JP2002527404A5 - - Google Patents
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- JP2002527404A5 JP2002527404A5 JP2000575533A JP2000575533A JP2002527404A5 JP 2002527404 A5 JP2002527404 A5 JP 2002527404A5 JP 2000575533 A JP2000575533 A JP 2000575533A JP 2000575533 A JP2000575533 A JP 2000575533A JP 2002527404 A5 JP2002527404 A5 JP 2002527404A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- flt4
- polypeptide
- antigen
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 description 76
- 239000000427 antigen Substances 0.000 description 50
- 102000036639 antigens Human genes 0.000 description 50
- 108091007433 antigens Proteins 0.000 description 50
- 229920001184 polypeptide Polymers 0.000 description 50
- 102000004196 processed proteins & peptides Human genes 0.000 description 50
- 108090000765 processed proteins & peptides Proteins 0.000 description 50
- 101150009958 FLT4 gene Proteins 0.000 description 48
- 102000016663 Vascular Endothelial Growth Factor Receptor-3 Human genes 0.000 description 48
- 150000001875 compounds Chemical class 0.000 description 36
- 230000003511 endothelial effect Effects 0.000 description 25
- 230000002792 vascular Effects 0.000 description 25
- 239000003550 marker Substances 0.000 description 24
- 239000008194 pharmaceutical composition Substances 0.000 description 15
- 206010028980 Neoplasm Diseases 0.000 description 13
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 10
- 102000009519 Vascular Endothelial Growth Factor D Human genes 0.000 description 9
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 description 9
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 description 8
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 description 8
- 210000002889 endothelial cell Anatomy 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 239000002243 precursor Substances 0.000 description 8
- 210000001077 lymphatic endothelium Anatomy 0.000 description 7
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 description 6
- 102100037241 Endoglin Human genes 0.000 description 6
- 108010036395 Endoglin Proteins 0.000 description 6
- -1 Tie Proteins 0.000 description 6
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 description 6
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 6
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 description 6
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 102000027426 receptor tyrosine kinases Human genes 0.000 description 6
- 108091008598 receptor tyrosine kinases Proteins 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- 108010047303 von Willebrand Factor Proteins 0.000 description 6
- 102100036537 von Willebrand factor Human genes 0.000 description 6
- 229960001134 von willebrand factor Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 210000003556 vascular endothelial cell Anatomy 0.000 description 5
- 101600105505 Mus musculus Vascular endothelial growth factor C (isoform 1) Proteins 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 230000001613 neoplastic effect Effects 0.000 description 4
- 230000004075 alteration Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 239000002254 cytotoxic agent Substances 0.000 description 2
- 231100000599 cytotoxic agent Toxicity 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical class C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000000138 intercalating agent Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229930000184 phytotoxin Natural products 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 description 1
- 229960005314 suramin Drugs 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/169,079 US6824777B1 (en) | 1992-10-09 | 1998-10-09 | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| US09/169,079 | 1998-10-09 | ||
| PCT/US1999/023525 WO2000021560A1 (en) | 1998-10-09 | 1999-10-08 | Flt4 (VEGFR-3) AS A TARGET FOR TUMOR IMAGING AND ANTI-TUMOR THERAPY |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011000273A Division JP5784310B2 (ja) | 1998-10-09 | 2011-01-04 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| JP2011178553A Division JP5642637B2 (ja) | 1998-10-09 | 2011-08-17 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002527404A JP2002527404A (ja) | 2002-08-27 |
| JP2002527404A5 true JP2002527404A5 (https=) | 2007-02-22 |
| JP4841724B2 JP4841724B2 (ja) | 2011-12-21 |
Family
ID=22614189
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000575533A Expired - Fee Related JP4841724B2 (ja) | 1998-10-09 | 1999-10-08 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| JP2011000273A Expired - Lifetime JP5784310B2 (ja) | 1998-10-09 | 2011-01-04 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| JP2011178553A Expired - Fee Related JP5642637B2 (ja) | 1998-10-09 | 2011-08-17 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| JP2013097900A Pending JP2013209382A (ja) | 1998-10-09 | 2013-05-07 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| JP2015077656A Pending JP2015157829A (ja) | 1998-10-09 | 2015-04-06 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011000273A Expired - Lifetime JP5784310B2 (ja) | 1998-10-09 | 2011-01-04 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| JP2011178553A Expired - Fee Related JP5642637B2 (ja) | 1998-10-09 | 2011-08-17 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| JP2013097900A Pending JP2013209382A (ja) | 1998-10-09 | 2013-05-07 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| JP2015077656A Pending JP2015157829A (ja) | 1998-10-09 | 2015-04-06 | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US8444957B2 (https=) |
| EP (1) | EP1119371B1 (https=) |
| JP (5) | JP4841724B2 (https=) |
| CN (1) | CN100340291C (https=) |
| AT (1) | ATE489108T1 (https=) |
| AU (2) | AU774266B2 (https=) |
| CA (1) | CA2345276C (https=) |
| DE (1) | DE69942981D1 (https=) |
| DK (1) | DK1119371T3 (https=) |
| ES (1) | ES2357406T3 (https=) |
| NO (1) | NO20011759L (https=) |
| NZ (2) | NZ529063A (https=) |
| WO (1) | WO2000021560A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818220B1 (en) | 1994-11-14 | 2004-11-16 | Licentia Ltd. | Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof |
