WO1999064378A3 - Directed combinatorial compound library and high throughput assays for screening same - Google Patents

Directed combinatorial compound library and high throughput assays for screening same Download PDF

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Publication number
WO1999064378A3
WO1999064378A3 PCT/CA1999/000550 CA9900550W WO9964378A3 WO 1999064378 A3 WO1999064378 A3 WO 1999064378A3 CA 9900550 W CA9900550 W CA 9900550W WO 9964378 A3 WO9964378 A3 WO 9964378A3
Authority
WO
WIPO (PCT)
Prior art keywords
monomer
nucleoside
spacer
high throughput
compound library
Prior art date
Application number
PCT/CA1999/000550
Other languages
French (fr)
Other versions
WO1999064378A2 (en
Inventor
Jeremy Carver
James Dennis
Francois D Tropper
Uttam Saha
Lothar Ziser
Alessandro Datti
Rob Donovan
Original Assignee
Glycodesign Inc
Jeremy Carver
James Dennis
Francois D Tropper
Uttam Saha
Lothar Ziser
Alessandro Datti
Rob Donovan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycodesign Inc, Jeremy Carver, James Dennis, Francois D Tropper, Uttam Saha, Lothar Ziser, Alessandro Datti, Rob Donovan filed Critical Glycodesign Inc
Priority to CA002334338A priority Critical patent/CA2334338A1/en
Priority to EP99927613A priority patent/EP1086064A2/en
Priority to MXPA00012237A priority patent/MXPA00012237A/en
Priority to AU44930/99A priority patent/AU4493099A/en
Priority to JP2000553388A priority patent/JP2002517474A/en
Publication of WO1999064378A2 publication Critical patent/WO1999064378A2/en
Publication of WO1999064378A3 publication Critical patent/WO1999064378A3/en
Priority to NO20006244A priority patent/NO20006244L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Abstract

A combinatorial library comprising a predetermined collection of nucleoside peptide molecules for inhibiting the transfer of a sugar from a selected sugar nucleotide donor to a selected acceptor by a carbohydrate processing enzyme. The nucleoside peptide molecule comprises (a) a nucleoside monomer; (b) a spacer monomer coupled to the nucleoside monomer wherein the spacer monomer comprises one or more amide linked amino acid residues, or a peptidomimetic; and (c) cap monomers attached to the spacer monomer. The nucleoside peptide molecules differ from each other as to the identity of at least one element of the nucleoside monomer, spacer monomer, or cap monomer.
PCT/CA1999/000550 1998-06-10 1999-06-10 Directed combinatorial compound library and high throughput assays for screening same WO1999064378A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002334338A CA2334338A1 (en) 1998-06-10 1999-06-10 Directed combinatorial compound library and high throughput assays for screening same
EP99927613A EP1086064A2 (en) 1998-06-10 1999-06-10 Directed combinatorial compound library and high throughput assays for screening same
MXPA00012237A MXPA00012237A (en) 1998-06-10 1999-06-10 Directed combinatorial compound library and high throughput assays for screening same.
AU44930/99A AU4493099A (en) 1998-06-10 1999-06-10 Directed combinatorial compound library and high throughput assays for screening same
JP2000553388A JP2002517474A (en) 1998-06-10 1999-06-10 Directed combinatorial compound libraries and high-throughput assays for screening them
NO20006244A NO20006244L (en) 1998-06-10 2000-12-08 Corrected combinatorial compound library and high yield analyzes for screening thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8882898P 1998-06-10 1998-06-10
US60/088,828 1998-06-10
US12056299P 1999-02-17 1999-02-17
US60/120,562 1999-02-17

Publications (2)

Publication Number Publication Date
WO1999064378A2 WO1999064378A2 (en) 1999-12-16
WO1999064378A3 true WO1999064378A3 (en) 2000-09-21

Family

ID=26779099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000550 WO1999064378A2 (en) 1998-06-10 1999-06-10 Directed combinatorial compound library and high throughput assays for screening same

Country Status (8)

Country Link
EP (1) EP1086064A2 (en)
JP (1) JP2002517474A (en)
CN (1) CN1314913A (en)
AU (1) AU4493099A (en)
CA (1) CA2334338A1 (en)
MX (1) MXPA00012237A (en)
NO (1) NO20006244L (en)
WO (1) WO1999064378A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
US11965209B2 (en) 2003-09-18 2024-04-23 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60022762T2 (en) 1999-07-29 2006-07-13 National Institute Of Advanced Industrial Science And Technology POLYMERIZABLE BIOTIN DERIVATIVES, BIOPTIN POLYMER AND POLYMER REACTIVE ON STIMULATION BY AVIDIN
CA2390441A1 (en) * 1999-11-08 2001-05-17 Origenix Technologies, Inc. Combinatorial library synthesis and pharmaceutically active compounds produced thereby
US20020127598A1 (en) * 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
AU2001258234A1 (en) * 2000-05-11 2001-11-20 Glycozym Aps Methods of modulating functions of polypeptide galnac-transferases and of screening substances therefor, pharmaceutical compositions comprising such agents
US7338932B2 (en) 2000-05-11 2008-03-04 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
AU2002316118A1 (en) 2001-05-16 2002-11-25 Micrologix Biotech, Inc. Nucleic acid-based compounds and methods of use thereof
DE60324778D1 (en) 2002-03-15 2009-01-02 Nuevolution As AN IMPROVED METHOD FOR SYNTHESIS OF MATTRESS-RELATED MOLECULES
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
EP1545762A2 (en) 2002-09-27 2005-06-29 Carlsberg A/S Spatially encoded polymer matrix
ES2276311T3 (en) * 2003-06-19 2007-06-16 F. Hoffmann-La Roche Ag PROCESS TO PRADERATE DERIVATIVES OF 4 '-AZIDONUCLEOSIDO.
EP1670939B1 (en) 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
DK1934388T3 (en) * 2005-10-04 2013-02-25 Alchemia Ltd Process for drug development
MX2012011647A (en) * 2010-04-07 2012-11-29 Momenta Pharmaceuticals Inc Selection and use of host cells for production of glycoproteins.
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010296A1 (en) * 1993-10-12 1995-04-20 Glycomed Incorporated A library of glyco-peptides useful for identification of cell adhesion inhibitors
WO1995034294A1 (en) * 1994-06-15 1995-12-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Controlled release oral drug delivery system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010296A1 (en) * 1993-10-12 1995-04-20 Glycomed Incorporated A library of glyco-peptides useful for identification of cell adhesion inhibitors
WO1995034294A1 (en) * 1994-06-15 1995-12-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Controlled release oral drug delivery system

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9284600B2 (en) 2002-10-30 2016-03-15 Neuvolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US11965209B2 (en) 2003-09-18 2024-04-23 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Also Published As

Publication number Publication date
NO20006244D0 (en) 2000-12-08
WO1999064378A2 (en) 1999-12-16
AU4493099A (en) 1999-12-30
JP2002517474A (en) 2002-06-18
NO20006244L (en) 2001-02-08
CN1314913A (en) 2001-09-26
EP1086064A2 (en) 2001-03-28
CA2334338A1 (en) 1999-12-16
MXPA00012237A (en) 2002-11-15

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