JP2002542818A5 - - Google Patents
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- Publication number
- JP2002542818A5 JP2002542818A5 JP2000615738A JP2000615738A JP2002542818A5 JP 2002542818 A5 JP2002542818 A5 JP 2002542818A5 JP 2000615738 A JP2000615738 A JP 2000615738A JP 2000615738 A JP2000615738 A JP 2000615738A JP 2002542818 A5 JP2002542818 A5 JP 2002542818A5
- Authority
- JP
- Japan
- Prior art keywords
- neural
- dopaminergic
- cells
- stem cells
- neural stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 52
- 210000001178 neural stem cell Anatomy 0.000 description 26
- 210000001130 astrocyte Anatomy 0.000 description 21
- 210000005064 dopaminergic neuron Anatomy 0.000 description 20
- 101150026563 NR4A2 gene Proteins 0.000 description 19
- 230000003291 dopaminomimetic effect Effects 0.000 description 17
- 230000001537 neural effect Effects 0.000 description 14
- 210000005155 neural progenitor cell Anatomy 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 11
- 210000001259 mesencephalon Anatomy 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 239000003053 toxin Substances 0.000 description 10
- 231100000765 toxin Toxicity 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- 238000012216 screening Methods 0.000 description 6
- 210000000130 stem cell Anatomy 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 5
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 4
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 3
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 2
- 101800003838 Epidermal growth factor Proteins 0.000 description 2
- 102000034527 Retinoid X Receptors Human genes 0.000 description 2
- 108010038912 Retinoid X Receptors Proteins 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229940116977 epidermal growth factor Drugs 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000003061 neural cell Anatomy 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-MKOSUFFBSA-N 9-cis-retinol Chemical compound OC\C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-MKOSUFFBSA-N 0.000 description 1
- 102100037680 Fibroblast growth factor 8 Human genes 0.000 description 1
- 101001027382 Homo sapiens Fibroblast growth factor 8 Proteins 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13231799P | 1999-05-03 | 1999-05-03 | |
| US60/132,317 | 1999-05-03 | ||
| PCT/EP2000/003842 WO2000066713A2 (en) | 1999-05-03 | 2000-04-27 | Materials and methods relating to neuronal development |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002542818A JP2002542818A (ja) | 2002-12-17 |
| JP2002542818A5 true JP2002542818A5 (https=) | 2007-06-21 |
Family
ID=22453462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000615738A Pending JP2002542818A (ja) | 1999-05-03 | 2000-04-27 | ニューロンの発生に関連する材料及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7465582B1 (https=) |
| EP (1) | EP1173548B1 (https=) |
| JP (1) | JP2002542818A (https=) |
| AT (1) | ATE364688T1 (https=) |
| AU (1) | AU4752700A (https=) |
| CA (1) | CA2371260A1 (https=) |
| DE (1) | DE60035191T2 (https=) |
| DK (1) | DK1173548T3 (https=) |
| ES (1) | ES2290032T3 (https=) |
| WO (1) | WO2000066713A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129034B2 (en) | 2001-10-25 | 2006-10-31 | Cedars-Sinai Medical Center | Differentiation of whole bone marrow |
| JP2005507927A (ja) * | 2001-10-30 | 2005-03-24 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | パーキンソン病を処置するための方法および組成物 |
| EP1511839A4 (en) * | 2002-06-05 | 2005-11-16 | Es Cell Int Pte Ltd | GENERATION OF NEURAL STEM CELLS FROM UNDIFFERENCED HUMAN EMBRYONAL STEM CELLS |
