JP2002537353A5 - - Google Patents

Info

Publication number

JP2002537353A5

JP2002537353A5 JP2000600685A JP2000600685A JP2002537353A5 JP 2002537353 A5 JP2002537353 A5 JP 2002537353A5 JP 2000600685 A JP2000600685 A JP 2000600685A JP 2000600685 A JP2000600685 A JP 2000600685A JP 2002537353 A5 JP2002537353 A5 JP 2002537353A5

Authority

JP

Japan

Prior art keywords

seq

composition

composition according

adjuvant

oligonucleotide

Prior art date

2000-02-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 description 65
• 108090000623 proteins and genes Proteins 0.000 description 12
• 102000004169 proteins and genes Human genes 0.000 description 12
• 108091034117 Oligonucleotide Proteins 0.000 description 11
• 230000002163 immunogen Effects 0.000 description 11
• 239000002671 adjuvant Substances 0.000 description 10
• 239000012634 fragment Substances 0.000 description 10
• 241001465754 Metazoa Species 0.000 description 8
• 239000003921 oil Substances 0.000 description 6
• 235000019198 oils Nutrition 0.000 description 6
• 108090000765 processed proteins & peptides Proteins 0.000 description 6
• 241000588653 Neisseria Species 0.000 description 5
• 239000000427 antigen Substances 0.000 description 5
• 102000036639 antigens Human genes 0.000 description 5
• 108091007433 antigens Proteins 0.000 description 5
• 239000003995 emulsifying agent Substances 0.000 description 5
• 229960005486 vaccine Drugs 0.000 description 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
• 239000002773 nucleotide Substances 0.000 description 4
• 125000003729 nucleotide group Chemical group 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 3
• 229920001214 Polysorbate 60 Polymers 0.000 description 3
• 239000003814 drug Substances 0.000 description 3
• 230000028993 immune response Effects 0.000 description 3
• 230000001681 protective effect Effects 0.000 description 3
• 150000003212 purines Chemical class 0.000 description 3
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
• 241000588650 Neisseria meningitidis Species 0.000 description 2
• 241000588677 Neisseria meningitidis serogroup B Species 0.000 description 2
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 2
• 150000005690 diesters Chemical class 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 239000002158 endotoxin Substances 0.000 description 2
• 230000003053 immunization Effects 0.000 description 2
• 229960001438 immunostimulant agent Drugs 0.000 description 2
• 239000003022 immunostimulating agent Substances 0.000 description 2
• 230000003308 immunostimulating effect Effects 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 229920006008 lipopolysaccharide Polymers 0.000 description 2
• 229920001282 polysaccharide Polymers 0.000 description 2
• 239000005017 polysaccharide Substances 0.000 description 2
• 230000004044 response Effects 0.000 description 2
• 150000003505 terpenes Chemical class 0.000 description 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 2
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
• 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
• 206010062212 Neisseria infection Diseases 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
• 229940037003 alum Drugs 0.000 description 1
• 239000010775 animal oil Substances 0.000 description 1
• 239000012736 aqueous medium Substances 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 229920001400 block copolymer Polymers 0.000 description 1
• 210000002421 cell wall Anatomy 0.000 description 1
• 239000003599 detergent Substances 0.000 description 1
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
• 150000002170 ethers Chemical class 0.000 description 1
• 150000004676 glycans Chemical class 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 description 1
• -1 sorbitan triesters Chemical class 0.000 description 1
• 229940031439 squalene Drugs 0.000 description 1
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
• 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1