JP2002517474A - 定方向のコンビナトリアル化合物ライブラリおよびそれをスクリーニングするための高スループットアッセイ - Google Patents
定方向のコンビナトリアル化合物ライブラリおよびそれをスクリーニングするための高スループットアッセイInfo
- Publication number
- JP2002517474A JP2002517474A JP2000553388A JP2000553388A JP2002517474A JP 2002517474 A JP2002517474 A JP 2002517474A JP 2000553388 A JP2000553388 A JP 2000553388A JP 2000553388 A JP2000553388 A JP 2000553388A JP 2002517474 A JP2002517474 A JP 2002517474A
- Authority
- JP
- Japan
- Prior art keywords
- monomer
- nucleoside
- halogen
- sugar
- linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8882898P | 1998-06-10 | 1998-06-10 | |
| US60/088,828 | 1998-06-10 | ||
| US12056299P | 1999-02-17 | 1999-02-17 | |
| US60/120,562 | 1999-02-17 | ||
| PCT/CA1999/000550 WO1999064378A2 (en) | 1998-06-10 | 1999-06-10 | Directed combinatorial compound library and high throughput assays for screening same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002517474A true JP2002517474A (ja) | 2002-06-18 |
Family
ID=26779099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000553388A Pending JP2002517474A (ja) | 1998-06-10 | 1999-06-10 | 定方向のコンビナトリアル化合物ライブラリおよびそれをスクリーニングするための高スループットアッセイ |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1086064A2 (es) |
| JP (1) | JP2002517474A (es) |
| CN (1) | CN1314913A (es) |
| AU (1) | AU4493099A (es) |
| CA (1) | CA2334338A1 (es) |
| MX (1) | MXPA00012237A (es) |
| NO (1) | NO20006244L (es) |
| WO (1) | WO1999064378A2 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006527719A (ja) * | 2003-06-19 | 2006-12-07 | エフ．ホフマン−ラ ロシュ アーゲー | ４’−アジドヌクレオシド誘導体の調製方法 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1201667B1 (en) | 1999-07-29 | 2005-09-21 | National Institute of Advanced Industrial Science and Technology | Polymerizable biotin derivatives, biotin polymer, and polymer responsive to avidin stimulation |
| CA2390441A1 (en) | 1999-11-08 | 2001-05-17 | Origenix Technologies, Inc. | Combinatorial library synthesis and pharmaceutically active compounds produced thereby |
| US20020127598A1 (en) * | 2000-03-27 | 2002-09-12 | Wenqiang Zhou | Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby |
| WO2001085215A2 (en) * | 2000-05-11 | 2001-11-15 | Glycozym Aps | METHODS OF MODULATING FUNCTIONS OF POLYPEPTIDE GalNAc TRANSFERASES AND OF SCREENING SUBSTANCES THEREFOR, PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH AGENTS |
| US7338932B2 (en) | 2000-05-11 | 2008-03-04 | Glycozym Aps | Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments |
| KR100991975B1 (ko) | 2001-05-16 | 2010-11-04 | 미게닉스 인코포레이티드 | 핵산을 기본으로 하는 화합물 및 이의 사용방법 |
| WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| IL163822A0 (en) | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
| US10730906B2 (en) | 2002-08-01 | 2020-08-04 | Nuevolutions A/S | Multi-step synthesis of templated molecules |
| AU2003266932B2 (en) | 2002-09-27 | 2009-04-09 | Mpm-Holding Aps | Spatially encoded polymer matrix |
| PT1558744E (pt) | 2002-10-30 | 2011-09-22 | Nuevolution As | Codificação enzimática |
| ATE450609T1 (de) | 2002-12-19 | 2009-12-15 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
| US20070026397A1 (en) | 2003-02-21 | 2007-02-01 | Nuevolution A/S | Method for producing second-generation library |
| ATE447626T1 (de) | 2003-09-18 | 2009-11-15 | Nuevolution As | Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen |
| CN101278079B (zh) * | 2005-10-04 | 2012-09-19 | 阿尔卡米亚有限公司 | 药物设计方法 |
| DK3305900T3 (da) | 2005-12-01 | 2021-10-25 | Nuevolution As | Enzymatic encoding methods for efficient synthesis of large libraries |
| CN102917733A (zh) * | 2010-04-07 | 2013-02-06 | 动量制药公司 | 用于产生糖蛋白的宿主细胞的选择和用途 |
| LT2558577T (lt) | 2010-04-16 | 2019-03-12 | Nuevolution A/S | Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995010296A1 (en) * | 1993-10-12 | 1995-04-20 | Glycomed Incorporated | A library of glyco-peptides useful for identification of cell adhesion inhibitors |
| IL110024A (en) * | 1994-06-15 | 1998-04-05 | Yissum Res Dev Co | Controlled release oral drug delivery system containing hydrogel- forming polymer |
-
1999
- 1999-06-10 WO PCT/CA1999/000550 patent/WO1999064378A2/en not_active Application Discontinuation
- 1999-06-10 MX MXPA00012237A patent/MXPA00012237A/es not_active Application Discontinuation
- 1999-06-10 CN CN 99809486 patent/CN1314913A/zh active Pending
- 1999-06-10 EP EP99927613A patent/EP1086064A2/en not_active Withdrawn
- 1999-06-10 CA CA002334338A patent/CA2334338A1/en not_active Abandoned
- 1999-06-10 JP JP2000553388A patent/JP2002517474A/ja active Pending
- 1999-06-10 AU AU44930/99A patent/AU4493099A/en not_active Abandoned
-
2000
- 2000-12-08 NO NO20006244A patent/NO20006244L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006527719A (ja) * | 2003-06-19 | 2006-12-07 | エフ．ホフマン−ラ ロシュ アーゲー | ４’−アジドヌクレオシド誘導体の調製方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999064378A3 (en) | 2000-09-21 |
| MXPA00012237A (es) | 2002-11-15 |
| CA2334338A1 (en) | 1999-12-16 |
| EP1086064A2 (en) | 2001-03-28 |
| AU4493099A (en) | 1999-12-30 |
| WO1999064378A2 (en) | 1999-12-16 |
| CN1314913A (zh) | 2001-09-26 |
| NO20006244L (no) | 2001-02-08 |
| NO20006244D0 (no) | 2000-12-08 |
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