JP2002539455A5 - - Google Patents
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- Publication number
- JP2002539455A5 JP2002539455A5 JP2000605213A JP2000605213A JP2002539455A5 JP 2002539455 A5 JP2002539455 A5 JP 2002539455A5 JP 2000605213 A JP2000605213 A JP 2000605213A JP 2000605213 A JP2000605213 A JP 2000605213A JP 2002539455 A5 JP2002539455 A5 JP 2002539455A5
- Authority
- JP
- Japan
- Prior art keywords
- level
- saposin
- sample
- lysosomal storage
- baseline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 42
- 239000000523 sample Substances 0.000 description 39
- 102000017852 Saposin Human genes 0.000 description 37
- 108050007079 Saposin Proteins 0.000 description 37
- 208000015439 Lysosomal storage disease Diseases 0.000 description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 14
- 108010028144 alpha-Glucosidases Proteins 0.000 description 14
- 201000010099 disease Diseases 0.000 description 8
- 208000035475 disorder Diseases 0.000 description 7
- 238000012544 monitoring process Methods 0.000 description 6
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 description 5
- 101710116782 Lysosome-associated membrane glycoprotein 1 Proteins 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 5
- 230000002132 lysosomal effect Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000009007 Diagnostic Kit Methods 0.000 description 3
- 210000004381 amniotic fluid Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 102000004882 Lipase Human genes 0.000 description 2
- 108090001060 Lipase Proteins 0.000 description 2
- 102100038225 Lysosome-associated membrane glycoprotein 2 Human genes 0.000 description 2
- 101710116771 Lysosome-associated membrane glycoprotein 2 Proteins 0.000 description 2
- 208000027933 Mannosidase Deficiency disease Diseases 0.000 description 2
- 208000008955 Mucolipidoses Diseases 0.000 description 2
- 208000035032 Multiple sulfatase deficiency Diseases 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 201000007769 mucolipidosis Diseases 0.000 description 2
- 208000005340 mucopolysaccharidosis III Diseases 0.000 description 2
- 208000022018 mucopolysaccharidosis type 2 Diseases 0.000 description 2
- 201000006033 mucosulfatidosis Diseases 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 206010011777 Cystinosis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000024720 Fabry Disease Diseases 0.000 description 1
- 208000017462 Galactosialidosis Diseases 0.000 description 1
- 206010028095 Mucopolysaccharidosis IV Diseases 0.000 description 1
- 208000014060 Niemann-Pick disease Diseases 0.000 description 1
- 208000026589 Wolman disease Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000012253 mucopolysaccharidosis IVA Diseases 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12486499P | 1999-03-17 | 1999-03-17 | |
| US60/124,864 | 1999-03-17 | ||
| GBGB9908190.3A GB9908190D0 (en) | 1999-04-09 | 1999-04-09 | Diagnosis of lysosomal storage disorders using saposins and other markers |
| GB9908190.3 | 1999-04-09 | ||
| GB60/124,864 | 1999-04-09 | ||
| PCT/AU2000/000193 WO2000055632A1 (en) | 1999-03-17 | 2000-03-17 | Diagnosis of lysosomal storage disorders using saposins and other markers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010049695A Division JP2010139511A (ja) | 1999-03-17 | 2010-03-05 | サポシンおよび他のマーカーを用いるリソソーム貯蔵障害の診断 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539455A JP2002539455A (ja) | 2002-11-19 |
| JP2002539455A5 true JP2002539455A5 (enExample) | 2007-05-10 |
| JP4703008B2 JP4703008B2 (ja) | 2011-06-15 |
Family
ID=10851273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000605213A Expired - Fee Related JP4703008B2 (ja) | 1999-03-17 | 2000-03-17 | 被験体におけるリソソーム貯蔵障害の診断またはモニターのために少なくとも１つのサポシンのレベルを使用する方法 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP4703008B2 (enExample) |
| GB (1) | GB9908190D0 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1163527B1 (en) * | 1999-03-17 | 2009-03-04 | Women's And Children's Hospital | Diagnosis of lysosomal storage disorders using saposins and other markers |
| JP4833831B2 (ja) * | 2003-03-31 | 2011-12-07 | ウイミンズ、アンド、チルドランズ、ホスピトル | リソソーム蓄積症（ｌｄｓ）の多重スクリーニング |
| ES2731920T3 (es) * | 2013-05-14 | 2019-11-19 | Centogene Ag | Método para el diagnóstico de la enfermedad de Niemann-Pick |
-
1999
- 1999-04-09 GB GBGB9908190.3A patent/GB9908190D0/en not_active Ceased
-
2000
- 2000-03-17 JP JP2000605213A patent/JP4703008B2/ja not_active Expired - Fee Related
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