| EP1353952B1 (en) | 1994-11-14 | 2007-04-11 | Ludwig Institute For Cancer Research | Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy |
| US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
| US7423125B2 (en) | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
| DE69628652T3 (de) | 1995-09-08 | 2012-05-03 | Genentech, Inc. | Vegf-verwandtes protein |
| US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
| AU774266B2 (en) * | 1998-10-09 | 2004-06-24 | Vegenics Limited | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
| EP1553414A1 (en) * | 1999-04-13 | 2005-07-13 | Medarex, Inc. | Methods for the diagnosis and treatment of metastatic prostate tumors |
| AU3988401A (en) | 2000-02-25 | 2001-09-03 | Ludwig Inst Cancer Res | Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins |
| MXPA02003434A (es) | 2000-08-04 | 2002-09-02 | Human Genome Sciences Inc | Factor de crecimiento endotelial vascular 2. |
| US7611711B2 (en) | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
| CA2444632A1 (en) | 2001-04-13 | 2002-10-24 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| WO2005078097A2 (en) | 2004-02-10 | 2005-08-25 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING MULTIFUNCTIONAL SHORT INTERFERING NUCLEIC ACID (Multifunctional siNA) |
| US7109165B2 (en) | 2001-05-18 | 2006-09-19 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| CA2452058A1 (en) * | 2001-06-26 | 2003-01-09 | Imclone Systems Incorporated | Bispecific antibodies that bind to vegf receptors |
| US20030113324A1 (en) * | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
| AU2003207708A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| WO2005049852A2 (en) * | 2003-11-17 | 2005-06-02 | University Of Florida | Methods and compositions for inducing apoptosis |
| WO2005087177A2 (en) | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Chimeric anti-vegf-d antibodies and humanized anti-vegf-d antibodies and methods of using same |
| US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| EP1919944B1 (en) | 2005-08-15 | 2011-03-23 | Vegenics Pty Ltd | Modified vegf and pdgf with improved angiogenic properties |
| US8305579B2 (en) * | 2006-11-16 | 2012-11-06 | Thomas Pirrie Treynor | Sequential analysis of biological samples |
| US9201063B2 (en) | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
| US7629125B2 (en) | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US9677125B2 (en) | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| EP2538965B1 (en) | 2010-02-25 | 2017-04-12 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
| US20150246118A1 (en) | 2012-10-26 | 2015-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Lyve-1 antagonists for preventing or treating a pathological condition associated with lymphangiogenesis |
| PT2956476T (pt) | 2013-02-18 | 2020-02-21 | Vegenics Pty Ltd | Moléculas de ligação e usos destas |
| EP2994758B1 (en) | 2013-05-08 | 2017-12-20 | Opthea Limited | Biomarkers for age-related macular degeneration (amd) |
| KR102131370B1 (ko) | 2013-10-18 | 2020-07-08 | 삼성전자주식회사 | Vegf-c에 특이적으로 결합하는 폴리펩타이드 및 그의 용도 |
| CN114262683B (zh) * | 2022-03-01 | 2022-06-17 | 中国科学院动物研究所 | 一种表达vegfr3 d2多肽的细菌制剂及其构建方法和应用 |
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| US4652639A (en) | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
| US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
| ATE97498T1 (de) | 1984-01-30 | 1993-12-15 | Imp Cancer Res Tech | Verbesserungen an wachstumsfaktoren. |
| IL85688A0 (en) | 1987-03-11 | 1988-08-31 | Erba Carlo Spa | Immunoglobulin conjugates,their preparation and pharmaceutical compositions containing them |
| DE68926888T2 (de) | 1988-01-22 | 1997-01-09 | Zymogenetics Inc | Verfahren zur Herstellung von sekretierten Rezeptoranalogen |
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| US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| BR9207175A (pt) | 1992-10-28 | 1995-12-12 | Genentech Inc | Composição contendo antagonista de fator de crescimento de célula endotelial vascular sequência aminoácida de anticorpo monoclonal polipeptídeo e método de tratamento de tumor em mamífero |
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| DE69628652T3 (de) | 1995-09-08 | 2012-05-03 | Genentech, Inc. | Vegf-verwandtes protein |
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| CN1345247A (zh) | 1997-12-24 | 2002-04-17 | 路德维格癌症研究所 | 表达血管内皮生长因子d的表达载体和细胞系以及治疗黑素瘤的方法 |
| AU774266B2 (en) * | 1998-10-09 | 2004-06-24 | Vegenics Limited | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| KR101681886B1 (ko) | 2015-04-06 | 2016-12-12 | 서울대학교산학협력단 | 지르코니아 결합능을 가지는 펩타이드 |
-
1999
- 1999-10-08 AU AU13121/00A patent/AU774266B2/en not_active Ceased
- 1999-10-08 DK DK99956525.2T patent/DK1119371T3/da active
- 1999-10-08 ES ES99956525T patent/ES2357406T3/es not_active Expired - Lifetime
- 1999-10-08 NZ NZ529063A patent/NZ529063A/en unknown
- 1999-10-08 CA CA2345276A patent/CA2345276C/en not_active Expired - Fee Related
- 1999-10-08 DE DE69942981T patent/DE69942981D1/de not_active Expired - Lifetime
- 1999-10-08 NZ NZ511408A patent/NZ511408A/en unknown
- 1999-10-08 JP JP2000575533A patent/JP4841724B2/ja not_active Expired - Fee Related
- 1999-10-08 EP EP99956525A patent/EP1119371B1/en not_active Expired - Lifetime
- 1999-10-08 AT AT99956525T patent/ATE489108T1/de active
- 1999-10-08 WO PCT/US1999/023525 patent/WO2000021560A1/en not_active Ceased
- 1999-10-08 CN CNB998142859A patent/CN100340291C/zh not_active Expired - Fee Related
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2001
- 2001-04-06 NO NO20011759A patent/NO20011759L/no unknown
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2004
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2010
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2011
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- 2011-08-17 JP JP2011178553A patent/JP5642637B2/ja not_active Expired - Fee Related
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2013
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- 2013-05-07 JP JP2013097900A patent/JP2013209382A/ja active Pending
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2014
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2015
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