JP2002512525A - ビブリオ属(Vibrio)により産生されるプロテアーゼを含有する親水性組成物 - Google Patents
ビブリオ属(Vibrio)により産生されるプロテアーゼを含有する親水性組成物Info
- Publication number
- JP2002512525A JP2002512525A JP50253299A JP50253299A JP2002512525A JP 2002512525 A JP2002512525 A JP 2002512525A JP 50253299 A JP50253299 A JP 50253299A JP 50253299 A JP50253299 A JP 50253299A JP 2002512525 A JP2002512525 A JP 2002512525A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- vibrio
- protease
- enzyme
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/909—Vibrio
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.製薬学的に有効な量の酵素、および室温で最低100日間80パーセントより大 きな酵素活性を維持するのに有効な量のグリセリルココエートを含んで成る親水 性製薬学的組成物。 2.前記酵素がプロテアーゼである、請求の範囲1の組成物。 3.前記プロテアーゼがビブリオ属(Vibrio)により産生される細胞外中性プロテ アーゼである、請求の範囲2の組成物。 4.前記ビブリオ属(Vibrio)がビブリオ プロテオリティクス ストリーム(Vib rio proteolyticus stream)である、請求の範囲3の組成物。 5.創傷を創面切除するのに有用である、請求の範囲1の組成物。 6.創傷の治癒を促進するのに有用である、請求の範囲1の組成物。 7.前記プロテアーゼが配列番号1を有するDNA配列によりコードされる、請 求の範囲1の組成物。 8.グリセリンをさらに含んで成る、請求の範囲1の組成物。 9.抗菌剤をさらに含んで成る、請求の範囲1の組成物。 10.約0.5ないし約2.0%のプロテアーゼ、 約10.0ないし約70.0%のグリセリルココエート、 約0ないし約30.0%のグリセリルトリラウレート、 約0ないし約40.0%のグリセリン、 約0.05ないし約0.5%の抗菌剤、 約30.0ないし約80.0%の緩衝液 をさらに含んで成る、請求の範囲1の組成物。 11.請求の範囲1に記載の親水性製薬学的組成物を投与することを含んで成る 、こうした治療を必要とする対象からの壊死および/もしくは 非生存可能の組織の除去を提供する治療方法。 12.治療が、熱傷、骨折、外科的剥離、蓐瘡、治癒の遅い潰瘍、腱炎、滑液包 炎、膣炎、子宮頸炎、環状切除、会陰切開、毛巣嚢胞の疣贅、癰、日焼けおよび 凍傷から選択される状態の治療のために遂げられる、請求の範囲10の方法。 13.プロテアーゼがビブリオ属(Vibrio)により産生される中性プロテアーゼで ある、請求の範囲10の方法。 14.ビブリオ属(Vibrio)がビブリオ プロテオリティクス(Vibrio proteolyti cus)株である、請求の範囲12の方法。 15.組成物が局所に適用される、請求の範囲11の方法。 16.組成物が毎日約1ないし6回局所に適用される、請求の範囲15の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/867,331 US6017531A (en) | 1997-06-02 | 1997-06-02 | Hydrophilic composition containing protease produced by Vibrio |
US08/867,331 | 1997-06-02 | ||
PCT/US1998/010698 WO1998055604A1 (en) | 1997-06-02 | 1998-06-01 | Hydrophilic composition containing protease produced by vibrio |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002512525A true JP2002512525A (ja) | 2002-04-23 |
JP3621114B2 JP3621114B2 (ja) | 2005-02-16 |
JP2002512525A5 JP2002512525A5 (ja) | 2005-05-12 |
Family
ID=25349574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50253299A Expired - Fee Related JP3621114B2 (ja) | 1997-06-02 | 1998-06-01 | ビブリオ属(Vibrio)により産生されるプロテアーゼを含有する親水性組成物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US6017531A (ja) |
EP (1) | EP0988374B1 (ja) |
JP (1) | JP3621114B2 (ja) |
AT (1) | ATE425246T1 (ja) |
AU (1) | AU7695798A (ja) |
DE (1) | DE69840649D1 (ja) |
WO (1) | WO1998055604A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020518667A (ja) * | 2017-05-07 | 2020-06-25 | ローカス アイピー カンパニー、エルエルシー | 皮膚の健康のための化粧料組成物及びその使用方法 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2275552B1 (en) * | 1999-10-29 | 2015-09-09 | GlaxoSmithKline Biologicals SA | Neisserial antigenic peptides |
PT2270030E (pt) | 2000-02-28 | 2012-07-24 | Novartis Vaccines & Diagnostic | Expressão heteróloga de proteínas de neisseria |
US6548556B2 (en) | 2000-12-27 | 2003-04-15 | Healthpoint, Ltd. | Stable enzymatic wound debrider |
SK12772003A3 (sk) * | 2001-04-18 | 2004-07-07 | Prometic Biosciences Inc. | Stredne dlhé mastné kyseliny, glyceridy a analógy ako faktory prežitia a aktivácie neutrofilov |
