JP2002520297A5 - - Google Patents
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- JP2002520297A5 JP2002520297A5 JP2000558846A JP2000558846A JP2002520297A5 JP 2002520297 A5 JP2002520297 A5 JP 2002520297A5 JP 2000558846 A JP2000558846 A JP 2000558846A JP 2000558846 A JP2000558846 A JP 2000558846A JP 2002520297 A5 JP2002520297 A5 JP 2002520297A5
- Authority
- JP
- Japan
- Prior art keywords
- binding ligand
- targeting agent
- binding
- aminophospholipid
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003446 ligand Substances 0.000 description 18
- 239000003795 chemical substances by application Substances 0.000 description 15
- 230000008685 targeting Effects 0.000 description 14
- 102000002262 Thromboplastin Human genes 0.000 description 7
- 108010000499 Thromboplastin Proteins 0.000 description 7
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 4
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002254 cytotoxic agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 231100000599 cytotoxic agent Toxicity 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- YJGVMLPVUAXIQN-LGWHJFRWSA-N (5s,5ar,8ar,9r)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-LGWHJFRWSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- 102000000412 Annexin Human genes 0.000 description 1
- 108050008874 Annexin Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- 102100030802 Beta-2-glycoprotein 1 Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 229940122029 DNA synthesis inhibitor Drugs 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000010631 Kininogens Human genes 0.000 description 1
- 108010077861 Kininogens Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- 229940122803 Vinca alkaloid Drugs 0.000 description 1
- 229940009456 adriamycin Drugs 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940045799 anthracyclines and related substance Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002022 anti-cellular effect Effects 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- 108010023562 beta 2-Glycoprotein I Proteins 0.000 description 1
- 102000023732 binding proteins Human genes 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9258998P | 1998-07-13 | 1998-07-13 | |
| US60/092,589 | 1998-07-13 | ||
| US11060098P | 1998-12-02 | 1998-12-02 | |
| US60/110,600 | 1998-12-02 | ||
| PCT/US1999/015668 WO2000002587A1 (en) | 1998-07-13 | 1999-07-12 | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010019796A Division JP5478285B2 (ja) | 1998-07-13 | 2010-01-29 | アミノリン脂質に結合する結合体を用いる腫瘍血管系の処置および画像化 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520297A JP2002520297A (ja) | 2002-07-09 |
| JP2002520297A5 true JP2002520297A5 (https=) | 2006-09-14 |
Family
ID=26785826
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000558846A Pending JP2002520297A (ja) | 1998-07-13 | 1999-07-12 | アミノリン脂質に結合する治療結合体を用いる癌処置方法 |
| JP2010019796A Expired - Fee Related JP5478285B2 (ja) | 1998-07-13 | 2010-01-29 | アミノリン脂質に結合する結合体を用いる腫瘍血管系の処置および画像化 |
| JP2012262623A Expired - Fee Related JP5721693B2 (ja) | 1998-07-13 | 2012-11-30 | アミノリン脂質に結合する治療結合体を用いる癌処置方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010019796A Expired - Fee Related JP5478285B2 (ja) | 1998-07-13 | 2010-01-29 | アミノリン脂質に結合する結合体を用いる腫瘍血管系の処置および画像化 |
| JP2012262623A Expired - Fee Related JP5721693B2 (ja) | 1998-07-13 | 2012-11-30 | アミノリン脂質に結合する治療結合体を用いる癌処置方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US7067109B1 (https=) |
| EP (1) | EP1098665B9 (https=) |
| JP (3) | JP2002520297A (https=) |
| AT (1) | ATE230614T1 (https=) |
| AU (1) | AU750414B2 (https=) |
| BR (1) | BR9912053A (https=) |
| CA (1) | CA2331789C (https=) |
| DE (1) | DE69904831T2 (https=) |
| ES (1) | ES2188202T3 (https=) |
| IL (1) | IL140700A0 (https=) |
| NZ (1) | NZ508873A (https=) |
| WO (1) | WO2000002587A1 (https=) |
