JP2002531123A5 - - Google Patents
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- Publication number
- JP2002531123A5 JP2002531123A5 JP2000586893A JP2000586893A JP2002531123A5 JP 2002531123 A5 JP2002531123 A5 JP 2002531123A5 JP 2000586893 A JP2000586893 A JP 2000586893A JP 2000586893 A JP2000586893 A JP 2000586893A JP 2002531123 A5 JP2002531123 A5 JP 2002531123A5
- Authority
- JP
- Japan
- Prior art keywords
- animal
- host
- antibody
- psoriasis
- reduced immunity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 26
- 241001465754 Metazoa Species 0.000 claims 19
- 102000013462 Interleukin-12 Human genes 0.000 claims 8
- 108010065805 Interleukin-12 Proteins 0.000 claims 8
- 229940117681 interleukin-12 Drugs 0.000 claims 8
- 201000004681 Psoriasis Diseases 0.000 claims 7
- 239000012190 activator Substances 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 230000036039 immunity Effects 0.000 claims 7
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000000770 proinflammatory effect Effects 0.000 claims 5
- 231100000617 superantigen Toxicity 0.000 claims 5
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 3
- 239000002158 endotoxin Substances 0.000 claims 3
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 241000283984 Rodentia Species 0.000 claims 2
- 102000003800 Selectins Human genes 0.000 claims 2
- 108090000184 Selectins Proteins 0.000 claims 2
- 108010058061 alpha E integrins Proteins 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 108010024212 E-Selectin Proteins 0.000 claims 1
- 102100023471 E-selectin Human genes 0.000 claims 1
- 102000008072 Lymphokines Human genes 0.000 claims 1
- 108010074338 Lymphokines Proteins 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 108010035766 P-Selectin Proteins 0.000 claims 1
- 102100023472 P-selectin Human genes 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11164298P | 1998-12-09 | 1998-12-09 | |
| US60/111,642 | 1998-12-09 | ||
| PCT/US1999/029123 WO2000034459A1 (en) | 1998-12-09 | 1999-12-08 | Animal model for psoriasis for the prevention and treatment of psoriasis in humans |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004145466A Division JP4671265B2 (ja) | 1998-12-09 | 2004-05-14 | 乾癬の治療のための医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002531123A JP2002531123A (ja) | 2002-09-24 |
| JP3579355B2 JP3579355B2 (ja) | 2004-10-20 |
| JP2002531123A5 true JP2002531123A5 (https=) | 2005-04-07 |
Family
ID=22339643
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586893A Expired - Fee Related JP3579355B2 (ja) | 1998-12-09 | 1999-12-08 | ヒトの乾癬を予防及び治療するための乾癬モデル動物 |
| JP2004145466A Expired - Fee Related JP4671265B2 (ja) | 1998-12-09 | 2004-05-14 | 乾癬の治療のための医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004145466A Expired - Fee Related JP4671265B2 (ja) | 1998-12-09 | 2004-05-14 | 乾癬の治療のための医薬組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US6410824B1 (https=) |
| EP (2) | EP1336654A1 (https=) |
| JP (2) | JP3579355B2 (https=) |
| AT (1) | ATE305506T1 (https=) |
| AU (1) | AU1843200A (https=) |
| CA (1) | CA2353520C (https=) |
| DE (1) | DE69927520T2 (https=) |
| DK (1) | DK1137766T3 (https=) |
| ES (1) | ES2251248T3 (https=) |
| WO (1) | WO2000034459A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830751B1 (en) * | 1994-03-14 | 2004-12-14 | Genetics Institute, Llc | Use of IL-12 antagonists in the treatment of rheumatoid arthritis |
| US7883704B2 (en) * | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
| US6914128B1 (en) * | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| ATE363290T1 (de) * | 1999-10-04 | 2007-06-15 | Novartis Vaccines & Diagnostic | Cd40 antagonist zur behandlung von psoriasis |
| US6902734B2 (en) | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| AU2003285874A1 (en) * | 2002-10-16 | 2004-05-04 | Amgen Inc. | HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS |
| US20040260068A1 (en) * | 2004-02-26 | 2004-12-23 | Naoya Tsurushita | Humanized chicken antibodies |
| US20060171890A1 (en) * | 2005-01-28 | 2006-08-03 | Yeomans David C | Methods for evaluating the activity of candidate agents |
| EP1977007A4 (en) * | 2005-12-28 | 2009-11-11 | Centocor Ortho Biotech Inc | MARKERS AND METHOD FOR THE ASSESSMENT AND TREATMENT OF PSORIASIS AND RELATED DISEASES |
