JP2002524503A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002524503A5 JP2002524503A5 JP2000569796A JP2000569796A JP2002524503A5 JP 2002524503 A5 JP2002524503 A5 JP 2002524503A5 JP 2000569796 A JP2000569796 A JP 2000569796A JP 2000569796 A JP2000569796 A JP 2000569796A JP 2002524503 A5 JP2002524503 A5 JP 2002524503A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- group
- lower alkyl
- aminoalkyl
- alkoxyalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 description 111
- 125000003118 aryl group Chemical group 0.000 description 86
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 70
- 125000004103 aminoalkyl group Chemical group 0.000 description 70
- 125000000753 cycloalkyl group Chemical group 0.000 description 70
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 70
- 125000000278 alkyl amino alkyl group Chemical group 0.000 description 66
- 125000002877 alkyl aryl group Chemical group 0.000 description 62
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 45
- 125000003282 alkyl amino group Chemical group 0.000 description 38
- -1 alkoxycycloalkyl Chemical group 0.000 description 37
- 125000005350 hydroxycycloalkyl group Chemical group 0.000 description 33
- 125000002947 alkylene group Chemical group 0.000 description 29
- 150000001875 compounds Chemical class 0.000 description 18
- 238000000034 method Methods 0.000 description 13
- 125000005429 oxyalkyl group Chemical group 0.000 description 12
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 125000003107 substituted aryl group Chemical group 0.000 description 8
- 206010017533 Fungal infection Diseases 0.000 description 7
- 208000031888 Mycoses Diseases 0.000 description 7
- 0 C([C@]1*C1)[C@](CC1)C[C@@]1C1CC1 Chemical compound C([C@]1*C1)[C@](CC1)C[C@@]1C1CC1 0.000 description 5
- 125000004171 alkoxy aryl group Chemical group 0.000 description 4
- 125000005001 aminoaryl group Chemical group 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 3
- 241000223218 Fusarium Species 0.000 description 3
- 241001225321 Aspergillus fumigatus Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 201000007336 Cryptococcosis Diseases 0.000 description 2
- 241000221204 Cryptococcus neoformans Species 0.000 description 2
- 229940091771 aspergillus fumigatus Drugs 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10092898P | 1998-09-17 | 1998-09-17 | |
| US60/100,928 | 1998-09-17 | ||
| PCT/US1999/021383 WO2000015212A2 (en) | 1998-09-17 | 1999-09-15 | Antifungal activity of dicationic molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002524503A JP2002524503A (ja) | 2002-08-06 |
| JP2002524503A5 true JP2002524503A5 (enExample) | 2006-10-05 |
Family
ID=22282251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000569796A Withdrawn JP2002524503A (ja) | 1998-09-17 | 1999-09-15 | 二陽イオン分子の抗真菌活性 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6326395B1 (enExample) |
| EP (1) | EP1143959B1 (enExample) |
| JP (1) | JP2002524503A (enExample) |
| AT (1) | ATE344028T1 (enExample) |
| AU (2) | AU770656B2 (enExample) |
| CA (1) | CA2344445A1 (enExample) |
| DE (1) | DE69933890T2 (enExample) |
| ES (1) | ES2275362T3 (enExample) |
| WO (1) | WO2000015212A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0016565A (pt) * | 1999-12-20 | 2002-09-17 | Univ North Carolina | Compostos diamidina como ligantes de pequeno sulco de dna |
| US6569853B1 (en) * | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| CA2455497A1 (en) * | 2001-08-31 | 2003-03-06 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| AU2003302218A1 (en) | 2002-05-16 | 2004-06-18 | Genelabs Technologies, Inc | Aryl and heteroaryl compounds as antibacterial and antifungal agents |
| CA2504742A1 (en) * | 2002-11-27 | 2004-06-17 | University Of North Carolina At Chapel Hill | Process for synthesis bis-aryl diamidoxime compounds |
| US20050054708A1 (en) * | 2003-07-28 | 2005-03-10 | Nichols Matthew James | Combinations of drugs for the treatment of neoplasms |
| US20050080075A1 (en) * | 2003-08-25 | 2005-04-14 | Nichols M. James | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms |
| US20050100508A1 (en) * | 2003-11-12 | 2005-05-12 | Nichols M. J. | Methods for identifying drug combinations for the treatment of proliferative diseases |
| US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
| JP2007513175A (ja) * | 2003-12-05 | 2007-05-24 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 抗菌剤としてのカチオンで置換されたベンゾフラン |
| US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| WO2005086754A2 (en) * | 2004-03-08 | 2005-09-22 | Georgia State University Research Foundation, Inc. | Dicationic compounds for activity against trichomonas vaginalis |
| US7994225B2 (en) * | 2004-03-17 | 2011-08-09 | Rempex Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections |
| EP1732527A2 (en) * | 2004-03-17 | 2006-12-20 | Mpex Pharmaceuticals, Inc. | Use and administration of bacterial efflux pump inhibitors |
| AU2005233632A1 (en) | 2004-04-13 | 2005-10-27 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
| DE102004031656A1 (de) * | 2004-06-30 | 2006-01-19 | Merck Patent Gmbh | Tetrahydrochinoline |
| GB0619325D0 (en) * | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| DE102007013854A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Tetrahydrochinoline |
| DE102007013856A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydropyrrolochinoline |
| DE102007013855A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydrochinoline |
| EP2194981B1 (en) * | 2007-10-05 | 2011-11-23 | Université de Mons-Hainaut | Bisbenzimidazoles as antimalarial agents |
| WO2009084544A1 (ja) * | 2007-12-27 | 2009-07-09 | Idemitsu Kosan Co., Ltd. | 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子 |
| EP3159033B1 (en) | 2008-05-01 | 2019-02-27 | Bayer Intellectual Property GmbH | Catheter balloon drug adherence techniques and methods |
| EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US11141752B2 (en) | 2012-12-27 | 2021-10-12 | Kateeva, Inc. | Techniques for arrayed printing of a permanent layer with improved speed and accuracy |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2122208A1 (en) | 1971-05-05 | 1972-11-23 | Farbwerke Hoechst AG, vormals Meister Lucius & Brüning, 6000 Frankfurt | Diamidino-benzimidazole derivs - with fungistatic activity |
| JPS51110531A (en) | 1975-03-26 | 1976-09-30 | Eisai Co Ltd | Amijinokagobutsuno seizoho |
| JPS5922697B2 (ja) | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−（メタ−アミジノフエノキシ）−化合物 |
| DE2833135A1 (de) | 1978-07-28 | 1980-02-07 | Henkel Kgaa | Verwendung von substituierten oligocarbamidinen als mikrobistatika sowie diese enthaltende antimikrobielle mittel |
| US4397863A (en) | 1980-08-26 | 1983-08-09 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| US4324794A (en) | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| US4619942A (en) | 1982-04-08 | 1986-10-28 | University Of North Carolina | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds |
| US4940723A (en) | 1988-10-20 | 1990-07-10 | University Of North Carolina, Chapel Hill | Use of bis-(5-amidino-2-benzimidazolyl) methane (BABIM) to treat arthritis |
| US4963589A (en) | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
| US5202320A (en) | 1989-04-06 | 1993-04-13 | Tidwell Richard R | Method for treating leishmaniasis |
| US4933347A (en) | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
| US5206236A (en) | 1989-04-06 | 1993-04-27 | Tidwell Richard R | Method for the treatment of malaria |
| US5428051A (en) | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
| US5723288A (en) | 1994-05-06 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor |
| US5602172A (en) | 1994-05-06 | 1997-02-11 | The University Of North Carolina At Chapel Hill | Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor |
| US5667975A (en) | 1994-05-06 | 1997-09-16 | The University Of North Carolina | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans |
| US5521189A (en) | 1994-05-06 | 1996-05-28 | The University Of Nc At Ch | Methods of treating pneumocystis carinii pneumonia |
| US5643935A (en) | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
| US5668166A (en) | 1995-06-07 | 1997-09-16 | Georgia State University Research Foundation, Inc. | Methods of inhibiting pneumocystis carinii pneumonia and compounds useful therefor |
| US5723495A (en) | 1995-11-16 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Benzamidoxime prodrugs as antipneumocystic agents |
-
1999
- 1999-09-15 DE DE69933890T patent/DE69933890T2/de not_active Expired - Fee Related
- 1999-09-15 ES ES99969025T patent/ES2275362T3/es not_active Expired - Lifetime
- 1999-09-15 CA CA002344445A patent/CA2344445A1/en not_active Abandoned
- 1999-09-15 AT AT99969025T patent/ATE344028T1/de not_active IP Right Cessation
- 1999-09-15 WO PCT/US1999/021383 patent/WO2000015212A2/en not_active Ceased
- 1999-09-15 EP EP99969025A patent/EP1143959B1/en not_active Expired - Lifetime
- 1999-09-15 US US09/396,836 patent/US6326395B1/en not_active Expired - Lifetime
- 1999-09-15 AU AU60450/99A patent/AU770656B2/en not_active Ceased
- 1999-09-15 JP JP2000569796A patent/JP2002524503A/ja not_active Withdrawn
-
2004
- 2004-05-26 AU AU2004202311A patent/AU2004202311A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002524503A5 (enExample) | ||
| JP2001526218A5 (enExample) | ||
| JP2003523927A5 (enExample) | ||
| DE69931159D1 (de) | Antimikrobielle zusammensetzungen enthaltend taurolidin, zitronensäure und natriumzitrat | |
| DE60316779D1 (de) | Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen | |
| JP2019515884A5 (enExample) | ||
| FI914919A7 (fi) | AIDS-potilaiden neurologisten sairauksien hoidossa tehokkaat farmaseuttiset koostumukset, jotka sisältävät vaikuttavana aineena vähintään yhtä yhdistettä, joka on valittu ryhmästä, joka käsittää S-adenosyyli -L-metioniinisuolan, 5-metyylitetrahydrofool | |
| RU95122135A (ru) | Комбинация для профилактики и лечения спида, фармацевтическая композиция на ее основе | |
| RU99112577A (ru) | Новое применение 1,3-пропандиольных производных | |
| JP2019516739A5 (enExample) | ||
| WO2002040481A3 (en) | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof | |
| RU2003118411A (ru) | Кристаллические производные 1-метилкарбапенема | |
| SE9901573D0 (sv) | New compounds | |
| EP1050300A2 (en) | Selective antibacterial composition | |
| RU98101105A (ru) | Новое применение в медицинских целях | |
| KR950016760A (ko) | 치질 치료제 | |
| RU2004131214A (ru) | Способы лечения когнитивных расстройств | |
| RU2000106042A (ru) | Способ повышения биологической доступности фексофенадина и его производных | |
| US6498173B1 (en) | Synergistic combination comprising roflumilast and a pde-3 inhibitor | |
| JP2002537232A5 (enExample) | ||
| TR200103144T2 (tr) | Yeni bileşikler | |
| KR910018393A (ko) | 항바이러스제로서의 비대칭 2-(포스포노메톡시)프로필 구아닌 | |
| WO2024107783A3 (en) | Novel macrocyclic chalcone-amide derived antiviral agents | |
| JPS615017A (ja) | 抗潰瘍組成物 | |
| JP2003246730A5 (enExample) |