JP2002541074A - 皮膚細胞の分化及び／または増殖のレベル増大のためのビタミンｃ類似物の使用 - Google Patents
皮膚細胞の分化及び／または増殖のレベル増大のためのビタミンｃ類似物の使用Info
- Publication number
- JP2002541074A JP2002541074A JP2000606185A JP2000606185A JP2002541074A JP 2002541074 A JP2002541074 A JP 2002541074A JP 2000606185 A JP2000606185 A JP 2000606185A JP 2000606185 A JP2000606185 A JP 2000606185A JP 2002541074 A JP2002541074 A JP 2002541074A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- ascorbic acid
- effective amount
- level
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004927 skin cell Anatomy 0.000 title description 5
- 230000024245 cell differentiation Effects 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 150000003700 vitamin C derivatives Chemical class 0.000 title 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 84
- 210000003491 skin Anatomy 0.000 claims abstract description 49
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 40
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 39
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 39
- 239000000203 mixture Substances 0.000 claims abstract description 32
- 230000004069 differentiation Effects 0.000 claims abstract description 24
- 102000013127 Vimentin Human genes 0.000 claims abstract description 21
- 108010065472 Vimentin Proteins 0.000 claims abstract description 21
- 210000005048 vimentin Anatomy 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 19
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 18
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 18
- 102100023970 Keratin, type I cytoskeletal 10 Human genes 0.000 claims abstract description 17
- 210000002510 keratinocyte Anatomy 0.000 claims abstract description 16
- 108010065038 Keratin-10 Proteins 0.000 claims abstract description 15
- 210000002950 fibroblast Anatomy 0.000 claims abstract description 14
- 230000002500 effect on skin Effects 0.000 claims abstract description 11
- 230000035755 proliferation Effects 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 4
- 150000000996 L-ascorbic acids Chemical class 0.000 claims description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- -1 glycosyl ascorbic acid Chemical compound 0.000 claims description 2
- 150000002942 palmitic acid derivatives Chemical class 0.000 claims description 2
- 235000019260 propionic acid Nutrition 0.000 claims description 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims description 2
- 230000002950 deficient Effects 0.000 claims 2
- NEMFQSKAPLGFIP-UHFFFAOYSA-N magnesiosodium Chemical compound [Na].[Mg] NEMFQSKAPLGFIP-UHFFFAOYSA-N 0.000 claims 1
- 235000010378 sodium ascorbate Nutrition 0.000 claims 1
- 229960005055 sodium ascorbate Drugs 0.000 claims 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical group [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 abstract description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 16
- 108020004999 messenger RNA Proteins 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 9
- 230000003321 amplification Effects 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 210000004207 dermis Anatomy 0.000 description 6
- 210000002615 epidermis Anatomy 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- 230000000699 topical effect Effects 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 108010050808 Procollagen Proteins 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000003757 reverse transcription PCR Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 108020005096 28S Ribosomal RNA Proteins 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 102000011782 Keratins Human genes 0.000 description 3
- 108010076876 Keratins Proteins 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 241000208125 Nicotiana Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 210000001339 epidermal cell Anatomy 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 210000001821 langerhans cell Anatomy 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 238000010839 reverse transcription Methods 0.000 description 2
- 210000001626 skin fibroblast Anatomy 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 239000007762 w/o emulsion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 description 1
- 108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102220517121 Jerky protein homolog-like_L70M_mutation Human genes 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 description 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- YQOKLYTXVFAUCW-UHFFFAOYSA-N guanidine;isothiocyanic acid Chemical compound N=C=S.NC(N)=N YQOKLYTXVFAUCW-UHFFFAOYSA-N 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000013615 primer Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000001944 prunus armeniaca kernel oil Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR99/03675 | 1999-03-24 | ||
| FR9903675A FR2791259B1 (fr) | 1999-03-24 | 1999-03-24 | Utilisation de la vitamine c ou analogues pour augmenter le taux de differenciation et/ou de proliferation des cellules de la peau |