| CN104524567A (zh) * | 2007-01-16 | 2015-04-22 | 阿布维公司 | 用于治疗银屑病的方法 |
| CA2681752A1 (en) * | 2007-03-29 | 2008-10-09 | Abbott Laboratories | Crystalline anti-human 1l-12 antibodies |
| EP2274333A4 (en) * | 2008-03-18 | 2011-06-15 | Abbott Lab | PROCESS FOR TREATING PSORIASIS |
| US20110002918A1 (en) * | 2009-03-06 | 2011-01-06 | Photomedex | Methods of treating diseased tissue |
| ES2352929B1 (es) | 2009-08-14 | 2012-01-26 | Centro De Investigaciones Energeticas. Medioamb Ientales Y Tecnologicas (Ciemat) | Modelo humanizado de psoriasis |
| KR20120112384A (ko) * | 2009-09-14 | 2012-10-11 | 애보트 게엠베하 운트 콤파니 카게 | 건선을 치료하는 방법 |
| WO2012094623A2 (en) * | 2011-01-07 | 2012-07-12 | Abbott Laboratories | Anti-il-12/il-23 antibodies and uses thereof |
| AU2017241776B2 (en) | 2016-03-29 | 2024-06-20 | Janssen Biotech, Inc. | Treating psoriasis with increased interval dosing of anti-IL12 and/or -23 antibody |
| WO2018008902A1 (ko) * | 2016-07-05 | 2018-01-11 | 성균관대학교산학협력단 | 건선 유발 동물 모델 및 이의 용도 |
| TW201922780A (zh) * | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗il12/il23抗體治療狼瘡之安全且有效之方法 |
| EP3793521A4 (en) | 2018-05-18 | 2022-02-23 | Janssen Biotech, Inc. | SAFE AND EFFECTIVE METHOD OF TREATING LUPUS WITH AN ANTI-IL12/IL23 ANTIBODY |
| BR112021005467A2 (pt) | 2018-09-24 | 2021-06-22 | Janssen Biotech, Inc. | método seguro e eficaz para tratar colite ulcerativa com anticorpo anti-il12/il23 |
| WO2020234834A1 (en) | 2019-05-23 | 2020-11-26 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| KR20230023663A (ko) | 2020-05-21 | 2023-02-17 | 얀센 바이오테크 인코포레이티드 | Il-23 및 tnf 알파에 대한 항체의 병용 요법으로 염증성 장질환을 치료하는 방법 |
| WO2026058045A1 (en) | 2024-09-12 | 2026-03-19 | Takeda Pharmaceutical Company Limited | Alpha4beta7 inhibitor and il-23 inhibitor combination therapy |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2191870A (en) * | 1937-08-14 | 1940-02-27 | Wayne Pump Co | Liquid dispensing apparatus |
| US2224256A (en) * | 1938-08-05 | 1940-12-10 | Baker Chem Co J T | Pharmaceutical preparation |
| US2297692A (en) * | 1939-08-15 | 1942-10-06 | Bendix Aviat Corp | Fluid flywheel control |
| US2275692A (en) * | 1940-04-02 | 1942-03-10 | Sims Edward | Airplane aileron |
| US4824432A (en) * | 1981-03-24 | 1989-04-25 | S.V.S. Laboratories, Inc. | Method for treating AIDS and other immune deficiencies and immune disorders |
| US4362155A (en) * | 1981-03-24 | 1982-12-07 | Skurkovich Simon V | Method and apparatus for the treatment of autoimmune and allergic diseases |
| IL78444A (en) * | 1986-04-08 | 1992-05-25 | Yeda Res & Dev | Human gamma interferon-specific receptor protein,antibody against said protein,and compositions containing said protein and antibody |
| US5362490A (en) * | 1986-07-25 | 1994-11-08 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Human myelomonocyte interferon-gamma, and process for preparation and use thereof |
| NL8700927A (nl) | 1987-04-16 | 1988-11-16 | Stichting Rega V Z W | Anti-interferon-gamma-antilichamen; en hun therapeutische toepassing. |
| CA1335792C (en) * | 1987-08-18 | 1995-06-06 | Chaim O. Jacob | Method and dosage form using an antagonist to gamma interferon to control mhc-associated autoimmune disease |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8905400D0 (en) * | 1989-03-09 | 1989-04-19 | Jonker Margreet | Medicaments |
| IT1231727B (it) | 1989-08-11 | 1991-12-21 | Enrico Savoldi | Peptidi utili per la determinazione e la purificazione di anticorpi anti gamma interferone. |
| IL91562A0 (en) * | 1989-09-07 | 1990-04-29 | Yeda Res & Dev | Interferon-gamma receptor fragment and its production |
| US5632988A (en) * | 1989-10-23 | 1997-05-27 | Schering Corporation | Polypeptide inhibitors of gamma interferon |
| US6683046B1 (en) | 1989-12-22 | 2004-01-27 | Hoffmann-La Roche Inc. | Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto |
| WO1992006115A1 (en) * | 1990-09-27 | 1992-04-16 | Schering Corporation | Antagonists of human gamma interferon |
| US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US6129914A (en) | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
| JP3887011B2 (ja) | 1992-12-29 | 2007-02-28 | ジェネンテク,インコーポレイテッド | IFN−γインヒビターによる炎症性腸疾患の処置 |
