JP2002513156A5 - - Google Patents

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Publication number
JP2002513156A5
JP2002513156A5 JP2000546239A JP2000546239A JP2002513156A5 JP 2002513156 A5 JP2002513156 A5 JP 2002513156A5 JP 2000546239 A JP2000546239 A JP 2000546239A JP 2000546239 A JP2000546239 A JP 2000546239A JP 2002513156 A5 JP2002513156 A5 JP 2002513156A5
Authority
JP
Japan
Prior art keywords
phage display
library
internalized
display library
target cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000546239A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002513156A (ja
JP4493845B2 (ja
Filing date
Publication date
Priority claimed from US09/249,529 external-priority patent/US6794128B2/en
Application filed filed Critical
Publication of JP2002513156A publication Critical patent/JP2002513156A/ja
Publication of JP2002513156A5 publication Critical patent/JP2002513156A5/ja
Application granted granted Critical
Publication of JP4493845B2 publication Critical patent/JP4493845B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2000546239A 1998-04-24 1999-04-22 インターナライズする抗体を選択する方法 Expired - Fee Related JP4493845B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8295398P 1998-04-24 1998-04-24
US60/082,953 1998-04-24
US09/249,529 US6794128B2 (en) 1998-04-24 1999-02-12 Methods of selecting internalizing antibodies
US09/249,529 1999-02-12
PCT/US1999/008468 WO1999056129A1 (en) 1998-04-24 1999-04-22 Methods of selecting internalizing antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009170482A Division JP2009278993A (ja) 1998-04-24 2009-07-21 インターナライズする抗体を選択する方法

Publications (3)

Publication Number Publication Date
JP2002513156A JP2002513156A (ja) 2002-05-08
JP2002513156A5 true JP2002513156A5 (enExample) 2006-05-25
JP4493845B2 JP4493845B2 (ja) 2010-06-30

Family

ID=26768026

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000546239A Expired - Fee Related JP4493845B2 (ja) 1998-04-24 1999-04-22 インターナライズする抗体を選択する方法
JP2009170482A Pending JP2009278993A (ja) 1998-04-24 2009-07-21 インターナライズする抗体を選択する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009170482A Pending JP2009278993A (ja) 1998-04-24 2009-07-21 インターナライズする抗体を選択する方法

Country Status (8)

Country Link
US (3) US6794128B2 (enExample)
EP (1) EP1073905B1 (enExample)
JP (2) JP4493845B2 (enExample)
AT (1) ATE525385T1 (enExample)
AU (1) AU768784B2 (enExample)
CA (1) CA2326499C (enExample)
DK (1) DK1073905T3 (enExample)
WO (1) WO1999056129A1 (enExample)

