JP2002511415A5 - - Google Patents

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Publication number
JP2002511415A5
JP2002511415A5 JP2000543144A JP2000543144A JP2002511415A5 JP 2002511415 A5 JP2002511415 A5 JP 2002511415A5 JP 2000543144 A JP2000543144 A JP 2000543144A JP 2000543144 A JP2000543144 A JP 2000543144A JP 2002511415 A5 JP2002511415 A5 JP 2002511415A5
Authority
JP
Japan
Prior art keywords
hedgehog
compound
alkyl
aryl
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000543144A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002511415A (ja
JP5067986B2 (ja
Filing date
Publication date
Priority claimed from US09/090,622 external-priority patent/US6432970B2/en
Application filed filed Critical
Priority claimed from PCT/US1999/007811 external-priority patent/WO1999052534A1/en
Publication of JP2002511415A publication Critical patent/JP2002511415A/ja
Publication of JP2002511415A5 publication Critical patent/JP2002511415A5/ja
Application granted granted Critical
Publication of JP5067986B2 publication Critical patent/JP5067986B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2000543144A 1998-04-09 1999-04-09 ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用 Expired - Lifetime JP5067986B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8118698P 1998-04-09 1998-04-09
US8126398P 1998-04-09 1998-04-09
US60/081,263 1998-04-09
US60/081,186 1998-04-09
US09/090,622 US6432970B2 (en) 1998-04-09 1998-06-04 Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
US09/090,622 1998-06-04
PCT/US1999/007811 WO1999052534A1 (en) 1998-04-09 1999-04-09 Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010228790A Division JP2011037880A (ja) 1998-04-09 2010-10-08 ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用

Publications (3)

Publication Number Publication Date
JP2002511415A JP2002511415A (ja) 2002-04-16
JP2002511415A5 true JP2002511415A5 (enExample) 2006-08-03
JP5067986B2 JP5067986B2 (ja) 2012-11-07

Family

ID=27373925

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000543144A Expired - Lifetime JP5067986B2 (ja) 1998-04-09 1999-04-09 ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
JP2010228790A Pending JP2011037880A (ja) 1998-04-09 2010-10-08 ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010228790A Pending JP2011037880A (ja) 1998-04-09 2010-10-08 ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用

Country Status (6)

