JP2002513291A - 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離 - Google Patents

神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離

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Publication number
JP2002513291A
JP2002513291A JP54858198A JP54858198A JP2002513291A JP 2002513291 A JP2002513291 A JP 2002513291A JP 54858198 A JP54858198 A JP 54858198A JP 54858198 A JP54858198 A JP 54858198A JP 2002513291 A JP2002513291 A JP 2002513291A
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cells
population
stem cells
cns
nep
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JP2002513291A5 (enExample
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ラオ，マヘンドラ，エス．
メイヤー−プロッシェル，マーゴット
ムジタバ，ターミナ
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ユニバーシティー オブ ユタ リサーチ ファンデーション
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Publication of JP2002513291A publication Critical patent/JP2002513291A/ja
Publication of JP2002513291A5 publication Critical patent/JP2002513291A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP54858198A 1997-05-07 1998-05-07 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離 Ceased JP2002513291A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/852,744 1997-05-07
US08/852,744 US6361996B1 (en) 1997-05-07 1997-05-07 Neuroepithelial stem cells and glial-restricted intermediate precursors
US09/073,881 US6830927B2 (en) 1997-05-07 1998-05-06 Common neural progenitor for the CNS and PNS
US09/073,881 1998-05-06
PCT/US1998/009630 WO1998050526A1 (en) 1997-05-07 1998-05-07 Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor
US10/025,333 US7037720B2 (en) 1997-05-07 2001-12-19 Neuroepithelial stem cells and glial-restricted intermediate precursors

Publications (2)

Publication Number Publication Date
JP2002513291A true JP2002513291A (ja) 2002-05-08
JP2002513291A5 JP2002513291A5 (enExample) 2005-12-02

Family

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Family Applications (1)

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JP54858198A Ceased JP2002513291A (ja) 1997-05-07 1998-05-07 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離

Country Status (7)

