JP2002532498A5 - - Google Patents
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- Publication number
- JP2002532498A5 JP2002532498A5 JP2000588174A JP2000588174A JP2002532498A5 JP 2002532498 A5 JP2002532498 A5 JP 2002532498A5 JP 2000588174 A JP2000588174 A JP 2000588174A JP 2000588174 A JP2000588174 A JP 2000588174A JP 2002532498 A5 JP2002532498 A5 JP 2002532498A5
- Authority
- JP
- Japan
- Prior art keywords
- heart
- occlusion
- experimetria
- racemate
- chest
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000000038 chest Anatomy 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 208000001778 Coronary Occlusion Diseases 0.000 description 1
- 206010011086 Coronary artery occlusion Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008753 endothelial function Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9802897 | 1998-12-14 | ||
| HU9802897A HU226617B1 (en) | 1998-12-14 | 1998-12-14 | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| PCT/HU1999/000095 WO2000035914A1 (en) | 1998-12-14 | 1999-12-07 | Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011128516A Division JP5620340B2 (ja) | 1998-12-14 | 2011-06-08 | 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002532498A JP2002532498A (ja) | 2002-10-02 |
| JP2002532498A5 true JP2002532498A5 (OSRAM) | 2007-02-08 |
Family
ID=10991166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000588174A Withdrawn JP2002532498A (ja) | 1998-12-14 | 1999-12-07 | 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用 |
| JP2011128516A Expired - Lifetime JP5620340B2 (ja) | 1998-12-14 | 2011-06-08 | 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011128516A Expired - Lifetime JP5620340B2 (ja) | 1998-12-14 | 2011-06-08 | 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6384029B1 (OSRAM) |
| EP (1) | EP1147105B1 (OSRAM) |
| JP (2) | JP2002532498A (OSRAM) |
| KR (1) | KR100661774B1 (OSRAM) |
| AT (1) | ATE266027T1 (OSRAM) |
| AU (1) | AU765336B2 (OSRAM) |
| BG (1) | BG65179B1 (OSRAM) |
| BR (1) | BR9913982A (OSRAM) |
| CA (1) | CA2340734C (OSRAM) |
| CZ (1) | CZ300764B6 (OSRAM) |
| DE (1) | DE69917074T2 (OSRAM) |
| DK (1) | DK1147105T3 (OSRAM) |
| EE (1) | EE04551B1 (OSRAM) |
| ES (1) | ES2219091T3 (OSRAM) |
| HR (1) | HRP20010133B1 (OSRAM) |
| HU (1) | HU226617B1 (OSRAM) |
| IL (1) | IL141515A (OSRAM) |
| NO (1) | NO317649B1 (OSRAM) |
| PL (1) | PL196584B1 (OSRAM) |
| PT (1) | PT1147105E (OSRAM) |
| RS (1) | RS50129B (OSRAM) |
| RU (1) | RU2222538C2 (OSRAM) |
| SI (1) | SI1147105T1 (OSRAM) |
| SK (1) | SK285582B6 (OSRAM) |
| UA (1) | UA70340C2 (OSRAM) |
| WO (1) | WO2000035914A1 (OSRAM) |
| ZA (1) | ZA200101182B (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL371251A1 (en) | 2002-01-11 | 2005-06-13 | Biorex Kutato Es Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| KR100678577B1 (ko) * | 2006-09-11 | 2007-02-06 | 조만규 | 가정용 분전함 |
| ES2963910T3 (es) | 2008-06-26 | 2024-04-03 | Zevra Denmark As | Uso de Hsp70 como regulador de la actividad enzimática |
| CA2743782A1 (en) | 2008-11-18 | 2010-05-27 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for chorioretinal degenerative disease containing pyridine-3-carbaldehyde o-(piperidin-1-yl-propyl)-oxime derivative as active ingredient |
| PT2646044T (pt) | 2010-11-30 | 2019-11-12 | Orphazyme As | Métodos para aumentar a atividade intracelular de hsp70 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| HUE054957T2 (hu) | 2014-09-15 | 2021-10-28 | Orphazyme As | Arimoklomol készítése |
