisturizing property and elasticity maintaining effect are commercially available. Examples of such components include hyaluronic acid, mucopolysaccharides such as chondroitin sulfate described above, proteins such as collagen, trehalose, low-molecular-weight sugars such as sorbitol, vitamins, amino acid derivatives, and the like.
Examples thereof include ceramide, α-oryzanol, oils and fats such as refined camellia oil, and more recently, naturally derived ingredients having high safety tend to be respected.
【0007】具体的には、ヒアルロン酸とコンドロイチ
ン硫酸を含むムコ多糖類とコラーゲンと核酸とを含有す
ることを特徴とする美容健康食品(特開平10−165
138号)、活性酸素消去因子、抗アレルギー因子、皮
膚等改善因子、抗酸化因子を有する食品素材のいずれか
2種以上の混合物を主成分とする加工食品(特開平10
−70号)、コンキオリンもしくはその処理物からなる
食品(特開平8−173091号)、ムコ多糖とペプタ
イドとが結合した複合ムコ多糖を有する健康食品(特開
平9−98739号)、セラミドを含有する健康食品
(特開平11−113530号)等が挙げられる。Specifically, a beauty and health food characterized by containing mucopolysaccharide containing hyaluronic acid and chondroitin sulfate, collagen and nucleic acid (Japanese Patent Laid-Open No. 10-165).
No. 138), an active oxygen scavenging factor, an anti-allergic factor, a skin-improving factor, and an antioxidative factor.
-70), a food comprising conchiolin or a processed product thereof (JP-A-8-173091), a health food having a complex mucopolysaccharide in which a mucopolysaccharide and a peptide are bound (JP-A-9-98739), and a ceramide. Health food (JP-A-11-113530) and the like can be mentioned.
【0008】[0008]
【発明が解決しようとする課題】しかしながら、上記の
ような成分を配合した化粧品は、皮膚表面の保水性を高
めることはできるものの、その効果は一時的なものでし
かなく、根本的に皮膚の状態を改善するものではなかっ
た。However, although the cosmetics containing the above-mentioned components can increase the water retention on the skin surface, the effect is only temporary, and the effect on the skin is fundamentally increased. It did not improve the condition.
【0009】また、上記のような美容健康食品を摂取し
ても、その効果は必ずしも満足のいくものではなかっ
た。Further, even if the above beauty and health food is ingested, the effect is not always satisfactory.
【0010】したがって、本発明の目的は、経口摂取す
ることにより、皮膚の保水性を高め、しっとりとしたキ
メの細かな肌を得ることができる美肌促進剤を提供する
ことにある。Therefore, an object of the present invention is to provide a skin beautifying agent which, when orally ingested, enhances the water retention of the skin and makes it possible to obtain a moist and fine skin.
【0011】[0011]
【課題を解決するための手段】本発明者らは、上記目的
を達成するために鋭意研究した結果、燕窩の酵素分解物
を摂取することにより、肌にしっとり感がでて、落屑も
少なくなることを見出し、この知見に基づいて、本発明
を完成するに至った。Means for Solving the Problems As a result of intensive studies to achieve the above-mentioned object, the present inventors have found that the ingestion of the enzymatic decomposition product of the swallow pit gives the skin a moist feeling and less desquamation. Based on this finding, the present invention has been completed.
【0012】すなわち、本発明の美肌促進剤は、燕窩の
酵素分解物を有効成分として含有することを特徴とす
る。That is, the skin beautifying agent of the present invention is characterized by containing an enzyme decomposition product of a swallow as an active ingredient.
【0013】本発明においては、前記酵素分解物がプロ
テアーゼによる分解物であることが好ましい。In the present invention, it is preferable that the enzymatic decomposition product is a decomposition product by a protease.
【0014】また、前記酵素分解物の分子量が、2,0
00〜70,000であることが好ましい。The molecular weight of the enzymatic degradation product is 2,0.
It is preferably from 00 to 70,000.
【0015】本発明によれば、経口摂取することによ
り、皮膚の保水性を高め、しっとりとしたキメの細かな
肌を得ることができる美肌促進剤を提供できる。According to the present invention, it is possible to provide a skin beautifying agent capable of enhancing the water retention of the skin and obtaining a moist and fine skin by ingestion.
【0016】本発明の美肌促進剤は、更に、コラーゲン
及び/又はその酵素分解物を含有することが好ましい。
この態様によれば、コラーゲン及び/又はその酵素分解
物と燕窩の酵素分解物との相乗効果によって、美肌促進
効果をより高めることができる。The skin beautifying agent of the present invention preferably further contains collagen and / or an enzymatic decomposition product thereof.
According to this aspect, the synergistic effect of collagen and / or the enzymatic decomposition product thereof and the enzymatic decomposition product of the swallow can enhance the effect of promoting beautiful skin.
