JP2002537329A - 特定のウリジン、アデニン及びシチジン二リン酸並びにそれらの類似体による粘膜水和の促進方法 - Google Patents
特定のウリジン、アデニン及びシチジン二リン酸並びにそれらの類似体による粘膜水和の促進方法Info
- Publication number
- JP2002537329A JP2002537329A JP2000600636A JP2000600636A JP2002537329A JP 2002537329 A JP2002537329 A JP 2002537329A JP 2000600636 A JP2000600636 A JP 2000600636A JP 2000600636 A JP2000600636 A JP 2000600636A JP 2002537329 A JP2002537329 A JP 2002537329A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- hydrogen
- substituted
- alkylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| PCT/US2000/005282 WO2000050024A2 (en) | 1999-02-26 | 2000-02-25 | Method of promoting mucosal hydration with certain uridine, adenine and cytidine diphosphates and analogs thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2009173564A (ja) * | 2008-01-23 | 2009-08-06 | Yamasa Shoyu Co Ltd | 唾液分泌促進剤 |
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| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| US6872710B2 (en) | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| WO1999005155A2 (en) | 1997-07-25 | 1999-02-04 | Inspire Pharmaceuticals, Inc. | Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof |
| US6432454B1 (en) * | 1997-12-12 | 2002-08-13 | C. V. Technologies, Inc. | Processes of making north american ginseng fractions, products containing them, and use as immunomodulators |
| US6624150B2 (en) | 1999-02-26 | 2003-09-23 | Inspire Pharmaceuticals, Inc. | Method of treating gastrointestinal tract disease with purinergic receptor agonists |
| DE60015734D1 (de) | 1999-02-26 | 2004-12-16 | Inspire Pharmaceuticals Durham | Verwendung von dinukleotidtriphosphaten, cytidindiphosphaten und adenindiphosphaten zur herstellung einer pharmazeutischen zubereitung zur förderung der schleimauthydratation |
| US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| JP2003524636A (ja) * | 1999-12-22 | 2003-08-19 | インスパイアー ファーマシューティカルズ，インコーポレイティド | プリン性受容体アゴニストによる胃腸管の処置方法 |
| US6864243B1 (en) | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
| AU2001260643B9 (en) | 2000-05-30 | 2006-10-19 | Merck Sharp & Dohme Corp. | Ectocornea extension promoters |
| US6555675B2 (en) | 2000-08-21 | 2003-04-29 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists |
| US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
| US7132408B2 (en) | 2000-08-21 | 2006-11-07 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
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| JP2005508297A (ja) | 2001-06-25 | 2005-03-31 | インスパイアー ファーマシューティカルズ，インコーポレイティド | Ｐ２ｙプリン受容体作用物質による関節潤滑 |
| JP2005532254A (ja) | 2001-11-06 | 2005-10-27 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 炎症性疾患を治療又は予防する方法 |
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| US7179481B2 (en) * | 2002-09-19 | 2007-02-20 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| JP2006505585A (ja) * | 2002-10-18 | 2006-02-16 | モリケム メディシンズ， インコーポレイテッド | ランチビオティクスで眼乾燥症を処置する方法 |
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| US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
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| KR100870104B1 (ko) * | 2005-11-28 | 2008-11-26 | 주식회사 머젠스 | 안구건조증 치료 및 예방용 조성물 |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| SG10201708931XA (en) | 2012-12-17 | 2017-12-28 | Parion Sciences Inc | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
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| US4868154A (en) | 1986-02-19 | 1989-09-19 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with melanocyte stimulating hormones |
| US4753945A (en) | 1986-02-19 | 1988-06-28 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with phosphodiesterase inhibitors |
| US5628984A (en) | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US6159952A (en) * | 1996-11-07 | 2000-12-12 | Inspire Pharmaceuticals, Inc. | Method of treating bronchitis with uridine triphosphate and related compounds |
| CN1262556C (zh) | 1997-02-06 | 2006-07-05 | 印斯拜尔药品股份有限公司 | 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用 |
| DE60015734D1 (de) | 1999-02-26 | 2004-12-16 | Inspire Pharmaceuticals Durham | Verwendung von dinukleotidtriphosphaten, cytidindiphosphaten und adenindiphosphaten zur herstellung einer pharmazeutischen zubereitung zur förderung der schleimauthydratation |
-
2000
- 2000-02-25 DE DE60015734T patent/DE60015734D1/de not_active Expired - Lifetime
- 2000-02-25 JP JP2000600636A patent/JP2002537329A/ja active Pending
- 2000-02-25 AR ARP000100810A patent/AR023088A1/es unknown
- 2000-02-25 EP EP00914781A patent/EP1161246B1/en not_active Expired - Lifetime
- 2000-02-25 BR BR0008498-0A patent/BR0008498A/pt not_active Application Discontinuation
- 2000-02-25 WO PCT/US2000/005282 patent/WO2000050024A2/en not_active Ceased
- 2000-02-25 AU AU36126/00A patent/AU3612600A/en not_active Abandoned
- 2000-02-25 KR KR1020017010900A patent/KR20010114214A/ko not_active Withdrawn
- 2000-02-25 US US09/512,867 patent/US6331529B1/en not_active Expired - Fee Related
- 2000-02-25 MX MXPA01008547A patent/MXPA01008547A/es unknown
- 2000-02-25 CA CA002359891A patent/CA2359891A1/en not_active Abandoned
- 2000-02-25 AT AT00914781T patent/ATE281837T1/de not_active IP Right Cessation
-
2001
- 2001-12-03 US US10/005,267 patent/US6436910B1/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040059A1 (en) * | 1995-06-07 | 1996-12-19 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of lung disease |
| WO1998003177A1 (en) * | 1996-07-03 | 1998-01-29 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
| JP2001513568A (ja) * | 1997-08-29 | 2001-09-04 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 肺疾患を治療するためのウリジン５’−ジホスフェートとその類似体の使用 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009173564A (ja) * | 2008-01-23 | 2009-08-06 | Yamasa Shoyu Co Ltd | 唾液分泌促進剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000050024A2 (en) | 2000-08-31 |
| US20020052338A1 (en) | 2002-05-02 |
| DE60015734D1 (de) | 2004-12-16 |
| US6436910B1 (en) | 2002-08-20 |
| ATE281837T1 (de) | 2004-11-15 |
| MXPA01008547A (es) | 2003-06-06 |
| US6331529B1 (en) | 2001-12-18 |
| BR0008498A (pt) | 2002-02-05 |
| CA2359891A1 (en) | 2000-08-31 |
| AR023088A1 (es) | 2002-09-04 |
| EP1161246A2 (en) | 2001-12-12 |
| WO2000050024A3 (en) | 2001-07-05 |
| KR20010114214A (ko) | 2001-12-31 |
| EP1161246B1 (en) | 2004-11-10 |
| AU3612600A (en) | 2000-09-14 |
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