JP2002522082A - 哺乳類マロニルＣｏＡデカルボキシラーゼの阻害剤、作用物質および拮抗物質を同定するための組成物および方法 - Google Patents
哺乳類マロニルＣｏＡデカルボキシラーゼの阻害剤、作用物質および拮抗物質を同定するための組成物および方法Info
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- JP2002522082A JP2002522082A JP2000565145A JP2000565145A JP2002522082A JP 2002522082 A JP2002522082 A JP 2002522082A JP 2000565145 A JP2000565145 A JP 2000565145A JP 2000565145 A JP2000565145 A JP 2000565145A JP 2002522082 A JP2002522082 A JP 2002522082A
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- mcd
- coa
- malonyl
- protein
- activity
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- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9609398P | 1998-08-11 | 1998-08-11 | |
| US25120099A | 1999-02-16 | 1999-02-16 | |
| US60/096,093 | 1999-02-16 | ||
| US09/251,200 | 1999-02-16 | ||
| PCT/CA1999/000734 WO2000009710A2 (en) | 1998-08-11 | 1999-08-09 | Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002522082A true JP2002522082A (ja) | 2002-07-23 |
Family
ID=26791076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000565145A Pending JP2002522082A (ja) | 1998-08-11 | 1999-08-09 | 哺乳類マロニルＣｏＡデカルボキシラーゼの阻害剤、作用物質および拮抗物質を同定するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1127139A2 (de) |
| JP (1) | JP2002522082A (de) |
| KR (1) | KR20010085373A (de) |
| AU (1) | AU774628B2 (de) |
| CA (1) | CA2339088A1 (de) |
| WO (1) | WO2000009710A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| WO2002066035A2 (en) * | 2001-02-20 | 2002-08-29 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
| EP1505977B1 (de) * | 2002-05-21 | 2014-09-10 | Gilead Sciences, Inc. | Verabreichung eines partiellen fettsäure oxidationshemmers wie ranolazin zur behandlung von diabetes |
| JP4648317B2 (ja) | 2003-08-01 | 2011-03-09 | 中外製薬株式会社 | マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用なピペリジン化合物 |
| DE602004030017D1 (de) | 2003-08-01 | 2010-12-23 | Chugai Pharmaceutical Co Ltd | Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
| EP2208495B1 (de) | 2003-08-01 | 2011-12-14 | Chugai Seiyaku Kabushiki Kaisha | Azol-Verbindungen auf Cyanoguanidin-Basis als Malonyl-Coa Decarboxylase-Hemmer |
| EP1648564B1 (de) | 2003-08-01 | 2007-10-17 | Chugai Seiyaku Kabushiki Kaisha | Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
| WO2008106630A1 (en) * | 2007-03-01 | 2008-09-04 | Bristol-Myers Squibb Company | Coupled enzyme assay for measuring acetyl coa carboxylase and malonyl coa decarboxylase activity |
| CN115161380A (zh) * | 2022-06-21 | 2022-10-11 | 亚科因(武汉)生物技术有限公司 | α-酮戊二酸脱氢酶检测试剂盒及其应用 |
-
1999
- 1999-08-09 WO PCT/CA1999/000734 patent/WO2000009710A2/en not_active Application Discontinuation
- 1999-08-09 KR KR1020017001831A patent/KR20010085373A/ko not_active Application Discontinuation
- 1999-08-09 AU AU52729/99A patent/AU774628B2/en not_active Ceased
- 1999-08-09 EP EP99938082A patent/EP1127139A2/de not_active Withdrawn
- 1999-08-09 JP JP2000565145A patent/JP2002522082A/ja active Pending
- 1999-08-09 CA CA002339088A patent/CA2339088A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1127139A2 (de) | 2001-08-29 |
| WO2000009710A2 (en) | 2000-02-24 |
| WO2000009710A3 (en) | 2001-06-07 |
| CA2339088A1 (en) | 2000-02-24 |
| KR20010085373A (ko) | 2001-09-07 |
| AU5272999A (en) | 2000-03-06 |
| AU774628B2 (en) | 2004-07-01 |
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