【0017】本発明の美肌促進剤は、更に、グルコサミ
ン、核酸、SOD様物質、SOD活性誘導物質、ラクト
フェリンから選ばれた少なくとも1種を含有することが
好ましい。この態様によれば、上記各成分と燕窩の酵素
分解物との相乗効果によって、更に美肌促進効果を高め
ることができる。The skin beautifying agent of the present invention preferably further contains at least one selected from glucosamine, nucleic acids, SOD-like substances, SOD activity inducers and lactoferrin. According to this aspect, the synergistic effect of each of the above-mentioned components and the enzymatic decomposition product of the calyx can further enhance the beautiful skin promoting effect.
【0018】本発明の美肌促進剤は、更に、乳酸菌、腸
球菌、酵母又は真菌を培養して得られる培養物を少なく
とも1種含有することが好ましい。この態様によれば、
上記各種微生物が産生する様々な生理活性物質、例えば
アミノ酸類、有機酸類、ビタミンB群、オリゴ糖類、ペ
プチドグリカン、核酸等との相乗効果によって、更に美
肌促進効果を高めることができる。The skin beautifying agent of the present invention preferably further contains at least one culture product obtained by culturing lactic acid bacteria, enterococci, yeasts or fungi. According to this aspect,
The synergistic effect with various physiologically active substances produced by the various microorganisms, such as amino acids, organic acids, vitamin B group, oligosaccharides, peptidoglycan, nucleic acid, etc., can further enhance the skin beautifying effect.
【0019】[0019]
【発明の実施の形態】燕窩は、アナツバメが自らの唾液
を糸状にして作る巣であり、その成分としては、糖タン
パク質を多く含み、脂質はほとんど含まれていない。BEST MODE FOR CARRYING OUT THE INVENTION The swallow is a nest in which swallows make their saliva into filaments, and its components contain a large amount of glycoproteins and almost no lipids.
【0020】一般に市販されている燕窩には、毛や糞等
の汚れを取り除いて洗浄しただけのものから、燕窩のク
ズを集めて漂白と洗浄を繰り返して成形したものまで、
様々な種類があるが、本発明で用いる燕窩は、前処理に
おいて過度の洗浄や漂白等が行われていない燕窩を用い
ることが好ましい。Generally, commercially available swallows, from those which are simply cleaned by removing dirt such as hair and feces, to those which are collected by collecting dust from the swallows and molded by repeating bleaching and washing,
Although there are various types, it is preferable to use the swallows used in the present invention that have not been excessively washed or bleached in the pretreatment.
【0021】本発明の美肌促進剤の有効成分である燕窩
の酵素分解物は、燕窩又はその処理物(例えば燕窩の水
抽出物)を、プロテアーゼやプロテアーゼを含む複合酵
素等を用いて分解することにより得ることができる。The enzymatic decomposition product of Tsubame, which is an active ingredient of the skin beautifying agent of the present invention, is obtained by decomposing Tsubame or a processed product thereof (for example, an aqueous extract of Tsubaki) with protease or a complex enzyme containing protease. Can be obtained by
【0022】燕窩の酵素分解物の調製は、例えば次のよ
うにして行なうことができる。すなわち、粉砕した燕窩
に、その質量の10〜50倍の水を加えて膨潤させた
後、60〜130℃で、5秒〜30分間加熱処理する。
その後、適量の酵素を添加して、酵素の至適pH、至適
温度で0.5〜48時間酵素反応を行なう。酵素反応終
了後、加熱処理等により酵素を失活させ、反応液を濾過
して不溶物を除去することにより、燕窩の酵素分解物を
得ることができる。また、この酵素分解物は、必要に応
じて乾燥して粉末化してもよい。なお、上記の各工程に
おいては、適宜pH調整、脱色、脱臭等の操作を行なっ
てもよい。The enzymatic decomposition product of the swallow can be prepared, for example, as follows. That is, 10 to 50 times the mass of water is added to the crushed swallow to swell it, and then heat treatment is performed at 60 to 130 ° C. for 5 seconds to 30 minutes.
Then, an appropriate amount of enzyme is added, and the enzyme reaction is performed at the optimum pH and the optimum temperature of the enzyme for 0.5 to 48 hours. After the completion of the enzymatic reaction, the enzyme is inactivated by heat treatment or the like, and the reaction solution is filtered to remove insoluble matter, whereby an enzymatic decomposition product of the swallow can be obtained. In addition, this enzymatic decomposition product may be dried and powdered if necessary. In each of the above steps, operations such as pH adjustment, decolorization, deodorization and the like may be appropriately performed.
【0023】一方、燕窩の水抽出物を酵素分解する場合
には、粒径2mm以下、好ましくは150μm以下に粉
砕した燕窩に、その質量の10〜100倍の水を加え
て、1〜60℃、0.5〜48時間静置又は撹拌して抽
出を行なった後、60〜130℃、5秒〜30分間加熱
処理し、必要に応じて濾過して得られた水抽出液を用い
て、上記と同様にして酵素処理すればよい。On the other hand, in the case of enzymatically decomposing the water extract of the swallow, 1 to 60 ° C. is added to the swallow crushed to a particle size of 2 mm or less, preferably 150 μm or less, by adding 10 to 100 times its mass of water. After standing still for 0.5 to 48 hours or stirring to perform extraction, heat treatment is performed at 60 to 130 ° C. for 5 seconds to 30 minutes, and if necessary, using a water extract obtained by filtration, The enzyme treatment may be performed in the same manner as above.
