JP2002513541A5 - - Google Patents
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- Publication number
- JP2002513541A5 JP2002513541A5 JP2000523554A JP2000523554A JP2002513541A5 JP 2002513541 A5 JP2002513541 A5 JP 2002513541A5 JP 2000523554 A JP2000523554 A JP 2000523554A JP 2000523554 A JP2000523554 A JP 2000523554A JP 2002513541 A5 JP2002513541 A5 JP 2002513541A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- cells
- cell
- nkg2
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 description 32
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 description 27
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 description 27
- 238000000034 method Methods 0.000 description 23
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 description 17
- 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 description 15
- 101001109508 Homo sapiens NKG2-A/NKG2-B type II integral membrane protein Proteins 0.000 description 13
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 108010001880 NK Cell Lectin-Like Receptor Subfamily C Proteins 0.000 description 2
- 102000000834 NK Cell Lectin-Like Receptor Subfamily C Human genes 0.000 description 2
- 108091008877 NK cell receptors Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9725764.6 | 1997-12-04 | ||
| GBGB9725764.6A GB9725764D0 (en) | 1997-12-04 | 1997-12-04 | HLA-E binding |
| PCT/GB1998/003686 WO1999028748A2 (en) | 1997-12-04 | 1998-12-04 | Hla-e binding |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008314107A Division JP4437160B2 (ja) | 1997-12-04 | 2008-12-10 | Ｈｌａ−ｅ結合 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002513541A JP2002513541A (ja) | 2002-05-14 |
| JP2002513541A5 true JP2002513541A5 (https=) | 2006-01-19 |
| JP4336451B2 JP4336451B2 (ja) | 2009-09-30 |
Family
ID=10823165
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000523554A Expired - Lifetime JP4336451B2 (ja) | 1997-12-04 | 1998-12-04 | Ｈｌａ−ｅ結合 |
| JP2008314107A Expired - Lifetime JP4437160B2 (ja) | 1997-12-04 | 2008-12-10 | Ｈｌａ−ｅ結合 |
| JP2009191564A Expired - Lifetime JP5268828B2 (ja) | 1997-12-04 | 2009-08-21 | Ｈｌａ−ｅ結合 |
| JP2013006244A Abandoned JP2013081478A (ja) | 1997-12-04 | 2013-01-17 | Ｈｌａ−ｅ結合 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008314107A Expired - Lifetime JP4437160B2 (ja) | 1997-12-04 | 2008-12-10 | Ｈｌａ−ｅ結合 |
| JP2009191564A Expired - Lifetime JP5268828B2 (ja) | 1997-12-04 | 2009-08-21 | Ｈｌａ−ｅ結合 |
| JP2013006244A Abandoned JP2013081478A (ja) | 1997-12-04 | 2013-01-17 | Ｈｌａ−ｅ結合 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7410767B1 (https=) |
| EP (2) | EP1036327B1 (https=) |
| JP (4) | JP4336451B2 (https=) |
| AT (1) | ATE438096T1 (https=) |
| DE (1) | DE69841020D1 (https=) |
| GB (1) | GB9725764D0 (https=) |
| WO (1) | WO1999028748A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725764D0 (en) * | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
| KR20040041575A (ko) * | 2001-07-31 | 2004-05-17 | 칼 페터 쇠더스트룀 | 면역반응의 모듈화 조성물 및 모듈화 방법 |
| US20040072262A1 (en) | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
| CA2541241A1 (en) * | 2003-08-26 | 2005-03-03 | Danmarks Tekniske Universitet | A continuous process for the assembly of macromolecular substances and the subsequent capture and isolation of a macromolecular assembly, and a system suitable for the process |
| JP2007536522A (ja) * | 2004-05-07 | 2007-12-13 | ベックマン コールター インコーポレーティッド | Ｃｔｌの媒介による抗原提示細胞の溶解を検出するためのｍｈｃ架橋系 |
| US7678379B2 (en) | 2004-06-17 | 2010-03-16 | Beckman Coulter, Inc. | Mycobacterium tuberculosis epitopes and methods of use thereof |
| AU2005321017B2 (en) | 2004-12-28 | 2011-02-24 | Innate Pharma S.A. | Monoclonal antibodies against NKG2A |
| JP5368301B2 (ja) * | 2006-06-22 | 2013-12-18 | ノボ・ノルデイスク・エー／エス | 可溶性ヘテロ二量体レセプター及びその使用 |
| CN101484471B (zh) | 2006-06-30 | 2013-11-06 | 诺沃-诺迪斯克有限公司 | 抗-nkg2a抗体及其用途 |
| EP2628753A1 (en) | 2008-01-24 | 2013-08-21 | Novo Nordisk A/S | Humanized anti-human NKG2A monoclonal antibody |
| KR102047248B1 (ko) | 2011-06-17 | 2019-11-21 | 노보 노르디스크 에이/에스 | 침식성 세포의 선택적 제거 |
| EP2893003B1 (en) | 2012-09-04 | 2021-03-31 | Inven2 AS | Selective and controlled expansion of educated nk cells |
| HK1217968A1 (zh) * | 2013-03-12 | 2017-01-27 | 桑格摩生物科学股份有限公司 | 用於hla的修饰的方法和组合物 |
| EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| US20170081411A1 (en) * | 2014-03-15 | 2017-03-23 | Novartis Ag | Regulatable chimeric antigen receptor |
