JP2002543825A5 - - Google Patents
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- JP2002543825A5 JP2002543825A5 JP2000618312A JP2000618312A JP2002543825A5 JP 2002543825 A5 JP2002543825 A5 JP 2002543825A5 JP 2000618312 A JP2000618312 A JP 2000618312A JP 2000618312 A JP2000618312 A JP 2000618312A JP 2002543825 A5 JP2002543825 A5 JP 2002543825A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- pdz
- clasp
- peptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 102000004169 proteins and genes Human genes 0.000 description 30
- 108090000623 proteins and genes Proteins 0.000 description 30
- 108090000765 processed proteins & peptides Proteins 0.000 description 25
- 238000000034 method Methods 0.000 description 24
- -1 Clasp-2 Proteins 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 11
- 102000000470 PDZ domains Human genes 0.000 description 10
- 108050008994 PDZ domains Proteins 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 10
- 229920001184 polypeptide Polymers 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- 102100038077 CD226 antigen Human genes 0.000 description 8
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 description 8
- 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 description 6
- 102100032912 CD44 antigen Human genes 0.000 description 6
- 102100035793 CD83 antigen Human genes 0.000 description 6
- 102100031597 Dedicator of cytokinesis protein 2 Human genes 0.000 description 6
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 6
- 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 description 6
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 6
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 6
- 101000866237 Homo sapiens Dedicator of cytokinesis protein 2 Proteins 0.000 description 6
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 6
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 description 6
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 6
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 6
- 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 6
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 description 6
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 6
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 6
- 239000003112 inhibitor Substances 0.000 description 6
- 108010078791 Carrier Proteins Proteins 0.000 description 5
- 210000004899 c-terminal region Anatomy 0.000 description 4
- 108700019745 Disks Large Homolog 4 Proteins 0.000 description 3
- 102100024099 Disks large homolog 1 Human genes 0.000 description 3
- 102100022264 Disks large homolog 4 Human genes 0.000 description 3
- 101001053984 Homo sapiens Disks large homolog 1 Proteins 0.000 description 3
- 101000951365 Homo sapiens Disks large-associated protein 5 Proteins 0.000 description 3
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 230000008827 biological function Effects 0.000 description 3
- 101150069842 dlg4 gene Proteins 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 102100027123 55 kDa erythrocyte membrane protein Human genes 0.000 description 2
- 102100036514 Amyloid-beta A4 precursor protein-binding family A member 1 Human genes 0.000 description 2
- 108700006830 Drosophila Antp Proteins 0.000 description 2
- 101000928690 Homo sapiens Amyloid-beta A4 precursor protein-binding family A member 1 Proteins 0.000 description 2
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 description 2
- 108050007394 Kinesin-like protein KIF20B Proteins 0.000 description 2
- 102100035772 Regulator of G-protein signaling 12 Human genes 0.000 description 2
- 101710148337 Regulator of G-protein signaling 12 Proteins 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 101710192266 Tegument protein VP22 Proteins 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 230000003172 anti-dna Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000009918 complex formation Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 2
- 239000000816 peptidomimetic Substances 0.000 description 2
- 101100152504 Arabidopsis thaliana TAX2 gene Proteins 0.000 description 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 1