| US20060233771A1 (en) * | 2002-09-24 | 2006-10-19 | Ernesto Arenas | Methods for promoting dopaminergic neuronal development by using ng4a-subfamily and wnt-ligands |
| KR20040079669A (ko) * | 2003-03-10 | 2004-09-16 | 학교법인 한양학원 | Ｎｕｒｒ1 과발현에 의한 도파민성 신경세포의 분화방법 |
| WO2005003320A2 (en) * | 2003-07-02 | 2005-01-13 | Regents Of The University Of Minnesota | Neuronal differentiation of stem cells |
| EP1779867A4 (en) * | 2004-07-01 | 2009-12-02 | Eisai R&D Man Co Ltd | MEANS FOR PROMOTING NERVE REVENERATION |
| WO2007119180A2 (en) * | 2006-04-07 | 2007-10-25 | Neuro Therapeutics Ab | Survival and development of neural cells |
| EP1897937A1 (en) * | 2006-09-07 | 2008-03-12 | NeuroProgen GmbH Leipzig | Method of culturing NPCs |
| CA2700573C (en) | 2006-09-26 | 2016-11-22 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| CA2700436C (en) | 2006-09-28 | 2017-04-18 | John S. Yu | Cancer vaccines and vaccination methods |
| PL2328923T3 (pl) | 2008-09-02 | 2016-06-30 | Cedars Sinai Medical Center | Epitopy CD133 |
| KR101181423B1 (ko) * | 2009-01-30 | 2012-09-19 | 한양대학교 산학협력단 | Ｎｕｒｒ1 변이체 발현을 이용한 개선된 도파민 신경세포의유도방법 |
| EP2427485B1 (en) | 2009-05-07 | 2016-12-07 | ImmunoCellular Therapeutics, Ltd. | Cd133 epitopes |
| KR101358601B1 (ko) | 2011-12-30 | 2014-02-05 | 한양대학교 산학협력단 | 도파민 뉴런의 제조 방법 |
| ES2662333T3 (es) | 2013-02-14 | 2018-04-06 | Immunocellular Therapeutics Ltd. | Vacunas contra el cáncer y métodos de vacunación |
| JP6340216B2 (ja) | 2014-03-07 | 2018-06-06 | 株式会社日立ハイテクノロジーズ | 走査電子顕微鏡 |
| KR102203034B1 (ko) * | 2017-11-06 | 2021-01-14 | 한양대학교 산학협력단 | 중뇌 유래의 성상교세포와 도파민 신경줄기세포의 공동 이식에 의한 도파민 신경세포의 이식 치료 효과 개선 |
| JP2019106895A (ja) * | 2017-12-15 | 2019-07-04 | インダストリー‐ユニバーシティー コーぺレーション ファンデーション ハンヤン ユニバーシティ | 神経幹細胞または神経前駆細胞からドーパミン神経細胞への分化方法 |
| CN111484977B (zh) * | 2019-01-25 | 2023-05-16 | 中国科学院脑科学与智能技术卓越创新中心 | 重编程产生功能性去甲肾上腺素能神经元的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981165A (en) * | 1991-07-08 | 1999-11-09 | Neurospheres Holdings Ltd. | In vitro induction of dopaminergic cells |
| ES2167461T3 (es) | 1994-09-23 | 2002-05-16 | Neurospheres Holdings Ltd | Modelos in vitro de funcion y disfuncion del sistema nervioso central. |
| US6284539B1 (en) * | 1998-10-09 | 2001-09-04 | Neuralstem Biopharmaceuticals, Ltd. | Method for generating dopaminergic cells derived from neural precursors |
| US6312949B1 (en) | 1999-03-26 | 2001-11-06 | The Salk Institute For Biological Studies | Regulation of tyrosine hydroxylase expression |
| WO2001088104A2 (en) | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
| US20020114788A1 (en) | 2000-07-27 | 2002-08-22 | Ole Isacson | Cell implantation therapy for neurological diseases or disorders |
-
2000
- 2000-04-27 DE DE60035191T patent/DE60035191T2/de not_active Expired - Fee Related
- 2000-04-27 ES ES00929454T patent/ES2290032T3/es not_active Expired - Lifetime
- 2000-04-27 WO PCT/EP2000/003842 patent/WO2000066713A2/en not_active Ceased
- 2000-04-27 EP EP00929454A patent/EP1173548B1/en not_active Expired - Lifetime
- 2000-04-27 AU AU47527/00A patent/AU4752700A/en not_active Abandoned
- 2000-04-27 US US09/980,913 patent/US7465582B1/en not_active Expired - Fee Related
- 2000-04-27 AT AT00929454T patent/ATE364688T1/de not_active IP Right Cessation
- 2000-04-27 DK DK00929454T patent/DK1173548T3/da active
- 2000-04-27 CA CA002371260A patent/CA2371260A1/en not_active Abandoned
- 2000-04-27 JP JP2000615738A patent/JP2002542818A/ja active Pending
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