JP2002508398A - タンパク質−タンパク質相互作用を阻害するための化合物と方法 - Google Patents

タンパク質−タンパク質相互作用を阻害するための化合物と方法

Info

Publication number
JP2002508398A
JP2002508398A JP2000539163A JP2000539163A JP2002508398A JP 2002508398 A JP2002508398 A JP 2002508398A JP 2000539163 A JP2000539163 A JP 2000539163A JP 2000539163 A JP2000539163 A JP 2000539163A JP 2002508398 A JP2002508398 A JP 2002508398A
Authority
JP
Japan
Prior art keywords
compound
target protein
amino acid
group
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000539163A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002508398A5 (https=
Inventor
ジェフリー シー． ウェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2002508398A publication Critical patent/JP2002508398A/ja
Publication of JP2002508398A5 publication Critical patent/JP2002508398A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2000539163A 1997-12-12 1998-12-02 タンパク質−タンパク質相互作用を阻害するための化合物と方法 Withdrawn JP2002508398A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6954897P 1997-12-12 1997-12-12
US60/069,548 1997-12-12
US10351798P 1998-10-08 1998-10-08
US60/103,517 1998-10-08
PCT/US1998/025501 WO1999031265A1 (en) 1997-12-12 1998-12-02 Compounds and methods for the inhibition of protein-protein interactions

Publications (2)

Publication Number Publication Date
JP2002508398A true JP2002508398A (ja) 2002-03-19
JP2002508398A5 JP2002508398A5 (https=) 2006-01-12

Family

ID=26750190

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000539163A Withdrawn JP2002508398A (ja) 1997-12-12 1998-12-02 タンパク質−タンパク質相互作用を阻害するための化合物と方法

Country Status (5)

Country Link
US (2) US6465192B2 (https=)
EP (1) EP1038021A4 (https=)
JP (1) JP2002508398A (https=)
CA (1) CA2312913A1 (https=)
WO (1) WO1999031265A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003221884A1 (en) * 2002-04-10 2003-10-27 Transtech Pharma, Inc. System and method for data analysis, manipulation, and visualization
US7785647B2 (en) * 2005-07-25 2010-08-31 Advanced Cardiovascular Systems, Inc. Methods of providing antioxidants to a drug containing product
US20160144642A1 (en) * 2014-11-24 2016-05-26 Kyocera Document Solutions Inc. Printing device control method and system with executing command determined from image
CN117133371B (zh) * 2023-10-25 2024-01-05 烟台国工智能科技有限公司 基于人工断键的无模板单步逆合成方法及系统

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5372933A (en) 1988-10-03 1994-12-13 The Scripps Research Institute Polypeptides that mimic receptor-induced binding sites, and methods of using same
AU7048791A (en) * 1989-12-01 1991-06-26 Board Of Trustees Of The Leland Stanford Junior University Promotion of high specificity molecular assembly
US5723289A (en) * 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
DK0580737T3 (da) * 1991-04-10 2004-11-01 Scripps Research Inst Heterodimere receptorbiblioteker ved anvendelse af phagemider
FR2675804B1 (fr) * 1991-04-25 1995-04-07 Propeptide Sa Procede de synthese de peptides, nouveaux derives d'acides amines mis en óoeuvre dans ce procede et leurs procedes de preparation.
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US5552534A (en) 1991-08-22 1996-09-03 The Trustees Of The University Of Pennsylvania Non-Peptide peptidomimetics
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5552634A (en) * 1993-12-14 1996-09-03 Lsi Logic Corporation Method and apparatus for dissipating heat in an electronic device
US5571681A (en) * 1994-03-10 1996-11-05 The Scripps Research Institute Chemical event selection by suicide substrate conjugates
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
US6372933B1 (en) * 1999-08-26 2002-04-16 Smithkline Beecham Corporation Process for preparing certain phenyl urea compounds

Also Published As

Publication number Publication date
WO1999031265A1 (en) 1999-06-24
EP1038021A4 (en) 2005-02-16
US20020031780A1 (en) 2002-03-14
CA2312913A1 (en) 1999-06-24
EP1038021A1 (en) 2000-09-27
US20030003513A1 (en) 2003-01-02
US6465192B2 (en) 2002-10-15

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