JP2002534076A - 低密度組成物および同組成物を包含する微粒子 - Google Patents
低密度組成物および同組成物を包含する微粒子Info
- Publication number
- JP2002534076A JP2002534076A JP2000592387A JP2000592387A JP2002534076A JP 2002534076 A JP2002534076 A JP 2002534076A JP 2000592387 A JP2000592387 A JP 2000592387A JP 2000592387 A JP2000592387 A JP 2000592387A JP 2002534076 A JP2002534076 A JP 2002534076A
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- Prior art keywords
- low
- porous
- density
- granules
- enzyme
- Prior art date
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- Pending
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- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 229960001826 dimethylphthalate Drugs 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000011549 displacement method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
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- 230000005672 electromagnetic field Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
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- 230000007613 environmental effect Effects 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000007046 ethoxylation reaction Methods 0.000 description 1
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- 230000001747 exhibiting effect Effects 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
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- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229960004198 guanidine Drugs 0.000 description 1
- 229960000789 guanidine hydrochloride Drugs 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
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- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 239000004816 latex Substances 0.000 description 1
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- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
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- 239000002609 medium Substances 0.000 description 1
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- 239000002184 metal Substances 0.000 description 1
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- 235000013923 monosodium glutamate Nutrition 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000429 sodium aluminium silicate Substances 0.000 description 1
- 235000012217 sodium aluminium silicate Nutrition 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 229940045872 sodium percarbonate Drugs 0.000 description 1
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 1
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
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- 239000008117 stearic acid Substances 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
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- 230000002459 sustained effect Effects 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
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- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/12—Water-insoluble compounds
- C11D3/14—Fillers; Abrasives ; Abrasive compositions; Suspending or absorbing agents not provided for in one single group of C11D3/12; Specific features concerning abrasives, e.g. granulometry or mixtures
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/06—Powder; Flakes; Free-flowing mixtures; Sheets
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38672—Granulated or coated enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Glanulating (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11525599P | 1999-01-08 | 1999-01-08 | |
| US60/115,255 | 1999-01-08 | ||
| PCT/US2000/000464 WO2000040689A2 (en) | 1999-01-08 | 2000-01-07 | Low-density compositions and particulates including same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002534076A true JP2002534076A (ja) | 2002-10-15 |
