JP2002534219A - 標的細胞の経皮的な光力学的処置 - Google Patents

標的細胞の経皮的な光力学的処置

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Publication number
JP2002534219A
JP2002534219A JP2000593337A JP2000593337A JP2002534219A JP 2002534219 A JP2002534219 A JP 2002534219A JP 2000593337 A JP2000593337 A JP 2000593337A JP 2000593337 A JP2000593337 A JP 2000593337A JP 2002534219 A JP2002534219 A JP 2002534219A
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Prior art keywords
tumor
light
tissue
target
cells
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Pending
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JP2000593337A
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English (en)
Japanese (ja)
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JP2002534219A5 (https=
Inventor
ジェイムズ チェン，
Original Assignee
ライト サイエンシーズ コーポレイション
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Application filed by ライト サイエンシーズ コーポレイション filed Critical ライト サイエンシーズ コーポレイション
Publication of JP2002534219A publication Critical patent/JP2002534219A/ja
Publication of JP2002534219A5 publication Critical patent/JP2002534219A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Laser Surgery Devices (AREA)
  • Medicinal Preparation (AREA)
JP2000593337A 1999-01-15 2000-01-14 標的細胞の経皮的な光力学的処置 Pending JP2002534219A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11623499P 1999-01-15 1999-01-15
US60/116,234 1999-01-15
US09/271,575 1999-03-18
US09/271,575 US6602274B1 (en) 1999-01-15 1999-03-18 Targeted transcutaneous cancer therapy
PCT/US2000/000944 WO2000041727A1 (en) 1999-01-15 2000-01-14 Transcutaneous photodynamic treatment of targeted cells

Publications (2)

Publication Number Publication Date
JP2002534219A true JP2002534219A (ja) 2002-10-15
JP2002534219A5 JP2002534219A5 (https=) 2007-02-22

Family

ID=40418902

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000593337A Pending JP2002534219A (ja) 1999-01-15 2000-01-14 標的細胞の経皮的な光力学的処置

Country Status (6)

Country Link
US (7) US6602274B1 (https=)
EP (1) EP1140176A1 (https=)
JP (1) JP2002534219A (https=)
AU (1) AU2413700A (https=)
CA (1) CA2356776A1 (https=)
WO (1) WO2000041727A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012525411A (ja) * 2009-04-28 2012-10-22 セラムオプテック インダストリーズ インコーポレーテッド 経口投与のための新規の光増感剤製剤
JP5875578B2 (ja) * 2011-03-23 2016-03-02 国立大学法人 筑波大学 光線力学治療用ナノ粒子

Families Citing this family (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9294298A (en) * 1997-08-25 1999-03-16 Advanced Photodynamic Technologies, Inc. Treatment device for topical photodynamic therapy and method of making same
IL124722A0 (en) * 1998-06-02 1999-01-26 Oron Amir Ischemia laser treatment
DE19827417B4 (de) * 1998-06-19 2004-10-28 Hahn, Rainer, Dr.Med.Dent. Material zur unterschiedlichen Modifizierung der optischen Eigenschaften unterschiedlicher Zellen
US6183773B1 (en) * 1999-01-04 2001-02-06 The General Hospital Corporation Targeting of sebaceous follicles as a treatment of sebaceous gland disorders
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
WO2000041726A2 (en) 1999-01-15 2000-07-20 Light Sciences Corporation Noninvasive vascular therapy
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US7166719B2 (en) 2002-06-27 2007-01-23 Health Research, Inc. Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US20020049247A1 (en) * 2000-01-12 2002-04-25 Chen James C. Novel treatment for eye disease
US7351807B2 (en) * 2000-01-18 2008-04-01 Mallinckrodt Inc. Cyanine-sulfenates for dual phototherapy
WO2001058240A2 (en) * 2000-02-10 2001-08-16 Massachusetts Eye And Ear Infirmary Photodynamic therapy for treating conditions of the eye
EP2269645A3 (en) * 2000-08-16 2011-01-12 The General Hospital Corporation doing business as Massachusetts General Hospital Topical aminolevulinic acid-photodynamic therapy for acne vulgaris
WO2002064163A2 (en) * 2001-02-15 2002-08-22 Qlt Inc. Reduction or prevention of pdt related inflammation
US8078262B2 (en) * 2001-04-16 2011-12-13 The Johns Hopkins University Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies
CA2445898A1 (en) * 2001-05-01 2002-12-19 The General Hospital Corporation Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies
US20030031627A1 (en) * 2001-07-31 2003-02-13 Mallinckrodt Inc. Internal image antibodies for optical imaging and therapy
US7223282B1 (en) * 2001-09-27 2007-05-29 Advanced Cardiovascular Systems, Inc. Remote activation of an implantable device
US8308784B2 (en) 2006-08-24 2012-11-13 Jackson Streeter Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
US9993659B2 (en) * 2001-11-01 2018-06-12 Pthera, Llc Low level light therapy for enhancement of neurologic function by altering axonal transport rate
US7303578B2 (en) 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
US7534255B1 (en) 2003-01-24 2009-05-19 Photothera, Inc Low level light therapy for enhancement of neurologic function
US20030109906A1 (en) * 2001-11-01 2003-06-12 Jackson Streeter Low level light therapy for the treatment of stroke
US10683494B2 (en) * 2001-11-01 2020-06-16 Pthera LLC Enhanced stem cell therapy and stem cell production through the administration of low level light energy
EP1312353A1 (en) * 2001-11-16 2003-05-21 Ecole Polytechnique Federale De Lausanne (Epfl) Method for hair removal
EP1453546A2 (en) * 2001-12-04 2004-09-08 Nanospectra Biosciences, Inc. Treatment of angiogenesis disorders using targeted nanoparticles
US20030144712A1 (en) * 2001-12-20 2003-07-31 Jackson Streeter, M.D. Methods for overcoming organ transplant rejection
US10695577B2 (en) 2001-12-21 2020-06-30 Photothera, Inc. Device and method for providing phototherapy to the heart
US7316922B2 (en) * 2002-01-09 2008-01-08 Photothera Inc. Method for preserving organs for transplant
EP1467760A2 (en) * 2002-01-23 2004-10-20 Light Sciences Corporation Systems and methods for photodynamic therapy
US7041121B1 (en) * 2002-01-31 2006-05-09 Medtronicvidamed, Inc. Apparatus for treating prostate cancer and method for same
IL148921A0 (en) 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
WO2003084601A2 (en) * 2002-04-02 2003-10-16 Lumerx, Inc. Apparatus and methods using visible light for debilitating and/or killing microorganisms within the body
AU2003223613A1 (en) * 2002-04-16 2003-11-03 Lumerx, Inc Chemiluminescent light source using visible light for biotherapy
US20040153130A1 (en) * 2002-05-29 2004-08-05 Amir Oron Methods for treating muscular dystrophy
AU2003249742A1 (en) 2002-07-02 2004-01-23 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US7713294B2 (en) 2002-08-28 2010-05-11 Nomir Medical Technologies, Inc. Near infrared microbial elimination laser systems (NIMEL)