- 101000907578 Homo sapiens Forkhead box protein M1 Proteins 0.000 description 1
- 101001005128 Homo sapiens LIM domain kinase 1 Proteins 0.000 description 1
- 101000620894 Homo sapiens Lysophosphatidic acid phosphatase type 6 Proteins 0.000 description 1
- 101000590691 Homo sapiens MAGUK p55 subfamily member 2 Proteins 0.000 description 1
- 101001018294 Homo sapiens Microtubule-associated serine/threonine-protein kinase 3 Proteins 0.000 description 1
- 101001018298 Homo sapiens Microtubule-associated serine/threonine-protein kinase 4 Proteins 0.000 description 1
- 101001113469 Homo sapiens Partitioning defective 6 homolog alpha Proteins 0.000 description 1
- 101000922137 Homo sapiens Peripheral plasma membrane protein CASK Proteins 0.000 description 1
- 101001135804 Homo sapiens Protein tyrosine phosphatase receptor type C-associated protein Proteins 0.000 description 1
- 101000867413 Homo sapiens Segment polarity protein dishevelled homolog DVL-1 Proteins 0.000 description 1
- 102100029874 Kappa-casein Human genes 0.000 description 1
- 102100026023 LIM domain kinase 1 Human genes 0.000 description 1
- 102100032498 MAGUK p55 subfamily member 2 Human genes 0.000 description 1
- 102100033251 Microtubule-associated serine/threonine-protein kinase 3 Human genes 0.000 description 1
- 102100033252 Microtubule-associated serine/threonine-protein kinase 4 Human genes 0.000 description 1
- 102100023711 Partitioning defective 6 homolog alpha Human genes 0.000 description 1
- 102100036937 Protein tyrosine phosphatase receptor type C-associated protein Human genes 0.000 description 1
- 102100032758 Segment polarity protein dishevelled homolog DVL-1 Human genes 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13411899P | 1999-05-14 | 1999-05-14 | |
| US13411799P | 1999-05-14 | 1999-05-14 | |
| US13411499P | 1999-05-14 | 1999-05-14 | |
| US60/134,118 | 1999-05-14 | ||
| US60/134,114 | 1999-05-14 | ||
| US60/134,117 | 1999-05-14 | ||
| US16086099P | 1999-10-21 | 1999-10-21 | |
| US60/160,860 | 1999-10-21 | ||
| US16249899P | 1999-10-29 | 1999-10-29 | |
| US60/162,498 | 1999-10-29 | ||
| US17045399P | 1999-12-13 | 1999-12-13 | |
| US60/170,453 | 1999-12-13 | ||
| US17619500P | 2000-01-14 | 2000-01-14 | |
| US60/176,195 | 2000-01-14 | ||
| US18229600P | 2000-02-14 | 2000-02-14 | |
| US60/182,296 | 2000-02-14 | ||
| US19652700P | 2000-04-11 | 2000-04-11 | |
| US19652800P | 2000-04-11 | 2000-04-11 | |
| US19646000P | 2000-04-11 | 2000-04-11 | |
| US54727600A | 2000-04-11 | 2000-04-11 | |
| US19626700P | 2000-04-11 | 2000-04-11 | |
| US60/196267 | 2000-04-11 | ||
| US60/196,460 | 2000-04-11 | ||
| US09/547,276 | 2000-04-11 | ||
| US60/196,527 | 2000-04-11 | ||
| US60/196,528 | 2000-04-11 | ||
| PCT/US2000/013161 WO2000069896A2 (en) | 1999-05-14 | 2000-05-12 | Molecular interactions in haematopoietic cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011029100A Division JP2011102326A (ja) | 1999-05-14 | 2011-02-14 | 造血細胞内分子相互作用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002543825A JP2002543825A (ja) | 2002-12-24 |
| JP2002543825A5 true JP2002543825A5 (https=) | 2007-07-05 |
Family
ID=27584529
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000618312A Withdrawn JP2002543825A (ja) | 1999-05-14 | 2000-05-12 | 造血細胞内分子相互作用 |
| JP2011029100A Pending JP2011102326A (ja) | 1999-05-14 | 2011-02-14 | 造血細胞内分子相互作用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011029100A Pending JP2011102326A (ja) | 1999-05-14 | 2011-02-14 | 造血細胞内分子相互作用 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1178817A2 (https=) |
| JP (2) | JP2002543825A (https=) |
| ES (1) | ES2436624T3 (https=) |
| WO (2) | WO2000069896A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL140918A0 (en) | 1998-07-27 | 2002-02-10 | Genentech Inc | Improved transformation efficiency in phage display through modification of a coat protein |
| US6942981B1 (en) | 1999-05-14 | 2005-09-13 | Arbor Vita Corporation | Method of determining interactions with PDZ-domain polypeptides |
| US7510824B2 (en) | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| US7595297B2 (en) | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| AU2002215354A1 (en) * | 2000-10-13 | 2002-04-22 | Arbor Vita Corporation | Molecular interactions in hematopoietic cells |