| US10857219B2 (en) * | 2014-03-28 | 2020-12-08 | The Board Of Regents Of The University Of Oklahoma | Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| SMT202000562T1 (it) | 2014-09-16 | 2020-11-10 | Innate Pharma | Neutralizzazionne delle vie inibitorie nei linfociti |
| CA2959463A1 (en) | 2014-09-16 | 2016-03-24 | Innate Pharma | Treatment regimens using anti-nkg2a antibodies |
| KR20250067191A (ko) | 2014-09-17 | 2025-05-14 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| EP3209687A1 (en) | 2014-10-23 | 2017-08-30 | Innate Pharma | Treatment of cancers using anti-nkg2a agents |
| CA3012055A1 (en) | 2016-01-21 | 2017-07-27 | Innate Pharma | Neutralization of inhibitory pathways in lymphocytes |
| EP3573997A4 (en) * | 2017-01-24 | 2020-12-09 | Abexxa Biologics, Inc. | METHODS AND COMPOSITIONS INTENDED TO TARGE A COMPLEX INCLUDING A NON-CLASSIC HLA-I AND A NEO-ANTIGEN IN THE TREATMENT OF CANCER |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| KR102660336B1 (ko) | 2017-03-27 | 2024-04-26 | 내셔널 유니버시티 오브 싱가포르 | 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 |
| AU2019219454A1 (en) * | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| WO2019165307A1 (en) * | 2018-02-23 | 2019-08-29 | Abexxa Biologics, Inc. | Combination cancer therapy with anti-cancer agents and antibodies targeting a complex comprising non-classical hla-i and neoantigen |
| US11464840B2 (en) | 2018-02-26 | 2022-10-11 | Swey-Shen Chen | Universal non-classical MHC I vaccines: HLA-E-restricted antigenic peptides as universal vaccines to treat allergy, inflammation, autoimmune and infectious diseases, and cancers |
| EA202092147A1 (ru) | 2018-03-13 | 2021-03-04 | Иннейт Фарма | Лечение рака головы и шеи |
| EP3539552A1 (en) * | 2018-03-16 | 2019-09-18 | Deutsches Rheuma-Forschungszentrum Berlin | Activation and expansion of nkg2c+ nk cells |
| CN112055717B (zh) | 2018-04-02 | 2024-04-26 | 新加坡国立大学 | 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| US11274150B2 (en) | 2018-11-16 | 2022-03-15 | Bristol-Myers Squibb Company | Anti-human natural killer cell inhibitory receptor group 2A protein (NKG2A) antibodies |
| US12590148B2 (en) | 2018-11-26 | 2026-03-31 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| KR102943217B1 (ko) | 2018-12-02 | 2026-03-25 | 페이트 세러퓨틱스, 인코포레이티드 | 향상된 iPSC 유래 효과기 세포를 사용한 면역요법 |
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| GB201909509D0 (en) * | 2019-07-02 | 2019-08-14 | Immunocore Ltd | Peptide-MHC complexes |
| WO2022072508A1 (en) | 2020-09-30 | 2022-04-07 | Dren Bio, Inc. | Anti-cd94 antibodies and methods of use thereof |
| CA3229447A1 (en) * | 2021-08-20 | 2023-02-23 | Duke University | Antibodies that target hla-e-host peptide complexes and uses thereof |
| CN120019146A (zh) * | 2022-08-11 | 2025-05-16 | 宾夕法尼亚大学理事会 | 通用t细胞和组合物及它们的使用方法 |
| WO2024206190A1 (en) * | 2023-03-24 | 2024-10-03 | Duke University | Antibodies that target hla-e-host peptide complexes and uses thereof |
| WO2026016730A1 (zh) * | 2024-07-17 | 2026-01-22 | 广州瑞风生物科技股份有限公司 | 一种突变hla-e重链、hla-e三聚体及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03112486A (ja) | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | Ｈｌａ―ｂ３５遺伝子およびｄｎａプローブ並びに形質転換細胞 |
| JPH03112487A (ja) | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | ＨＬＡ―Ｂｗ５３遺伝子およびＤＮＡプローブ並びに形質転換細胞 |
| JPH03112485A (ja) | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | Ｈｌａ―ｃ遺伝子およびｄｎａプローブ並びに形質転換細胞 |
| GB9725764D0 (en) * | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
-
1997
- 1997-12-04 GB GBGB9725764.6A patent/GB9725764D0/en not_active Ceased
-
1998
- 1998-12-04 WO PCT/GB1998/003686 patent/WO1999028748A2/en not_active Ceased
- 1998-12-04 EP EP98959027A patent/EP1036327B1/en not_active Expired - Lifetime
- 1998-12-04 DE DE69841020T patent/DE69841020D1/de not_active Expired - Lifetime
- 1998-12-04 JP JP2000523554A patent/JP4336451B2/ja not_active Expired - Lifetime
- 1998-12-04 US US09/555,555 patent/US7410767B1/en not_active Expired - Fee Related
- 1998-12-04 EP EP09165917A patent/EP2144065A1/en not_active Withdrawn
- 1998-12-04 AT AT98959027T patent/ATE438096T1/de not_active IP Right Cessation
-
2008
- 2008-04-25 US US12/109,990 patent/US20080274475A1/en not_active Abandoned
- 2008-12-10 JP JP2008314107A patent/JP4437160B2/ja not_active Expired - Lifetime
-
2009
- 2009-08-21 JP JP2009191564A patent/JP5268828B2/ja not_active Expired - Lifetime
-
2013
- 2013-01-17 JP JP2013006244A patent/JP2013081478A/ja not_active Abandoned
-
2015
- 2015-04-10 US US14/683,835 patent/US20150361180A1/en not_active Abandoned
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