US20080131968A1 (en) * 2002-08-28 2008-06-05 Nomir Medical Technologies, Inc. Near-infrared electromagnetic modification of cellular steady-state membrane potentials
US20040126272A1 (en) * 2002-08-28 2004-07-01 Eric Bornstein Near infrared microbial elimination laser system
US8506979B2 (en) 2002-08-28 2013-08-13 Nomir Medical Technologies, Inc. Near-infrared electromagnetic modification of cellular steady-state membrane potentials
US20040156743A1 (en) * 2002-08-28 2004-08-12 Eric Bornstein Near infrared microbial elimination laser system
US20040132002A1 (en) * 2002-09-17 2004-07-08 Jackson Streeter Methods for preserving blood
EP1417974A1 (en) * 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
US7255560B2 (en) * 2002-12-02 2007-08-14 Nomir Medical Technologies, Inc. Laser augmented periodontal scaling instruments
US20040220513A1 (en) * 2003-03-04 2004-11-04 Jackson Streeter Low level light therapy for the enhancement of hepatic functioning
ATE442861T1 (de) * 2003-03-07 2009-10-15 Univ Texas Gegen antikörper gerichtete photodynamische therapie
US10376711B2 (en) 2003-03-14 2019-08-13 Light Sciences Oncology Inc. Light generating guide wire for intravascular use
US20080269846A1 (en) * 2003-03-14 2008-10-30 Light Sciences Oncology, Inc. Device for treatment of blood vessels using light
CN2885311Y (zh) 2006-01-18 2007-04-04 郑成福 经尿道光动力疗法前列腺治疗仪
US7344555B2 (en) 2003-04-07 2008-03-18 The United States Of America As Represented By The Department Of Health And Human Services Light promotes regeneration and functional recovery after spinal cord injury
CA2465051C (en) * 2003-04-23 2014-11-18 John Tulip Switched photodynamic apparatus
US20070020272A1 (en) * 2003-04-30 2007-01-25 Tayyaba Hasan Indirectly linked photosensitizer immunoconjugates, processes for the production thereof and methods of use thereof
US7470124B2 (en) * 2003-05-08 2008-12-30 Nomir Medical Technologies, Inc. Instrument for delivery of optical energy to the dental root canal system for hidden bacterial and live biofilm thermolysis
CA2446663A1 (en) * 2003-10-24 2005-04-24 Shane Burch Bone-treatment instrument and method
US7553326B2 (en) * 2003-11-24 2009-06-30 Sweet Richard M Method and apparatus for preventing dialysis graft intimal hyperplasia
US8267883B2 (en) * 2004-02-06 2012-09-18 Depuy Spine, Inc. Photocatalytic implant having a sensor
US7744555B2 (en) * 2004-02-06 2010-06-29 Depuy Spine, Inc. Implant having a photocatalytic unit
US20060004317A1 (en) * 2004-06-30 2006-01-05 Christophe Mauge Hydrocephalus shunt
US20060079947A1 (en) * 2004-09-28 2006-04-13 Tankovich Nikolai I Methods and apparatus for modulation of the immune response using light-based fractional treatment
RU2290972C2 (ru) * 2004-11-19 2007-01-10 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Способ фотодинамической терапии онкологических заболеваний
US20060173514A1 (en) * 2005-02-02 2006-08-03 Advanced Photodynamic Technologies, Inc. Wound treatment device for photodynamic therapy and method of using same
US20060200212A1 (en) * 2005-02-17 2006-09-07 Brawn Peter R Light therapy device for treatment of bone disorders and biostimulation of bone and soft tissue
US20070248930A1 (en) 2005-02-17 2007-10-25 Biolux Research Ltd. Light therapy apparatus and methods
US8157807B2 (en) 2005-06-02 2012-04-17 The Invention Science Fund I, Llc Skin treatment including patterned light
US8540701B2 (en) * 2005-03-04 2013-09-24 The Invention Science Fund I, Llc Hair treatment system
US8679101B2 (en) * 2005-03-04 2014-03-25 The Invention Science Fund I, Llc Method and system for temporary hair removal
US20060200114A1 (en) * 2005-03-04 2006-09-07 Searete Llc, A Limited Liability Corporation Of State Of Delaware Hair removal system with light source array
US8529560B2 (en) 2005-03-04 2013-09-10 The Invention Science Fund I, Llc Hair treatment system
US20060276859A1 (en) * 2005-06-02 2006-12-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Photopatterning of skin
US20060240096A1 (en) * 2005-04-22 2006-10-26 Kugler Chad J Devices and methods for treating the gastrointestinal system
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US20070032846A1 (en) * 2005-08-05 2007-02-08 Bran Ferren Holographic tattoo
US9055958B2 (en) * 2005-06-29 2015-06-16 The Invention Science Fund I, Llc Hair modification using converging light
US20070038270A1 (en) * 2005-07-05 2007-02-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multi step photopatterning of skin
WO2007004045A2 (en) * 2005-07-05 2007-01-11 Universite De Lausanne Use of a photosensitizing agent in the treatment or prevention of an inflammation-associated disorder in the gastrointestinal tract of a mammal
US8386183B2 (en) * 2005-07-21 2013-02-26 The Invention Science Fund I, Llc Selective resonant reconfiguration of chemical structures
US9211332B2 (en) 2005-07-21 2015-12-15 The Invention Science Fund I, Llc Selective resonance of bodily agents
US20070021924A1 (en) * 2005-07-21 2007-01-25 Ishikawa Muriel Y Selective resonance of chemical structures
US8346484B2 (en) 2005-07-21 2013-01-01 The Invention Science Fund I, Llc Selective resonance of chemical structures
US9427465B2 (en) 2005-07-21 2016-08-30 Deep Science, Llc Selective resonance of chemical structures
JP2009502258A (ja) * 2005-07-21 2009-01-29 ノミール・メディカル・テクノロジーズ・インコーポレーテッド 標的部位の生物学的汚染物質のレベルを下げる方法
US8386186B2 (en) * 2005-07-21 2013-02-26 The Invention Science Fund I, Llc Selective resonance of chemical structures
US8195403B2 (en) * 2005-07-21 2012-06-05 The Invention Science Fund I, Llc Selective resonance of bodily agents
US8364412B2 (en) * 2005-07-21 2013-01-29 The Invention Science Fund I, Llc Selective resonance of chemical structures
US20070021927A1 (en) * 2005-07-21 2007-01-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Selective resonance of chemical structures
US7976571B2 (en) * 2005-08-02 2011-07-12 Wolfgang Neuberger Photodynamic therapy irradiation system for the treatment of superficial hyperproliferative tissue growth
US20070065420A1 (en) * 2005-08-23 2007-03-22 Johnson Lanny L Ultrasound Therapy Resulting in Bone Marrow Rejuvenation
US20070048340A1 (en) * 2005-08-31 2007-03-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multi step patterning of a skin surface
JP2009506874A (ja) * 2005-09-06 2009-02-19 ライト サイエンシーズ オンコロジー， インコーポレイテッド 体の内腔内の治療のための埋め込み型装置
WO2007056498A2 (en) * 2005-11-07 2007-05-18 Light Sciences Oncology, Inc Light delivery apparatus