Families Citing this family (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5814464A (en) * | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| KR20010020443A (ko) | 1997-04-30 | 2001-03-15 | 캐서린 구 | 생체내 세포 치사를 이미지화시키는 방법 |
| US7569674B2 (en) * | 1998-05-04 | 2009-08-04 | Innexus Biotechnology International Limited | Autophilic antibodies |
| US20040185039A1 (en) * | 2002-08-30 | 2004-09-23 | Heinz Kohler | Therapeutic applications of noncovalent dimerizing antibodies |
| US20050033033A1 (en) * | 1998-05-04 | 2005-02-10 | Heinz Kohler | Trans-membrane-antibody induced inhibition of apoptosis |
| US6300308B1 (en) * | 1997-12-31 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions for inducing autoimmunity in the treatment of cancers |
| US20090208418A1 (en) * | 2005-04-29 | 2009-08-20 | Innexus Biotechnology Internaltional Ltd. | Superantibody synthesis and use in detection, prevention and treatment of disease |
| US6818213B1 (en) * | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
| US7067109B1 (en) | 1998-07-13 | 2006-06-27 | Board Of Regents, The University Of Texas System | Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids |
| CA2333147C (en) * | 1998-07-13 | 2012-02-07 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
| US6406693B1 (en) * | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
| EP1520588B1 (en) | 1998-07-13 | 2014-12-24 | Board Of Regents, The University Of Texas System | Uses of antibodies to aminophospholipids for cancer treatment |
| US6361774B1 (en) * | 1999-09-17 | 2002-03-26 | Immunomedics, Inc. | Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug |
| IL126447A (en) * | 1998-10-04 | 2004-09-27 | Vascular Biogenics Ltd | An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis |
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| US6602274B1 (en) * | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
| US6521424B2 (en) * | 1999-06-07 | 2003-02-18 | Immunex Corporation | Recombinant expression of Tek antagonists |
| CA2401411A1 (en) * | 1999-08-30 | 2001-03-08 | Mustapha Abdelouahed | Diagnostic assay for type 2 heparin-induced thrombocytopenia |
| US6777439B2 (en) * | 2000-05-30 | 2004-08-17 | Advanced Research & Technology Institute, Inc. | Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways |
| US7445802B2 (en) * | 2000-12-26 | 2008-11-04 | Yeda Research And Development Co. Ltd | Site-specific in situ generation of allicin using a targeted alliinase delivery system for the treatment of cancers, tumors, infectious diseases and other allicin-sensitive diseases |
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| US20040001839A1 (en) * | 2000-12-29 | 2004-01-01 | Avigdor Levanon | Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
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| US7635680B2 (en) * | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
| US7635676B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
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| CA2443314C (en) * | 2001-04-03 | 2006-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
| WO2002080754A2 (en) * | 2001-04-03 | 2002-10-17 | Theseus Imaging Corporation | Methods for using annexin for detecting cell death in vivo and treating associated conditions |
| US20050013778A1 (en) * | 2001-04-03 | 2005-01-20 | Theseus Imaging Corporation | Methods and compositions for predicting the response to a therapeutic regimen in a subject having a disease associated with cell death |
| DE10127712A1 (de) * | 2001-06-07 | 2002-12-19 | Torsten Witte | Anwendung von IgM-Antikörpern gegen dsDNA beim systemischen Lupus erythematodes mit Nephritis |
| US6763760B2 (en) * | 2001-07-03 | 2004-07-20 | Hansen Conly L | Machine for injecting liquids |
| DE10145254A1 (de) * | 2001-09-13 | 2003-04-10 | November Ag Molekulare Medizin | Verwendung eines Proteins zur Herstellung eines Medikaments zur Stimulierung einer inflammatorischen zellulären Immunantwort |
