JP2002508398A5 - - Google Patents
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- Publication number
- JP2002508398A5 JP2002508398A5 JP2000539163A JP2000539163A JP2002508398A5 JP 2002508398 A5 JP2002508398 A5 JP 2002508398A5 JP 2000539163 A JP2000539163 A JP 2000539163A JP 2000539163 A JP2000539163 A JP 2000539163A JP 2002508398 A5 JP2002508398 A5 JP 2002508398A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- amino acid
- target protein
- acid side
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 description 89
- 102000004169 proteins and genes Human genes 0.000 description 77
- 108090000623 proteins and genes Proteins 0.000 description 77
- 125000003275 alpha amino acid group Chemical group 0.000 description 53
- 238000009739 binding Methods 0.000 description 49
- 230000004962 physiological condition Effects 0.000 description 30
- 238000000034 method Methods 0.000 description 21
- 239000000203 mixture Substances 0.000 description 14
- 230000009257 reactivity Effects 0.000 description 13
- 125000005647 linker group Chemical group 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 230000005764 inhibitory process Effects 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 5
- 230000008859 change Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000004850 protein–protein interaction Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6954897P | 1997-12-12 | 1997-12-12 | |
| US60/069,548 | 1997-12-12 | ||
| US10351798P | 1998-10-08 | 1998-10-08 | |
| US60/103,517 | 1998-10-08 | ||
| PCT/US1998/025501 WO1999031265A1 (en) | 1997-12-12 | 1998-12-02 | Compounds and methods for the inhibition of protein-protein interactions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508398A JP2002508398A (ja) | 2002-03-19 |
| JP2002508398A5 true JP2002508398A5 (https=) | 2006-01-12 |
Family
ID=26750190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000539163A Withdrawn JP2002508398A (ja) | 1997-12-12 | 1998-12-02 | タンパク質−タンパク質相互作用を阻害するための化合物と方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6465192B2 (https=) |
| EP (1) | EP1038021A4 (https=) |
| JP (1) | JP2002508398A (https=) |
| CA (1) | CA2312913A1 (https=) |
| WO (1) | WO1999031265A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003221884A1 (en) * | 2002-04-10 | 2003-10-27 | Transtech Pharma, Inc. | System and method for data analysis, manipulation, and visualization |
| US7785647B2 (en) * | 2005-07-25 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Methods of providing antioxidants to a drug containing product |
| US20160144642A1 (en) * | 2014-11-24 | 2016-05-26 | Kyocera Document Solutions Inc. | Printing device control method and system with executing command determined from image |
| CN117133371B (zh) * | 2023-10-25 | 2024-01-05 | 烟台国工智能科技有限公司 | 基于人工断键的无模板单步逆合成方法及系统 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5372933A (en) | 1988-10-03 | 1994-12-13 | The Scripps Research Institute | Polypeptides that mimic receptor-induced binding sites, and methods of using same |
| AU7048791A (en) * | 1989-12-01 | 1991-06-26 | Board Of Trustees Of The Leland Stanford Junior University | Promotion of high specificity molecular assembly |
| US5723289A (en) * | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
| DK0580737T3 (da) * | 1991-04-10 | 2004-11-01 | Scripps Research Inst | Heterodimere receptorbiblioteker ved anvendelse af phagemider |
| FR2675804B1 (fr) * | 1991-04-25 | 1995-04-07 | Propeptide Sa | Procede de synthese de peptides, nouveaux derives d'acides amines mis en óoeuvre dans ce procede et leurs procedes de preparation. |
| FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
| US5552534A (en) | 1991-08-22 | 1996-09-03 | The Trustees Of The University Of Pennsylvania | Non-Peptide peptidomimetics |
| US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US5552634A (en) * | 1993-12-14 | 1996-09-03 | Lsi Logic Corporation | Method and apparatus for dissipating heat in an electronic device |
| US5571681A (en) * | 1994-03-10 | 1996-11-05 | The Scripps Research Institute | Chemical event selection by suicide substrate conjugates |
| US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
| US6372933B1 (en) * | 1999-08-26 | 2002-04-16 | Smithkline Beecham Corporation | Process for preparing certain phenyl urea compounds |
-
1998
- 1998-12-02 EP EP98961858A patent/EP1038021A4/en not_active Withdrawn
- 1998-12-02 JP JP2000539163A patent/JP2002508398A/ja not_active Withdrawn
- 1998-12-02 WO PCT/US1998/025501 patent/WO1999031265A1/en not_active Ceased
- 1998-12-02 CA CA002312913A patent/CA2312913A1/en not_active Abandoned
- 1998-12-10 US US09/208,665 patent/US6465192B2/en not_active Expired - Fee Related
-
2002
- 2002-08-15 US US10/219,405 patent/US20030003513A1/en not_active Abandoned
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