| WO2002066954A2 (en) * | 2001-02-16 | 2002-08-29 | Arbor Vita Corporation | Pdz domain interactions and lipid rafts |
| JPWO2002088175A1 (ja) * | 2001-04-24 | 2004-08-19 | 大塚製薬株式会社 | クローン病抗体結合性ペプチド及びクローン病の検査方法 |
| AU2011211347B2 (en) * | 2001-05-07 | 2015-02-19 | Agriculture Victoria Services Pty Ltd | Modification of plant and seed development and plant responses to stresses and stimuli (3) |
| DE10124342A1 (de) * | 2001-05-18 | 2002-11-28 | Biotecon Diagnostics Gmbh | Verfahren zum Nachweis von Mikroorganismen der Spezies Yersinia pestis/Yersinia pseudotuberculosis und/oder zur Differzierung zwischen Yersinia pestis und Yersinia pseudotuberculosis |
| US20030148264A1 (en) * | 2001-07-06 | 2003-08-07 | Genentech, Inc. | Phage displayed PDZ domain ligands |
| EP1443951A4 (en) * | 2001-08-03 | 2006-05-03 | Arbor Vita Corp | MOLECULAR INTERACTIONS IN CELLS |
| AU2003291558B2 (en) * | 2001-08-03 | 2009-08-13 | Arbor Vita Corporation | Molecular interactions in neurons |
| JP2003199459A (ja) | 2002-01-07 | 2003-07-15 | Japan Science & Technology Corp | リンパ球遊走制御機能欠失モデル非ヒト動物 |
| US9408381B2 (en) | 2004-12-21 | 2016-08-09 | Musc Foundation For Research Development | Alpha Connexin c-Terminal (ACT) peptides for use in transplant |
| AU2012202117B2 (en) * | 2004-12-21 | 2014-06-26 | Musc Foundation For Research Development | Compositions and methods for promoting wound healing and tissue regeneration |
| RU2438696C2 (ru) | 2004-12-21 | 2012-01-10 | Маск Фаундейшн Фор Рисерч Дивелопмент | Композиции и способы, используемые для ускорения заживления ран и регенерации тканей |
| CA2598029A1 (en) * | 2005-02-24 | 2006-10-05 | The Scripps Research Institute | Isolated myeloid-like bone marrow cell populations and methods of treatment therewith |
| WO2007005948A2 (en) * | 2005-07-01 | 2007-01-11 | Arbor Vita Corporation | Methods and compositions for diagnosis and treatment of viral and bacterial infections |
| WO2007071448A2 (en) * | 2005-12-23 | 2007-06-28 | Partnership & Corp. Technology Transfer | Synthetic peptides for use as inhibitors of neurotransmitter secretion and as inducers of muscle relaxation |
| CA2648629C (en) * | 2006-04-07 | 2017-08-29 | University Of Tsukuba | Graft-versus-host disease predicting marker and use thereof |
| DK2819682T3 (en) | 2012-03-01 | 2017-08-21 | Firststring Res Inc | TOPICAL GELLS CONTAINING ALPHA-CONNEXIN C-TERMINAL (ACT) PEPTIDES |
| CN107109410B (zh) | 2014-08-22 | 2021-11-02 | 奥克兰联合服务有限公司 | 通道调节剂 |
| US20210139932A1 (en) * | 2017-05-03 | 2021-05-13 | Biomarin Pharmaceutical Inc. | Improved lentiviruses for transduction of hematopoietic stem cells |
| AU2019403393B2 (en) * | 2018-12-20 | 2026-04-16 | The University Of Chicago | Methods and compositions related to therapeutic peptides for cancer therapy |
| EP4199947A4 (en) | 2020-08-18 | 2024-10-16 | Onchilles Pharma, Inc. | Modified porcine pancreatic elastase proteins |
| MX2023004631A (es) | 2020-10-22 | 2023-07-20 | Xequel Bio Inc | Formulaciones peptidicas y usos oftalmicos de las mismas. |
| CN114457005B (zh) * | 2022-01-12 | 2024-03-26 | 佛山市妇幼保健院 | 一种小儿尿道平滑肌细胞的分离纯化方法 |
| WO2024199407A1 (en) * | 2023-03-31 | 2024-10-03 | Qihan Hong Kong Limited | Cancer immunotherapies using engineered cells |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6911526B2 (en) * | 1996-07-22 | 2005-06-28 | The Trustees Of Columbia University In The City Of New York | Compounds that inhibit the interaction between signal-transducing proteins and the GLGF (PDZ/DHR) domain and uses thereof |
-
2000
- 2000-05-12 EP EP00932386A patent/EP1178817A2/en not_active Withdrawn
- 2000-05-12 ES ES10186068.2T patent/ES2436624T3/es not_active Expired - Lifetime
- 2000-05-12 WO PCT/US2000/013161 patent/WO2000069896A2/en not_active Ceased
- 2000-05-12 WO PCT/US2000/013166 patent/WO2000069897A2/en not_active Ceased
- 2000-05-12 JP JP2000618312A patent/JP2002543825A/ja not_active Withdrawn
-
2011
- 2011-02-14 JP JP2011029100A patent/JP2011102326A/ja active Pending
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