Country Link
EP (1) EP1067939B1 (enExample)
JP (2) JP5067986B2 (enExample)
AU (1) AU768130B2 (enExample)
CA (1) CA2326654C (enExample)
IL (2) IL138645A0 (enExample)
WO (1) WO1999052534A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098196B1 (en) * 1999-10-13 2006-08-29 Johns Hopkins University School Of Medicine Regulators of the hedgehog pathway, compositions and uses related thereto
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP2002524528A (ja) 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
US6291516B1 (en) * 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
AU2005201269C1 (en) * 1999-01-13 2008-09-04 Curis, Inc. Regulators of the PCT or smoothened pathway, compositions and uses related thereto
AU780358B2 (en) * 1999-06-08 2005-03-17 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
IL133809A0 (en) * 1999-12-30 2001-04-30 Yeda Res & Dev Steroidal alkaloids and pharmaceutical compositions comprising them
EP1294752A2 (en) * 2000-06-16 2003-03-26 Curis, Inc. Angiogenesis-modulating compositions and uses
DK1387674T3 (en) * 2000-10-13 2017-04-10 Curis Inc Hedgehog antagonists, methods and uses related thereto
CA2452152A1 (en) 2001-07-02 2002-10-10 Sinan Tas Use of cyclopamine in the treatment of psoriasis
ES2534400T3 (es) * 2001-07-02 2015-04-22 Sinan Tas Uso de ciclopamina en el tratamiento de carcinoma de células basales y otros tumores
RU2308948C2 (ru) * 2001-07-02 2007-10-27 ТАШ Шинан Применение циклопамина для лечения базально-клеточной эпителиомы (карциномы) и других опухолей
ATE404200T1 (de) * 2002-04-22 2008-08-15 Univ Johns Hopkins Med Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
AU2006283040B2 (en) 2005-08-22 2011-08-25 The Johns Hopkins University Hedgehog pathway antagonists to treat disease
JP2009209099A (ja) * 2008-03-05 2009-09-17 Kumamoto Univ 動脈硬化の予防・治療剤
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
CN102202737B (zh) 2008-11-03 2014-03-26 伊莱利利公司 二取代的2,3-二氮杂萘hedgehog通路拮抗剂
EP2358698B1 (en) 2008-11-17 2012-09-05 Eli Lilly and Company Tetrasubstituted pyridazine as hedgehog pathway antagonists
KR101335770B1 (ko) 2008-11-17 2013-12-12 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
JP2009143963A (ja) * 2009-03-25 2009-07-02 Sinan Tas 腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ／スムーズンド信号を使用する腫瘍を治療するための製薬組成物
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
FR2948367A1 (fr) 2009-07-24 2011-01-28 Centre Nat Rech Scient Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog
WO2012170546A1 (en) * 2011-06-06 2012-12-13 University Of Iowa Research Foundation Methods of inhibiting muscle atrophy
FR2967498B1 (fr) 2010-11-16 2015-01-02 Centre Nat Rech Scient Utilisation de derives de quinolinone comme outil de recherche
FR2980477B1 (fr) 2011-09-23 2013-10-18 Centre Nat Rech Scient Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications
JP2014028835A (ja) * 2013-09-18 2014-02-13 Sinan Tas 基底細胞癌及び他の腫瘍の治療におけるシクロパミンの使用方法
CN106124677B (zh) * 2015-12-31 2018-01-16 广西梧州制药（集团）股份有限公司 一种平贝母药材指纹图谱的建立方法
CN109879933B (zh) * 2019-01-30 2023-06-06 河北科技大学 一类含磷酰基化合物及其应用
CN116349204A (zh) 2020-10-13 2023-06-27 奋进生物医药公司 治疗纤维化的方法
US12447148B2 (en) 2024-03-05 2025-10-21 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES258451A1 (es) 1960-04-01 1960-09-16 Abbott Lab Un metodo para obtener una composiciën farmaceutica en forma de dosificaciën oral
US3121043A (en) 1960-05-11 1964-02-11 Scient Associates Inc Sustained release pharmaceutical preparation and methods for making same
AT280497B (de) * 1968-03-05 1970-04-10 Chemie Linz Ag Verfahren zur Herstellung von neuen, ungesättigten Aminosteroiden
AT300214B (de) * 1970-04-24 1972-07-25 Chemie Linz Ag Verfahren zur Herstellung von Piperidylsteroiden
NZ193564A (en) * 1979-05-02 1985-01-31 Aruba Pty Ltd Steroid alkaloids from solanum sodomeum and pharmaceutical compositions
US5026882A (en) * 1988-12-23 1991-06-25 Smithkline Beecham Corporation Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase
AU654474B2 (en) * 1990-01-18 1994-11-10 Cura Nominees Pty Ltd Glycoalkaloids
KR970005241B1 (ko) 1990-07-18 1997-04-14 주식회사 엘지화학 두발화장품 조성물
JPH04230696A (ja) * 1990-12-28 1992-08-19 Sanwa Shiyouyaku Kk 新規なステロイド系化合物および制癌剤
US6566092B1 (en) 1994-02-25 2003-05-20 The Trustees Of Columbia University In The City Of New York DNA encoding a vertebrate homolog of hedgehog, Vhh-1, expressed by the notochord, and uses thereof
US6027882A (en) 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
AU7979998A (en) * 1997-06-20 1999-01-04 University Of Utah Research Foundation Use of plant-alkaloids to enhance innate immunity defense mechanisms

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