WO2007084981A2 (en) * 2006-01-19 2007-07-26 The Regents Of The University Of Michigan System and method for photoacoustic imaging and monitoring of laser therapy
WO2007087374A2 (en) * 2006-01-24 2007-08-02 Nomir Medical Technologies, Inc. Optical method and device for modulation of biochemical processes in adipose tissue
US10357662B2 (en) 2009-02-19 2019-07-23 Pthera LLC Apparatus and method for irradiating a surface with light
US20090254154A1 (en) 2008-03-18 2009-10-08 Luis De Taboada Method and apparatus for irradiating a surface with pulsed light
US7575589B2 (en) 2006-01-30 2009-08-18 Photothera, Inc. Light-emitting device and method for providing phototherapy to the brain
US20070208400A1 (en) * 2006-03-01 2007-09-06 The General Hospital Corporation System and method for providing cell specific laser therapy of atherosclerotic plaques by targeting light absorbers in macrophages
US20070208331A1 (en) * 2006-03-02 2007-09-06 Chu Michael S Systems and methods of treatment within a gastrointestinal lumen
WO2007106415A2 (en) * 2006-03-10 2007-09-20 Massachusetts Institute Of Technology Triggered self-assembly conjugates and nanosystems
HRP20060149B1 (en) * 2006-04-19 2008-11-30 Institut "Ruđer Bošković" Intelligent sequential illuminator photodynamic therapy
US20070255356A1 (en) * 2006-04-28 2007-11-01 Ondine International, Ltd. Photodisinfection delivery devices and methods
WO2007130465A2 (en) * 2006-05-02 2007-11-15 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US7465312B2 (en) 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US8057464B2 (en) * 2006-05-03 2011-11-15 Light Sciences Oncology, Inc. Light transmission system for photoreactive therapy
US8585707B2 (en) * 2006-06-07 2013-11-19 Gary S. Rogers Continuous low irradiance photodynamic therapy method
US20080033412A1 (en) * 2006-08-01 2008-02-07 Harry Thomas Whelan System and method for convergent light therapy having controllable dosimetry
US20080233051A1 (en) * 2006-09-08 2008-09-25 Prasad Paras N Nanoparticles for two-photon activated photodynamic therapy and imaging
US20090035576A1 (en) * 2006-09-08 2009-02-05 Prasad Paras N Nanoparticles for two-photon activated photodynamic therapy and imaging
US20110309267A1 (en) * 2010-06-16 2011-12-22 California Institute Of Technology Iterative time-reversal enhanced transmission solving approach
US20080123083A1 (en) * 2006-11-29 2008-05-29 The Regents Of The University Of Michigan System and Method for Photoacoustic Guided Diffuse Optical Imaging
WO2008067455A2 (en) * 2006-11-30 2008-06-05 Stryker Corporation System and method for targeted activation of a pharmaceutical agent within the body cavity that is activated by the application of energy
US20080173093A1 (en) * 2007-01-18 2008-07-24 The Regents Of The University Of Michigan System and method for photoacoustic tomography of joints
US20080221211A1 (en) * 2007-02-02 2008-09-11 Jackson Streeter Method of treatment of neurological injury or cancer by administration of dichloroacetate
WO2008103982A2 (en) * 2007-02-23 2008-08-28 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
US8376013B2 (en) * 2008-03-11 2013-02-19 Duke University Plasmonic assisted systems and methods for interior energy-activation from an exterior source
ES2454974T3 (es) 2007-06-27 2014-04-14 The General Hospital Corporation Aparato para la inhibición óptica de la terapia fotodinámica
US20090104212A1 (en) * 2007-08-06 2009-04-23 Immunolight Methods and systems for treating cell proliferation disorders using two-photon simultaneous absorption
EP2197546A1 (en) * 2007-09-14 2010-06-23 Light Sciences Oncology, Inc. Systems, devices, and methods for photoactive assisted resection
CA2705859A1 (en) * 2007-10-15 2009-04-23 John P. Stokes Convergent well irradiating plaque for choroidal melanoma
EP2222636B1 (en) 2007-12-21 2013-04-10 Ligand Pharmaceuticals Inc. Selective androgen receptor modulators (sarms) and uses thereof
ES2689302T3 (es) * 2008-02-13 2018-11-13 Andreas Rose Dispositivo de suministro de luz que proporciona un patrón radial de emisión de luz
US8770203B2 (en) * 2008-07-14 2014-07-08 Immunolight, Llc. Advanced methods and systems for treating cell proliferation disorders
US7993640B2 (en) 2008-08-06 2011-08-09 Light Sciences Oncology, Inc. Enhancement of light activated therapy by immune augmentation using anti-CTLA-4 antibody
DE102008038309A1 (de) * 2008-08-19 2010-02-25 Theuer, Axel E., Prof. Dr.-Ing. habil. Vorrichtung zur Zerstörung von Tumorzellen oder Erregern im Blutkreislauf
US7848035B2 (en) 2008-09-18 2010-12-07 Photothera, Inc. Single-use lens assembly
WO2010035268A2 (en) * 2008-09-29 2010-04-01 Dr. Eyal Bressler Ltd. Device for photodynamical therapy of cancer
US10195459B2 (en) 2008-09-29 2019-02-05 Tom Kerber Device for photodynamical therapy of cancer
USRE49724E1 (en) 2008-09-29 2023-11-14 Tom Kerber Device for photodynamical therapy of cancer
WO2010056732A1 (en) 2008-11-12 2010-05-20 Marv Enterprises Llc Utilization of stents for the treatment of blood borne carcinomas
US9216386B2 (en) * 2009-03-17 2015-12-22 Marv Enterprises, LLC Sequential extracorporeal treatment of bodily fluids
US20100241038A1 (en) * 2009-03-20 2010-09-23 Bwt Property, Inc. Phototherapy Method for Assisting Transvenous Lead Placement
US8808733B2 (en) 2009-03-31 2014-08-19 The Board Of Trustees Of The University Of Arkansas Method of controlled drug release from a liposome carrier
US20100256125A1 (en) * 2009-04-06 2010-10-07 Zila Pharmaceuticals, Inc. Use of improved toluidine blue in photodynamic therapy
WO2010134007A2 (en) 2009-05-19 2010-11-25 Ramot At Tel Aviv University Ltd. Low-level energy laser therapy
US20110008372A1 (en) * 2009-07-08 2011-01-13 Light Sciences Oncology, Inc. Enhancement of light activated drug therapy through combination with other therapeutic agents
US8348929B2 (en) 2009-08-05 2013-01-08 Rocin Laboratories, Inc. Endoscopically-guided tissue aspiration system for safely removing fat tissue from a patient
US8465471B2 (en) 2009-08-05 2013-06-18 Rocin Laboratories, Inc. Endoscopically-guided electro-cauterizing power-assisted fat aspiration system for aspirating visceral fat tissue within the abdomen of a patient
US20110213336A1 (en) 2009-08-05 2011-09-01 Cucin Robert L Method of and apparatus for sampling, processing and collecting tissue and reinjecting the same into human patients
US20120209359A1 (en) 2009-08-14 2012-08-16 Light Sciences Oncology Inc. Low-profile intraluminal light delivery system and methods of using the same
US20110206737A1 (en) * 2010-02-24 2011-08-25 Empire Technology Development Llc Photosensitizer-containing composition