| US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| RU2021117465A (ru) | 2016-04-29 | 2021-07-22 | Орфазим А/С | Аримокломол для лечения ассоциированных с глюкоцереброзидазой нарушений |
| WO2018215597A1 (en) | 2017-05-24 | 2018-11-29 | Orphazyme A/S | Heat shock protein inducers and frontotemporal disorders |
| BR112020024182A2 (pt) | 2018-05-28 | 2021-03-30 | Orphazyme A/S | Métodos para detectar proteína de choque térmico 70, para diagnosticar uma doença apresentando um nível reduzido de proteína de choque térmico 70, para selecionar um paciente tendo uma doença apresentando um nível reduzido de hsp70, para monitorar progressão de doença em um indivíduo, para monitorar a eficácia de uma terapia para tratamento de uma doença, e, para ajustar a dosagem de um derivado de hidroxilamina de molécula pequena. |
| IL303026A (en) | 2020-11-19 | 2023-07-01 | Zevra Denmark As | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT395853B (de) * | 1991-01-31 | 1993-03-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| WO1997016349A1 (en) * | 1995-11-03 | 1997-05-09 | Global Trading Uk Limited | Apparatus for dispensing and filling bags at a checkout counter of a supermarket |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells |
-
1998
- 1998-12-14 HU HU9802897A patent/HU226617B1/hu not_active IP Right Cessation
-
1999
- 1999-07-12 UA UA2001063850A patent/UA70340C2/uk unknown
- 1999-12-07 AU AU17906/00A patent/AU765336B2/en not_active Expired
- 1999-12-07 IL IL14151599A patent/IL141515A/xx not_active IP Right Cessation
- 1999-12-07 AT AT99961225T patent/ATE266027T1/de active
- 1999-12-07 SI SI9930566T patent/SI1147105T1/xx unknown
- 1999-12-07 HR HR20010133A patent/HRP20010133B1/xx not_active IP Right Cessation
- 1999-12-07 RS YUP-250/01A patent/RS50129B/sr unknown
- 1999-12-07 PL PL346767A patent/PL196584B1/pl not_active IP Right Cessation
- 1999-12-07 CA CA002340734A patent/CA2340734C/en not_active Expired - Lifetime
- 1999-12-07 DK DK99961225T patent/DK1147105T3/da active
- 1999-12-07 WO PCT/HU1999/000095 patent/WO2000035914A1/en not_active Ceased
- 1999-12-07 BR BR9913982-0A patent/BR9913982A/pt not_active Application Discontinuation
- 1999-12-07 DE DE69917074T patent/DE69917074T2/de not_active Expired - Lifetime
- 1999-12-07 PT PT99961225T patent/PT1147105E/pt unknown
- 1999-12-07 EE EEP200100188A patent/EE04551B1/xx not_active IP Right Cessation
- 1999-12-07 JP JP2000588174A patent/JP2002532498A/ja not_active Withdrawn
- 1999-12-07 CZ CZ20011550A patent/CZ300764B6/cs not_active IP Right Cessation
- 1999-12-07 EP EP99961225A patent/EP1147105B1/en not_active Expired - Lifetime
- 1999-12-07 RU RU2001118854/04A patent/RU2222538C2/ru not_active IP Right Cessation
- 1999-12-07 SK SK234-2001A patent/SK285582B6/sk not_active IP Right Cessation
- 1999-12-07 ES ES99961225T patent/ES2219091T3/es not_active Expired - Lifetime
- 1999-12-07 KR KR1020017002870A patent/KR100661774B1/ko not_active Expired - Fee Related
- 1999-12-07 US US09/762,949 patent/US6384029B1/en not_active Expired - Lifetime
-
2001
- 2001-02-12 ZA ZA200101182A patent/ZA200101182B/en unknown
- 2001-03-14 BG BG105342A patent/BG65179B1/bg unknown
- 2001-05-10 NO NO20012310A patent/NO317649B1/no not_active IP Right Cessation
-
2011
- 2011-06-08 JP JP2011128516A patent/JP5620340B2/ja not_active Expired - Lifetime
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