JP2002508923A - 心肥大において差示的に発現される遺伝子、ならびに処置および診断におけるそれらの使用 - Google Patents

心肥大において差示的に発現される遺伝子、ならびに処置および診断におけるそれらの使用

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Publication number
JP2002508923A
JP2002508923A JP2000520565A JP2000520565A JP2002508923A JP 2002508923 A JP2002508923 A JP 2002508923A JP 2000520565 A JP2000520565 A JP 2000520565A JP 2000520565 A JP2000520565 A JP 2000520565A JP 2002508923 A JP2002508923 A JP 2002508923A
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protein
nucleic acid
seq
group
gene
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JP2000520565A
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JP2002508923A5 (enExample
Inventor
リチャード エイ. シムケッツ,
デイビッド ジー. ロウエ,
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キュラジェン コーポレイション
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Publication of JP2002508923A5 publication Critical patent/JP2002508923A5/ja
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0053Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
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  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2000520565A 1997-11-10 1998-11-10 心肥大において差示的に発現される遺伝子、ならびに処置および診断におけるそれらの使用 Pending JP2002508923A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6504897P 1997-11-10 1997-11-10
US09/189,618 1998-11-09
US60/065,048 1998-11-09
US09/189,618 US6610480B1 (en) 1997-11-10 1998-11-09 Treatment and diagnosis of cardiac hypertrophy
PCT/US1998/023953 WO1999024571A2 (en) 1997-11-10 1998-11-10 Differentially expressed genes in cardiac hypertrophy and their uses in treatment and diagnosis

Publications (2)

Publication Number Publication Date
JP2002508923A true JP2002508923A (ja) 2002-03-26
JP2002508923A5 JP2002508923A5 (enExample) 2006-03-02

Family

ID=26745148

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000520565A Pending JP2002508923A (ja) 1997-11-10 1998-11-10 心肥大において差示的に発現される遺伝子、ならびに処置および診断におけるそれらの使用
JP2006323823A Withdrawn JP2007135219A (ja) 1997-11-10 2006-11-30 通信システムにおけるビデオフレーム転送方法と装置

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006323823A Withdrawn JP2007135219A (ja) 1997-11-10 2006-11-30 通信システムにおけるビデオフレーム転送方法と装置

Country Status (6)

Country Link
US (1) US6610480B1 (enExample)
EP (1) EP1030916A2 (enExample)
JP (2) JP2002508923A (enExample)
AU (1) AU1395399A (enExample)
CA (1) CA2309360A1 (enExample)
WO (1) WO1999024571A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012506031A (ja) * 2008-10-17 2012-03-08 エフ.ホフマン−ラ ロシュ アーゲー 心不全の評価におけるビグリカンの使用

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875567B1 (en) 1997-11-10 2005-04-05 Genentech, Inc. Method of detecting cardiac hypertrophy through probe hybridization and gene expression analysis
CA2383252A1 (en) 1999-08-24 2001-03-01 Medicure International Inc. Treatment of cardiovascular related pathologies
US20040072170A1 (en) * 2000-05-30 2004-04-15 Bunk Daniela Beck Nee Novel target genes for diseases of the heart
DE10126371A1 (de) * 2001-05-30 2003-02-27 Medigene Ag Verfahren zur Identifizierung von Substanzen gegen Herzmuskelzellen-Hypertrophie
WO2002103355A1 (fr) * 2001-06-18 2002-12-27 Takeda Chemical Industries, Ltd. Agents prophylactiques/remedes pour maladies cardiaques
WO2003006687A2 (en) * 2001-07-10 2003-01-23 Medigene Ag Novel target genes for diseases of the heart
ITMI20012205A1 (it) * 2001-10-22 2003-04-22 Nanorganics Llc Metodo e mezzi per l'identificazione precoce di rischi di scompenso cardiaco
US7482132B2 (en) 2001-12-13 2009-01-27 Sanofi-Aventis Deutschland Gmbh Method for determining the activity of ornithine decarboxylase and for identifying effectors of ornithine decarboxylase activity
DE10161412A1 (de) * 2001-12-13 2003-07-03 Aventis Pharma Gmbh Verfahren zur Bestimmung der Aktivität der Ornithin-Decarboxylase sowie zur Identifizierung von Effektoren der Ornithin-Decarboxylase-Aktivität
WO2003059948A1 (en) * 2002-01-15 2003-07-24 Medigene Ag Dilated cardiomyopathy associated gene-2 (dcmag-2): a cytoplasmatic inducer of sarcomeric remodeling in cardiomyocytes
EP3070174B1 (en) 2004-05-11 2019-11-06 Ncardia AG Drug discovery based on in vitro differentiated cells
US20070179815A1 (en) * 2006-01-20 2007-08-02 Heartscreen America, Inc. Medical screening system and method
JP2009544306A (ja) * 2006-07-25 2009-12-17 ドイチェス クレブスフォルシュングスツェントルム 拡張型心筋症に共通の遺伝子発現シグネチャー
EP2912458B1 (en) 2012-10-24 2018-07-18 NYU Winthrop Hospital Non-invasive biomarker to identify subjects at risk of preterm delivery
JP2020533595A (ja) 2017-09-13 2020-11-19 プロジェニティ, インコーポレイテッド 子癇前症バイオマーカならびに関連するシステムおよび方法
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69535221T2 (de) * 1994-04-25 2007-09-13 Genentech, Inc., South San Francisco Cardiotrophin und verwendung davon
US5972693A (en) 1995-10-24 1999-10-26 Curagen Corporation Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012506031A (ja) * 2008-10-17 2012-03-08 エフ.ホフマン−ラ ロシュ アーゲー 心不全の評価におけるビグリカンの使用

Also Published As

Publication number Publication date
CA2309360A1 (en) 1999-05-20
AU1395399A (en) 1999-05-31
EP1030916A2 (en) 2000-08-30
WO1999024571A2 (en) 1999-05-20
JP2007135219A (ja) 2007-05-31
US6610480B1 (en) 2003-08-26
WO1999024571A3 (en) 1999-08-26

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