CA2371994C - Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs - Google Patents
Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs Download PDFInfo
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- CA2371994C CA2371994C CA2371994A CA2371994A CA2371994C CA 2371994 C CA2371994 C CA 2371994C CA 2371994 A CA2371994 A CA 2371994A CA 2371994 A CA2371994 A CA 2371994A CA 2371994 C CA2371994 C CA 2371994C
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
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- Immunology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US12179299P | 1999-02-26 | 1999-02-26 | |
| US60/121,792 | 1999-02-26 | ||
| PCT/IB2000/000176 WO2000050075A2 (en) | 1999-02-26 | 2000-02-09 | Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs |
Publications (2)
| Publication Number | Publication Date |
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| CA2371994A1 CA2371994A1 (en) | 2000-08-31 |
| CA2371994C true CA2371994C (en) | 2010-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2371994A Expired - Fee Related CA2371994C (en) | 1999-02-26 | 2000-02-09 | Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs |
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| US (1) | US8221761B1 (enExample) |
| EP (1) | EP1154790B1 (enExample) |
| JP (2) | JP4812942B2 (enExample) |
| AT (1) | ATE279943T1 (enExample) |
| AU (1) | AU2457100A (enExample) |
| CA (1) | CA2371994C (enExample) |
| DE (1) | DE60015084T2 (enExample) |
| ES (1) | ES2228454T3 (enExample) |
| HK (1) | HK1042425B (enExample) |
| PT (1) | PT1154790E (enExample) |
| WO (1) | WO2000050075A2 (enExample) |
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| CA2266656A1 (en) | 1996-09-17 | 1998-03-26 | Chiron Corporation | Compositions and methods for treating intracellular diseases |
| US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| EP1228217B1 (en) | 1999-04-30 | 2012-11-21 | Novartis Vaccines and Diagnostics S.r.l. | Conserved neisserial antigens |
| EP1860191A3 (en) * | 1999-05-19 | 2008-02-13 | Novartis Vaccines and Diagnostics S.r.l. | Combination neisserial compositions |
| DE60044005D1 (de) | 1999-11-29 | 2010-04-22 | Novartis Vaccines & Diagnostic | 85 kDa Antigen von Neisseria |
| CN101139590B (zh) | 2000-02-28 | 2012-07-18 | 启龙股份公司 | 奈瑟球菌蛋白质的杂交表达 |
| CN1306956C (zh) | 2001-04-17 | 2007-03-28 | 希龙公司 | 诱导功能活性抗体的脑膜炎球菌b抗原表位的分子模拟物 |
| US7838015B2 (en) * | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| CN100354297C (zh) * | 2001-10-03 | 2007-12-12 | 希龙公司 | 辅助的脑膜炎球菌组合物 |
| CA2471968C (en) * | 2001-10-06 | 2013-07-23 | Merial Limited | Immunostimulatory nucleic acids and use thereof |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| DE60335477D1 (de) | 2002-10-11 | 2011-02-03 | Novartis Vaccines & Diagnostic | Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| US20110293700A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| PT3246044T (pt) | 2010-08-23 | 2021-02-15 | Wyeth Llc | Formulações estáveis de antigénios de rlp2086 de neisseria meningitidis |
| AU2011300409B2 (en) | 2010-09-10 | 2015-03-26 | Wyeth Llc | Non-lipidated variants of Neisseria meningitidis ORF2086 antigens |
| EP2640190A4 (en) | 2010-11-05 | 2016-05-11 | Selecta Biosciences Inc | MODIFIED NICOTINIC COMPOUNDS AND ASSOCIATED METHODS |
| CN109172819A (zh) | 2011-07-29 | 2019-01-11 | 西莱克塔生物科技公司 | 产生体液和细胞毒性t淋巴细胞（ctl）免疫应答的合成纳米载体 |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US8986710B2 (en) | 2012-03-09 | 2015-03-24 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| MX369534B (es) | 2013-09-08 | 2019-11-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos. |
| RU2723045C2 (ru) | 2015-02-19 | 2020-06-08 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их получения |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| SG10202111092UA (en) | 2017-01-31 | 2021-11-29 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| CA3155669A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
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| HU212924B (en) * | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
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| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
| US20060002949A1 (en) * | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| AU738513B2 (en) | 1997-02-28 | 2001-09-20 | University Of Iowa Research Foundation, The | Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders |
| EP1005368B1 (en) * | 1997-03-10 | 2009-09-02 | Ottawa Hospital Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide in combination with alum as adjuvants |
