JP2002516061A - チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 - Google Patents
チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質Info
- Publication number
- JP2002516061A JP2002516061A JP2000516019A JP2000516019A JP2002516061A JP 2002516061 A JP2002516061 A JP 2002516061A JP 2000516019 A JP2000516019 A JP 2000516019A JP 2000516019 A JP2000516019 A JP 2000516019A JP 2002516061 A JP2002516061 A JP 2002516061A
- Authority
- JP
- Japan
- Prior art keywords
- thymidine kinase
- enzyme
- nucleic acid
- acid molecule
- thymidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US6181297P | 1997-10-14 | 1997-10-14 | |
| US60/061,812 | 1997-10-14 | ||
| PCT/US1998/021672 WO1999019466A2 (en) | 1997-10-14 | 1998-10-14 | Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities |
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| JP2012000673A Withdrawn JP2012115270A (ja) | 1997-10-14 | 2012-01-05 | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
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| DE (1) | DE69838483T2 (enExample) |
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| AU2001296864A1 (en) | 2000-08-31 | 2002-03-13 | Mayo Foundation For Medical Education And Research | Detection of varicella-zoster virus |
| US7691571B2 (en) | 2001-01-31 | 2010-04-06 | Mayo Foundation For Medical Education And Research | Detection of bordetella |
| WO2002061390A2 (en) | 2001-01-31 | 2002-08-08 | Mayo Foundation For Medical Education And Research | Detection of herpes simplex virus |
| US7439271B2 (en) | 2001-06-27 | 2008-10-21 | The Gillette Company | Reduction of hair growth |
| WO2003100045A1 (en) * | 2002-05-23 | 2003-12-04 | Wolfgang Knecht | Plant thymidine kinases and their use |
| SI1509600T1 (sl) | 2002-05-23 | 2009-06-30 | Wolfgang Knecht | Rastlinske timidinske kinaze in njihova uporaba |
| US7074598B2 (en) | 2002-09-25 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of vancomycin-resistant enterococcus spp. |
| US7365176B2 (en) | 2002-09-26 | 2008-04-29 | Mayo Foundation For Medical Education And Research | Detection of Epstein-Barr virus |
| US7074599B2 (en) | 2002-09-27 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of mecA-containing Staphylococcus spp. |
| US7427475B2 (en) | 2003-11-18 | 2008-09-23 | Mayo Foundation For Medical Education And Research | Detection of group B streptococcus |
| GB0413702D0 (en) | 2004-06-18 | 2004-07-21 | Molmed Spa | Thymidine kinase |
| US9534239B2 (en) | 2011-09-06 | 2017-01-03 | Novozymes A/S | Glucoamylase variants and polynucleotides encoding same |
| ES2900102T3 (es) * | 2013-02-20 | 2022-03-15 | Univ Emory | Composiciones para la secuenciación de ácidos nucleicos en mezclas |
| EP2970945B1 (en) | 2013-03-14 | 2024-05-01 | GenVivo, Inc. | Improved thymidine kinase gene |
| WO2014209553A1 (en) | 2013-06-04 | 2014-12-31 | Virginia Commonwealth University | Use of a truncated ccn1 promoter for cancer diagnostics, therapeutics and theranostics |
| EP3004872B1 (en) | 2013-06-04 | 2017-10-18 | Virginia Commonwealth University | Mda-9/syntenin promoter to image and treat metastatic cancer cells |
| WO2014197535A1 (en) | 2013-06-04 | 2014-12-11 | Virginia Commonwealth University | Recombinant cancer therapeutic cytokine |
| US9454494B2 (en) * | 2014-08-01 | 2016-09-27 | Honeywell International Inc. | Encrypting a communication from a device |
| CA2971186A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| US11253546B2 (en) | 2014-12-15 | 2022-02-22 | The Regents Of The University Of California | Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20 |
| US20180030478A1 (en) | 2016-07-01 | 2018-02-01 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
| JP2019530440A (ja) | 2016-09-02 | 2019-10-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | インターロイキン６受容体α結合単鎖可変断片を含む方法および組成物 |
| WO2019108777A1 (en) * | 2017-11-29 | 2019-06-06 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
| EP3781130A4 (en) | 2018-04-11 | 2022-01-26 | Precision Molecular Inc. | COMBINATION THERAPIES FOR THE TREATMENT OF CANCER |