RU2455921C2 (ru) * 2010-03-04 2012-07-20 Сергей Дмитриевич Фокеев Способ лечения рака легкого, осложненного кровотечением
JP5719159B2 (ja) * 2010-03-15 2015-05-13 ソニー株式会社 評価装置
DE102010013307B4 (de) * 2010-03-29 2022-12-15 Karl Storz Se & Co. Kg Lichtquelleneinrichtung für endoskopische oder exoskopische Anwendungen
WO2012048423A1 (en) 2010-10-13 2012-04-19 Biolux Research Limited Method and apparatus for tooth regulation with heavy forces
EP2648651B1 (en) 2010-12-08 2016-11-23 Biolux Research Limited Apparatuses useful for regulating bone remodeling or tooth movement using light therapy and a functional appliance
EP2691152B1 (en) 2011-03-27 2017-06-21 Ramot at Tel Aviv University, Ltd. Low level laser therapy for alzheimer's disease
US10029115B2 (en) 2011-04-08 2018-07-24 Sanovas Intellectual Property, Llc Photodynamic therapy for tumors with localized delivery
US9694075B2 (en) 2011-04-08 2017-07-04 Sanovas, Inc. Treatment of hypoxic tumors with localized oxygenation
WO2013005379A1 (ja) * 2011-07-01 2013-01-10 Ｓｂｉファーマ株式会社 光増感剤又は５－アミノレブリン酸類を用いる光線力学的治療
US9849087B2 (en) 2011-11-08 2017-12-26 The Board Of Trustees Of The University Of Arkansas Methods and compositions for X-ray induced release from pH sensitive liposomes
US20150027950A1 (en) * 2012-03-27 2015-01-29 Marv Enterprises, LLC Treatment for atherosclerosis
US20130280671A1 (en) 2012-04-19 2013-10-24 Biolux Research Ltd. Intra-oral light therapy apparatuses and methods for their use
US10589120B1 (en) 2012-12-31 2020-03-17 Gary John Bellinger High-intensity laser therapy method and apparatus
US9662509B2 (en) 2013-05-23 2017-05-30 Cook Medical Technologies Llc Intraluminal activation system and method of activating an inactive agent
EP3498211B1 (en) 2013-08-09 2024-12-25 The General Hospital Corporation Apparatus for treating dermal melasma
EP3456700A1 (en) 2013-10-18 2019-03-20 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
JP6484235B2 (ja) 2013-10-22 2019-03-13 バイオルックス リサーチ リミテッド 口腔内光治療装置及びその使用方法
US9516995B2 (en) 2013-12-17 2016-12-13 Biovision Technologies, Llc Surgical device for performing a sphenopalatine ganglion block procedure
US9510743B2 (en) 2013-12-17 2016-12-06 Biovision Technologies, Llc Stabilized surgical device for performing a sphenopalatine ganglion block procedure
US10016580B2 (en) 2013-12-17 2018-07-10 Biovision Technologies, Llc Methods for treating sinus diseases
US9694163B2 (en) 2013-12-17 2017-07-04 Biovision Technologies, Llc Surgical device for performing a sphenopalatine ganglion block procedure
CA2935743A1 (en) 2014-01-04 2015-07-09 Vijay Agarwal Device and method for use of photodynamic therapy
US11534622B2 (en) * 2014-08-18 2022-12-27 Immunolight, Llc Non-invasive systems and methods for selective activation of photoreactive responses
KR101686145B1 (ko) * 2015-05-18 2016-12-13 한국과학기술원 인도시아닌 그린-리포좀 복합체를 포함하는 암 치료용 조성물
US9962443B2 (en) 2015-09-16 2018-05-08 LA JOLLA NANOMEDICAL. Inc. Cellular activity targeted nanoparticle system and methods of producing the nanoparticle system
CN107375943B (zh) * 2017-08-01 2020-06-23 上海市皮肤病医院 一种靶向抗皮肤鳞状细胞癌的共载超级变形脂质体及其制备方法和应用
US11638833B2 (en) 2017-08-02 2023-05-02 Multi Radiance Medical Reducing light polution in photobiomodulation therapy of a patients eye
WO2019028222A1 (en) 2017-08-02 2019-02-07 Multi Radiance Medical SYSTEM AND METHOD FOR DIRECTING LIGHT IN THE EYE OF A PATIENT
US11251635B2 (en) 2017-12-19 2022-02-15 Welch Allyn, Inc. Vital signs monitor with a removable and dischargable battery
WO2019136335A1 (en) * 2018-01-05 2019-07-11 Gencyte Therapeutics, Inc. Precision molecular adaptor system for car-t immunotherapy
US10525240B1 (en) 2018-06-28 2020-01-07 Sandler Scientific LLC Sino-nasal rinse delivery device with agitation, flow-control and integrated medication management system
CA3280998A1 (en) 2019-02-13 2025-10-30 Alpheus Medical, Inc. Non-invasive sonodynamic therapy
WO2020214834A1 (en) 2019-04-19 2020-10-22 Ligand Pharmaceuticals Inc. Crystalline forms and methods of producing crystalline forms of a compound
WO2020243319A1 (en) 2019-05-29 2020-12-03 Sonalasense, Inc. Sonosensitization
WO2020244751A1 (en) * 2019-06-05 2020-12-10 Biofrontera Bioscience Gmbh Illumination for photodynamic therapy
WO2020251975A1 (en) * 2019-06-10 2020-12-17 University Of South Florida Methods for treating cancer using x-ray-induced near infrared photoimmunotherapy
CA3185803A1 (en) 2020-08-07 2022-02-10 Vijay Agarwal Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
US11529153B2 (en) 2020-08-21 2022-12-20 University Of Washington Vaccine generation
WO2022040258A1 (en) 2020-08-21 2022-02-24 University Of Washington Disinfection method and apparatus
US11425905B2 (en) 2020-09-02 2022-08-30 University Of Washington Antimicrobial preventive netting
WO2022072821A1 (en) * 2020-10-02 2022-04-07 Colorado State University Research Foundation Compositions comprising inactivated microbes, and methods for use and production thereof
WO2022103775A1 (en) 2020-11-12 2022-05-19 Singletto Inc. Microbial disinfection for personal protection equipment
US12359369B2 (en) 2022-08-11 2025-07-15 Singletto Inc. Skin protection against microbial particles
WO2024173795A1 (en) * 2023-02-17 2024-08-22 California Institute Of Technology Activatable drug conjugates and therapeutic applications thereof
US20250065147A1 (en) * 2023-08-23 2025-02-27 Virginia Commonwealth University Systems and methods for photodynamic therapy
WO2026006003A1 (en) * 2024-06-14 2026-01-02 Virginia Commonwealth University Systems and methods for photodynamic therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032001A1 (en) * 1994-05-23 1995-11-30 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio Societa' Per Azioni Photodynamic conjugates with biocidal properties
JPH08505069A (ja) * 1992-11-20 1996-06-04 ユニバーシティ オブ ブリティッシュ コロンビア 感光剤を活性化する方法

Family Cites Families (232)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US127224A (en) * 1872-05-28 Improvement in cotton-seed cleaners
US46983A (en) * 1865-03-28 Improvement in treating ores
US49247A (en) * 1865-08-08 Improvement in the manufacture of pyroligneous acid
US10500A (en) * 1854-02-07 Tool-holder
US5456A (en) * 1848-02-22 Machine foe
US49502A (en) * 1865-08-22 Improved process for purifying coal-oil
US114434A (en) * 1871-05-02 Improvement in dry-earth closets
US87205A (en) * 1869-02-23 Improved velocipede
US127230A (en) * 1872-05-28 Improvement in lamp-chimney cleaners
US1272224A (en) * 1916-05-04 1918-07-09 James R Combs Change-making machine.