| US6818222B1 (en) * | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| US6426334B1 (en) * | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| DE69838294T2 (de) | 1997-05-20 | 2009-08-13 | Ottawa Health Research Institute, Ottawa | Verfahren zur Herstellung von Nukleinsäurekonstrukten |
| ATE432348T1 (de) * | 1997-06-06 | 2009-06-15 | Univ California | Inhibitoren von immunstimulatorischen dna sequenz aktivität |
| GB9711990D0 (en) * | 1997-06-11 | 1997-08-06 | Smithkline Beecham Biolog | Vaccine |
| WO1999030737A1 (en) * | 1997-12-16 | 1999-06-24 | Chiron Corporation | Use of microparticles combined with submicron oil-in-water emulsions |
| GB9727262D0 (en) * | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| SG152917A1 (en) * | 1998-01-14 | 2009-06-29 | Chiron Srl | Neisseria meningitidis antigens |
| GB9808932D0 (en) * | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
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| GB9810276D0 (en) * | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
| GB9820003D0 (en) * | 1998-09-14 | 1998-11-04 | Smithkline Beecham Biolog | Novel compounds |
| GB9826886D0 (en) * | 1998-12-07 | 1999-01-27 | Smithkline Beecham Biolog | Novel compounds |
| EP1144643A1 (en) * | 1999-01-15 | 2001-10-17 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Neisseria meningitidis antigen |
| JP2004537956A (ja) * | 1999-01-22 | 2004-12-24 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規化合物 |
| US6558670B1 (en) * | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
| TR200103018T2 (tr) * | 1999-04-19 | 2002-02-21 | Beecham Biologicals S.A. Smithkline | İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri. |
| EP1228217B1 (en) * | 1999-04-30 | 2012-11-21 | Novartis Vaccines and Diagnostics S.r.l. | Conserved neisserial antigens |
| GB9928196D0 (en) * | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| EP2275129A3 (en) * | 2000-01-17 | 2013-11-06 | Novartis Vaccines and Diagnostics S.r.l. | Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins |
| AU3108001A (en) * | 2000-01-20 | 2001-12-24 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for inducing a th2 immune response |
| CN101139590B (zh) * | 2000-02-28 | 2012-07-18 | 启龙股份公司 | 奈瑟球菌蛋白质的杂交表达 |
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| US20040258702A1 (en) * | 2000-06-22 | 2004-12-23 | Blonder Joan P. | Vaccine delivery |
| CN101428006A (zh) * | 2000-09-28 | 2009-05-13 | 诺华疫苗和诊断公司 | 微粒体组合物及其生产方法 |
| ATE320792T1 (de) * | 2000-09-28 | 2006-04-15 | Chiron Corp | Mikropartikel zur verabreichung von heterologen nukleinsäure |
| GB0103424D0 (en) * | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
| CN1306956C (zh) * | 2001-04-17 | 2007-03-28 | 希龙公司 | 诱导功能活性抗体的脑膜炎球菌b抗原表位的分子模拟物 |
| US6541554B2 (en) * | 2001-05-17 | 2003-04-01 | Milliken & Company | Low-shrink polypropylene fibers |
| JP2006512401A (ja) * | 2001-06-05 | 2006-04-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ナノエマルジョンワクチン |
| GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
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2000
- 2000-02-09 AU AU24571/00A patent/AU2457100A/en not_active Abandoned
- 2000-02-09 ES ES00902831T patent/ES2228454T3/es not_active Expired - Lifetime
- 2000-02-09 EP EP00902831A patent/EP1154790B1/en not_active Expired - Lifetime
- 2000-02-09 US US09/914,454 patent/US8221761B1/en not_active Expired - Fee Related
- 2000-02-09 AT AT00902831T patent/ATE279943T1/de active
- 2000-02-09 CA CA2371994A patent/CA2371994C/en not_active Expired - Fee Related
- 2000-02-09 PT PT00902831T patent/PT1154790E/pt unknown
- 2000-02-09 WO PCT/IB2000/000176 patent/WO2000050075A2/en not_active Ceased
- 2000-02-09 HK HK02102264.3A patent/HK1042425B/en not_active IP Right Cessation
- 2000-02-09 JP JP2000600685A patent/JP4812942B2/ja not_active Expired - Fee Related
- 2000-02-09 DE DE60015084T patent/DE60015084T2/de not_active Expired - Lifetime
-
2010
- 2010-05-18 JP JP2010114804A patent/JP2010174044A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010174044A (ja) | 2010-08-12 |
| HK1042425B (en) | 2005-04-01 |
| JP4812942B2 (ja) | 2011-11-09 |
| AU2457100A (en) | 2000-09-14 |
| EP1154790B1 (en) | 2004-10-20 |
| JP2002537353A (ja) | 2002-11-05 |
| WO2000050075A3 (en) | 2001-01-11 |
| DE60015084D1 (de) | 2004-11-25 |
| ES2228454T3 (es) | 2005-04-16 |
| HK1042425A1 (en) | 2002-08-16 |
| ATE279943T1 (de) | 2004-11-15 |
| PT1154790E (pt) | 2005-03-31 |
| EP1154790A2 (en) | 2001-11-21 |
| US8221761B1 (en) | 2012-07-17 |
| WO2000050075A2 (en) | 2000-08-31 |
| CA2371994A1 (en) | 2000-08-31 |
| DE60015084T2 (de) | 2006-02-16 |
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Legal Events
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| EEER | Examination request | ||
| MKLA | Lapsed |
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