| JP2002534076A5 JP2002534076A5 (https=) | 2007-02-15 |
Family
ID=22360201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000592387A Pending JP2002534076A (ja) | 1999-01-08 | 2000-01-07 | 低密度組成物および同組成物を包含する微粒子 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6534466B2 (https=) |
| EP (1) | EP1149151B1 (https=) |
| JP (1) | JP2002534076A (https=) |
| CN (1) | CN1336954A (https=) |
| AT (1) | ATE321838T1 (https=) |
| AU (1) | AU2497100A (https=) |
| CA (1) | CA2354529A1 (https=) |
| DE (1) | DE60026970T2 (https=) |
| DK (1) | DK1149151T3 (https=) |
| ES (1) | ES2257999T3 (https=) |
| HK (1) | HK1044017A1 (https=) |
| MX (1) | MXPA01006944A (https=) |
| WO (1) | WO2000040689A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2638000A (en) * | 1999-02-02 | 2000-08-25 | Procter & Gamble Company, The | Low density enzyme granulates and compositions employing same |
| EP1490485B1 (en) * | 2002-03-27 | 2015-03-04 | Novozymes A/S | Granules with filamentous coatings |
| US7419947B2 (en) * | 2002-03-27 | 2008-09-02 | Novozymes A/S | Process for preparing granules with filamentous coatings |
| US7531365B2 (en) * | 2004-01-08 | 2009-05-12 | International Flavors & Fragrances Inc. | Analysis of the headspace proximate a substrate surface containing fragrance-containing microcapsules |
| FR2864962B1 (fr) * | 2004-01-08 | 2007-09-14 | Seppic Sa | Nouveaux granules filmogenes poreux, procede pour leur preparation et application dans le pelliculage des comprimes et confiseries |
| JP2008521995A (ja) * | 2004-11-30 | 2008-06-26 | エルジー ハウスホールド アンド ヘルス ケア エルティーディー． | 衣類の肌触りを向上させることができる粉末洗剤組成物及びその製造方法 |
| US20100015588A1 (en) * | 2005-07-20 | 2010-01-21 | Satoru Funakoshi | Multilayered model tooth for dental training |
| EP2497374A3 (en) | 2005-10-12 | 2013-11-27 | Danisco US Inc. | Stable, durable granules with active agents |
| US8496966B2 (en) * | 2005-10-24 | 2013-07-30 | Cycle Group, Inc. | Quick dissolving carrier granules |
| JP5209643B2 (ja) * | 2007-01-11 | 2013-06-12 | ノボザイムス アクティーゼルスカブ | 活性化合物を含む粒子 |
| KR101392380B1 (ko) * | 2007-02-21 | 2014-05-07 | 주식회사 엘지생활건강 | 산성형태의 수용성 고분자를 함유하는 분말세제 입자 및그의 제조방법 |
| DK2155867T3 (en) * | 2007-05-10 | 2016-01-25 | Danisco Us Inc | STABLE ENZYMATIC SYSTEMS FOR GENERATION OF peracid |
| MX346974B (es) | 2008-02-14 | 2017-04-07 | Danisco Us Inc | Granulos pequeños que contienen enzimas. |
| WO2011090980A1 (en) | 2010-01-20 | 2011-07-28 | Danisco Us Inc. | Mold treatment |
| MX350545B (es) * | 2010-07-20 | 2017-09-08 | The Procter & Gamble Company * | Partículas de suministro con pluralidad de núcleos. |
| CN102433225B (zh) * | 2011-12-29 | 2013-02-20 | 青岛蔚蓝生物集团有限公司 | 一种碱性蛋白酶包衣微丸及其制备方法 |
| DK3699271T3 (da) | 2012-02-07 | 2024-12-09 | Danisco Us Inc | Granulat- og pelletsammensætninger, der omfatter phytase og phytinsyre, og fremgangsmåde til fremstilling deraf |
| WO2013119470A1 (en) | 2012-02-07 | 2013-08-15 | Danisco Us Inc. | Glycosylation as a stabilizer for phytase |
| US20130284637A1 (en) | 2012-04-30 | 2013-10-31 | Danisco Us Inc. | Unit-dose format perhydrolase systems |
| US20150140172A1 (en) | 2012-06-20 | 2015-05-21 | Danisco Us Inc. | Sandwich granule |
| DK2874506T3 (da) | 2012-07-18 | 2019-07-15 | Danisco Us Inc | Fremgangsmåde til fremstilling af enzymgranulater |
| AR098006A1 (es) | 2013-10-15 | 2016-04-27 | Danisco Us Inc | Gránulo de arcilla |
| DK3068879T3 (da) | 2013-11-14 | 2020-03-16 | Danisco Us Inc | Stabile enzymer opnået ved glykeringsreduktion |
| FR3025052B1 (fr) * | 2014-08-19 | 2017-12-15 | Isorg | Dispositif de detection d'un rayonnement electromagnetique en materiaux organiques |
| CN104479909B (zh) * | 2014-12-01 | 2017-07-21 | 湖南新鸿鹰生物工程有限公司 | 一种含真菌α‑淀粉酶的洗涤复合酶及其制备方法 |