| WO2003028840A2 (en) * | 2001-09-27 | 2003-04-10 | Board Of Regents, The University Of Texas System | Combined compositions and methods for tumor vasculature coagulation and treatment |
| US8158106B2 (en) * | 2001-10-05 | 2012-04-17 | Surmodics, Inc. | Particle immobilized coatings and uses thereof |
| US7261875B2 (en) | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
| JP4242590B2 (ja) * | 2002-01-11 | 2009-03-25 | 俊一 塩澤 | 慢性関節リウマチの疾患感受性遺伝子、及びその利用 |
| US20030133938A1 (en) * | 2002-01-15 | 2003-07-17 | Penichet Manuel L. | Antibody-avidin fusion proteins as cytotoxic drugs |
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| US9745380B2 (en) * | 2002-03-01 | 2017-08-29 | Immunomedics, Inc. | RS7 antibodies |
| US20040022731A1 (en) * | 2002-04-26 | 2004-02-05 | Alexei Bogdanov | In vivo imaging of apoptosis |
| ATE510553T1 (de) * | 2002-05-17 | 2011-06-15 | Univ Texas | Beta-2-glycoprotein 1 als angiogenesehemmer |
| AU2003237870A1 (en) * | 2002-06-07 | 2003-12-22 | The Brigham & Women's Hospital, Inc. | Method and composition for inhibing or slowing blood coagulation |
| US20040208877A1 (en) * | 2002-07-01 | 2004-10-21 | Avigdor Levanon | Antibodies and uses thereof |
| RU2005101622A (ru) * | 2002-07-01 | 2006-01-27 | Савиент Фармасьютикалс, Инк (Us) | Композиции и способы терапевтического лечения |
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| KR20120068769A (ko) * | 2002-07-15 | 2012-06-27 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도 |
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| US7378386B2 (en) * | 2002-07-15 | 2008-05-27 | Board Of Regents, The University Of Texas System | Anti-viral treatment methods using phosphatidylethanolamine-binding peptide derivatives |
| US7572448B2 (en) * | 2002-07-15 | 2009-08-11 | Board Of Regents, The University Of Texas System | Combined cancer treatment methods using selected antibodies to aminophospholipids |
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| US7455833B2 (en) | 2002-07-15 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7906115B2 (en) * | 2002-07-15 | 2011-03-15 | Thorpe Philip E | Combinations kits and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7790159B2 (en) | 2002-07-15 | 2010-09-07 | Board Of Regents, The University Of Texas System | Methods, combinations and kits for treating viral infections using immunoconjugates and antibodies to aminophospholipids |
| US20040131622A1 (en) * | 2002-07-15 | 2004-07-08 | Board Of Regents | Combinations and kits for treating viral infections using immunoconjugates to aminophospholipids |
| US7622118B2 (en) * | 2002-07-15 | 2009-11-24 | Board Of Regents, The University Of Texas System | Cancer treatment methods using selected antibodies to aminophospholipids |
| US7247303B2 (en) * | 2002-07-15 | 2007-07-24 | Board Of Regents, The University Of Texas System | Selected antibody CDRs for binding to aminophospholipids |
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| US7678386B2 (en) * | 2002-07-15 | 2010-03-16 | Board Of Regents The University Of Texas | Liposomes coated with selected antibodies that bind to aminophospholipids |
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| WO2005079831A1 (en) * | 2004-02-13 | 2005-09-01 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hcnp peptides for the modulation of cardio-vascular physiology and diuresis |
| US20060003020A1 (en) * | 2004-03-11 | 2006-01-05 | The Regents Of The University Of Michigan | Anti-metastatic ability of mibefradil and gadolinium |
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| JP5139058B2 (ja) * | 2004-06-02 | 2013-02-06 | シドニー キンメル キャンサー センター | 新形成または新生脈管構造の検出、画像化および処置のための血管標的 |
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- 2014-03-05 US US14/197,672 patent/US20140205544A1/en not_active Abandoned
-
2016
- 2016-03-24 US US15/079,700 patent/US20160199509A1/en not_active Abandoned
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