| CA3129883A1 (en) * | 2019-02-14 | 2020-08-20 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
| CN109735571A (zh) * | 2019-03-11 | 2019-05-10 | 四川药智联恒科技有限公司 | 双自杀基因慢病毒表达载体及其应用 |
| KR20240099339A (ko) * | 2021-10-25 | 2024-06-28 | 젠비보, 인크. | 치료제 전달을 위한 조성물 및 방법 |
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| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
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| USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
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| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
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| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
| GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
| JPH07507689A (ja) | 1992-06-08 | 1995-08-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 特定組織のターゲティング方法及び組成物 |
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| FR2705361B1 (fr) | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| CA2167706A1 (en) | 1993-07-27 | 1995-02-09 | Nigel Fraser | Modified dna virus vectors and uses therefor |
| EP0694070B1 (en) | 1993-09-15 | 2002-04-10 | Chiron Corporation | Recombinant alphavirus vectors |
| FR2712603B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
| EP0758387B1 (en) * | 1994-05-02 | 2001-12-19 | University of Washington | Thymidine kinase mutants |
| FR2723962B1 (fr) * | 1994-08-25 | 1996-10-31 | Univ Paris Curie | Hsv1-tk modifiee fonctionnelle |
| CZ294497B6 (cs) * | 1996-02-09 | 2005-01-12 | Gencell Sa | Sekvence nukleové kyseliny kódující nové varianty enzymu thymidinkinázy a farmaceutické kompozice obsahující takovou nukleovou kyselinu nebo variantu thymidinkinázy |
| FR2746016B1 (fr) * | 1996-03-15 | 1998-04-17 | Combinaisons d'enzymes pour la destruction de cellules proliferatives | |
| JP2002516061A (ja) * | 1997-10-14 | 2002-06-04 | ダーウィン モレキュラー コーポレイション | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
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1998
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- 1998-10-14 EP EP10182771A patent/EP2386629A1/en not_active Withdrawn
- 1998-10-14 AT AT98953487T patent/ATE374247T1/de not_active IP Right Cessation
-
2008
- 2008-07-04 JP JP2008176378A patent/JP5070145B2/ja not_active Expired - Fee Related
-
2009
- 2009-05-08 US US12/463,283 patent/US7888114B2/en not_active Expired - Fee Related
- 2009-05-08 US US12/463,261 patent/US7888091B2/en not_active Expired - Fee Related
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2010
- 2010-12-29 US US12/981,428 patent/US8236541B2/en not_active Expired - Fee Related
- 2010-12-29 US US12/981,418 patent/US8163528B2/en not_active Expired - Fee Related
-
2011
- 2011-11-30 US US13/308,188 patent/US20120142071A1/en not_active Abandoned
- 2011-11-30 US US13/308,164 patent/US20120149890A1/en not_active Abandoned
-
2012
- 2012-01-05 JP JP2012000673A patent/JP2012115270A/ja not_active Withdrawn
- 2012-06-29 US US13/538,503 patent/US20130011903A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008301828A (ja) | 2008-12-18 |
| US20110165653A1 (en) | 2011-07-07 |
| CA2306443A1 (en) | 1999-04-22 |
| US20120149890A1 (en) | 2012-06-14 |
| US20120142071A1 (en) | 2012-06-07 |
| DE69838483T2 (de) | 2008-07-03 |
| DE69838483D1 (de) | 2007-11-08 |
| JP2012115270A (ja) | 2012-06-21 |
| JP5070145B2 (ja) | 2012-11-07 |
| WO1999019466A2 (en) | 1999-04-22 |
| EP1025212B1 (en) | 2007-09-26 |
| EP2386630A1 (en) | 2011-11-16 |
| US20100112685A1 (en) | 2010-05-06 |
| US7888091B2 (en) | 2011-02-15 |
| US20130011903A1 (en) | 2013-01-10 |
| US8163528B2 (en) | 2012-04-24 |
| EP1025212A2 (en) | 2000-08-09 |
| ATE374247T1 (de) | 2007-10-15 |
| WO1999019466A3 (en) | 1999-07-08 |
| US8236541B2 (en) | 2012-08-07 |
| EP2386629A1 (en) | 2011-11-16 |
| US7888114B2 (en) | 2011-02-15 |
| US20110136221A1 (en) | 2011-06-09 |
| US20090298156A1 (en) | 2009-12-03 |
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