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US7563874B2 (en) * 1998-08-31 2009-07-21 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
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US9034329B2 (en) * 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7780882B2 (en) * 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
EP1157041B1 (en) 1999-03-01 2005-06-01 Genentech, Inc. Antibodies for cancer therapy and diagnosis
US7045283B2 (en) * 2000-10-18 2006-05-16 The Regents Of The University Of California Methods of high-throughput screening for internalizing antibodies
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DE60144063D1 (de) 2000-12-18 2011-03-31 Dyax Corp Gerichtete bibliotheken die genetisch verpackt sind
US20030104402A1 (en) * 2001-01-23 2003-06-05 University Of Rochester Methods of producing or identifying intrabodies in eukaryotic cells
CN1596306A (zh) * 2001-03-07 2005-03-16 荧合金股份有限公司 用于将dna导入靶细胞的筛选方法
US20030194798A1 (en) * 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
ITRM20010408A1 (it) 2001-07-10 2003-01-10 Univ Napoli Federico Ii Mini-anticorpo umano citotossico per cellule tumorali che esprimono il recettore erbb2.
US20030073104A1 (en) * 2001-10-02 2003-04-17 Belcher Angela M. Nanoscaling ordering of hybrid materials using genetically engineered mesoscale virus
WO2003062375A2 (en) * 2001-12-19 2003-07-31 Genentech, Inc. Stabilizing polypeptides which have been exposed to urea
US7332585B2 (en) * 2002-04-05 2008-02-19 The Regents Of The California University Bispecific single chain Fv antibody molecules and methods of use thereof
US7332580B2 (en) * 2002-04-05 2008-02-19 The Regents Of The University Of California Bispecific single chain Fv antibody molecules and methods of use thereof
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US20050064508A1 (en) * 2003-09-22 2005-03-24 Semzyme Peptide mediated synthesis of metallic and magnetic materials
US9701754B1 (en) * 2002-10-23 2017-07-11 City Of Hope Covalent disulfide-linked diabodies and uses thereof
ATE533853T1 (de) * 2004-02-24 2011-12-15 Allergan Inc Botulinumtoxin-screening-assays
WO2007094754A2 (en) * 2005-01-27 2007-08-23 The Regents Of The University Of Califordnia Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
MX2007013200A (es) * 2005-04-22 2008-03-24 Johnson & Johnson Composicion de inmunoliposoma para el direccionamiento hacia un receptor de la celula her2.
WO2007142781A1 (en) 2006-05-15 2007-12-13 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
WO2008040348A2 (en) * 2006-10-03 2008-04-10 Genmab A/S High througput methods for characterization of antibodies
US20100104572A1 (en) * 2006-11-02 2010-04-29 Sylvie Luria Methods for screening for therapeutic molecules and use of the molecules therefrom
WO2008140493A2 (en) * 2006-11-21 2008-11-20 The Regents Of The University Of Californina Anti-egfr family antibodies, bispecific anti-egfr family antibodies and methods of use thereof
CA2680741A1 (en) * 2007-03-22 2009-01-15 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US20090175784A1 (en) 2007-05-11 2009-07-09 Joshua Goldstein Anti-Alpha V Immunoliposome Composition, Methods, and Uses
BRPI0814558A2 (pt) * 2007-07-09 2015-01-06 Univ Georgetown Métodos para aagerar resposta imune usando liberação de ácido nucléico mediada por lipossoma catiônico
US9000131B2 (en) * 2008-07-31 2015-04-07 The Regents Of The University Of California Antibodies that neutralize botulinum neurotoxins
AU2009331178A1 (en) * 2008-12-26 2011-08-11 Forerunner Pharma Research Co., Ltd. Diagnosis and treatment of cancer using anti-LGR7 antibody
US8609095B2 (en) 2010-03-04 2013-12-17 Symphogen A/S Anti-HER2 antibodies and compositions
TW201141519A (en) * 2010-03-04 2011-12-01 Symphogen As Anti-HER2 antibodies and compositions
WO2012047427A2 (en) 2010-08-31 2012-04-12 The Regents Of The University Of California Antibodies for botulinum neurotoxins
WO2012112730A2 (en) 2011-02-15 2012-08-23 Merrimack Pharmaceuticals, Inc. Compositions and methods for delivering nucleic acid to a cell
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US9097721B2 (en) 2012-02-29 2015-08-04 The Board Of Trustees Of The University Of Illinois Compositions comprising engineered phosphothreonine affinity reagents, methods of making, and methods of use
MX374317B (es) 2013-06-28 2025-03-06 X Body Inc Selecciones fenotípicas, descubrimiento del antígeno objetivo y uso de los mismos para la identificación de epítopes objetivo específicos de células objetivo.
EP3779440A1 (en) 2013-09-23 2021-02-17 X-Body, Inc. Methods and compositions for generation of binding agents against cell surface antigens
CN104894652A (zh) * 2015-06-25 2015-09-09 黄薇 一种cTnI人源化单链抗体库的构建及应用
CN105273084B (zh) * 2015-09-25 2018-10-09 中国人民解放军第四军医大学 靶向HER2的人源化改造的非内化单链抗体P2h2及应用
CA3026236C (en) * 2016-06-03 2021-01-26 Samsung Life Public Welfare Foundation Method for screening antibody using patient-derived tumor spheroids
JP6996821B2 (ja) 2016-06-26 2022-02-04 ジェノヴァ バイオファーマシューティカルズ リミテッド 抗体ファージディスプレイライブラリー
EP3717682A4 (en) 2017-11-30 2021-09-01 University of Delhi, South Campus LIBRARY OF ANTIBODY FRAGMENTS AND ITS USES

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US6054312A (en) * 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors

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