JP2005501814A (ja) * | 2001-05-16 | 2005-01-20 | バイオマリン ファーマシューティカル インコーポレイテッド | ビブリオリシンまたはその改変体を用いるプリオンの破壊 |
US7364565B2 (en) | 2001-07-27 | 2008-04-29 | Ramot At Tel Aviv University Ltd. | Controlled enzymatic removal and retrieval of cells |
US20030021775A1 (en) * | 2001-07-27 | 2003-01-30 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Device for and method of controlled enzymatic removal and retrieval of tissue |
US20030198631A1 (en) * | 2002-04-18 | 2003-10-23 | Healthpoint, Ltd. | Thermolysin enzymatic wound debrider |
US7785584B2 (en) | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409719A (en) * | 1967-05-23 | 1968-11-05 | Baxter Laboratories Inc | Debridement agent |
US3677900A (en) * | 1970-05-04 | 1972-07-18 | Univ Lehigh | Method of producing collagenase with a species of vibrio |
US4329430A (en) * | 1979-06-04 | 1982-05-11 | Klein Gerold K V | Enzyme mixture |
US4420484A (en) * | 1979-08-13 | 1983-12-13 | Sterling Drug Inc. | Basic amino or ammonium antimicrobial agent-polyethylene glycol ester surfactant-betaine and/or amine oxide surfactant compositions and method of use therof |
US4276281A (en) * | 1980-09-04 | 1981-06-30 | Crikelair George F | Burn treatment |
US4668228A (en) * | 1985-03-12 | 1987-05-26 | Johnson & Johnson Products, Inc. | Debriding tape |
US4865983A (en) * | 1987-12-04 | 1989-09-12 | W. R. Grace & Co.-Conn. | Cleaning compositions containing protease produced by vibrio and method of use |
US4894222A (en) * | 1988-04-04 | 1990-01-16 | Neutrogena Corporation | Waterproof sunscreen |
US5104656A (en) * | 1989-06-16 | 1992-04-14 | Seth Pyare L | Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent |
US5145681A (en) * | 1990-08-15 | 1992-09-08 | W. R. Grace & Co.-Conn. | Compositions containing protease produced by vibrio and method of use in debridement and wound healing |
CA2046802C (en) * | 1990-08-15 | 2007-05-22 | Donald Zane Fortney | Compositions containing protease produced by vibrio and method of use in debridement and wound healing |
-
1997
- 1997-06-02 US US08/867,331 patent/US6017531A/en not_active Expired - Fee Related
-
1998
- 1998-06-01 AT AT98924891T patent/ATE425246T1/de not_active IP Right Cessation
- 1998-06-01 WO PCT/US1998/010698 patent/WO1998055604A1/en active Application Filing
- 1998-06-01 DE DE69840649T patent/DE69840649D1/de not_active Expired - Fee Related
- 1998-06-01 EP EP98924891A patent/EP0988374B1/en not_active Expired - Lifetime
- 1998-06-01 JP JP50253299A patent/JP3621114B2/ja not_active Expired - Fee Related
- 1998-06-01 AU AU76957/98A patent/AU7695798A/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020518667A (ja) * | 2017-05-07 | 2020-06-25 | ローカス アイピー カンパニー、エルエルシー | 皮膚の健康のための化粧料組成物及びその使用方法 |
Also Published As
Publication number | Publication date |
---|---|
EP0988374A4 (en) | 2006-08-09 |
AU7695798A (en) | 1998-12-21 |
ATE425246T1 (de) | 2009-03-15 |
US6017531A (en) | 2000-01-25 |
WO1998055604A1 (en) | 1998-12-10 |
EP0988374B1 (en) | 2009-03-11 |
DE69840649D1 (de) | 2009-04-23 |
EP0988374A1 (en) | 2000-03-29 |
JP3621114B2 (ja) | 2005-02-16 |
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