BR0016565A - Compostos diamidina como ligantes de pequeno sulco de dna - Google Patents

Compostos diamidina como ligantes de pequeno sulco de dna

Info

Publication number
BR0016565A
BR0016565A BR0016565-4A BR0016565A BR0016565A BR 0016565 A BR0016565 A BR 0016565A BR 0016565 A BR0016565 A BR 0016565A BR 0016565 A BR0016565 A BR 0016565A
Authority
BR
Brazil
Prior art keywords
dna
compounds
processes
sequences
bind
Prior art date
Application number
BR0016565-4A
Other languages
English (en)
Inventor
David W Wilson
David Boykin
Richard R Tidwell
Original Assignee
Univ North Carolina
Univ Georgia State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Univ Georgia State Res Found filed Critical Univ North Carolina
Publication of BR0016565A publication Critical patent/BR0016565A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSTOS DIAMIDINA COMO LIGANTES DE PEQUENO SULCO DE DNA". Derivados assimétricos de furamidinas com um dos anéis fenila de furamidina substituído com um benzimidazol foram verificados por análises de pegadas quantitativas ligarem-se a sítios contendo GC sobre DNA mais fortemente que a seq³ências AT puras. Estes compostos foram mostrados ligarem-se no pequeno sulco em específicas seq³ências contendo GC de DNA em uma maneira altamente cooperativa como um dímero empilhado. Compostos da presente invenção encontram uso em ligação seletiva de seq³ência mista de DNA, e também podem ser usados em processos de regulagem de expressão de gene, processos de tratamento de infecções oportunísticas e câncer, assim como em processos de detecção de certas seq³ências de DNA.
BR0016565-4A 1999-12-20 2000-12-20 Compostos diamidina como ligantes de pequeno sulco de dna BR0016565A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17286399P 1999-12-20 1999-12-20
PCT/US2000/034794 WO2001046175A1 (en) 1999-12-20 2000-12-20 Diamidine compounds as dna minor groove binders

Publications (1)

Publication Number Publication Date
BR0016565A true BR0016565A (pt) 2002-09-17

Family

ID=22629529

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016565-4A BR0016565A (pt) 1999-12-20 2000-12-20 Compostos diamidina como ligantes de pequeno sulco de dna

Country Status (12)

Country Link
US (3) US6613787B2 (pt)
EP (1) EP1244651B1 (pt)
JP (1) JP2003519623A (pt)
AU (2) AU781375B2 (pt)
BR (1) BR0016565A (pt)
CA (1) CA2392150A1 (pt)
DE (1) DE60032022T2 (pt)
ES (1) ES2276713T3 (pt)
HK (1) HK1050358A1 (pt)
MX (1) MXPA02005937A (pt)
NZ (1) NZ519209A (pt)
WO (1) WO2001046175A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046175A1 (en) * 1999-12-20 2001-06-28 The University Of North Carolina At Chapel Hill Diamidine compounds as dna minor groove binders
US7163955B2 (en) 2001-01-13 2007-01-16 The University Of North Carolina At Chapel Hill Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
EP1837024A3 (en) * 2001-01-13 2007-11-14 University Of North Carolina At Chapel Hill Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
JP4368582B2 (ja) * 2001-01-13 2009-11-18 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 牛ウイルス性下痢ウイルス（ｂｖｄｖ）感染およびｃ型肝炎ウイルス（ｈｃｖ）感染を処置するのに有用な化合物、方法、および組成物
CA2504740A1 (en) * 2002-11-27 2004-06-17 University Of North Carolina At Chapel Hill Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents
BRPI0409777A (pt) * 2003-04-30 2006-05-30 Pharmacia Corp compostos que apresentam uma parte bicìclica fundida para ligação com o sulco menor de dnadf
US7262223B2 (en) 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
GB0404574D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Amino acids
US20070276020A1 (en) * 2004-03-08 2007-11-29 Boykin David W Dicationic Compounds For Activity Against Trichomonas Vaginalis
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
CA2559208A1 (en) * 2004-03-17 2005-09-29 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
US20100249175A1 (en) * 2005-12-02 2010-09-30 Wilson W David Dicationic compounds which selectively recognize G-quadruplex DNA
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US20100331368A1 (en) * 2007-10-17 2010-12-30 Tidwell Richard R 2,5-diaryl selenophene compounds, aza 2,5-diaryl thiophene compounds, and their prodrugs as antiprotozoal agents
EP2855482B1 (en) 2012-04-30 2017-03-01 MedImmune Limited Pyrrolobenzodiazepines
BR112014027190B1 (pt) 2012-04-30 2020-03-03 Medimmune Limited Composto de pirrolobenzodiazepinas, sua composição farmacêutica e seu uso
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
CA2983740C (en) 2015-05-01 2021-04-20 Gen-Probe Incorporated Multiplex invasive cleavage assays
US11043305B1 (en) * 2018-02-02 2021-06-22 Immuneering Corporation Systems and methods for rapid gene set enrichment analysis
CN111362834B (zh) * 2020-02-26 2021-04-02 湖南大学 一种具有抗耐药性的抗菌脒类低聚物及其制作方法和用途
KR102460579B1 (ko) * 2020-06-26 2022-10-31 선문대학교 산학협력단 푸라미딘 및 hbc를 포함하는 뇌암 치료, 개선 또는 예방용 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4397851A (en) * 1981-12-22 1983-08-09 Merck & Co., Inc. 2,3-Dihalo-2,3-(disubstituted) propanoate antimicrobial compounds
WO1995008540A1 (en) * 1993-09-22 1995-03-30 The Wellcome Foundation Limited Bis(amidinobenzimidazolyl)alkanes as antiviral agents
US5723288A (en) 1994-05-06 1998-03-03 The University Of North Carolina At Chapel Hill Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor
US5667975A (en) 1994-05-06 1997-09-16 The University Of North Carolina Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans
AU6966696A (en) * 1995-10-05 1997-04-28 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
AU770656B2 (en) * 1998-09-17 2004-02-26 Duke University Antifungal activity of dicationic molecules
WO2001046175A1 (en) * 1999-12-20 2001-06-28 The University Of North Carolina At Chapel Hill Diamidine compounds as dna minor groove binders
JP4368582B2 (ja) * 2001-01-13 2009-11-18 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 牛ウイルス性下痢ウイルス（ｂｖｄｖ）感染およびｃ型肝炎ウイルス（ｈｃｖ）感染を処置するのに有用な化合物、方法、および組成物

Also Published As

Publication number Publication date
JP2003519623A (ja) 2003-06-24
HK1050358A1 (en) 2003-06-20
US6867227B2 (en) 2005-03-15
EP1244651B1 (en) 2006-11-22
US20020123634A1 (en) 2002-09-05
US7160914B2 (en) 2007-01-09
AU781375B2 (en) 2005-05-19
US20050158785A1 (en) 2005-07-21
NZ519209A (en) 2003-11-28
ES2276713T3 (es) 2007-07-01
EP1244651A1 (en) 2002-10-02
AU2005203740A1 (en) 2005-09-15
AU2587401A (en) 2001-07-03
CA2392150A1 (en) 2001-06-28
US6613787B2 (en) 2003-09-02
WO2001046175A1 (en) 2001-06-28
AU2005203740B2 (en) 2007-08-23
DE60032022D1 (de) 2007-01-04
DE60032022T2 (de) 2007-05-16
MXPA02005937A (es) 2004-08-12
US20040053981A1 (en) 2004-03-18

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13, 24 E 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.