JP2002539848A5 - - Google Patents
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- JP2002539848A5 JP2002539848A5 JP2000608792A JP2000608792A JP2002539848A5 JP 2002539848 A5 JP2002539848 A5 JP 2002539848A5 JP 2000608792 A JP2000608792 A JP 2000608792A JP 2000608792 A JP2000608792 A JP 2000608792A JP 2002539848 A5 JP2002539848 A5 JP 2002539848A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- nucleic acid
- assay
- primer
- single base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 53
- 238000003556 assay Methods 0.000 description 16
- 108020004707 nucleic acids Proteins 0.000 description 13
- 150000007523 nucleic acids Chemical class 0.000 description 13
- 102000039446 nucleic acids Human genes 0.000 description 13
- 239000000523 sample Substances 0.000 description 12
- 230000029142 excretion Effects 0.000 description 8
- 230000035772 mutation Effects 0.000 description 8
- 210000001124 body fluid Anatomy 0.000 description 7
- 210000000349 chromosome Anatomy 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 3
- 208000003200 Adenoma Diseases 0.000 description 2
- 206010001233 Adenoma benign Diseases 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000007826 nucleic acid assay Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000004915 pus Anatomy 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/277,016 US6143529A (en) | 1996-08-14 | 1999-03-26 | Methods for improving sensitivity and specificity of screening assays |
| US09/277,016 | 1999-03-26 | ||
| PCT/US2000/007882 WO2000058514A2 (en) | 1999-03-26 | 2000-03-24 | Methods for improving sensitivity and specificity of screening assays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010113710A Division JP2010172347A (ja) | 1999-03-26 | 2010-05-17 | スクリーニングアッセイの感度および特異性を改良するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002539848A JP2002539848A (ja) | 2002-11-26 |
| JP2002539848A5 true JP2002539848A5 (enExample) | 2007-09-20 |
Family
ID=23059077
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000608792A Pending JP2002539848A (ja) | 1999-03-26 | 2000-03-24 | スクリーニングアッセイの感度および特異性を改良するための方法 |
| JP2010113710A Pending JP2010172347A (ja) | 1999-03-26 | 2010-05-17 | スクリーニングアッセイの感度および特異性を改良するための方法 |
| JP2013057677A Pending JP2013116131A (ja) | 1999-03-26 | 2013-03-21 | スクリーニングアッセイの感度および特異性を改良するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010113710A Pending JP2010172347A (ja) | 1999-03-26 | 2010-05-17 | スクリーニングアッセイの感度および特異性を改良するための方法 |
| JP2013057677A Pending JP2013116131A (ja) | 1999-03-26 | 2013-03-21 | スクリーニングアッセイの感度および特異性を改良するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6143529A (enExample) |
| EP (1) | EP1185693B1 (enExample) |
| JP (3) | JP2002539848A (enExample) |
| AT (1) | ATE337413T1 (enExample) |
| AU (1) | AU761722B2 (enExample) |
| CA (1) | CA2369045C (enExample) |
| DE (1) | DE60030281T2 (enExample) |
| WO (1) | WO2000058514A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268136B1 (en) * | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
| US6406857B1 (en) | 1997-06-16 | 2002-06-18 | Exact Sciences Corporation | Methods for stool sample preparation |
| US6818404B2 (en) * | 1997-10-23 | 2004-11-16 | Exact Sciences Corporation | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples |
| ATE330032T1 (de) | 1999-02-25 | 2006-07-15 | Exact Sciences Corp | Verfahren zur erhaltung der dns-integrität |
| CA2366778C (en) * | 1999-04-09 | 2008-07-22 | Exact Sciences Corporation | Methods for detecting nucleic acids indicative of cancer |
| US6586177B1 (en) * | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| US6849403B1 (en) * | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
| EP1238113B1 (en) | 1999-12-07 | 2010-02-24 | EXACT Sciences Corporation | Detection of lung neoplasms in stool |
| US6919174B1 (en) * | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
| US7250252B2 (en) * | 1999-12-30 | 2007-07-31 | David Aaron Katz | Amplification based polymorphism detection |
| US6585646B2 (en) * | 2000-11-29 | 2003-07-01 | Hermetic Diagnostics, Inc. | Screening test and procedure using skin patches |
| US6911308B2 (en) * | 2001-01-05 | 2005-06-28 | Exact Sciences Corporation | Methods for detecting, grading or monitoring an H. pylori infection |
| US6428964B1 (en) | 2001-03-15 | 2002-08-06 | Exact Sciences Corporation | Method for alteration detection |
| US6727354B2 (en) * | 2001-12-12 | 2004-04-27 | Quest Diagnostics Investments, Inc. | Compositions and methods for TIGR genotyping assays |
| US20030180765A1 (en) * | 2002-02-01 | 2003-09-25 | The Johns Hopkins University | Digital amplification for detection of mismatch repair deficient tumor cells |
| WO2003071252A2 (en) | 2002-02-15 | 2003-08-28 | Exact Sciences Corporation | Methods for analysis of molecular events |