【0024】このようにして得られる燕窩の酵素分解物
の分子量は500〜200,000が好ましく、2,0
00〜70,000がより好ましい。The molecular weight of the enzyme-decomposed product of the calyx obtained in this manner is preferably 500 to 200,000,
More preferably, it is from 00 to 70,000.
【0025】上記のようにして得られた燕窩の酵素分解
物は、そのまま本発明の美肌促進剤として用いることが
できる。また、更に賦形剤、甘味料、香料、着色料等を
添加して顆粒状、錠剤、カプセル剤等にすることもでき
る。The enzyme-decomposed product of the calyx obtained as described above can be used as it is as the skin beautifying agent of the present invention. Further, excipients, sweeteners, flavors, colorants and the like can be further added to give granules, tablets, capsules and the like.
【0026】本発明の美肌促進剤の有効摂取量は、燕窩
の酵素分解物(乾物換算)として10〜5,000mg
/1人1日である。したがって、本発明の美肌促進剤に
おける上記燕窩の酵素分解物の含有量は、該酵素分解物
を乾物換算で、1日当り10〜5,000mg摂取でき
るように含むことが好ましく、50〜500mg摂取で
きるように含むことがより好ましい。The effective ingestion amount of the skin beautifying agent of the present invention is 10 to 5,000 mg as an enzyme decomposition product (converted to dry matter) of the swallow.
/ One person a day. Therefore, the content of the enzyme decomposed product of the above-mentioned crevice in the skin beautifying agent of the present invention is preferably such that the enzyme decomposed product can be ingested in an amount of 10 to 5,000 mg / day in terms of dry matter, and 50 to 500 mg can be ingested. Is more preferable.
【0027】また、本発明の美肌促進剤は、更にコラー
ゲン及び/又はその酵素分解物を含有することが好まし
い。コラーゲンは、飲食品に使用可能な品質のものであ
れば特に制限なく用いることができる。消化、吸収性の
点からコラーゲンの酵素分解物がより好ましく用いられ
る。コラーゲンの酵素分解物は、コラーゲンをプロテア
ーゼ等の酵素で分解することにより調製できる。酵素分
解の条件は、特に制限はなく、使用する酵素の至適p
H、至適温度で酵素反応を行なえばよい。なお、市販の
コラーゲンの酵素分解物を用いてもよく、例えば「水溶
性コラーゲンペプチドPA」(商品名、協和発酵工業
(株)社製)等を用いることができる。The skin beautifying agent of the present invention preferably further contains collagen and / or an enzymatic decomposition product thereof. Collagen can be used without particular limitation as long as it has a quality that can be used for food and drink. From the viewpoint of digestion and absorbability, enzymatic degradation products of collagen are more preferably used. The enzymatic decomposition product of collagen can be prepared by decomposing collagen with an enzyme such as protease. The conditions for enzymatic degradation are not particularly limited, and the optimum p of the enzyme used is
It suffices to carry out the enzymatic reaction at H at an optimum temperature. Commercially available enzymatic degradation products of collagen may be used, and for example, “water-soluble collagen peptide PA” (trade name, manufactured by Kyowa Hakko Kogyo Co., Ltd.) and the like can be used.
【0028】本発明の美肌促進剤におけるコラーゲン
(乾物換算)の含有量は、1日当り0.1〜10g、よ
り好ましくは1〜6g摂取できるように含むことが好ま
しい。The content of collagen (as dry matter) in the skin beautifying agent of the present invention is preferably 0.1 to 10 g, and more preferably 1 to 6 g per day.
【0029】コラーゲンは、従来より、美容健康食品に
用いられており、燕窩の酵素分解物と併用することによ
り、相乗的な美肌効果が期待できる。Collagen has been conventionally used in beauty and health foods, and a synergistic skin beautifying effect can be expected when it is used in combination with an enzymatic decomposition product of the swallow.
【0030】更に、本発明の美肌促進剤は、グルコサミ
ン、核酸、SOD様物質、SOD活性誘導物質、ラクト
フェリンから選ばれた少なくとも1種を含有していても
よい。Furthermore, the skin beautifying agent of the present invention may contain at least one selected from glucosamine, nucleic acids, SOD-like substances, SOD activity inducers and lactoferrin.
【0031】グルコサミンは、天然のアミノ糖で、動物
体内における軟骨や結合組織等のムコ多糖類の構成成分
として広く分布しており、燕窩の酵素分解物と併用する
ことにより、相乗的な美肌効果が期待できる。Glucosamine is a natural amino sugar, which is widely distributed as a constituent component of mucopolysaccharides such as cartilage and connective tissue in the body of an animal, and when used in combination with an enzymatic decomposition product of the pit, synergistic skin beautiful effects are obtained. Can be expected.
【0032】本発明の美肌促進剤におけるグルコサミン
(乾物換算)の含有量は、1日当り0.5g以上、より
好ましくは1.0〜2.0g摂取できるように含むこと
が好ましい。The content of glucosamine (as dry matter) in the skin beautifying agent of the present invention is preferably 0.5 g or more per day, more preferably 1.0 to 2.0 g.