NL80628C (https=) 1949-07-23
BE506677A (https=) 1950-10-31
NL95406C (https=) 1954-08-20
JPS51159879U (https=) 1975-06-12 1976-12-20
JPS5384998U (https=) 1976-12-15 1978-07-13
US4337759A (en) 1979-10-10 1982-07-06 John M. Popovich Radiant energy concentration by optical total internal reflection
JPS57185220A (en) 1981-05-07 1982-11-15 Yakult Honsha Co Ltd Carcinostatic agent containing chlorophyll derivative as active component
JPS57185220U (https=) 1981-05-21 1982-11-25
US4521762A (en) 1981-08-27 1985-06-04 Gte Automatic Electric Laboratories, Incorporated Integratable D/A converter
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4577636A (en) * 1982-11-23 1986-03-25 The Beth Israel Hospital Association Method for diagnosis of atherosclerosis
US4693885A (en) 1984-07-18 1987-09-15 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4675338A (en) 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
WO1986001720A1 (en) 1984-09-13 1986-03-27 Cytogen Corporation Antibody therapeutic agent conjugates
US4753958A (en) 1985-02-07 1988-06-28 University Of Cal Photochemotherapy of epithelial diseases with derivatives of hematoporphyrins
US4693556A (en) 1985-06-04 1987-09-15 Laser Therapeutics, Inc. Apparatus for producing a spherical pattern of light and method of manufacture
KR910009202B1 (ko) 1985-10-23 1991-11-04 니혼메디피직스 가부시끼가이샤 포르피린 유도체의 제조방법
US5534506A (en) * 1986-01-02 1996-07-09 University Of Toledo Use of purpurins, chlorins and purpurin- and chlorin-containing compositions
US5811248A (en) 1986-03-31 1998-09-22 Charter Ventures Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof
US4861876A (en) 1986-11-26 1989-08-29 Wayne State University Hematoporphyrin derivative and method of preparation and purification
US5494793A (en) 1986-12-15 1996-02-27 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
US5171749A (en) * 1987-01-20 1992-12-15 University Of British Columbia Wavelength-specific cytotoxic agents
US5283255A (en) 1987-01-20 1994-02-01 The University Of British Columbia Wavelength-specific cytotoxic agents
US4878891A (en) 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
US4957481A (en) 1987-10-01 1990-09-18 U.S. Bioscience Photodynamic therapeutic technique
JPH0629196B2 (ja) * 1987-12-01 1994-04-20 甲子郎 梅村 超音波による腫瘍治療用生理作用増強剤
US5919217A (en) 1987-12-08 1999-07-06 Medic-Light, Inc. Portable phototherapy unit
US4823244A (en) 1988-01-29 1989-04-18 Niagara Medical Innovations Inc. Light source assembly
US5026367A (en) 1988-03-18 1991-06-25 Cardiovascular Laser Systems, Inc. Laser angioplasty catheter and a method for use thereof
US5053006A (en) * 1988-04-19 1991-10-01 Watson Brant D Method for the permanent occlusion of arteries
US5002962A (en) 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5198460A (en) 1988-07-20 1993-03-30 Health Research Inc. Pyropheophorbides and their use in photodynamic therapy
US4998930A (en) 1988-08-03 1991-03-12 Phototherapeutic Systems Intracavity laser phototherapy method
US5055446A (en) 1988-10-21 1991-10-08 University Of Cincinnati Method to improve survival of patients during sepsis by diet composition
US5028594A (en) * 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US5284869A (en) 1991-12-17 1994-02-08 Emil Bisaccia Photophoresis methods for treating atherosclerosis and for preventing restenosis following angioplasty
US5041078A (en) 1989-03-06 1991-08-20 Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas Photodynamic viral deactivation with sapphyrins
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
US4997639A (en) * 1989-11-27 1991-03-05 Nippon Petrochemicals Company, Limited Method for detecting cholesterol deposited in bodies of mammals
US5543514A (en) 1989-12-21 1996-08-06 Board Of Regents, The University Of Texas System Water-soluble sapphyrins
US5594136A (en) * 1989-12-21 1997-01-14 Pharmacyclics, Inc. Texaphyrin solid supports and devices
CA2075489C (en) 1990-01-08 2002-01-01 Leroy M. Wood Submersible lens fiberoptic assembly
GB9014307D0 (en) 1990-06-27 1990-08-15 Scient Generics Ltd Method of treatment and compositions therefor
US5484778C1 (en) 1990-07-17 2001-05-08 Univ Cleveland Hospitals Phthalocynine photosensitizers for photodynamic therapy and methods for their use
US5549660A (en) 1990-11-15 1996-08-27 Amron, Ltd. Method of treating acne
US5500009A (en) * 1990-11-15 1996-03-19 Amron, Ltd. Method of treating herpes
JP3154742B2 (ja) * 1991-04-30 2001-04-09 日本石油化学株式会社 哺乳類の動脈硬化症治療剤
EP0544895B1 (en) 1991-06-21 1997-08-27 Baxter International Inc. Method for inactivating pathogens in a body fluid
US5769844A (en) 1991-06-26 1998-06-23 Ghaffari; Shahriar Conventional light-pumped high power system for medical applications
US5263925A (en) 1991-07-22 1993-11-23 Gilmore Jr Thomas F Photopheresis blood treatment
US5209235A (en) * 1991-09-13 1993-05-11 Cardiovascular Imaging Systems, Inc. Ultrasonic imaging catheter assembly and method for identification of the same
US5770592A (en) 1991-11-22 1998-06-23 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization using angiostatic steroids
IL100545A (en) 1991-12-29 1995-03-15 Dimotech Ltd Photodynamic Healing Therapy Device
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US6890555B1 (en) * 1992-02-05 2005-05-10 Qlt, Inc. Liposome compositions of porphyrin photosensitizers
US5330741A (en) * 1992-02-24 1994-07-19 The Regents Of The University Of California Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
PT627940E (pt) 1992-03-05 2003-07-31 Univ Texas Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5655832A (en) 1992-04-16 1997-08-12 Tir Technologies, Inc. Multiple wavelength light processor
US5676453A (en) 1992-04-16 1997-10-14 Tir Technologies, Inc. Collimating TIR lens devices employing fluorescent light sources