| CA2506066A1 (en) * | 2002-11-15 | 2004-06-03 | Genomic Health, Inc. | Gene expression profiling of egfr positive cancer |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| WO2004071572A2 (en) * | 2003-02-06 | 2004-08-26 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| CA2516553C (en) * | 2003-02-20 | 2013-04-16 | Genomic Health, Inc. | Use of intronic rna to measure gene expression |
| ITMI20030434A1 (it) | 2003-03-07 | 2004-09-08 | Istituto Oncologico Romagnolo Coope Rativa Sociale | Metodo per l'individuazione di tumori del colon-retto. |
| CA2527321A1 (en) * | 2003-05-30 | 2004-12-23 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| WO2005039382A2 (en) * | 2003-06-24 | 2005-05-06 | Genomic Health | Prediction of likelihood of cancer recurrence |
| EP1644858B1 (en) | 2003-07-10 | 2017-12-06 | Genomic Health, Inc. | Expression profile algorithm and test for cancer prognosis |
| AU2004284434A1 (en) * | 2003-10-16 | 2005-05-06 | Genomic Health, Inc. | qRT-PCR assay system for gene expression profiling |
| JP4718490B2 (ja) * | 2003-12-23 | 2011-07-06 | ジェノミック ヘルス， インコーポレイテッド | フラグメント化ｒｎａの全般的増幅 |
| CA2848463A1 (en) | 2004-04-09 | 2005-10-27 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| EP1751306A1 (en) * | 2004-04-30 | 2007-02-14 | Yale University | Methods and compositions for cancer diagnosis |
| WO2006026654A2 (en) | 2004-08-27 | 2006-03-09 | Exact Sciences Corporation | Method for detecting a recombinant event |
| WO2006047481A2 (en) * | 2004-10-22 | 2006-05-04 | Redpath Integrated Pathology, Inc. | Enhanced amplifiability of minute fixative-treated tissue samples, minute stained cytology samples, and other minute sources of dna |
| US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
| JP4939425B2 (ja) * | 2004-11-05 | 2012-05-23 | ジェノミック ヘルス， インコーポレイテッド | 乳癌の治療反応の予後および予測の分子指標 |
| CA3061785A1 (en) | 2004-11-05 | 2006-05-18 | Genomic Health, Inc. | Predicting response to chemotherapy using gene expression markers |
| WO2006094149A2 (en) * | 2005-03-01 | 2006-09-08 | Exact Sciences Corporation | Methods and compositions for detecting adenoma |
| US9777314B2 (en) | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
| US20070248546A1 (en) * | 2005-11-09 | 2007-10-25 | Exact Sciences Corporation | Clinical algorithm for excluding patients identified in virtual imaging |
| JPWO2008090930A1 (ja) * | 2007-01-23 | 2010-05-20 | オリンパス株式会社 | 癌の診断方法 |
| EP2218792A4 (en) * | 2007-11-20 | 2010-12-08 | Olympus Corp | PROCESS FOR PREPARATION OF A KOTPROBE, SOLUTION FOR PREPARATION OF A KOTPROBE AND KOTSAMMELKIT |
| WO2009102788A2 (en) | 2008-02-15 | 2009-08-20 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| GB201107466D0 (en) | 2011-05-05 | 2011-06-15 | Loktionov Alexandre | Device and method for non-invasive collection of colorectal mucocellular layer and disease detection |
| US9341628B2 (en) | 2012-11-30 | 2016-05-17 | Interpace Diagnostics Corporation | Methods for measuring carcinoembryonic antigen |
| JP6294614B2 (ja) | 2013-05-08 | 2018-03-14 | 有限会社マイテック | 癌関連物質の定量方法 |
| US10253358B2 (en) | 2013-11-04 | 2019-04-09 | Exact Sciences Development Company, Llc | Multiple-control calibrators for DNA quantitation |
| EP3084004A4 (en) | 2013-12-19 | 2017-08-16 | Exact Sciences Corporation | Synthetic nucleic acid control molecules |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| ES2902174T3 (es) | 2016-07-19 | 2022-03-25 | Exact Sciences Dev Co Llc | ADN de control metilado |
| EP3488003B1 (en) | 2016-07-19 | 2023-10-25 | Exact Sciences Corporation | Nucleic acid control molecules from non-human organisms |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE501439C2 (sv) * | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| AU5310296A (en) * | 1995-03-17 | 1996-10-08 | John Wayne Cancer Institute | Detection of melanoma or breast metastases with a multiple marker assay |
| DE19736691A1 (de) * | 1997-08-22 | 1999-02-25 | Michael Prof Dr Med Giesing | Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen |
-
1999
- 1999-03-26 US US09/277,016 patent/US6143529A/en not_active Expired - Lifetime
-
2000
- 2000-03-24 WO PCT/US2000/007882 patent/WO2000058514A2/en not_active Ceased
- 2000-03-24 AT AT00918364T patent/ATE337413T1/de not_active IP Right Cessation
- 2000-03-24 DE DE60030281T patent/DE60030281T2/de not_active Expired - Lifetime
- 2000-03-24 AU AU39189/00A patent/AU761722B2/en not_active Ceased
- 2000-03-24 JP JP2000608792A patent/JP2002539848A/ja active Pending
- 2000-03-24 CA CA2369045A patent/CA2369045C/en not_active Expired - Fee Related
- 2000-03-24 EP EP00918364A patent/EP1185693B1/en not_active Expired - Lifetime
-
2010
- 2010-05-17 JP JP2010113710A patent/JP2010172347A/ja active Pending
-
2013
- 2013-03-21 JP JP2013057677A patent/JP2013116131A/ja active Pending
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