【0033】核酸は、一般に食品に使用されているもの
であれば特に制限なく用いることができ、例えば、鮭等
の白子由来の核蛋白を酸、アルカリ分解又は酵素処理し
たもの(例えば、商品名「DNA na」、日産化学工
業(株)社製)、ビール酵母由来の核蛋白を酸、アルカ
リ分解したもの(例えば、商品名「酵母リボ核酸」、キ
リンビール(株)社製)等が挙げられる。The nucleic acid can be used without particular limitation as long as it is one generally used in foods. For example, a nuclear protein derived from white salmon such as salmon is treated with acid, alkali or enzyme (for example, trade name). "DNA na", manufactured by Nissan Chemical Industries, Ltd.), a brewer's yeast-derived nuclear protein that is decomposed with an acid and an alkali (for example, trade name "yeast ribonucleic acid", manufactured by Kirin Brewery Co., Ltd.) and the like. To be
【0034】核酸には、肌の老化防止効果があることが
知られており、燕窩の酵素分解物と併用することによ
り、相乗的な美肌効果が期待できる。Nucleic acid is known to have a skin anti-aging effect, and a synergistic skin beautifying effect can be expected by using it in combination with an enzyme decomposition product of the pit.
【0035】本発明の美肌促進剤における核酸(乾物換
算)の含有量は、1日当り0.5〜2.0g、より好ま
しくは1.0〜1.5g摂取できるように含むことが好
ましい。The content of nucleic acid (as dry matter) in the skin beautifying agent of the present invention is preferably 0.5 to 2.0 g, more preferably 1.0 to 1.5 g per day.
【0036】SOD様物質とは、スーパーオキサイドデ
スムターゼ様活性を有する抗酸化物質をいい、例えばβ
−カロチン、ビタミンE、ビタミンC等が挙げられる。The SOD-like substance means an antioxidant substance having a superoxide desmutase-like activity, for example, β
-Carotene, vitamin E, vitamin C and the like.
【0037】また、SOD活性誘導物質とは、摂取する
ことにより、生体内のSOD様活性を高める作用を有す
る物質をいい、例えばメロンの抽出エキスを原料とした
「オキシカイン」(商品名、販売元:コンビ株式会社)
等が挙げられる。Further, the SOD activity inducer means a substance having an action of enhancing SOD-like activity in the living body by ingestion, and for example, "oxycaine" (trade name, sold by an extract of melon) is used as a raw material. : Combi Corporation)
Etc.
【0038】SOD様物質やSOD活性誘導物質を摂取
することにより、生体内で発生するフリーラジカルを消
去できるので、燕窩の酵素分解物と併用することによ
り、相乗的な美肌効果が期待できる。By ingesting an SOD-like substance or an SOD activity inducer, free radicals generated in the living body can be eliminated. Therefore, when used in combination with the enzymatic decomposition product of the swallow, a synergistic skin-beautifying effect can be expected.
【0039】本発明の美肌促進剤におけるSOD様物質
の含有量は、例えば、β−カロチンの場合は1日当り1
0mg以上、より好ましくは15〜30mg摂取できる
ように含むことが好ましい。また、ビタミンEの場合は
1日当り100〜1,000mg、より好ましくは30
0〜700mg摂取できるように含むことが好ましい。
また、ビタミンCの場合は1日当り50〜3,000m
g、より好ましくは100〜2,000mg摂取できる
ように含むことが好ましい。The content of the SOD-like substance in the skin beautifying agent of the present invention is, for example, in the case of β-carotene, 1 per day.
It is preferably contained so that 0 mg or more, more preferably 15 to 30 mg can be ingested. Further, in the case of vitamin E, 100 to 1,000 mg per day, more preferably 30
It is preferably contained so that 0 to 700 mg can be ingested.
In the case of vitamin C, 50 to 3,000m per day
g, more preferably 100 to 2,000 mg so that it can be ingested.
【0040】また、本発明の美肌促進剤におけるSOD
活性誘導物質の含有量は、1日当り5〜1,000m
g、より好ましくは100〜500mg摂取できるよう
に含むことが好ましい。The SOD in the skin beautifying agent of the present invention
Content of activity inducer is 5-1,000m per day
g, more preferably 100 to 500 mg so that it can be ingested.
【0041】ラクトフェリンは、哺乳類の乳汁等に含ま
れている分子量約8万の鉄結合性糖蛋白である。ラクト
フェリンは、経口摂取することにより皮膚をしっとりと
させる効果を有しており、燕窩の酵素分解物と併用する
ことにより、相乗的な美肌効果が期待できる。Lactoferrin is an iron-binding glycoprotein having a molecular weight of about 80,000 contained in milk of mammals. Lactoferrin has an effect of moisturizing the skin when orally ingested, and a synergistic skin beautifying effect can be expected by using it in combination with an enzymatic decomposition product of the swallow.
