JP2002524421A5 - - Google Patents
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- Publication number
- JP2002524421A5 JP2002524421A5 JP2000568510A JP2000568510A JP2002524421A5 JP 2002524421 A5 JP2002524421 A5 JP 2002524421A5 JP 2000568510 A JP2000568510 A JP 2000568510A JP 2000568510 A JP2000568510 A JP 2000568510A JP 2002524421 A5 JP2002524421 A5 JP 2002524421A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- vegf
- hus
- factor
- organ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 29
- 238000000034 method Methods 0.000 description 27
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 17
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 17
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 17
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 6
- 208000034841 Thrombotic Microangiopathies Diseases 0.000 description 5
- 239000000556 agonist Substances 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 230000006870 function Effects 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 108010041308 Endothelial Growth Factors Proteins 0.000 description 1
- 206010043561 Thrombocytopenic purpura Diseases 0.000 description 1
- 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9969498P | 1998-09-09 | 1998-09-09 | |
| US60/099,694 | 1998-09-09 | ||
| US12640699P | 1999-03-26 | 1999-03-26 | |
| US60/126,406 | 1999-03-26 | ||
| US12661599P | 1999-03-27 | 1999-03-27 | |
| US60/126,615 | 1999-03-27 | ||
| PCT/US1999/020480 WO2000013702A2 (en) | 1998-09-09 | 1999-09-09 | Use of an angiogenic factor for the treatment of microvascular angiopathies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002524421A JP2002524421A (ja) | 2002-08-06 |
| JP2002524421A5 true JP2002524421A5 (https=) | 2006-10-26 |
Family
ID=27378887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000568510A Pending JP2002524421A (ja) | 1998-09-09 | 1999-09-09 | 微小血管障害の処置 |
| JP2000568511A Pending JP2002532382A (ja) | 1998-09-09 | 1999-09-09 | 高血圧を処置する方法およびそこでの使用のための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000568511A Pending JP2002532382A (ja) | 1998-09-09 | 1999-09-09 | 高血圧を処置する方法およびそこでの使用のための組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6352975B1 (https=) |
| EP (2) | EP1112083B1 (https=) |
| JP (2) | JP2002524421A (https=) |
| AT (2) | ATE260675T1 (https=) |
| AU (2) | AU5910599A (https=) |
| BR (2) | BR9913564A (https=) |
| CA (2) | CA2340320C (https=) |
| DE (2) | DE69912815T2 (https=) |
| DK (2) | DK1112083T3 (https=) |
| ES (2) | ES2211165T3 (https=) |
| IL (2) | IL141687A0 (https=) |
| PT (2) | PT1109571E (https=) |
| WO (2) | WO2000013703A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6352975B1 (en) * | 1998-09-09 | 2002-03-05 | Scios Inc. | Methods of treating hypertension and compositions for use therein |
| US6783954B2 (en) * | 1999-03-05 | 2004-08-31 | Compugen Ltd. | VEGF nucleic acid and amino acid sequences |
| IL148674A0 (en) * | 1999-11-02 | 2002-09-12 | Genentech Inc | Modulation of enos activity and therapeutic uses thereof |
| US7078382B1 (en) | 1999-11-02 | 2006-07-18 | Genentech, Inc. | Modulation of eNOS activity and therapeutic uses thereof |
| US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| DE60235761D1 (de) | 2001-08-01 | 2010-05-06 | Univ Bristol Clifton | Isoform des vegfs |
| EP1427323A4 (en) * | 2001-08-20 | 2004-09-15 | Univ Virginia | USE OF S-NITROSOTHIOL SIGNALING TO TREAT BREATH CONTROL DISORDERS |
| US7981863B2 (en) * | 2001-09-19 | 2011-07-19 | Neuronova Ab | Treatment of Parkinson's disease with PDGF |
| US7795213B2 (en) | 2001-12-13 | 2010-09-14 | Posco | Methods of contacting β amyloid protein with VEGF |
| US20030171556A1 (en) * | 2001-12-13 | 2003-09-11 | Chi-Bom Chae | Beta-amyloid binding factors and inhibitors thereof |
| US7335362B2 (en) | 2002-07-19 | 2008-02-26 | Beth Israel Deaconess Medical Center | Methods of treating pre-eclampsia or eclampsia |
| JP2006068401A (ja) * | 2004-09-03 | 2006-03-16 | Kyushu Institute Of Technology | 人工血管 |