Country Link
US (5) US6361996B1 (enExample)
EP (1) EP0983344A4 (enExample)
JP (1) JP2002513291A (enExample)
AU (1) AU751581C (enExample)
CA (1) CA2289021C (enExample)
IL (1) IL132584A0 (enExample)
WO (1) WO1998050526A1 (enExample)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263402B1 (en) * 1998-10-19 2012-09-11 Cornell Research Foundation, Inc. Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US20050042749A1 (en) 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
EP1287116A2 (en) 2000-05-17 2003-03-05 Geron Corporation Neural progenitor cell populations
US6897061B1 (en) * 2000-06-16 2005-05-24 Spinal Cord Society Transdifferentiation of glial cells
US20030223972A1 (en) 2002-02-15 2003-12-04 Goldman Steven A. Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells
US7207743B2 (en) * 2002-05-28 2007-04-24 Polivka Parking Solutions Llc Method and apparatus for constructing an automotive vehicle parking lot
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US20050101014A1 (en) 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
AR046076A1 (es) * 2003-07-18 2005-11-23 Otsuka Pharma Co Ltd Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida
EP1682075A4 (en) * 2003-11-07 2009-12-09 Univ Florida BREEDING AND DIFFERENTIATION OF NEURAL CREATOR CELLS
AU2005209169B2 (en) 2004-01-16 2010-12-16 Carnegie Mellon University Cellular labeling for nuclear magnetic resonance techniques
AU2005252434B2 (en) * 2004-06-09 2011-11-24 The University Court Of The University Of Edinburgh Neural stem cells
CN101106955A (zh) * 2005-01-19 2008-01-16 菲迪亚高级生物聚合物有限公司 用于sci和pnt再生的透明质酸衍生物和神经干细胞
WO2008020815A1 (en) 2006-08-15 2008-02-21 Agency For Science, Technology And Research Mesenchymal stem cell conditioned medium
US7803364B2 (en) 2005-11-17 2010-09-28 The Cleveland Clinic Foundation Multipotent neural stem cells
WO2007120911A2 (en) * 2006-04-14 2007-10-25 Carnegie Mellon University Cellular labeling and quantification for nuclear magnetic resonance techniques
EP2012832A2 (en) * 2006-04-14 2009-01-14 Celsense, Inc. Methods for assessing cell labeling
US8163075B2 (en) 2006-10-31 2012-04-24 Sensient Colors Llc Inks comprising modified pigments and methods for making and using the same
US20100119493A1 (en) * 2007-04-17 2010-05-13 University Of Rochester Telencephalic Glial-Restricted Cell Populations and Related Compositions and Methods
CA2693678C (en) * 2007-07-10 2017-02-14 Carnegie Mellon University Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques
AU2008288785B2 (en) 2007-08-23 2014-08-21 Sensient Colors Inc. Self-dispersed pigments and methods for making and using the same
CN101939362A (zh) 2008-01-30 2011-01-05 杰龙公司 用于培养干细胞衍生的少突胶质细胞前体细胞的合成表面
WO2009116951A2 (en) 2008-03-17 2009-09-24 Agency For Science, Technology And Research Microcarriers for stem cell culture
WO2009134435A2 (en) * 2008-05-02 2009-11-05 Celsense Inc. Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications
US9709553B2 (en) 2008-05-08 2017-07-18 University Of Rochester Treating myelin diseases with optimized cell preparations
US9688956B2 (en) 2008-06-05 2017-06-27 National Cheng Kung University Method for preserving proliferation and differentiation potential of mesenchymal stem cells
WO2010008486A2 (en) 2008-06-24 2010-01-21 Parkinsons Institute Pluripotent cell lines and methods of use thereof
US20110236356A1 (en) * 2008-12-12 2011-09-29 Nova Southeastern University Methods of isolating and using stem cells
CN102325878A (zh) 2008-12-23 2012-01-18 斯特姆塞尔思加利福尼亚有限公司 少突胶质前体细胞的靶向细胞群及制备与使用方法
KR20110135989A (ko) 2009-04-07 2011-12-20 센션트 컬러스 엘엘씨 자가-분산 입자 및 그의 제조 및 사용 방법
AU2010276264B2 (en) 2009-07-21 2013-09-19 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
SG10201404280XA (en) 2009-07-21 2014-10-30 Abt Holding Co Use of stem cells to reduce leukocyte extravasation
WO2011096825A1 (en) * 2010-02-05 2011-08-11 Auckland Uniservices Limited Cell programming
DK2539436T3 (da) 2010-02-25 2021-10-18 Abt Holding Co Modulering af makrofagaktivering
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US8433419B2 (en) 2010-10-13 2013-04-30 Cardiac Pacemakers, Inc. Method and apparatus for controlling neurostimulation according to physical state
WO2012168295A1 (en) 2011-06-06 2012-12-13 ReGenesys BVBA Expansion of stem cells in hollow fiber bioreactors