【0042】本発明の美肌促進剤におけるラクトフェリ
ン(乾物換算)の含有量は、1日当り0.5g以上、よ
り好ましくは1〜1.5g摂取できるように含むことが
好ましい。The content of lactoferrin (on a dry matter basis) in the skin beautifying agent of the present invention is preferably 0.5 g or more per day, more preferably 1 to 1.5 g.
【0043】更にまた、本発明の美肌促進剤は、乳酸
菌、腸球菌、酵母又は真菌を培養して得られる培養物を
少なくとも1種含有していてもよい。Furthermore, the skin beautifying agent of the present invention may contain at least one culture product obtained by culturing lactic acid bacteria, enterococci, yeasts or fungi.
【0044】上記乳酸菌としては、Lactobacillus bulg
aricus、Lactobacillus casei、Lactobacillus acidoph
ilus、Lactobacillus lactis、Streptococcus thermoph
ilus等が好ましい。上記腸球菌としては、Enterococcus
faecalis等が好ましい。上記酵母としては、Saccharom
yces serevisiae等が好ましい。上記真菌としては、Asp
ergills oryzae、Aspergills sojae等が好ましい。Examples of the lactic acid bacteria include Lactobacillus bulg
aricus , Lactobacillus casei , Lactobacillus acidoph
ilus , Lactobacillus lactis , Streptococcus thermoph
ilus and the like are preferred. The Enterococcus is Enterococcus
faecalis and the like are preferable. As the above yeast, Saccharom
yces serevisiae and the like are preferable. As the above fungus, Asp
ergills oryzae , Aspergills sojae and the like are preferable.
【0045】また、上記微生物を培養する培地として
は、例えば以下のような培地が挙げられる。Further, examples of the medium for culturing the above-mentioned microorganism include the following mediums.
【0046】乳酸菌又は腸球菌を培養する培地として
は、例えば酵母エキス0.5質量%、ブドウ糖1質量
%、ポリペプトン1質量%を含む培地が好ましく挙げら
れる。The medium for culturing lactic acid bacteria or enterococci is preferably a medium containing 0.5% by mass of yeast extract, 1% by mass of glucose and 1% by mass of polypeptone.
【0047】酵母を培養する培地としては、例えば米浸
出液20質量%、酵母エキス0.5質量%を含む培地が
好ましく挙げられる。As a medium for culturing yeast, for example, a medium containing 20% by mass of rice leachate and 0.5% by mass of yeast extract is preferable.
【0048】真菌を培養する培地としては、例えば馬鈴
薯浸出液20質量%、ブドウ糖2質量%、酵母エキス
0.5質量%を含む培地が好ましく挙げられる。As a medium for culturing a fungus, for example, a medium containing 20% by mass of potato leachate, 2% by mass of glucose and 0.5% by mass of yeast extract is preferable.
【0049】なお、上記の馬鈴薯浸出液は、皮を剥いた
馬鈴薯20〜100gをすりおろし、これに水を加えて
1時間煮沸して布で濾した後、水を加えて1,000m
Lとしたものである。また、米浸出液は、米20gに水
を加えて1時間煮沸して布で濾した後、水を加えて1,
000mLとしたものである。The potato leachate described above was grated from 20 to 100 g of peeled potatoes, water was added to this, and the mixture was boiled for 1 hour and strained with a cloth, and then water was added to 1,000 m.
This is L. The rice leachate was prepared by adding water to 20 g of rice, boiling it for 1 hour, filtering it with a cloth, and then adding water.
It is set to 000 mL.
【0050】本発明においては、上記のような培地を用
いて、各微生物を培養した培養液を殺菌、濾過した後、
適宜濃縮したもの、あるいはそれを乾燥、粉末化したも
の等を用いることができる。このような微生物の培養物
には、様々な生理活性物質、例えばアミノ酸類、有機酸
類、ビタミンB群、オリゴ糖類(ガラクトオリゴ糖、フ
ラクトオリゴ糖等)、ペプチドグリカン、核酸等が含ま
れており、燕窩の酵素分解物と併用することにより、相
乗的な美肌促進効果が期待できる。なお、培養条件は、
培養する微生物に応じて適宜を設定すればよい。In the present invention, the culture medium in which each microorganism is cultured is sterilized and filtered using the above-mentioned medium,
It is possible to use an appropriately concentrated product, or a product obtained by drying or powdering it. Such a microorganism culture contains various physiologically active substances such as amino acids, organic acids, vitamin B group, oligosaccharides (galacto-oligosaccharides, fructooligosaccharides, etc.), peptidoglycan, nucleic acids, etc. When used in combination with an enzymatic degradation product, a synergistic effect of promoting beautiful skin can be expected. The culture conditions are
It may be set appropriately according to the microorganism to be cultured.
【0051】本発明の美肌促進剤における上記培養物
(乾物換算)の含有量は、1日当り10g以上、より好
ましくは20〜40g摂取できるように含むことが好ま
しい。The content of the above culture (dry matter conversion) in the skin beautifying agent of the present invention is preferably 10 g or more, more preferably 20 to 40 g per day.
【0052】本発明の美肌促進剤は、医薬品、栄養補助
食品等としてそのまま摂取してもよく、あるいは飲料、
ゼリー、グミ、キャンディー、ガム、スナック菓子、焼
き菓子、レトルト食品、インスタント食品等の様々な飲
食品に添加して摂取してもよい。The skin beautifying agent of the present invention may be taken as it is as a drug, a dietary supplement, or a beverage,
It may be ingested by adding it to various foods and drinks such as jelly, gummy candy, candy, gum, snacks, baked goods, retort foods and instant foods.
【0053】本発明の美肌促進剤の飲食品への好ましい
添加量は、飲食品1食分当り、燕窩の酵素分解物を乾物
換算で10〜5,000mgであり、より好ましくは5
0〜500mgである。The amount of the skin beautifying agent of the present invention to be added to the food or drink is preferably 10 to 5,000 mg, in terms of dry matter, of the enzyme decomposition product of the swallow pit per serving of the food or drink, and more preferably 5.
It is 0 to 500 mg.
【0054】飲食品への燕窩の酵素分解物の添加量が上
記範囲外であると、充分な美肌効果が得られなかった
り、コスト的に高くなりすぎてしまうといった問題があ
る。If the amount of the enzyme-decomposed product of Tsubame to the food or drink is out of the above range, there is a problem that a sufficient skin beautifying effect cannot be obtained or the cost becomes too high.
【0055】[0055]
【実施例】以下、実施例を挙げて本発明を具体的に説明
する。EXAMPLES The present invention will be specifically described below with reference to examples.
【0056】実施例
市販の無漂白の燕窩を粉砕機で粉砕して、100メッシ
ュパス(粒径150μm以下)の燕窩粉末を得、この燕
窩粉末に、約50倍量(質量)の水を加えて5℃で3〜
24時間膨潤させた後、121℃、15分間加熱処理し
た。Example Commercially available unbleached swallows were crushed by a crusher to obtain a swallow powder of 100 mesh pass (particle size 150 μm or less), and about 50 times (mass) amount of water was added to this swallow powder. 3 at 5 ℃
After swelling for 24 hours, it was heat-treated at 121 ° C. for 15 minutes.
【0057】この処理液を冷却した後、pHを調整し、
燕窩粉末に対して2質量%の量のプロテアーゼ含有酵素
(商品名「パンクレアチンF」、天野製薬(株)製)を
添加して、45℃で3時間反応させた。After cooling this treatment liquid, the pH was adjusted,
2% by mass of protease-containing enzyme (trade name "Pancreatin F", manufactured by Amano Pharmaceutical Co., Ltd.) was added to the swallow powder, and the mixture was reacted at 45 ° C for 3 hours.
【0058】この反応液をpH7.0に調整し、90℃
で5分間加熱して酵素を失活させた後、濾過して濾液を
回収した。この濾液を濃縮後、凍結乾燥して、燕窩の酵
素分解物を得た。The pH of this reaction solution was adjusted to 7.0 and the temperature was adjusted to 90 ° C.
The mixture was heated for 5 minutes to deactivate the enzyme, and then filtered to collect the filtrate. After concentrating this filtrate, it was freeze-dried to obtain an enzymatic decomposition product of a swallow.
【0059】試験例
・被験サンプル:実施例で得られた燕窩の酵素分解物
24質量%と、その他賦形剤等を含有する顆粒状製剤
(1.5g/1包)
実施例で得られた燕窩の酵素分解物24質量%と、コ
ラーゲンの酵素分解物42.94質量%と、その他賦形
剤等を含有する顆粒状製剤(1.5g/1包)
コラーゲンの酵素分解物42.94質量%と、その他
賦形剤等を含有する顆粒状製剤(1.5g/1包)
なお、上記コラーゲンの酵素分解物としては、「水溶性
コラーゲンペプチドPA」(商品名、協和発酵工業
(株)社製)を用いた。また、各被験サンプルは、賦形
剤等として、還元麦芽糖水飴、デキストリン、ステビ
ア、リン酸カルシウムを同比率で含み、質量の調整には
エリスリトールを使用した。Test Example / Test Sample: Granular preparation (1.5 g / pack) containing 24% by mass of the enzymatic decomposition product of the swallow obtained in the Example and other excipients, etc. Obtained in the Example Granule-shaped preparation (1.5 g / pack) containing 24% by mass of enzymatic decomposition product of swallow, 42.94% by mass of enzymatic decomposition product of collagen, and 42.94% by mass of enzymatic decomposition product of collagen %, And a granular preparation containing 1.5% and other excipients (1.5 g / pack) As the enzymatic decomposition product of collagen, "water-soluble collagen peptide PA" (trade name, Kyowa Hakko Kogyo Co., Ltd.) (Manufactured by the company) was used. In addition, each test sample contained reduced maltose syrup, dextrin, stevia, and calcium phosphate in the same proportion as an excipient, and erythritol was used for adjusting the mass.
