JP2002519325A - 二環性ｓＰＬＡ２インヒビター - Google Patents

二環性ｓＰＬＡ２インヒビター

Info

Publication number
JP2002519325A
JP2002519325A JP2000556786A JP2000556786A JP2002519325A JP 2002519325 A JP2002519325 A JP 2002519325A JP 2000556786 A JP2000556786 A JP 2000556786A JP 2000556786 A JP2000556786 A JP 2000556786A JP 2002519325 A JP2002519325 A JP 2002519325A
Authority
JP
Japan
Prior art keywords
pyrrolo
ethyl
oxy
pyrimidin
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000556786A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002519325A5 (enExample
Inventor
ダレル・ロバート・ハッチソン
マイケル・ジョン・マルティネリ
トーマス・マイケル・ウィルソン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JP2002519325A publication Critical patent/JP2002519325A/ja
Publication of JP2002519325A5 publication Critical patent/JP2002519325A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000556786A 1998-06-30 1999-06-23 二環性ｓＰＬＡ２インヒビター Withdrawn JP2002519325A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9124898P 1998-06-30 1998-06-30
US60/091,248 1998-06-30
PCT/US1999/014213 WO2000000201A1 (en) 1998-06-30 1999-06-23 BICYCLIC sPLA2 INHIBITORS

Publications (2)

Publication Number Publication Date
JP2002519325A true JP2002519325A (ja) 2002-07-02
JP2002519325A5 JP2002519325A5 (enExample) 2006-07-20

Family

ID=22226793

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000556786A Withdrawn JP2002519325A (ja) 1998-06-30 1999-06-23 二環性ｓＰＬＡ２インヒビター

Country Status (8)

Country Link
US (1) US6384041B1 (enExample)
EP (1) EP1091738B1 (enExample)
JP (1) JP2002519325A (enExample)
AT (1) ATE347362T1 (enExample)
AU (1) AU4710699A (enExample)
CA (1) CA2335448A1 (enExample)
DE (1) DE69934311D1 (enExample)
WO (1) WO2000000201A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000621A1 (en) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Compounds exhibiting x-type spla2 inhibiting effect
AU2001280461A1 (en) * 2000-08-04 2002-02-18 Eli Lilly And Company Substituted pyrrole compounds and their use as spla2 inhibitors
US6730694B1 (en) 2001-07-20 2004-05-04 Eli Lilly And Company sPLA2 inhibitors
GB0121033D0 (en) * 2001-08-30 2001-10-24 Novartis Ag Organic compounds
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
AR043692A1 (es) * 2003-02-06 2005-08-10 Novartis Ag 2-cianopirrolopirimidinas y sus usos farmaceuticos
GB0302748D0 (en) * 2003-02-06 2003-03-12 Novartis Ag Organic compounds
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
MX2011011517A (es) 2009-04-29 2012-06-19 Amarin Corp Plc Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo.
US10088469B2 (en) 2012-08-30 2018-10-02 Qiagen Gmbh Method for obtaining blood plasma from a whole blood sample
DE102012215957A1 (de) 2012-09-10 2014-05-15 Schaeffler Technologies Gmbh & Co. Kg Resolverlager
DE102012023252B4 (de) 2012-11-29 2016-11-10 Selux Ag Leuchte mit Elektroladestation für Elektrofahrzeuge
DE102013101611B3 (de) 2013-02-19 2014-07-10 HvS-Consulting AG Verschlüsselungsverfahren für e-mails
DE102013022275A1 (de) 2013-03-28 2014-10-02 Elmos Semiconductor Ag Straßenbeleuchtung
CN103204857A (zh) * 2013-05-08 2013-07-17 兰州聚成生物科技有限公司 一种4-氯-2-(甲硫基)-7h-吡咯并[2,3-d]嘧啶的合成方法
DE102013215468A1 (de) 2013-08-06 2015-02-12 Schaeffler Technologies Gmbh & Co. Kg Tauchlageranordnung und Verfahren zur Abdichtung derselben
EP2902692B1 (de) 2013-12-06 2017-10-25 MAGNA STEYR Engineering AG & Co KG Bauteil eines Tanksystems
WO2015158361A1 (en) 2014-04-14 2015-10-22 Shanghai Amphenol Airwave Communication Electronics Co., Ltd. Windshield antenna
EP3396430B1 (en) 2017-04-27 2023-08-16 Euroimmun Medizinische Labordiagnostika AG Optical scanning arrangement and method
US11529354B2 (en) 2017-09-05 2022-12-20 President And Fellows Of Harvard College Methods and compositions for the treatment of tuberculosis
CN107915738B (zh) * 2017-11-14 2019-07-26 海化生命(厦门)科技有限公司 用于合成巴瑞替尼的关键中间体2的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3867386A (en) * 1969-11-04 1975-02-18 American Home Prod 5-amino-2,6-substituted-7h-pyrrolo(2,3-d)pyrimidines and related compounds
US5916922A (en) 1996-12-03 1999-06-29 Eli Lilly And Company Phenyl glyoxamides as SPLA2 inhibitors

Also Published As

Publication number Publication date
CA2335448A1 (en) 2000-01-06
AU4710699A (en) 2000-01-17
US6384041B1 (en) 2002-05-07
ATE347362T1 (de) 2006-12-15
DE69934311D1 (de) 2007-01-18
EP1091738A1 (en) 2001-04-18
EP1091738A4 (en) 2003-03-05
EP1091738B1 (en) 2006-12-06
WO2000000201A1 (en) 2000-01-06

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