JP2002511271A - 新規膜メタロプロテアーゼｎｅｐｉｉ及び治療において有用な阻害因子のスクリーニングのためのその使用 - Google Patents

新規膜メタロプロテアーゼｎｅｐｉｉ及び治療において有用な阻害因子のスクリーニングのためのその使用

Info

Publication number
JP2002511271A
JP2002511271A JP2000543624A JP2000543624A JP2002511271A JP 2002511271 A JP2002511271 A JP 2002511271A JP 2000543624 A JP2000543624 A JP 2000543624A JP 2000543624 A JP2000543624 A JP 2000543624A JP 2002511271 A JP2002511271 A JP 2002511271A
Authority
JP
Japan
Prior art keywords
nep
seq
polypeptide
cell
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000543624A
Other languages
English (en)
Japanese (ja)
Inventor
ウイメ，タニヤ
グロ，クロード
ローズ，クリステイアヌ
ボノム，マリ−シヤンタル
フアシネツテイ，パトリシア
シユバルツ，ジヤン−シヤルル
Original Assignee
アンステイテユ・ナシオナル・ドウ・ラ・サンテ・エ・ドウ・ラ・ルシエルシユ・メデイカル（アンセルム）
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by アンステイテユ・ナシオナル・ドウ・ラ・サンテ・エ・ドウ・ラ・ルシエルシユ・メデイカル（アンセルム） filed Critical アンステイテユ・ナシオナル・ドウ・ラ・サンテ・エ・ドウ・ラ・ルシエルシユ・メデイカル（アンセルム）
Publication of JP2002511271A publication Critical patent/JP2002511271A/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2000543624A 1998-04-08 1999-04-07 新規膜メタロプロテアーゼｎｅｐｉｉ及び治療において有用な阻害因子のスクリーニングのためのその使用 Withdrawn JP2002511271A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR98/04389 1998-04-08
FR9804389A FR2777291B1 (fr) 1998-04-08 1998-04-08 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
PCT/FR1999/000807 WO1999053077A1 (fr) 1998-04-08 1999-04-07 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie

Publications (1)

Publication Number Publication Date
JP2002511271A true JP2002511271A (ja) 2002-04-16

Family

ID=9525008

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000543624A Withdrawn JP2002511271A (ja) 1998-04-08 1999-04-07 新規膜メタロプロテアーゼｎｅｐｉｉ及び治療において有用な阻害因子のスクリーニングのためのその使用

Country Status (5)

Country Link
EP (1) EP1068336A2 (fr)
JP (1) JP2002511271A (fr)
CA (1) CA2325599A1 (fr)
FR (1) FR2777291B1 (fr)
WO (1) WO1999053077A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020086405A1 (en) * 2000-09-25 2002-07-04 Inmaculada Silos-Santiago 56638, a novel human neprilysin protease and uses thereof
CA2260376A1 (fr) * 1999-02-11 2000-08-11 Universite De Montreal Nouvelles metalloproteases de la famille de la neprilysine
EP1069188A1 (fr) * 1999-07-15 2001-01-17 Sanofi-Synthelabo Métallopeptidases membranaires de type neprolysin
DK1234025T3 (da) 1999-11-19 2008-11-17 Solvay Pharm Bv Humane enzymer fra metalloproteasefamilien
JP2001275687A (ja) * 2000-04-04 2001-10-09 Masafumi Matsuo 膜結合型メタロプロテアーゼ及びその可溶性分泌型
US6991916B2 (en) 2000-07-14 2006-01-31 Pfizer Inc. Compounds for the treatment of sexual dysfunction
GB0017387D0 (en) * 2000-07-14 2000-08-30 Pfizer Ltd Novel enzyme

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960700A (en) * 1986-12-24 1990-10-02 Genentech, Inc. Compositions and methods for the synthesis and assay of a mammalian enkephalinase

Also Published As

Publication number Publication date
WO1999053077A1 (fr) 1999-10-21
CA2325599A1 (fr) 1999-10-21
FR2777291A1 (fr) 1999-10-15
FR2777291B1 (fr) 2000-07-07
EP1068336A2 (fr) 2001-01-17

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Legal Events

Date Code Title Description
A300 Withdrawal of application because of no request for examination

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20060704