【0060】・試験方法:20〜50代の健常な女性9
名を、試験群1(燕窩の酵素分解物投与群)、試験群2
(燕窩の酵素分解物+コラーゲンの酵素分解物投与
群)、比較群(コラーゲンの酵素分解物投与群)に分
け、各被験サンプルを4包/日(6g/日)56日間連
続で摂取してもらった。Test method: healthy women in their 20s to 50s 9
Names are Test Group 1 (enzyme hydrolyzate administration group of Tsubame), Test Group 2
The test sample was divided into (enzyme-decomposed product of swallows + enzyme-decomposed product of collagen) and comparative group (enzyme-decomposed product of collagen), and each test sample was ingested continuously for 4 days / pack (6 g / day) for 56 days. received.
【0061】・評価方法:被験者の皮膚表面のレプリカ
を、試験開始前(T0)、試験終了時(T2)にそれぞ
れ採取した。なお、レプリカの採集は、レプリカ採取キ
ット
・デルモテスト「DIAGNOSKIN」(商品名、B
IO−ECラボラトリー社製)を用いて、各被験者によ
り行なってもらった。具体的には、円形の粘着部を有す
るデルモテスト薄片を、前腕内側部の皮膚の表面に約3
0秒間軽く圧着して、該粘着部に皮膚表面のレプリカを
採取した。Evaluation method: A replica of the skin surface of the subject was collected before the start of the test (T0) and at the end of the test (T2). In addition, the replica collection is based on the replica collection kit Dermotest "DIAGNOSKIN" (brand name, B
IO-EC Laboratory Co., Ltd.). Specifically, a Delmotest thin piece with a circular adhesive part was applied to the surface of the skin on the inner part of the forearm for about 3 times.
Lightly pressure-bonded for 0 seconds, and a replica of the skin surface was collected on the adhesive portion.
【0062】各レプリカを光学顕微鏡によって検査、写
真撮影し、表1に示す評価基準に基づいて、これらのレ
プリカの評価を行なった。この評価基準は、BIO−E
Cラボラトリー社のデータベースに基いて点数化したも
のである。Each replica was inspected and photographed with an optical microscope, and these replicas were evaluated based on the evaluation criteria shown in Table 1. This evaluation standard is BIO-E.
It is a score based on the database of C Laboratory.
【0063】[0063]
【表1】 [Table 1]
【0064】その結果を表2に示す。なお、表中のスコ
アーは、点数が高いほど皮膚の保湿度が高く、皮膚の状
態が良好であることを意味し、点数が低いほど皮膚の乾
燥度が高く、皮膚の状態が悪いことを意味する。The results are shown in Table 2. The score in the table means that the higher the score, the higher the moisture retention of the skin and the better the skin condition, and the lower the score, the higher the dryness of the skin and the poorer skin condition. To do.
【0065】[0065]
【表2】 [Table 2]
【0066】表2の結果から、試験群1、試験群2は、
比較群に比べて、皮膚の状態が改善される傾向があるこ
とが分かる。特に、燕窩の酵素分解物及びコラーゲンの
酵素分解物を摂取した試験群2においては、皮膚の状態
の改善の度合いが大きいことが分かる。From the results of Table 2, the test groups 1 and 2 are
It can be seen that the skin condition tends to be improved as compared with the comparison group. In particular, it can be seen that the degree of improvement of the skin condition is large in the test group 2 ingesting the enzymatic decomposition product of the swallow and the enzymatic decomposition product of collagen.
【0067】また、各被験者の皮膚のレプリカの光学顕
微鏡写真を図1〜9に示す。図1〜3は試験群1、図4
〜6は試験群2、図7〜9は比較群のものである。な
お、(a)は試験前(T0)のレプリカ、(b)は試験
終了時(T2)のレプリカである。Optical micrographs of a skin replica of each subject are shown in FIGS. 1 to 3 are test group 1 and FIG.
6 to 6 are for the test group 2 and FIGS. 7 to 9 are for the comparison group. In addition, (a) is a replica before the test (T0), and (b) is a replica at the end of the test (T2).
【0068】図1〜6(試験群1、2)においては、試
験前の状態に比べて試験終了時の状態の方が、落屑が減
少しており、皮膚の状態が改善されていることが分か
る。一方、図7〜9(比較群)においては、試験前の状
態と試験終了時の状態にほとんど変化が認められないこ
とが分かる。In FIGS. 1 to 6 (test groups 1 and 2), the state at the end of the test had less desquamation and the skin condition was improved compared to the state before the test. I understand. On the other hand, in FIGS. 7 to 9 (comparative group), it can be seen that almost no change is observed between the state before the test and the state at the end of the test.
【0069】[0069]
【発明の効果】以上説明したように本発明によれば、燕
窩の酵素分解物を有効成分として含有させることによ
り、皮膚の潤いを向上させ、しっとりとしたキメの細か
な肌を得ることのできる美肌促進剤を提供できる。As described above, according to the present invention, it is possible to improve the moisturization of the skin and to obtain a moist and fine skin by containing the enzymatic decomposition product of the swallow pit as an active ingredient. A skin beautifying agent can be provided.
【図1】被験者No.1の皮膚のレプリカの顕微鏡写真
を示す図である。1] Subject No. It is a figure which shows the microscope picture of the replica of 1 skin.
