IL132584A0 - Generation characterization and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor - Google Patents
Generation characterization and isolation of neuroepithelial stem cells and lineage restricted intermediate precursorInfo
- Publication number
- IL132584A0 IL132584A0 IL13258498A IL13258498A IL132584A0 IL 132584 A0 IL132584 A0 IL 132584A0 IL 13258498 A IL13258498 A IL 13258498A IL 13258498 A IL13258498 A IL 13258498A IL 132584 A0 IL132584 A0 IL 132584A0
- Authority
- IL
- Israel
- Prior art keywords
- isolation
- stem cells
- intermediate precursor
- neuroepithelial stem
- lineage restricted
- Prior art date
Links
- 238000012512 characterization method Methods 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0661—Smooth muscle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/852,744 US6361996B1 (en) | 1997-05-07 | 1997-05-07 | Neuroepithelial stem cells and glial-restricted intermediate precursors |
| US09/073,881 US6830927B2 (en) | 1997-05-07 | 1998-05-06 | Common neural progenitor for the CNS and PNS |
| PCT/US1998/009630 WO1998050526A1 (en) | 1997-05-07 | 1998-05-07 | Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor |
| US10/025,333 US7037720B2 (en) | 1997-05-07 | 2001-12-19 | Neuroepithelial stem cells and glial-restricted intermediate precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL132584A0 true IL132584A0 (en) | 2001-03-19 |
Family
ID=37057261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13258498A IL132584A0 (en) | 1997-05-07 | 1998-05-07 | Generation characterization and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US6361996B1 (enExample) |
| EP (1) | EP0983344A4 (enExample) |
| JP (1) | JP2002513291A (enExample) |
| AU (1) | AU751581C (enExample) |
| CA (1) | CA2289021C (enExample) |
| IL (1) | IL132584A0 (enExample) |
| WO (1) | WO1998050526A1 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263402B1 (en) * | 1998-10-19 | 2012-09-11 | Cornell Research Foundation, Inc. | Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
| AU2001263199B2 (en) | 2000-05-17 | 2004-09-16 | Asterias Biotherapeutics, Inc. | Neural progenitor cell populations |
| US7250294B2 (en) | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| US6897061B1 (en) * | 2000-06-16 | 2005-05-24 | Spinal Cord Society | Transdifferentiation of glial cells |
| CA2476376C (en) | 2002-02-15 | 2014-10-21 | Cornell Research Foundation, Inc. | Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells |
| US7207743B2 (en) * | 2002-05-28 | 2007-04-24 | Polivka Parking Solutions Llc | Method and apparatus for constructing an automotive vehicle parking lot |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US20050101014A1 (en) | 2002-07-11 | 2005-05-12 | Keirstead Hans S. | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| AR046076A1 (es) * | 2003-07-18 | 2005-11-23 | Otsuka Pharma Co Ltd | Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida |
| EP1682075A4 (en) * | 2003-11-07 | 2009-12-09 | Univ Florida | BREEDING AND DIFFERENTIATION OF NEURAL CREATOR CELLS |
| US8147806B2 (en) | 2004-01-16 | 2012-04-03 | Carnegie Mellon University | Cellular labeling for nuclear magnetic resonance techniques |
| CA2569978C (en) * | 2004-06-09 | 2017-06-06 | The University Court Of The University Of Edinburgh | Neural stem cells |
| MX2007008668A (es) * | 2005-01-19 | 2008-02-11 | Fidia Advanced Biopolymers Srl | Derivado de acido hialuronico y celulas germinales neurales para la regeneracion de una lesion de medula espinal o de una transeccion de nervio periferico. |
| US7803364B2 (en) | 2005-11-17 | 2010-09-28 | The Cleveland Clinic Foundation | Multipotent neural stem cells |