| US20030059428A1 (en) * | 1993-02-26 | 2003-03-27 | Boris Skurkovich | Treatment of autoimmune diseases |
| US5888511A (en) | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| EP0659766A1 (en) * | 1993-11-23 | 1995-06-28 | Schering-Plough | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| ZA95960B (en) * | 1994-03-14 | 1995-10-10 | Genetics Inst | Use of interleukin-12 antagonists in the treatment of autoimmune diseases |
| US6830751B1 (en) * | 1994-03-14 | 2004-12-14 | Genetics Institute, Llc | Use of IL-12 antagonists in the treatment of rheumatoid arthritis |
| US5622701A (en) | 1994-06-14 | 1997-04-22 | Protein Design Labs, Inc. | Cross-reacting monoclonal antibodies specific for E- and P-selectin |
| JPH08289699A (ja) * | 1995-04-24 | 1996-11-05 | Chemo Sero Therapeut Res Inst | 自己免疫疾患モデル動物及びその作製方法 |
| EP0823941A4 (en) * | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| US5880146A (en) * | 1995-06-07 | 1999-03-09 | Fuji Immunopharmaceuticals Corporation | Inhibition of IL-12-induced IFN-γ synthesis by specific bis-phenol compounds as a method of immune modulation |
| US5780027A (en) * | 1995-07-14 | 1998-07-14 | Meiogen Biotechnology Corporation | Methods of treatment of down syndrome by interferon antagonists |
| US20020025316A1 (en) * | 1995-08-18 | 2002-02-28 | Ferguson Mark Williams James | Pharmaceutical composition containing inhibitors of interferon-gamma |
| GB2304342A (en) | 1995-08-18 | 1997-03-19 | Univ Manchester | Pharmaceutical comprising either an inhibitor or a stimulator of interferon gamma |
| US5945576A (en) | 1996-04-05 | 1999-08-31 | Brigham & Women's Hospital, Inc. | Mouse model of psoriasis |
| WO1997037679A1 (en) * | 1996-04-10 | 1997-10-16 | Board Of Trustees Of The University Of Illinois | Interferon-gamma anti-inflammatory methods, compounds, and pharmaceutical compositions |
| WO1998016248A1 (en) * | 1996-10-11 | 1998-04-23 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12 |
| SK122199A3 (en) * | 1997-03-18 | 2000-12-11 | Basf Ag | Methods and compositions for modulating responsiveness to corticosteroids |
| US6054487A (en) * | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
| AU8860298A (en) * | 1997-07-17 | 1999-02-10 | F. Hoffmann-La Roche Ag | Dihomo-seco-cholestanes with two unsaturated bones in the side chain |
| AU9262598A (en) | 1997-08-18 | 1999-03-08 | Innogenetics N.V. | Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders |
| CA2224256C (en) | 1997-12-09 | 2013-04-30 | I.N.S.E.R.M. | Method for treating established spontaneous auto-immune diseases in mammals |
| WO1999037682A2 (en) * | 1998-01-23 | 1999-07-29 | F.Hoffmann-La Roche Ag | Antibodies against human il-12 |
| JP2002531466A (ja) * | 1998-12-01 | 2002-09-24 | プロテイン デザイン ラブス, インコーポレイテッド | γ−インターフェロンに対するヒト化抗体 |
| US6914128B1 (en) * | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
-
1999
- 1999-12-08 JP JP2000586893A patent/JP3579355B2/ja not_active Expired - Fee Related
- 1999-12-08 CA CA002353520A patent/CA2353520C/en not_active Expired - Fee Related
- 1999-12-08 AU AU18432/00A patent/AU1843200A/en not_active Abandoned
- 1999-12-08 ES ES99961957T patent/ES2251248T3/es not_active Expired - Lifetime
- 1999-12-08 EP EP03001299A patent/EP1336654A1/en not_active Withdrawn
- 1999-12-08 AT AT99961957T patent/ATE305506T1/de active
- 1999-12-08 DE DE69927520T patent/DE69927520T2/de not_active Expired - Lifetime
- 1999-12-08 DK DK99961957T patent/DK1137766T3/da active
- 1999-12-08 EP EP99961957A patent/EP1137766B1/en not_active Expired - Lifetime
- 1999-12-08 US US09/457,912 patent/US6410824B1/en not_active Expired - Lifetime
- 1999-12-08 WO PCT/US1999/029123 patent/WO2000034459A1/en not_active Ceased
-
2002
- 2002-03-26 US US10/108,191 patent/US20020194631A1/en not_active Abandoned
- 2002-09-12 US US10/243,197 patent/US20030056233A1/en not_active Abandoned
-
2004
- 2004-05-14 JP JP2004145466A patent/JP4671265B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-16 US US13/679,022 patent/US9078876B2/en not_active Expired - Fee Related
-
2014
- 2014-07-01 US US14/321,144 patent/US9072725B2/en not_active Expired - Fee Related
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