US5806955A (en) 1992-04-16 1998-09-15 Tir Technologies, Inc. TIR lens for waveguide injection
US5404869A (en) 1992-04-16 1995-04-11 Tir Technologies, Inc. Faceted totally internally reflecting lens with individually curved faces on facets
US5613769A (en) 1992-04-16 1997-03-25 Tir Technologies, Inc. Tir lens apparatus having non-circular configuration about an optical axis
US5807881A (en) 1992-05-27 1998-09-15 Quadra Logic Technologies, Inc. Method for selectively reducing activated leukocyte cell population
US5776966A (en) 1992-05-27 1998-07-07 University Of British Columbia Selective cell inactivation in blood
EP0646019B9 (en) 1992-06-09 2002-12-18 Neorx Corporation Biotin-DOTA conjugates and their use in pretargeting methods
US6217869B1 (en) * 1992-06-09 2001-04-17 Neorx Corporation Pretargeting methods and compounds
US5976535A (en) 1992-06-09 1999-11-02 Neorx Corporation Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore
US5298018A (en) * 1992-08-14 1994-03-29 Pdt Cardiovascular, Inc. Method for treating cardiovascular disease through adjunctive photodynamic therapy
PL308116A1 (en) 1992-09-21 1995-07-24 Quadra Logic Technologies Percutaneous in vivo activation of a photosensitive factor present in blood
GB2272278B (en) 1992-10-23 1997-04-09 Cancer Res Campaign Tech Light source
US5700243A (en) 1992-10-30 1997-12-23 Pdt Systems, Inc. Balloon perfusion catheter
US5368841A (en) 1993-02-11 1994-11-29 The General Hospital Corporation Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides
US5482698A (en) 1993-04-22 1996-01-09 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin polymer conjugates
JP3565442B2 (ja) * 1993-04-22 2004-09-15 新日本石油化学株式会社 哺乳類の関節炎の診断剤および／または治療剤
US5445608A (en) 1993-08-16 1995-08-29 James C. Chen Method and apparatus for providing light-activated therapy
US5420768A (en) 1993-09-13 1995-05-30 Kennedy; John Portable led photocuring device
US5514669A (en) 1993-09-29 1996-05-07 Medical College Of Ohio Use of photodynamic therapy to treat prostatic tissue
US5441531A (en) 1993-10-18 1995-08-15 Dusa Pharmaceuticals Inc. Illuminator and methods for photodynamic therapy
US5913834A (en) 1993-11-04 1999-06-22 Francais; Caramia System for imparting sensory effects across a mother's abdomen to a fetus and monitoring effects on the fetus
US6015897A (en) * 1993-12-07 2000-01-18 Neorx Corporation Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
IL108918A (en) 1994-03-10 1997-04-15 Medic Lightech Ltd Apparatus for efficient photodynamic treatment
US5798349A (en) 1994-03-14 1998-08-25 The General Hospital Corporation Use of green porphyrins to treat neovasculature in the eye
US5556612A (en) 1994-03-15 1996-09-17 The General Hospital Corporation Methods for phototherapeutic treatment of proliferative skin diseases
US5448582A (en) 1994-03-18 1995-09-05 Brown University Research Foundation Optical sources having a strongly scattering gain medium providing laser-like action
US5851225A (en) 1994-03-18 1998-12-22 Spectra Science Corporation Photoemitting catheters and other structures suitable for use in photo-dynamic therapy and other applications
US5616140A (en) 1994-03-21 1997-04-01 Prescott; Marvin Method and apparatus for therapeutic laser treatment
US5989245A (en) 1994-03-21 1999-11-23 Prescott; Marvin A. Method and apparatus for therapeutic laser treatment
US5474528A (en) 1994-03-21 1995-12-12 Dusa Pharmaceuticals, Inc. Combination controller and patch for the photodynamic therapy of dermal lesion
DE69514262T2 (de) 1994-03-23 2001-10-11 Hamamatsu Photonics K.K., Hamamatsu Katheter mit Lichtleitfaser
US5456661A (en) 1994-03-31 1995-10-10 Pdt Cardiovascular Catheter with thermally stable balloon
US5498710A (en) * 1994-04-22 1996-03-12 Health Research, Inc. Alkyl ether analogues of benzoporphyrin derivatives
US5591847A (en) * 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages
US5519534A (en) 1994-05-25 1996-05-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane
AU3374795A (en) 1994-08-29 1996-03-22 Prizm Pharmaceuticals, Inc. Conjugates of vascular endothelial growth factor with targeted agents
US5698866A (en) 1994-09-19 1997-12-16 Pdt Systems, Inc. Uniform illuminator for phototherapy
DE69519384T2 (de) 1994-09-29 2001-05-23 British Telecomm Optische Faser mit Quantenpunkten
US6027726A (en) * 1994-09-30 2000-02-22 Inex Phamaceuticals Corp. Glycosylated protein-liposome conjugates and methods for their preparation
US5591855A (en) 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
WO1996014206A1 (en) 1994-11-08 1996-05-17 Spectra Science Corporation Semiconductor nanocrystal display materials and display apparatus employing same
US5746494A (en) 1994-11-22 1998-05-05 Asahi Kogaku Kogyo Kabushiki Kaisha Illuminating apparatus of endoscope
US5985353A (en) 1994-12-01 1999-11-16 University Of Massachusetts Lowell Biomolecular synthesis of quantum dot composites
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5745882A (en) 1995-01-09 1998-04-28 Us West Marketing Resources Group, Inc. Electronic classified advertising interface method and instructions with continuous search notification
US5882328A (en) 1995-01-13 1999-03-16 Qlt Phototherapeutics, Inc. Method to prevent transplant rejection
US6107325A (en) 1995-01-17 2000-08-22 Qlt Phototherapeutics, Inc. Green porphyrins as immunomodulators
US5643334A (en) * 1995-02-07 1997-07-01 Esc Medical Systems Ltd. Method and apparatus for the diagnostic and composite pulsed heating and photodynamic therapy treatment
US6176842B1 (en) 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
NL9500495A (nl) 1995-03-13 1996-10-01 Cordis Europ Balloncatheter met een enkel lumen en samenstel van een dergelijke catheter en een lichtgeleider.
