JP2002531091A5 - - Google Patents

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Publication number
JP2002531091A5
JP2002531091A5 JP2000585406A JP2000585406A JP2002531091A5 JP 2002531091 A5 JP2002531091 A5 JP 2002531091A5 JP 2000585406 A JP2000585406 A JP 2000585406A JP 2000585406 A JP2000585406 A JP 2000585406A JP 2002531091 A5 JP2002531091 A5 JP 2002531091A5
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JP
Japan
Prior art keywords
leu
pth1r
receptor
val
pth3r
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000585406A
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English (en)
Japanese (ja)
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JP2002531091A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1999/028207 external-priority patent/WO2000032775A1/en
Publication of JP2002531091A publication Critical patent/JP2002531091A/ja
Publication of JP2002531091A5 publication Critical patent/JP2002531091A5/ja
Pending legal-status Critical Current

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JP2000585406A 1998-11-30 1999-11-30 Pth1rおよびpth3rレセプター Pending JP2002531091A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11046798P 1998-11-30 1998-11-30
US60/110,467 1998-11-30
PCT/US1999/028207 WO2000032775A1 (en) 1998-11-30 1999-11-30 Pth1r and pth3r receptors

Publications (2)

Publication Number Publication Date
JP2002531091A JP2002531091A (ja) 2002-09-24
JP2002531091A5 true JP2002531091A5 (cg-RX-API-DMAC7.html) 2006-11-24

Family

ID=22333168

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000585406A Pending JP2002531091A (ja) 1998-11-30 1999-11-30 Pth1rおよびpth3rレセプター

Country Status (5)

Country Link
US (3) US6541220B1 (cg-RX-API-DMAC7.html)
EP (1) EP1135489A1 (cg-RX-API-DMAC7.html)
JP (1) JP2002531091A (cg-RX-API-DMAC7.html)
AU (2) AU4217299A (cg-RX-API-DMAC7.html)
WO (2) WO2000032771A1 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1123401A1 (en) * 1998-10-22 2001-08-16 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
EP1133560B1 (en) * 1998-11-25 2010-02-17 The General Hospital Corporation Human parathyroid hormone modifications, preparation and use
DE69938064T2 (de) * 1998-11-25 2009-01-15 The General Hospital Corp., Boston Aminoterminal modifizierte parathyroidhormon (pth) analoge
AU4217299A (en) * 1998-11-30 2000-06-19 General Hospital Corporation, The Pth1r and pth3r receptors, methods and uses thereof
US7057012B1 (en) * 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
WO2000039278A2 (en) * 1998-12-31 2000-07-06 The General Hospital Corporation Pth functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
WO2000040698A1 (en) * 1998-12-31 2000-07-13 The General Hospital Corporation Pth receptor and screening assay utilizing the same
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
KR100491737B1 (ko) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 공기 정화 기능의 모기 퇴치기
EP1439854B1 (en) 2001-07-23 2016-12-14 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
AU2002951372A0 (en) * 2002-09-13 2002-09-26 St Vincent's Institute Of Medical Research Parathyroid hormone-like polypeptides
EP1610813A4 (en) * 2003-03-19 2009-07-01 Gen Hospital Corp CONFORMATION RESTRICTED PARATHORMONE WITH A HELIX STABILIZERS
US7910544B2 (en) * 2003-07-17 2011-03-22 The General Hospital Corporation Conformationally constrained parthyroid hormone (PTH) analogs
US20060068426A1 (en) * 2004-08-20 2006-03-30 Tam James P Cyclic peptides and antibodies thereof
US8143374B2 (en) * 2006-08-04 2012-03-27 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
EP2650009B8 (en) * 2007-08-01 2018-07-18 The General Hospital Corporation Screening methods using G-protein coupled receptors and related compositions
WO2010051473A2 (en) * 2008-10-31 2010-05-06 The Uab Research Foundation Identifying parathyroid hormone agonists and antagonists
WO2011143406A2 (en) 2010-05-13 2011-11-17 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
EP3490600A1 (en) * 2016-08-01 2019-06-05 Xoma (Us) Llc Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof
JP2021516222A (ja) 2018-03-16 2021-07-01 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法
WO2022235929A1 (en) * 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor
CN114874325B (zh) * 2022-06-01 2023-02-14 南京医科大学 抗人pth1r胞外区阻断型单域抗体及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423037A (en) 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
US5010010A (en) 1986-10-22 1991-04-23 Selmer-Sande, A.S. Production of human parathyroid hormone from microorganisms
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
ATE287898T1 (de) * 1991-04-05 2005-02-15 Gen Hospital Corp Parathyroid-hormon-rezeptor und seine kodierende dna
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
NZ246456A (en) 1991-12-17 1997-03-24 Procter & Gamble Pharma Use of bone active phosphonate and a parathyroid hormone to prepare medicaments for a thirty day treatment regimen for osteoporosis
US5814603A (en) 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5496801A (en) 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
EP1123401A1 (en) * 1998-10-22 2001-08-16 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
DE69938064T2 (de) * 1998-11-25 2009-01-15 The General Hospital Corp., Boston Aminoterminal modifizierte parathyroidhormon (pth) analoge
EP1133560B1 (en) * 1998-11-25 2010-02-17 The General Hospital Corporation Human parathyroid hormone modifications, preparation and use
AU4217299A (en) * 1998-11-30 2000-06-19 General Hospital Corporation, The Pth1r and pth3r receptors, methods and uses thereof
JP4723144B2 (ja) 1999-09-29 2011-07-13 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン(pth)のポリペプチド誘導体

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