JP2002511385A5 - - Google Patents

Info

Publication number

JP2002511385A5

JP2002511385A5 JP2000522934A JP2000522934A JP2002511385A5 JP 2002511385 A5 JP2002511385 A5 JP 2002511385A5 JP 2000522934 A JP2000522934 A JP 2000522934A JP 2000522934 A JP2000522934 A JP 2000522934A JP 2002511385 A5 JP2002511385 A5 JP 2002511385A5

Authority

JP

Japan

Prior art keywords

medicament

mammal

cytokines

disease

dry powder

Prior art date

1998-12-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 description 6
• 102000004127 Cytokines Human genes 0.000 description 4
• 108090000695 Cytokines Proteins 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• 239000008194 pharmaceutical composition Substances 0.000 description 4
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 3
• 239000002253 acid Substances 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• 150000001413 amino acids Chemical group 0.000 description 2
• 230000003110 anti-inflammatory effect Effects 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 229940112141 dry powder inhaler Drugs 0.000 description 2
• 239000012634 fragment Substances 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 229940071648 metered dose inhaler Drugs 0.000 description 2
• 238000000034 method Methods 0.000 description 2
• 239000006199 nebulizer Substances 0.000 description 2
• 239000000825 pharmaceutical preparation Substances 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 108090000765 processed proteins & peptides Proteins 0.000 description 2
• 230000000770 proinflammatory effect Effects 0.000 description 2
• 208000024891 symptom Diseases 0.000 description 2
• -1 Amino Chemical group 0.000 description 1
• 102000013455 Amyloid beta-Peptides Human genes 0.000 description 1
• 108010090849 Amyloid beta-Peptides Proteins 0.000 description 1
• 102000007079 Peptide Fragments Human genes 0.000 description 1
• 108010033276 Peptide Fragments Proteins 0.000 description 1
• 230000001934 delay Effects 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 229920001184 polypeptide Polymers 0.000 description 1
• 102000004196 processed proteins & peptides Human genes 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1