US5686113A (en) 1995-03-21 1997-11-11 Temple University Of The Commonwealth System Of Higher Education Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses
US5576013A (en) 1995-03-21 1996-11-19 Eastern Virginia Medical School Treating vascular and neoplastic tissues
FR2732094A1 (fr) 1995-03-22 1996-09-27 Philips Eclairage Generateur de lumiere pour fibres optiques
US5735817A (en) 1995-05-19 1998-04-07 Shantha; T. R. Apparatus for transsphenoidal stimulation of the pituitary gland and adjoining brain structures
US5571152A (en) 1995-05-26 1996-11-05 Light Sciences Limited Partnership Microminiature illuminator for administering photodynamic therapy
US5703896A (en) 1995-06-07 1997-12-30 The Regents Of The University Of Colorado Silicon quantum dot laser
US6032070A (en) 1995-06-07 2000-02-29 University Of Arkansas Method and apparatus for detecting electro-magnetic reflection from biological tissue
JPH0947518A (ja) 1995-06-26 1997-02-18 Lederle Japan Ltd フォトダイナミックセラピ用光ファイバレーザ導光プローブ
IT1275571B (it) * 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
JP2961074B2 (ja) * 1995-09-06 1999-10-12 明治製菓株式会社 光化学療法用の新生血管閉塞剤
CA2231114A1 (en) 1995-09-06 1997-03-13 The Research Foundation Of State University Of New York Two-photon upconverting dyes and applications
US5824080A (en) 1995-09-28 1998-10-20 The General Hospital Corporation Photochemistry for the preparation of biologic grafts--allografts and xenografts
US5776175A (en) 1995-09-29 1998-07-07 Esc Medical Systems Ltd. Method and apparatus for treatment of cancer using pulsed electromagnetic radiation
DE29517716U1 (de) 1995-11-08 1996-01-25 Herbert Waldmann GmbH & Co, 78056 Villingen-Schwenningen Gerät zur fotodynamischen Bestrahlung
WO1997026885A1 (en) 1996-01-23 1997-07-31 The General Hospital Corporation Doing Business As Massachusetts General Hospital Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors
AU2118497A (en) 1996-02-29 1997-09-16 Cytopharm, Inc. A novel phototherapeutic method for treating cancer and/or dermatological diseases and conditions
US5835648A (en) 1996-03-07 1998-11-10 Miravant Systems, Inc. Surface illuminator for photodynamic therapy
US5800478A (en) 1996-03-07 1998-09-01 Light Sciences Limited Partnership Flexible microcircuits for internal light therapy
US5770730A (en) 1996-03-08 1998-06-23 Health Research, Inc. Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
US5952366A (en) 1996-03-08 1999-09-14 Health Research, Inc. Alkyl ether analogs of chlorins having an N-substituted imide ring
NZ331977A (en) * 1996-03-26 2000-07-28 Pharmacyclics Inc Texaphyrin in photodynamic therapy of pigment-related lesions
US6135620A (en) 1996-04-10 2000-10-24 Re-Energy, Inc. CCFL illuminated device
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6013053A (en) 1996-05-17 2000-01-11 Qlt Photo Therapeutics Inc. Balloon catheter for photodynamic therapy
EP0954336B1 (en) 1996-06-04 2004-02-25 Pharmacyclics, Inc. Membrane incorporation of texaphyrins
US5709653A (en) 1996-07-25 1998-01-20 Cordis Corporation Photodynamic therapy balloon catheter with microporous membrane
US5797868A (en) 1996-07-25 1998-08-25 Cordis Corporation Photodynamic therapy balloon catheter
US5814008A (en) 1996-07-29 1998-09-29 Light Sciences Limited Partnership Method and device for applying hyperthermia to enhance drug perfusion and efficacy of subsequent light therapy
WO1998006456A1 (en) 1996-08-08 1998-02-19 Light Sciences Limited Partnership Method and apparatus to treat gingival and periodontal disease
US5904147A (en) 1996-08-16 1999-05-18 University Of Massachusetts Intravascular catheter and method of controlling hemorrhage during minimally invasive surgery
US5715837A (en) 1996-08-29 1998-02-10 Light Sciences Limited Partnership Transcutaneous electromagnetic energy transfer
US5849027A (en) 1996-09-04 1998-12-15 Mbg Technologies, Inc. Photodynamic therapy method and apparatus
US5913884A (en) 1996-09-19 1999-06-22 The General Hospital Corporation Inhibition of fibrosis by photodynamic therapy
US5702432A (en) 1996-10-03 1997-12-30 Light Sciences Limited Partnership Intracorporeal light treatment of blood
US5942534A (en) 1996-10-10 1999-08-24 The General Hospital Corporation Photodynamic therapy for the treatment of osteoarthritis
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US7390668B2 (en) 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
US5832931A (en) 1996-10-30 1998-11-10 Photogen, Inc. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
US5741316A (en) 1996-12-02 1998-04-21 Light Sciences Limited Partnership Electromagnetic coil configurations for power transmission through tissue
US6080160A (en) 1996-12-04 2000-06-27 Light Sciences Limited Partnership Use of shape memory alloy for internally fixing light emitting device at treatment site
US6021347A (en) 1996-12-05 2000-02-01 Herbst; Ewa Electrochemical treatment of malignant tumors
US5793781A (en) 1997-01-24 1998-08-11 Spectra Science Corporation Solid state source for generating intense light for photodynamic therapy and photomedicine
US5997569A (en) 1997-01-29 1999-12-07 Light Sciences Limited Partnership Flexible and adjustable grid for medical therapy
US5876427A (en) 1997-01-29 1999-03-02 Light Sciences Limited Partnership Compact flexible circuit configuration
US5782896A (en) 1997-01-29 1998-07-21 Light Sciences Limited Partnership Use of a shape memory alloy to modify the disposition of a device within an implantable medical probe
US5746495A (en) 1997-02-05 1998-05-05 Klamm; Thomas L. Portable work light with optical fiber adapter
US5824657A (en) 1997-03-18 1998-10-20 Cubist Pharmaceuticals, Inc. Aminoacyl sulfamides for the treatment of hyperproliferative disorders
GB2323284B (en) 1997-03-19 2001-01-03 Rusch Mfg Device for photodynamic therapy of pituitary tumours
US5817048A (en) 1997-03-20 1998-10-06 Brown University Research Foundation Ultrasonic alternative to laser-based photodynamic therapy
US5827186A (en) 1997-04-11 1998-10-27 Light Sciences Limited Partnership Method and PDT probe for minimizing CT and MRI image artifacts
US5957960A (en) 1997-05-05 1999-09-28 Light Sciences Limited Partnership Internal two photon excitation device for delivery of PDT to diffuse abnormal cells
CZ294715B6 (cs) 1997-05-07 2005-02-16 Qlt Inc. Ethylenglykol estery monohydrobenzoporfyrinových derivátů jako fotoaktivní činidla
IL120891A0 (en) 1997-05-22 1997-09-30 Technion Res & Dev Foundation Photodynamic and sonodynamic therapy and agents for use therefor
US5926320A (en) 1997-05-29 1999-07-20 Teldedyne Lighting And Display Products, Inc. Ring-lens system for efficient beam formation
US5757557A (en) 1997-06-09 1998-05-26 Tir Technologies, Inc. Beam-forming lens with internal cavity that prevents front losses
US5921244A (en) 1997-06-11 1999-07-13 Light Sciences Limited Partnership Internal magnetic device to enhance drug therapy