| DK3270893T3 (da) | 2015-03-19 | 2021-11-01 | Danisco Us Inc | Stabile granulater med lav indre vandaktivitet |
| WO2016201069A1 (en) * | 2015-06-09 | 2016-12-15 | Danisco Us Inc | Low-density enzyme-containing particles |
| EP3707255A1 (en) | 2017-11-09 | 2020-09-16 | Basf Se | Coatings of enzyme particles comprising organic white pigments |
| CA3098454A1 (en) | 2018-04-26 | 2019-10-31 | Danisco Us Inc | Method for increasing stability of phytase in a solid composition and a granule composition comprising phosphate and phytase |
| NL2021893B1 (en) | 2018-10-26 | 2020-05-13 | Citeq B V | Biological pest control agent |
| BR112022000351A2 (pt) | 2019-07-09 | 2022-05-10 | Dupont Nutrition Biosci Aps | Composições de enzima particuladas revestidas de gordura |
| AU2020375621A1 (en) | 2019-10-28 | 2022-04-28 | Danisco Us Inc | Methods and compositions for remediating cyanuric acid in aqueous liquids |
| CN111701545B (zh) * | 2020-06-04 | 2022-03-25 | 上海工程技术大学 | 一种适用于生产微胶囊型土壤调理剂的滴丸生产系统 |
| WO2023019073A1 (en) * | 2021-08-13 | 2023-02-16 | Ppg Industries Ohio, Inc. | Coating compositions, methods for using them and systems that include them |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS536484A (en) * | 1976-07-07 | 1978-01-20 | Novo Industri As | Production of granular enzyme agent |
| JPS6445500A (en) * | 1987-07-15 | 1989-02-17 | Colgate Palmolive Co | Non-aqueous liquid cloth treatment composition |
| JPH01112983A (ja) * | 1987-08-21 | 1989-05-01 | Novo Ind As | 酵素含有粒質物 |
| JPH04503305A (ja) * | 1989-02-20 | 1992-06-18 | ノボ ノルディスク アクティーゼルスカブ | 酵素含有粒質物および該粒質物の製法 |
| JPH06511381A (ja) * | 1991-10-10 | 1994-12-22 | ジェネンコア インターナショナル インコーポレーテッド | 無粉塵酵素の製造方法 |
| JPH07500013A (ja) * | 1991-10-07 | 1995-01-05 | ジェネンコア インターナショナル インコーポレーテッド | 被覆した酵素含有顆粒 |
| JPH08500375A (ja) * | 1992-08-14 | 1996-01-16 | ゾルファイ エンツィーメス ゲゼルシャフト ミツト ベシユレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 新規の酵素粒状物 |
| JPH08512340A (ja) * | 1993-07-05 | 1996-12-24 | ヘンケル・コマンディットゲゼルシャフト・アウフ・アクチェン | 洗浄および清浄製剤用のコーティングした酵素組成物 |
| WO1997043482A1 (en) * | 1996-05-13 | 1997-11-20 | Genencor International, Inc. | Enzyme granulate for washing and cleaning |
| JP2002512654A (ja) * | 1997-06-27 | 2002-04-23 | ザ、プロクター、エンド、ギャンブル、カンパニー | 低密度酵素粒子を含む非水性液体洗剤組成物 |
| JP2002530479A (ja) * | 1998-11-13 | 2002-09-17 | ジェネンコア インターナショナル インコーポレーテッド | 流動床による低密度顆粒 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57188435A (en) | 1981-05-14 | 1982-11-19 | Meisei Shokai:Kk | Manufacture of colored fine hollow sphere |
| NZ208612A (en) | 1983-06-24 | 1991-09-25 | Genentech Inc | Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations |
| US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5185258A (en) | 1984-05-29 | 1993-02-09 | Genencor International, Inc. | Subtilisin mutants |
| JPS6192570A (ja) | 1984-10-12 | 1986-05-10 | Showa Denko Kk | 酵素造粒法 |
| US4689297A (en) | 1985-03-05 | 1987-08-25 | Miles Laboratories, Inc. | Dust free particulate enzyme formulation |
| US4931195A (en) * | 1987-07-15 | 1990-06-05 | Colgate-Palmolive Company | Low viscosity stable non-aqueous suspension containing organophilic clay and low density filler |
| FR2618157B1 (fr) | 1988-07-15 | 1994-01-21 | Colgate Palmolive Cy | Suspension non aqueuse stable contenant une argile organophile et une charge a basse densite |
| WO1991009941A1 (en) | 1989-12-21 | 1991-07-11 | Novo Nordisk A/S | Enzyme containing preparation and detergent containing such preparation |
| US5814501A (en) | 1990-06-04 | 1998-09-29 | Genencor International, Inc. | Process for making dust-free enzyme-containing particles from an enzyme-containing fermentation broth |
| US5324649A (en) * | 1991-10-07 | 1994-06-28 | Genencor International, Inc. | Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof |
| DE4329463A1 (de) * | 1993-09-01 | 1995-03-02 | Cognis Bio Umwelt | Mehrenzymgranulate |
| ATE268381T1 (de) | 1995-10-06 | 2004-06-15 | Genencor Int | Mikrogranulaten zur nahrungs- oder futteranwendung |
| US5668099A (en) | 1996-02-14 | 1997-09-16 | The Procter & Gamble Company | Process for making a low density detergent composition by agglomeration with an inorganic double salt |
| CN1242060C (zh) | 1997-12-20 | 2006-02-15 | 金克克国际有限公司 | 基体颗粒 |
| NZ505298A (en) | 1997-12-20 | 2002-10-25 | Genencor Int | Enzyme (protease) granule formulations with salt hydrate and polymer coating having high solubility and increased stability |
| EP1021525A1 (en) | 1997-12-20 | 2000-07-26 | Genencor International, Inc. | Fluidized bed matrix granule |
-
2000
- 2000-01-07 DE DE60026970T patent/DE60026970T2/de not_active Revoked
- 2000-01-07 EP EP00903190A patent/EP1149151B1/en not_active Revoked
- 2000-01-07 JP JP2000592387A patent/JP2002534076A/ja active Pending
- 2000-01-07 CA CA002354529A patent/CA2354529A1/en not_active Abandoned
- 2000-01-07 WO PCT/US2000/000464 patent/WO2000040689A2/en not_active Ceased
- 2000-01-07 HK HK02105584.9A patent/HK1044017A1/zh unknown
- 2000-01-07 DK DK00903190T patent/DK1149151T3/da active
- 2000-01-07 AT AT00903190T patent/ATE321838T1/de not_active IP Right Cessation
- 2000-01-07 CN CN00802597A patent/CN1336954A/zh active Pending
- 2000-01-07 ES ES00903190T patent/ES2257999T3/es not_active Expired - Lifetime
- 2000-01-07 MX MXPA01006944A patent/MXPA01006944A/es unknown
- 2000-01-07 AU AU24971/00A patent/AU2497100A/en not_active Abandoned
- 2000-01-07 US US09/479,693 patent/US6534466B2/en not_active Expired - Lifetime
-
2002
- 2002-07-01 US US10/187,781 patent/US6583099B2/en not_active Expired - Lifetime
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS536484A (en) * | 1976-07-07 | 1978-01-20 | Novo Industri As | Production of granular enzyme agent |
| JPS6445500A (en) * | 1987-07-15 | 1989-02-17 | Colgate Palmolive Co | Non-aqueous liquid cloth treatment composition |
| JPH01112983A (ja) * | 1987-08-21 | 1989-05-01 | Novo Ind As | 酵素含有粒質物 |
| JPH04503305A (ja) * | 1989-02-20 | 1992-06-18 | ノボ ノルディスク アクティーゼルスカブ | 酵素含有粒質物および該粒質物の製法 |
| JPH07500013A (ja) * | 1991-10-07 | 1995-01-05 | ジェネンコア インターナショナル インコーポレーテッド | 被覆した酵素含有顆粒 |
| JPH06511381A (ja) * | 1991-10-10 | 1994-12-22 | ジェネンコア インターナショナル インコーポレーテッド | 無粉塵酵素の製造方法 |
| JPH08500375A (ja) * | 1992-08-14 | 1996-01-16 | ゾルファイ エンツィーメス ゲゼルシャフト ミツト ベシユレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 新規の酵素粒状物 |
| JPH08512340A (ja) * | 1993-07-05 | 1996-12-24 | ヘンケル・コマンディットゲゼルシャフト・アウフ・アクチェン | 洗浄および清浄製剤用のコーティングした酵素組成物 |
| WO1997043482A1 (en) * | 1996-05-13 | 1997-11-20 | Genencor International, Inc. | Enzyme granulate for washing and cleaning |
| JP2002512654A (ja) * | 1997-06-27 | 2002-04-23 | ザ、プロクター、エンド、ギャンブル、カンパニー | 低密度酵素粒子を含む非水性液体洗剤組成物 |
| JP2002530479A (ja) * | 1998-11-13 | 2002-09-17 | ジェネンコア インターナショナル インコーポレーテッド | 流動床による低密度顆粒 |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01006944A (es) | 2003-09-10 |
| US6534466B2 (en) | 2003-03-18 |
| WO2000040689A2 (en) | 2000-07-13 |
| US20020082183A1 (en) | 2002-06-27 |
| AU2497100A (en) | 2000-07-24 |
| ES2257999T3 (es) | 2006-08-16 |
| DE60026970D1 (de) | 2006-05-18 |
| US20020193275A1 (en) | 2002-12-19 |
| CN1336954A (zh) | 2002-02-20 |
| US6583099B2 (en) | 2003-06-24 |
| CA2354529A1 (en) | 2000-07-13 |
| DE60026970T2 (de) | 2006-11-30 |
| WO2000040689A3 (en) | 2000-11-30 |
| HK1044017A1 (zh) | 2002-10-04 |
| DK1149151T3 (da) | 2006-07-31 |
| ATE321838T1 (de) | 2006-04-15 |
| EP1149151A2 (en) | 2001-10-31 |
| EP1149151B1 (en) | 2006-03-29 |
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