| PCT/FR2000/000561 WO2000056278A1 (fr) | 1999-03-24 | 2000-03-07 | Utilisation de la vitamine c ou analogues pour stimuler la synthese de cellules de la peau |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002541074A true JP2002541074A (ja) | 2002-12-03 |
Family
ID=9543584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000606185A Pending JP2002541074A (ja) | 1999-03-24 | 2000-03-07 | 皮膚細胞の分化及び／または増殖のレベル増大のためのビタミンｃ類似物の使用 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1165033A1 (fr) |
| JP (1) | JP2002541074A (fr) |
| AR (1) | AR018230A1 (fr) |
| AU (1) | AU3172600A (fr) |
| CA (1) | CA2364608A1 (fr) |
| FR (1) | FR2791259B1 (fr) |
| TW (1) | TWI225410B (fr) |
| UY (1) | UY26063A1 (fr) |
| WO (1) | WO2000056278A1 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004352627A (ja) * | 2003-05-28 | 2004-12-16 | Kuraray Co Ltd | 皮膚外用剤 |
| JP2008105983A (ja) * | 2006-10-25 | 2008-05-08 | Nicca Chemical Co Ltd | 線維芽細胞増殖促進剤、皮膚外用剤、浴用剤及び飲食物 |
| JP2008105985A (ja) * | 2006-10-25 | 2008-05-08 | Nicca Chemical Co Ltd | ヒアルロン酸産生促進剤、皮膚外用剤、浴用剤及び飲食物 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10050274A1 (de) * | 2000-10-09 | 2002-04-18 | Henkel Kgaa | Verfahren zur in vitro Bestimmung der Hautalterung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6281307A (ja) * | 1985-10-04 | 1987-04-14 | Kanebo Ltd | 皮膚化粧料 |
| FR2612775B1 (fr) * | 1987-03-25 | 1991-10-11 | Thorel Jean | Compositions pour la prevention et le traitement de la degenerescence cutanee |
| US4938969A (en) * | 1988-11-14 | 1990-07-03 | Milor Scientific, Ltd. | Method for the treatment of aging or photo-damaged skin |
| WO1995003028A1 (fr) * | 1993-07-23 | 1995-02-02 | Morris Herstein | Composition cosmetique stimulant le renouvellement de la peau, avec effet prolonge d'elimination de l'irritation |
| FR2737971B1 (fr) * | 1995-08-25 | 1997-11-14 | Lvmh Rech | Utilisation de la vitamine c ou de ses derives ou analogues pour stimuler la synthese de l'elastine cutanee |
-
1999
- 1999-03-24 FR FR9903675A patent/FR2791259B1/fr not_active Expired - Fee Related
-
2000
- 2000-03-07 AU AU31726/00A patent/AU3172600A/en not_active Abandoned
- 2000-03-07 JP JP2000606185A patent/JP2002541074A/ja active Pending
- 2000-03-07 WO PCT/FR2000/000561 patent/WO2000056278A1/fr not_active Application Discontinuation
- 2000-03-07 EP EP00909442A patent/EP1165033A1/fr not_active Ceased
- 2000-03-07 CA CA002364608A patent/CA2364608A1/fr not_active Abandoned
- 2000-03-14 UY UY26063A patent/UY26063A1/es not_active Application Discontinuation
- 2000-03-20 TW TW089105043A patent/TWI225410B/zh not_active IP Right Cessation
- 2000-03-22 AR ARP000101265A patent/AR018230A1/es unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004352627A (ja) * | 2003-05-28 | 2004-12-16 | Kuraray Co Ltd | 皮膚外用剤 |
| JP2008105983A (ja) * | 2006-10-25 | 2008-05-08 | Nicca Chemical Co Ltd | 線維芽細胞増殖促進剤、皮膚外用剤、浴用剤及び飲食物 |
| JP2008105985A (ja) * | 2006-10-25 | 2008-05-08 | Nicca Chemical Co Ltd | ヒアルロン酸産生促進剤、皮膚外用剤、浴用剤及び飲食物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2364608A1 (fr) | 2000-09-28 |
| EP1165033A1 (fr) | 2002-01-02 |
| UY26063A1 (es) | 2000-10-31 |
| AR018230A1 (es) | 2001-10-31 |
| FR2791259B1 (fr) | 2001-08-17 |
| FR2791259A1 (fr) | 2000-09-29 |
| WO2000056278A1 (fr) | 2000-09-28 |
| TWI225410B (en) | 2004-12-21 |
| AU3172600A (en) | 2000-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3556167B2 (ja) | 抗グリケーション剤としての３，３’，５，５’−テトラヒドロキシスチルベンの使用 | |
| CN103314005B (zh) | 在皮肤和/或粘膜的治疗和/或护理中有用的肽以及它们在化妆品组合物或药用组合物中的用途 | |
| JP3333243B2 (ja) | 蛋白分画、その単離法、該蛋白分画を含有する有効物質濃縮物、及び該蛋白分画を含有する、皮膚手入れ及び／又は炎症性皮膚病の治療用製剤 | |
| JP2001058916A (ja) | 抗グリケーション剤としての少なくとも１種のヒドロキシスチルベンの使用 | |
| JP5918783B2 (ja) | マイクロｒｎａの制御因子を用いて皮膚を治療する方法 | |
| JP2004505007A (ja) | 抗グリケーション剤としての少なくとも１つのスノキ属植物の抽出物の使用 | |
| EP1089704B1 (fr) | Lotion trichologique pour applications topiques | |
| JP2964183B2 (ja) | 皮膚外用剤 | |
| JP2000229834A (ja) | 化粧料 | |
| US20240148632A1 (en) | Topical compositions containing n-acyl dipeptide derivatives and glycolic acid | |
| JP2000136124A (ja) | 皮膚外用剤 | |
| JP3159419B2 (ja) | 化粧料 | |
| JP2018039751A (ja) | 表皮細胞間機能強化剤 | |
| JP2002541074A (ja) | 皮膚細胞の分化及び／または増殖のレベル増大のためのビタミンｃ類似物の使用 | |
| JPH0348165B2 (fr) | ||
| JP2001503447A (ja) | 老化皮膚の処置用組成物および方法 | |
| JP7135106B2 (ja) | 頭皮頭髪用組成物 | |
| US20210188911A1 (en) | Peptides of use in the preventive and curative treatment of alopecia | |
| JP3686394B2 (ja) | 抗老化剤、メイラード反応阻害剤、コラゲナーゼ活性阻害剤及びこれらを含有する皮膚老化防止用化粧料 | |
| JP2002308753A (ja) | エラスターゼ活性阻害剤とエストロゲン様活性剤およびこれらを含有する抗皮膚老化剤 | |
| JP2000026269A (ja) | 化粧料 | |
| JP2003519663A (ja) | ディクトヨタル（Ｄｉｃｔｙｏｔａｌ）抽出物の局所薬組成物の製造での使用 | |
| JP4954450B2 (ja) | 弾性繊維形成の不全、欠損又は無秩序による病状に対処するための、リシルオキシダーゼのアイソフォームの活性の誘導 | |
| JP4041674B2 (ja) | 細胞への酸素送達の強化に役立つ方法および組成物 | |
| WO2023222847A1 (fr) | Agoniste du récepteur olfactif 2a4/7 pour favoriser la pousse des cheveux et améliorer l'aspect esthétique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20040727 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20041022 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20041029 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041109 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20050104 |