EP3766962B1 (en) 2013-02-06 2025-10-22 University of Rochester Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders
KR102057601B1 (ko) 2013-03-15 2019-12-19 웨이크 포리스트 유니버시티 헬스 사이언시즈 신경 전구 세포 분화
KR102161726B1 (ko) 2013-04-12 2020-10-06 사베리오 라프란체스카 이식용 장기의 개선
EP2992088B1 (en) 2013-04-30 2019-08-21 Katholieke Universiteit Leuven Cell therapy for myelodysplastic syndromes
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
WO2017147212A1 (en) 2016-02-22 2017-08-31 The Regents Of The University Of California Compositions and methods for imaging cell populations
CA3019514A1 (en) 2016-03-30 2017-10-05 Asterias Biotherapeutics, Inc. Oligodendrocyte progenitor cell compositions
AU2018215170B2 (en) * 2017-01-31 2021-11-11 Osaka University Differentiation control method for pluripotent stem cells
EP3621434B1 (en) 2017-05-10 2026-07-15 University of Rochester Glial progenitor cells for use in treating schizophrenia
AU2019342741B2 (en) 2018-09-19 2025-12-11 Lineage Cell Therapeutics, Inc. Methods for differentiating pluripotent stem cells in dynamic suspension culture
AU2020210757B2 (en) * 2019-01-23 2026-04-16 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells
JP7728747B2 (ja) 2019-08-23 2025-08-25 サナ バイオテクノロジー，インコーポレイテッド Ｃｄ２４発現細胞およびそれらの用途
EP4125961A1 (en) 2020-03-25 2023-02-08 Sana Biotechnology, Inc. Hypoimmunogenic neural cells for the treatment of neurological disorders and conditions
AU2021325941A1 (en) 2020-08-13 2023-03-09 Sana Biotechnology, Inc. Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
US20240226164A1 (en) 2021-05-27 2024-07-11 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
CA3225283A1 (en) 2021-07-14 2023-01-19 Sonja SCHREPFER Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
AU2022325231A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
AU2022325955A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
US20260053851A1 (en) 2021-08-11 2026-02-26 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells
AU2022326565A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
WO2025061158A1 (zh) 2023-09-20 2025-03-27 士泽生物医药（苏州）有限公司 一种表达mcl1的低免疫原性细胞及其制备方法
AU2025208175A1 (en) 2024-01-12 2026-06-25 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08500245A (ja) * 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411883A (en) * 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
US5589376A (en) 1992-07-27 1996-12-31 California Institute Of Technology Mammalian neural crest stem cells
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08500245A (ja) * 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
JPN4007016138, Ｓｏｃｉｅｔｙ ｆｏｒ Ｎｅｕｒｏｓｃｉｅｎｃｅ，１９９６，Ｖｏｌ．２２，ｐ．５２７，２１５．１２ *
JPN4007016139, Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ，１９９５，Ｖｏｌ．１５，Ｎｏ．５，ｐ．３６５３−３６６１ *
JPN4007016140, Ｇｅｎｅｓ ＆ Ｄｅｖｅｌｏｐｍｅｎｔ，１９９６，Ｖｏｌ．１０，Ｎｏ．２４，ｐ．３１２９−３１４０ *
JPN4007016480, Ｄｅｖｅｌｏｐｍｅｎｔａｌ Ｂｉｏｌｏｇｙ，１９９８，Ｖｏｌ．２００，ｐ．１−１５ *
JPN6008050264, Ｓｏｃｉｅｔｙ ｆｏｒ Ｎｅｕｒｏｓｃｉｅｎｃｅ，１９９６，Ｖｏｌ．２２，ｐ．５２７，２１５．１２ *
JPN6008050266, Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ，１９９５，Ｖｏｌ．１５，Ｎｏ．５，ｐ．３６５３−３６６１ *
JPN6008050269, Ｇｅｎｅｓ ＆ Ｄｅｖｅｌｏｐｍｅｎｔ，１９９６，Ｖｏｌ．１０，Ｎｏ．２４，ｐ．３１２９−３１４０ *
JPN6008050271, Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｃｙｔｏｌｏｇｙ，１９９２，Ｖｏｌ．２１，Ｎｏ．９，ｐ．６３５−６４７ *
JPN6008050273, Ｄｅｖｅｌｏｐｍｅｎｔａｌ Ｂｉｏｌｏｇｙ，１９９８，Ｖｏｌ．２００，ｐ．１−１５ *
JPN6008050275, Ｄｅｖｅｌｏｐｍｅｎｔａｌ Ｂｉｏｌｏｇｙ，１９９７，Ｖｏｌ．１８８，ｐ．４８−６３ *
JPN6009049890, Ｄｅｖｅｌｏｐｍｅｎｔａｌ Ｂｉｏｌｏｇｙ，１９９２，Ｖｏｌ．１５２，ｐ．３６３−３７２ *
JPN6009049892, Ｃｅｌｌ Ｂｉｏｌｏｇｙ，１９９２，Ｖｏｌ．３，ｐ．４１３−４２２ *
JPN6009049894, Ｎｅｕｒｏｎ，１９９０，Ｖｏｌ．５，ｐ．６１５−６２５ *
JPN6009049895, Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ，１９９２，Ｖｏｌ．１２，Ｎｏ．７，ｐ．２７５１−２７６４ *
JPN6009049898, Ｄｅｖｅｌｐｏｍｅｎｔａｌ Ｂｒａｉｎ Ｒｅｓｅａｒｃｈ，１９９０，Ｖｏｌ．５４，ｐ．２３５−２４８ *
JPN6009049899, Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｌｅｔｔｅｒｓ，１９９３，Ｖｏｌ．１６３，ｐ．２２７−２３０ *
JPN6009049901, ＧＬＩＡ，１９９６，Ｖｏｌ．１６，ｐ．２７−３９ *

Also Published As

Publication number Publication date
EP0983344A1 (en) 2000-03-08
EP0983344A4 (en) 2000-09-27
AU7481198A (en) 1998-11-27
AU751581B2 (en) 2002-08-22
AU751581C (en) 2003-06-19
US20100015702A1 (en) 2010-01-21
US6830927B2 (en) 2004-12-14
US6361996B1 (en) 2002-03-26
US20020045251A1 (en) 2002-04-18
US20020142460A1 (en) 2002-10-03
US7595194B2 (en) 2009-09-29
CA2289021C (en) 2013-07-09
US7037720B2 (en) 2006-05-02
IL132584A0 (en) 2001-03-19
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CA2289021A1 (en) 1998-11-12

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