| JP2009533684A (ja) * | 2006-04-14 | 2009-09-17 | カーネギー・メロン・ユニバーシティ | 核磁気共鳴技術のための細胞標識及び定量 |
| US20070258886A1 (en) * | 2006-04-14 | 2007-11-08 | Celsense Inc. | Methods for assessing cell labeling |
| EP2054506A1 (en) | 2006-08-15 | 2009-05-06 | Agency for Science, Technology and Research | Mesenchymal stem cell conditioned medium |
| US7927416B2 (en) | 2006-10-31 | 2011-04-19 | Sensient Colors Inc. | Modified pigments and methods for making and using the same |
| WO2008131004A1 (en) * | 2007-04-17 | 2008-10-30 | University Of Rochester | Telencephalic glial-restricted cell populations and related compositions and methods |
| AU2008275578B2 (en) * | 2007-07-10 | 2014-04-10 | Carnegie Mellon University | Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques |
| WO2009026552A2 (en) | 2007-08-23 | 2009-02-26 | Sensient Colors Inc. | Self-dispersed pigments and methods for making and using the same |
| EP2240536B1 (en) | 2008-01-30 | 2019-09-04 | Asterias Biotherapeutics, Inc. | Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells |
| JP2011514169A (ja) | 2008-03-17 | 2011-05-06 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 幹細胞培養のためのマイクロキャリア |
| ES2611103T3 (es) * | 2008-05-02 | 2017-05-04 | Celsense Inc. | Composiciones y métodos para producir emulsiones para técnicas de resonancia magnética nuclear y otras aplicaciones |
| CA2723382A1 (en) | 2008-05-08 | 2009-11-12 | University Of Rochester | Treating myelin diseases with optimized cell preparations |
| US9688956B2 (en) | 2008-06-05 | 2017-06-27 | National Cheng Kung University | Method for preserving proliferation and differentiation potential of mesenchymal stem cells |
| US8669048B2 (en) | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
| WO2010068946A1 (en) * | 2008-12-12 | 2010-06-17 | Nova Southeastern University | Methods of isolating and using stem cells |
| US20100158878A1 (en) | 2008-12-23 | 2010-06-24 | Alexandra Capela | Target populations of oligodendrocyte precursor cells and methods of making and using same |
| US9221986B2 (en) | 2009-04-07 | 2015-12-29 | Sensient Colors Llc | Self-dispersing particles and methods for making and using the same |
| SG10201404281YA (en) | 2009-07-21 | 2014-09-26 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
| AU2010276201B2 (en) | 2009-07-21 | 2013-10-17 | Healios K.K. | Use of stem cells to reduce leukocyte extravasation |
| JP6002581B2 (ja) * | 2010-02-05 | 2016-10-05 | オークランド ユニサービシズ リミテッドAuckland Uniservices Limited | 細胞プログラミング |
| SG10201501402UA (en) | 2010-02-25 | 2015-04-29 | Abt Holding Co | Modulation of macrophage activation |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| US8433419B2 (en) | 2010-10-13 | 2013-04-30 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling neurostimulation according to physical state |
| KR102073530B1 (ko) | 2011-06-06 | 2020-02-04 | 리제네시스 비브이비에이 | 중공 섬유 생물 반응기에서의 줄기 세포의 확장 |
| EP2954046B1 (en) | 2013-02-06 | 2025-10-15 | University Of Rochester | Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders |
| CA2907327C (en) | 2013-03-15 | 2020-04-07 | Wake Forest University Health Sciences | Neural progenitor cell differentiation |
| AU2014250761B2 (en) | 2013-04-12 | 2019-02-28 | Robert J. Deans | Improving organs for transplantation |
| AU2014266935B2 (en) | 2013-04-30 | 2020-06-11 | Katholieke Universiteit Leuven | Cell therapy for myelodysplastic syndromes |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
| US11406721B2 (en) | 2016-02-22 | 2022-08-09 | The Regents Of The University Of California | Compositions and methods for imaging cell populations |
