JP2002535387A5 - - Google Patents
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- Publication number
- JP2002535387A5 JP2002535387A5 JP2000595973A JP2000595973A JP2002535387A5 JP 2002535387 A5 JP2002535387 A5 JP 2002535387A5 JP 2000595973 A JP2000595973 A JP 2000595973A JP 2000595973 A JP2000595973 A JP 2000595973A JP 2002535387 A5 JP2002535387 A5 JP 2002535387A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- racemic
- thioester
- deoxyerythronolide
- fch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007970 thio esters Chemical class 0.000 description 13
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 6
- 239000002243 precursor Substances 0.000 description 4
- 229960003276 erythromycin Drugs 0.000 description 3
- 229930001119 polyketide Natural products 0.000 description 3
- 150000003881 polyketide derivatives Chemical class 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 description 1
- -1 2-methylthiazolyl Chemical group 0.000 description 1
- 101150065749 Churc1 gene Proteins 0.000 description 1
- 102100038239 Protein Churchill Human genes 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000005110 aryl thio group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 description 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000005543 phthalimide group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11738499P | 1999-01-27 | 1999-01-27 | |
| US60/117,384 | 1999-01-27 | ||
| PCT/US2000/002397 WO2000044717A2 (en) | 1999-01-27 | 2000-01-27 | Synthesis of oligoketides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002535387A JP2002535387A (ja) | 2002-10-22 |
| JP2002535387A5 true JP2002535387A5 (enExample) | 2007-03-01 |
Family
ID=22372623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000595973A Pending JP2002535387A (ja) | 1999-01-27 | 2000-01-27 | オリゴケチドの合成 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6492562B1 (enExample) |
| EP (1) | EP1144375A2 (enExample) |
| JP (1) | JP2002535387A (enExample) |
| AU (1) | AU3353500A (enExample) |
| CA (1) | CA2361040A1 (enExample) |
| WO (1) | WO2000044717A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| WO2001060833A2 (en) | 2000-02-18 | 2001-08-23 | Kosan Biosciences, Inc. | Motilide compounds |
| ATE360086T1 (de) * | 2000-02-24 | 2007-05-15 | Kyowa Hakko Kogyo Kk | Verfahren zur herstellung von avermectinderivaten |
| US7680601B1 (en) | 2000-05-30 | 2010-03-16 | Kosan Biosciences | Design of polyketide synthase genes |
| JP2004520008A (ja) * | 2000-08-09 | 2004-07-08 | コーサン バイオサイエンシーズ， インコーポレイテッド | ポリケチドの化学合成において使用するための生物中間体 |
| JP2005519996A (ja) * | 2001-10-18 | 2005-07-07 | ミシガン ステイト ユニバーシティー | オキサゾリジノン類の製造方法及びその使用方法 |
| US7189549B2 (en) * | 2002-06-14 | 2007-03-13 | Kosan Biosciences, Inc. | Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof |
| ES2375714T3 (es) * | 2002-02-19 | 2012-03-05 | Dow Agrosciences Llc | Nuevas poliquétido-sintetasas productoras de espinosina. |
| AU2003248694A1 (en) * | 2002-06-13 | 2003-12-31 | Kosan Biosciences, Inc. | Methods and cells for improved production of polyketides |
| US7427493B2 (en) | 2002-06-28 | 2008-09-23 | Kosan Biosciences Incorporated | Recombinant genes for polyketide modifying enzymes |
| EP1527160A4 (en) * | 2002-07-31 | 2005-09-14 | Univ Leland Stanford Junior | PREPARATION OF GLYCOSYLATED MACROLIDES IN E. COLI |
| DK1532131T3 (da) | 2002-08-29 | 2009-02-09 | Pfizer | Motilid-forbindelser |
| WO2004044180A2 (en) | 2002-11-12 | 2004-05-27 | Kosan Biosciences, Inc. | Method for producing polyketides |
| US7459294B2 (en) * | 2003-08-08 | 2008-12-02 | Kosan Biosciences Incorporated | Method of producing a compound by fermentation |
| US7211568B2 (en) * | 2003-12-18 | 2007-05-01 | Kosan Biosciences Incorporated | 9-Desoxoerythromycin compounds as prokinetic agents |
| US7229814B2 (en) * | 2004-05-05 | 2007-06-12 | Regents Of The University Of Minnesota | Nucleic acids and polypeptides involved in the production of cryptophycin |
| US7595300B2 (en) * | 2005-12-13 | 2009-09-29 | Kosan Biosciences Incorporated | 7-quinolyl ketolide antibacterial agents |
| US7566558B2 (en) * | 2006-07-28 | 2009-07-28 | Regents Of The University Of Michigan | Nucleic acids and polypeptides involved in the production of cryptophycin |
| US7800965B2 (en) | 2008-03-10 | 2010-09-21 | Micron Technology, Inc. | Digit line equilibration using access devices at the edge of sub-arrays |
| WO2017099674A2 (en) * | 2015-12-09 | 2017-06-15 | Ptt Global Chemical Public Company Limited | Ion exchange resin for producing bisphenol, and a method for producing bisphenol using said ion exchange resin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824513A (en) | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
| US6066721A (en) * | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
| NZ500693A (en) * | 1997-04-30 | 2004-01-30 | Kosan Biosciences Inc | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
-
2000
- 2000-01-27 AU AU33535/00A patent/AU3353500A/en not_active Abandoned
- 2000-01-27 US US09/492,733 patent/US6492562B1/en not_active Expired - Fee Related
- 2000-01-27 CA CA002361040A patent/CA2361040A1/en not_active Abandoned
- 2000-01-27 WO PCT/US2000/002397 patent/WO2000044717A2/en not_active Ceased
- 2000-01-27 EP EP00911673A patent/EP1144375A2/en not_active Ceased
- 2000-01-27 JP JP2000595973A patent/JP2002535387A/ja active Pending
-
2002
- 2002-08-07 US US10/214,653 patent/US20030096374A1/en not_active Abandoned
- 2002-08-08 US US10/215,964 patent/US7022825B2/en not_active Expired - Lifetime
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