| CN101277704A (zh) * | 2005-04-12 | 2008-10-01 | 因特拉迪格姆公司 | 用于治疗癌症及其它新血管生成疾病的RNAi治疗剂的组合物和方法 |
| US7893244B2 (en) * | 2005-04-12 | 2011-02-22 | Intradigm Corporation | Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases |
| US8440619B2 (en) * | 2005-08-31 | 2013-05-14 | National University Corporation Kagawa University | Utilization of hypertension/hypercardia-preventing effect of D-allose |
| ES2600781T3 (es) * | 2008-12-04 | 2017-02-10 | Curna, Inc. | Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf |
| GB0921525D0 (en) * | 2009-12-08 | 2010-01-27 | Isis Innovation | Product and method |
| WO2018183625A1 (en) | 2017-03-30 | 2018-10-04 | Wake Forest University Health Sciences | Methods of treatment for kidney disease |
| CN113418940B (zh) * | 2021-06-24 | 2023-03-14 | 电子科技大学 | 一种基于x射线示踪颗粒的检测方法及检测装置 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456550A (en) | 1982-11-22 | 1984-06-26 | President And Fellows Of Harvard College | Vascular permeability factor |
| US5240848A (en) | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
| ATE152626T1 (de) | 1989-03-24 | 1997-05-15 | Univ California | Endothelialer zellwachsfaktor, isolierung und expression |
| US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5219739A (en) | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
| US5240714A (en) * | 1989-08-29 | 1993-08-31 | Rof Jose M S | Non-digoxin-like Na+, K+ -ATPase inhibitory factor |
| US5318957A (en) * | 1992-09-02 | 1994-06-07 | The United States Of America As Represented By The Department Of Health And Human Services | Method of stimulating angiogenesis |
| KR100695590B1 (ko) * | 1996-11-01 | 2007-03-14 | 아크 테라퓨틱스 리미티드 | 산화질소 또는 프로스타시클린 생산을 자극하는 약제의 치료학적 용도 및 전달 기구 |
| US6485942B1 (en) * | 1997-02-14 | 2002-11-26 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production |
| US6352975B1 (en) * | 1998-09-09 | 2002-03-05 | Scios Inc. | Methods of treating hypertension and compositions for use therein |
-
1999
- 1999-09-09 US US09/392,932 patent/US6352975B1/en not_active Expired - Lifetime
- 1999-09-09 JP JP2000568510A patent/JP2002524421A/ja active Pending
- 1999-09-09 DK DK99946776T patent/DK1112083T3/da active
- 1999-09-09 PT PT99968631T patent/PT1109571E/pt unknown
- 1999-09-09 CA CA002340320A patent/CA2340320C/en not_active Expired - Fee Related
- 1999-09-09 WO PCT/US1999/020481 patent/WO2000013703A2/en not_active Ceased
- 1999-09-09 BR BR9913564-7A patent/BR9913564A/pt not_active Application Discontinuation
- 1999-09-09 ES ES99946776T patent/ES2211165T3/es not_active Expired - Lifetime
- 1999-09-09 AU AU59105/99A patent/AU5910599A/en not_active Abandoned
- 1999-09-09 ES ES99968631T patent/ES2216630T3/es not_active Expired - Lifetime
- 1999-09-09 WO PCT/US1999/020480 patent/WO2000013702A2/en not_active Ceased
- 1999-09-09 IL IL14168799A patent/IL141687A0/xx unknown
- 1999-09-09 IL IL14168699A patent/IL141686A0/xx unknown
- 1999-09-09 JP JP2000568511A patent/JP2002532382A/ja active Pending
- 1999-09-09 AT AT99968631T patent/ATE260675T1/de not_active IP Right Cessation
- 1999-09-09 DE DE69912815T patent/DE69912815T2/de not_active Expired - Fee Related
- 1999-09-09 PT PT99946776T patent/PT1112083E/pt unknown
- 1999-09-09 CA CA002340728A patent/CA2340728C/en not_active Expired - Fee Related
- 1999-09-09 EP EP99946776A patent/EP1112083B1/en not_active Expired - Lifetime
- 1999-09-09 AT AT99946776T patent/ATE253934T1/de not_active IP Right Cessation
- 1999-09-09 AU AU60285/99A patent/AU6028599A/en not_active Abandoned
- 1999-09-09 DK DK99968631T patent/DK1109571T3/da active
- 1999-09-09 BR BR9913533-7A patent/BR9913533A/pt not_active Application Discontinuation
- 1999-09-09 EP EP99968631A patent/EP1109571B1/en not_active Expired - Lifetime
- 1999-09-09 DE DE69915310T patent/DE69915310T2/de not_active Expired - Fee Related
-
2002
- 2002-02-26 US US10/083,817 patent/US20020193288A1/en not_active Abandoned
-
2003
- 2003-12-31 US US10/749,706 patent/US20040224885A1/en not_active Abandoned
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