【図2】被験者No.2の皮膚のレプリカの顕微鏡写真
を示す図である。2] Subject No. It is a figure which shows the microscope picture of the replica of the skin of 2.
【図3】被験者No.3の皮膚のレプリカの顕微鏡写真
を示す図である。3] Subject No. It is a figure which shows the microscope picture of the replica of the skin of FIG.
【図4】被験者No.4の皮膚のレプリカの顕微鏡写真
を示す図である。4] Subject No. 4 is a view showing a micrograph of a skin replica of FIG.
【図5】被験者No.5の皮膚のレプリカの顕微鏡写真
を示す図である。5] Subject No. 5 is a view showing a micrograph of a skin replica of FIG.
【図6】被験者No.6の皮膚のレプリカの顕微鏡写真
を示す図である。6] Subject No. 6 is a view showing a micrograph of a skin replica of No. 6; FIG.
【図7】被験者No.7の皮膚のレプリカの顕微鏡写真
を示す図である。7] Subject No. It is a figure which shows the micrograph of the replica of the skin of FIG.
【図8】被験者No.8の皮膚のレプリカの顕微鏡写真
を示す図である。FIG. 8: Subject No. 8 is a view showing a micrograph of a skin replica of FIG.
【図9】被験者No.9の皮膚のレプリカの顕微鏡写真
を示す図である。9] Subject No. FIG. 9 shows a micrograph of a skin replica of No. 9.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 FI テーマコート゛(参考) A61K 35/70 A61K 35/70 35/72 35/72 35/74 35/74 G 38/16 45/00 38/17 A61P 17/16 45/00 A61K 37/12 A61P 17/16 37/14 Fターム(参考) 4B018 LB08 LB10 MD20 MD23 MD27 MD44 MD69 MD80 MD81 MD85 ME14 MF12 4C084 AA02 AA19 AA22 BA43 MA02 MA52 NA14 ZA891 4C086 AA01 AA02 EA02 EA16 MA03 MA52 NA14 ZA89 4C087 AA01 AA02 BB33 BC01 BC11 BC55 MA02 MA52 NA14 ZA89─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. 7 Identification code FI theme code (reference) A61K 35/70 A61K 35/70 35/72 35/72 35/74 35/74 G 38/16 45/00 38/17 A61P 17/16 45/00 A61K 37/12 A61P 17/16 37/14 F term (reference) 4B018 LB08 LB10 MD20 MD23 MD27 MD44 MD69 MD80 MD81 MD85 ME14 MF12 4C084 AA02 AA19 AA22 BA43 MA02 MA52 NA14 ZA891 4C086 AA01 AA02 EA02 EA16 MA03 MA52 NA14 ZA89 4C087 AA01 AA02 BB33 BC01 BC11 BC55 MA02 MA52 NA14 ZA89
Claims (6)
することを特徴とする美肌促進剤。1. A skin beautifying agent comprising an enzyme decomposition product of a swallow as an active ingredient.
解物である、請求項1に記載の美肌促進剤。2. The skin beautifying agent according to claim 1, wherein the enzymatic decomposition product is a decomposition product of a protease.
〜70,000である、請求項1又は2に記載の美肌促
進剤。3. The enzymatic decomposition product has a molecular weight of 2,000.
The skin beautifying agent according to claim 1 or 2, which is ˜70,000.
解物を含有する、請求項1〜3のいずれか一つに記載の
美肌促進剤。4. The skin beautifying agent according to claim 1, further comprising collagen and / or an enzymatic decomposition product thereof.
質、SOD活性誘導物質、ラクトフェリンから選ばれた
少なくとも1種を含有する、請求項1〜4のいずれか一
つに記載の美肌促進剤。5. The skin beautifying agent according to claim 1, further comprising at least one selected from glucosamine, nucleic acid, SOD-like substance, SOD activity inducer, and lactoferrin.
培養して得られる培養物を少なくとも1種含有する、請
求項1〜5のいずれか一つに記載の美肌促進剤。6. The skin beautifying agent according to claim 1, further comprising at least one culture product obtained by culturing lactic acid bacteria, enterococci, yeasts or fungi.
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JP2001297314A JP4976629B2 (en) | 2001-09-27 | 2001-09-27 | Skin promotion agent |
KR1020020055132A KR100894528B1 (en) | 2001-09-27 | 2002-09-11 | Skin care agent |
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JP2001297314A JP4976629B2 (en) | 2001-09-27 | 2001-09-27 | Skin promotion agent |
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JP2003095961A true JP2003095961A (en) | 2003-04-03 |
JP4976629B2 JP4976629B2 (en) | 2012-07-18 |
Family
ID=19118418
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JP2001297314A Expired - Lifetime JP4976629B2 (en) | 2001-09-27 | 2001-09-27 | Skin promotion agent |
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CN107348294B (en) * | 2017-07-08 | 2020-09-04 | 广州富诺营养科技有限公司 | Cubilose collagen solid beverage and preparation method thereof |
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Also Published As
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KR100894528B1 (en) | 2009-04-22 |
JP4976629B2 (en) | 2012-07-18 |
KR20030027666A (en) | 2003-04-07 |
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