JP2002516662A5 - - Google Patents
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- Publication number
- JP2002516662A5 JP2002516662A5 JP2000541960A JP2000541960A JP2002516662A5 JP 2002516662 A5 JP2002516662 A5 JP 2002516662A5 JP 2000541960 A JP2000541960 A JP 2000541960A JP 2000541960 A JP2000541960 A JP 2000541960A JP 2002516662 A5 JP2002516662 A5 JP 2002516662A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- variant
- nucleic acid
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 34
- 108020004707 nucleic acids Proteins 0.000 description 22
- 150000007523 nucleic acids Chemical class 0.000 description 22
- 125000003275 alpha amino acid group Chemical group 0.000 description 20
- 108090001123 antibodies Proteins 0.000 description 9
- 102000004965 antibodies Human genes 0.000 description 9
- 229960005486 vaccines Drugs 0.000 description 9
- 101700008727 opuBC Proteins 0.000 description 8
- 239000002671 adjuvant Substances 0.000 description 5
- 230000000240 adjuvant Effects 0.000 description 5
- 239000000969 carrier Substances 0.000 description 5
- 210000004027 cells Anatomy 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 206010061353 Pneumococcal infection Diseases 0.000 description 3
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 3
- 229920000160 (ribonucleotides)n+m Polymers 0.000 description 2
- 210000001106 Chromosomes, Artificial, Yeast Anatomy 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 229960001231 Choline Drugs 0.000 description 1
- 229920002676 Complementary DNA Polymers 0.000 description 1
- 101710015954 HVA1 Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-Methionine Natural products CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 101700065814 LEA2 Proteins 0.000 description 1
- 101700021338 LEC Proteins 0.000 description 1
- 101700077545 LECC Proteins 0.000 description 1
- 101700028499 LECG Proteins 0.000 description 1
- 101700063913 LECT Proteins 0.000 description 1
- 210000001989 Nasopharynx Anatomy 0.000 description 1
- 101710034340 Os04g0173800 Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001580 bacterial Effects 0.000 description 1
- 108091006028 chimera Proteins 0.000 description 1
- CRBHXDCYXIISFC-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CC[O-] CRBHXDCYXIISFC-UHFFFAOYSA-N 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000009910 diseases by infectious agent Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 101700036391 lecA Proteins 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 101700001016 mbhA Proteins 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 108010045030 monoclonal antibodies Proteins 0.000 description 1
- 102000005614 monoclonal antibodies Human genes 0.000 description 1
- 239000000546 pharmaceutic aid Substances 0.000 description 1
- 108091008117 polyclonal antibodies Proteins 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002797 proteolythic Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8087898P | 1998-04-07 | 1998-04-07 | |
| US09/056,019 | 1998-04-07 | ||
| US09/056,019 US6858706B2 (en) | 1998-04-07 | 1998-04-07 | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| US60/080,878 | 1998-04-07 | ||
| PCT/US1999/007669 WO1999051188A2 (fr) | 1998-04-07 | 1999-04-07 | Polypeptide comprenant l'acide amine d'un produit tronque de la proteine a n-terminale fixant la choline, vaccin derive de ce polypeptide et ses utilisations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002516662A JP2002516662A (ja) | 2002-06-11 |
| JP2002516662A5 true JP2002516662A5 (fr) | 2006-06-01 |
| JP4739521B2 JP4739521B2 (ja) | 2011-08-03 |
Family
ID=26734874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000541960A Expired - Fee Related JP4739521B2 (ja) | 1998-04-07 | 1999-04-07 | Ｎ−末端コリン結合プロテインａ切端形のアミノ酸を含むポリペプチド、それに由来するワクチンおよびその使用 |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP4739521B2 (fr) |
| KR (1) | KR100638503B1 (fr) |
| CN (1) | CN1191851C (fr) |
| AU (2) | AU3479699A (fr) |
| BR (1) | BR9909910A (fr) |
| CA (1) | CA2326388C (fr) |
| HU (1) | HUP0102306A3 (fr) |
| IL (1) | IL138939A0 (fr) |
| MX (1) | MXPA00009899A (fr) |
| NO (1) | NO20005081L (fr) |
| NZ (1) | NZ507983A (fr) |
| PL (1) | PL193132B1 (fr) |
| TR (1) | TR200003498T2 (fr) |
| WO (1) | WO1999051188A2 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| LT3017827T (lt) | 2005-12-22 | 2019-01-10 | Glaxosmithkline Biologicals S.A. | Pneumokokinė polisacharidinė konjuguota vakcina |
| KR20100045445A (ko) | 2007-06-26 | 2010-05-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 스트렙토코쿠스 뉴모니애 캡슐 다당류 컨쥬게이트를 포함하는 백신 |
| JP5749642B2 (ja) | 2008-04-16 | 2015-07-15 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| BR112013029514A2 (pt) | 2011-05-17 | 2019-09-24 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, e, método de tratar ou impedir uma doença |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6592876B1 (en) * | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| JP2000511411A (ja) * | 1996-05-01 | 2000-09-05 | ザ ロックフェラー ユニヴァーシティ | 抗―肺炎球菌ワクチン用のコリン結合タンパク質 |
| US6420135B1 (en) * | 1996-10-31 | 2002-07-16 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
| JP2002503087A (ja) * | 1996-11-12 | 2002-01-29 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ストレプトコッカス・ニューモニアのｃ３結合タンパク質 |
| CN1200731C (zh) * | 1998-04-07 | 2005-05-11 | 免疫医疗公司 | 用作疫苗的肺炎球菌胆碱结合蛋白衍生物 |
| US6858706B2 (en) * | 1998-04-07 | 2005-02-22 | St. Jude Children's Research Hospital | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
-
1999
- 1999-04-07 KR KR1020007011206A patent/KR100638503B1/ko not_active IP Right Cessation
- 1999-04-07 CA CA2326388A patent/CA2326388C/fr not_active Expired - Fee Related
- 1999-04-07 JP JP2000541960A patent/JP4739521B2/ja not_active Expired - Fee Related
- 1999-04-07 AU AU34796/99A patent/AU3479699A/en not_active Withdrawn
- 1999-04-07 NZ NZ507983A patent/NZ507983A/xx not_active IP Right Cessation
- 1999-04-07 BR BR9909910-1A patent/BR9909910A/pt not_active Application Discontinuation
- 1999-04-07 AU AU34797/99A patent/AU764811B2/en not_active Ceased
- 1999-04-07 WO PCT/US1999/007669 patent/WO1999051188A2/fr active IP Right Grant
- 1999-04-07 IL IL13893999A patent/IL138939A0/xx unknown
- 1999-04-07 MX MXPA00009899A patent/MXPA00009899A/es unknown
- 1999-04-07 TR TR2000/03498T patent/TR200003498T2/xx unknown
- 1999-04-07 PL PL347946A patent/PL193132B1/pl unknown
- 1999-04-07 CN CNB998108545A patent/CN1191851C/zh not_active Expired - Fee Related
- 1999-04-07 HU HU0102306A patent/HUP0102306A3/hu unknown
-
2000
- 2000-10-09 NO NO20005081A patent/NO20005081L/no not_active Application Discontinuation
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