WO2000009710A3 - Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists - Google Patents
Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists Download PDFInfo
- Publication number
- WO2000009710A3 WO2000009710A3 PCT/CA1999/000734 CA9900734W WO0009710A3 WO 2000009710 A3 WO2000009710 A3 WO 2000009710A3 CA 9900734 W CA9900734 W CA 9900734W WO 0009710 A3 WO0009710 A3 WO 0009710A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- methods
- antagonists
- agonists
- malonyl coa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Definitions
- VOILLEY N ET AL "Cloning and expression of rat pancreatic beta-cell malonyl - CoA decarboxylase.” retrieved from STN
Abstract
Description
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002339088A CA2339088A1 (en) | 1998-08-11 | 1999-08-09 | Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists |
EP99938082A EP1127139A2 (en) | 1998-08-11 | 1999-08-09 | Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists |
AU52729/99A AU774628B2 (en) | 1998-08-11 | 1999-08-09 | Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists |
KR1020017001831A KR20010085373A (en) | 1998-08-11 | 1999-08-09 | Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists |
JP2000565145A JP2002522082A (en) | 1998-08-11 | 1999-08-09 | Compositions and methods for identifying inhibitors, agonists and antagonists of mammalian malonyl-CoA decarboxylase |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9609398P | 1998-08-11 | 1998-08-11 | |
US25120099A | 1999-02-16 | 1999-02-16 | |
US09/251,200 | 1999-02-16 | ||
US60/096,093 | 1999-02-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000009710A2 WO2000009710A2 (en) | 2000-02-24 |
WO2000009710A3 true WO2000009710A3 (en) | 2001-06-07 |
Family
ID=26791076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1999/000734 WO2000009710A2 (en) | 1998-08-11 | 1999-08-09 | Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1127139A2 (en) |
JP (1) | JP2002522082A (en) |
KR (1) | KR20010085373A (en) |
AU (1) | AU774628B2 (en) |
CA (1) | CA2339088A1 (en) |
WO (1) | WO2000009710A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03007441A (en) * | 2001-02-20 | 2004-10-15 | Chugai Pharmaceutical Co Ltd | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators. |
US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
US20040063717A1 (en) * | 2002-05-21 | 2004-04-01 | Andrew Wolff | Method of treating diabetes |
DE602004014937D1 (en) | 2003-08-01 | 2008-08-21 | Chugai Pharmaceutical Co Ltd | PIPERIDINE COMPOUNDS AS MALONYL-COA DECARBOXYLASE HEMMER |
EP1653944B1 (en) | 2003-08-01 | 2010-11-10 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors |
JP4773960B2 (en) | 2003-08-01 | 2011-09-14 | 中外製薬株式会社 | Cyanoguanidine-type azole compounds useful as malonyl-CoA decarboxylase inhibitors |
ATE375810T1 (en) | 2003-08-01 | 2007-11-15 | Chugai Pharmaceutical Co Ltd | CYANOAMIDE COMPOUNDS AS USEFUL MALONYL-COA DECARBOXYLASE INHIBITORS |
WO2008106630A1 (en) * | 2007-03-01 | 2008-09-04 | Bristol-Myers Squibb Company | Coupled enzyme assay for measuring acetyl coa carboxylase and malonyl coa decarboxylase activity |
-
1999
- 1999-08-09 CA CA002339088A patent/CA2339088A1/en not_active Abandoned
- 1999-08-09 EP EP99938082A patent/EP1127139A2/en not_active Withdrawn
- 1999-08-09 KR KR1020017001831A patent/KR20010085373A/en not_active Application Discontinuation
- 1999-08-09 AU AU52729/99A patent/AU774628B2/en not_active Ceased
- 1999-08-09 JP JP2000565145A patent/JP2002522082A/en active Pending
- 1999-08-09 WO PCT/CA1999/000734 patent/WO2000009710A2/en not_active Application Discontinuation
Non-Patent Citations (5)
Title |
---|
BIOCHEMICAL JOURNAL, (1999 MAY 15) 340 ( PT 1) 213-7. * |
BONALDO ET AL.: "Normalization and Substraction: Two Approaches to Facilitate Gene Discovery.", GENOME RES., vol. 6, September 1996 (1996-09-01), pages 791 - 806, XP002039972 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; VOILLEY N ET AL: "Cloning and expression of rat pancreatic beta-cell malonyl - CoA decarboxylase.", XP002124721, retrieved from STN Database accession no. 1999247914 * |
DYCK ET AL.: "Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation.", AM. J. PHYSIOL., vol. 44, no. 6, December 1998 (1998-12-01), pages H2122 - H2129, XP000857359 * |
MITZEN ET AL.: "Malonate, Malonyl-Coenzyme A, and Acetyl-Coenzyme A in Developing Rat Brain.", J. NEUROCHEM., vol. 43, no. 2, 1984, pages 499 - 506, XP000857197 * |
Also Published As
Publication number | Publication date |
---|---|
AU5272999A (en) | 2000-03-06 |
AU774628B2 (en) | 2004-07-01 |
EP1127139A2 (en) | 2001-08-29 |
KR20010085373A (en) | 2001-09-07 |
CA2339088A1 (en) | 2000-02-24 |
WO2000009710A2 (en) | 2000-02-24 |
JP2002522082A (en) | 2002-07-23 |
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