US5766222A (en) 1997-07-07 1998-06-16 Petit; Michael G. Nipple illuminator for photodynamic therapy
US6165440A (en) 1997-07-09 2000-12-26 Board Of Regents, The University Of Texas System Radiation and nanoparticles for enhancement of drug delivery in solid tumors
US6058937A (en) * 1997-07-18 2000-05-09 Miravant Systems, Inc. Photodynamic Therapy of highly vascularized tissue
WO1999004628A1 (en) * 1997-07-28 1999-02-04 Dermatolazer Technologies Ltd. Phototherapy based method for treating pathogens and composition for effecting same
US6048359A (en) 1997-08-25 2000-04-11 Advanced Photodynamic Technologies, Inc. Spatial orientation and light sources and method of using same for medical diagnosis and photodynamic therapy
US5924788A (en) 1997-09-23 1999-07-20 Teledyne Lighting And Display Products Illuminating lens designed by extrinsic differential geometry
US6183444B1 (en) 1998-05-16 2001-02-06 Microheart, Inc. Drug delivery module
US6138681A (en) 1997-10-13 2000-10-31 Light Sciences Limited Partnership Alignment of external medical device relative to implanted medical device
US5865840A (en) 1997-10-22 1999-02-02 Light Sciences Limited Partnership Enhancement of light activation effect by immune augmentation
US6071944A (en) 1997-11-12 2000-06-06 Bowling Green State University Method of treatment of pigmented cancer cells utilizing photodynamic therapy
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20030030342A1 (en) 1998-02-10 2003-02-13 Chen James C. Contactless energy transfer apparatus
US5945762A (en) 1998-02-10 1999-08-31 Light Sciences Limited Partnership Movable magnet transmitter for inducing electrical current in an implanted coil
US6331744B1 (en) 1998-02-10 2001-12-18 Light Sciences Corporation Contactless energy transfer apparatus
US6281611B1 (en) 1998-02-10 2001-08-28 Light Sciences Corporation Use of moving element to produce heat
US5997842A (en) 1998-04-13 1999-12-07 Light Sciences Limited Partnership Radionuclide excited phosphorescent material for administering PDT
AU3969099A (en) 1998-05-13 1999-11-29 Light Sciences Limited Partnership Controlled activation of targeted radionuclides
US6103751A (en) 1998-06-22 2000-08-15 Health Research, Inc. Carotene analogs of porphyrins, chlorins and bacteriochlorins as therapeutic and diagnostic agents
US6416531B2 (en) 1998-06-24 2002-07-09 Light Sciences Corporation Application of light at plural treatment sites within a tumor to increase the efficacy of light therapy
US7067109B1 (en) * 1998-07-13 2006-06-27 Board Of Regents, The University Of Texas System Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
US6096066A (en) 1998-09-11 2000-08-01 Light Sciences Limited Partnership Conformal patch for administering light therapy to subcutaneous tumors
EP1115888B1 (en) 1998-09-24 2008-03-12 Indiana University Research and Technology Corporation Water-soluble luminescent quantum dots and bioconjugates thereof
US6117862A (en) 1998-10-09 2000-09-12 Qlt, Inc. Model and method for angiogenesis inhibition
WO2000027365A1 (en) 1998-11-10 2000-05-18 Biocrystal Limited Functionalized nanocrystals and their use in detection systems
US20010049502A1 (en) 1998-11-25 2001-12-06 Light Sciences Corporation Guide sheath for repeated placement of a device
US6344050B1 (en) 1998-12-21 2002-02-05 Light Sciences Corporation Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue
WO2000041726A2 (en) 1999-01-15 2000-07-20 Light Sciences Corporation Noninvasive vascular therapy
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
JP2002534483A (ja) 1999-01-15 2002-10-15 ライト サイエンシーズ コーポレイション 代謝性骨障害または骨転移のための治療的組成物
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
US6162242A (en) * 1999-01-21 2000-12-19 Peyman; Gholam A. Selective photodynamic treatment
US6273904B1 (en) 1999-03-02 2001-08-14 Light Sciences Corporation Polymer battery for internal light device
US6620929B1 (en) 1999-04-14 2003-09-16 University Of British Columbia 1,3-Dipolar cycloadditions to polypyrrolic macrocycles
US6210425B1 (en) 1999-07-08 2001-04-03 Light Sciences Corporation Combined imaging and PDT delivery system
US6238426B1 (en) 1999-07-19 2001-05-29 Light Sciences Corporation Real-time monitoring of photodynamic therapy over an extended time
US20030114434A1 (en) 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US6319273B1 (en) 1999-12-16 2001-11-20 Light Sciences Corporation Illuminating device for treating eye disease
US6534040B2 (en) 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7166719B2 (en) * 2002-06-27 2007-01-23 Health Research, Inc. Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
US20020049247A1 (en) 2000-01-12 2002-04-25 Chen James C. Novel treatment for eye disease
CA2376001A1 (en) 2000-03-30 2001-10-11 Martinus Bernardus Vrouenraets Photodynamic therapy compounds
US6624187B1 (en) 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
US6520669B1 (en) 2000-06-19 2003-02-18 Light Sciences Corporation Flexible substrate mounted solid-state light sources for exterior vehicular lighting
US6765092B2 (en) 2000-07-21 2004-07-20 North Carolina State University Regioisomerically pure oxochlorins and methods of synthesis
US6559374B2 (en) * 2000-07-21 2003-05-06 North Carolina State University Trans beta substituted chlorins and methods of making and using the same
US6580228B1 (en) 2000-08-22 2003-06-17 Light Sciences Corporation Flexible substrate mounted solid-state light sources for use in line current lamp sockets
US20040029788A1 (en) * 2000-11-01 2004-02-12 Hans-Markus Bender Methods and compositions for the treatment of diseases of the eye
US20020127224A1 (en) 2001-03-02 2002-09-12 James Chen Use of photoluminescent nanoparticles for photodynamic therapy
US6495585B2 (en) 2001-03-07 2002-12-17 Health Research, Inc. Method for treating hyperproliferative tissue in a mammal
WO2002098882A1 (en) 2001-06-01 2002-12-12 Ceramoptec Industries, Inc. Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture
EP1467760A2 (en) 2002-01-23 2004-10-20 Light Sciences Corporation Systems and methods for photodynamic therapy
AU2003249742A1 (en) * 2002-07-02 2004-01-23 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US20050085455A1 (en) * 2003-10-16 2005-04-21 Light Sciences Corporation Photodynamic therapy for local adipocyte reduction

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505069A (ja) * 1992-11-20 1996-06-04 ユニバーシティ オブ ブリティッシュ コロンビア 感光剤を活性化する方法
WO1995032001A1 (en) * 1994-05-23 1995-11-30 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio Societa' Per Azioni Photodynamic conjugates with biocidal properties

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012525411A (ja) * 2009-04-28 2012-10-22 セラムオプテック インダストリーズ インコーポレーテッド 経口投与のための新規の光増感剤製剤
JP5875578B2 (ja) * 2011-03-23 2016-03-02 国立大学法人 筑波大学 光線力学治療用ナノ粒子

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