| US11920155B2 (en) | 2016-03-30 | 2024-03-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| MY192056A (en) * | 2017-01-31 | 2022-07-25 | Univ Osaka | Method for controlling differentiation of pluripotent stem cells |
| CN110913689A (zh) | 2017-05-10 | 2020-03-24 | 罗切斯特大学 | 治疗神经精神病症的方法 |
| US12365872B2 (en) | 2018-09-19 | 2025-07-22 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| US11603518B2 (en) | 2019-01-23 | 2023-03-14 | Asterias Biotherapeutics, Inc. | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
| EP4017508A1 (en) | 2019-08-23 | 2022-06-29 | Sana Biotechnology, Inc. | Cd24 expressing cells and uses thereof |
| MX2022011831A (es) | 2020-03-25 | 2023-01-04 | Sana Biotechnology Inc | Células neurales hipoinmunogénicas para el tratamiento de trastornos y afecciones neurológicas. |
| MX2023001831A (es) | 2020-08-13 | 2023-06-29 | Sana Biotechnology Inc | Métodos de tratamiento de pacientes sensibilizados con células hipoinmunogénicas y métodos y composiciones asociados. |
| KR20240013135A (ko) | 2021-05-27 | 2024-01-30 | 사나 바이오테크놀로지, 인크. | 조작된 hla-e 또는 hla-g를 포함하는 저면역원성 세포 |
| AU2022309875A1 (en) | 2021-07-14 | 2024-01-25 | Sana Biotechnology, Inc. | Altered expression of y chromosome-linked antigens in hypoimmunogenic cells |
| EP4384598A1 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| IL310702A (en) | 2021-08-11 | 2024-04-01 | Sana Biotechnology Inc | Inducible systems for altering gene expression in hypoimmunogenic cells |
| EP4384544A1 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| WO2023019225A2 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025151838A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411883A (en) * | 1989-12-26 | 1995-05-02 | Somatix Therapy Corporation | Proliferated neuron progenitor cell product and process |
| US5589376A (en) | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
| AU678988B2 (en) * | 1992-07-27 | 1997-06-19 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| US5753506A (en) * | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
-
1997
- 1997-05-07 US US08/852,744 patent/US6361996B1/en not_active Expired - Lifetime
-
1998
- 1998-05-06 US US09/073,881 patent/US6830927B2/en not_active Expired - Fee Related
- 1998-05-07 JP JP54858198A patent/JP2002513291A/ja not_active Ceased
- 1998-05-07 CA CA2289021A patent/CA2289021C/en not_active Expired - Fee Related
- 1998-05-07 EP EP98922212A patent/EP0983344A4/en not_active Withdrawn
- 1998-05-07 IL IL13258498A patent/IL132584A0/xx not_active IP Right Cessation
- 1998-05-07 WO PCT/US1998/009630 patent/WO1998050526A1/en not_active Ceased
- 1998-05-07 AU AU74811/98A patent/AU751581C/en not_active Ceased
-
2001
- 2001-12-19 US US10/025,333 patent/US7037720B2/en not_active Expired - Fee Related
-
2006
- 2006-05-01 US US11/415,056 patent/US7595194B2/en not_active Expired - Fee Related
-
2009
- 2009-09-28 US US12/568,419 patent/US20100015702A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2289021C (en) | 2013-07-09 |
| WO1998050526A1 (en) | 1998-11-12 |
| US20020142460A1 (en) | 2002-10-03 |
| US20020045251A1 (en) | 2002-04-18 |
| US7037720B2 (en) | 2006-05-02 |
| US6830927B2 (en) | 2004-12-14 |
| AU751581C (en) | 2003-06-19 |
| US20100015702A1 (en) | 2010-01-21 |
| US6361996B1 (en) | 2002-03-26 |
| EP0983344A4 (en) | 2000-09-27 |
| US20060199264A1 (en) | 2006-09-07 |
| US7595194B2 (en) | 2009-09-29 |
| EP0983344A1 (en) | 2000-03-08 |
| AU751581B2 (en) | 2002-08-22 |
| AU7481198A (en) | 1998-11-27 |
| JP2002513291A (ja) | 2002-05-08 |
| CA2289021A1 (en) | 1998-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |