JP2002502830A5 - - Google Patents

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Publication number
JP2002502830A5
JP2002502830A5 JP2000530236A JP2000530236A JP2002502830A5 JP 2002502830 A5 JP2002502830 A5 JP 2002502830A5 JP 2000530236 A JP2000530236 A JP 2000530236A JP 2000530236 A JP2000530236 A JP 2000530236A JP 2002502830 A5 JP2002502830 A5 JP 2002502830A5
Authority
JP
Japan
Prior art keywords
protein
polysaccharide conjugate
restricted
solid phase
polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000530236A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002502830A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1999/002416 external-priority patent/WO1999039739A1/en
Publication of JP2002502830A publication Critical patent/JP2002502830A/ja
Publication of JP2002502830A5 publication Critical patent/JP2002502830A5/ja
Withdrawn legal-status Critical Current

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JP2000530236A 1998-02-05 1999-02-04 タンパク質−多糖コンジュゲートおよびワクチンの製造中に遊離タンパク質を除去するための、接近が制限された媒介材料を用いる簡素化された方法 Withdrawn JP2002502830A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7379098P 1998-02-05 1998-02-05
US60/073,790 1998-02-05
PCT/US1999/002416 WO1999039739A1 (en) 1998-02-05 1999-02-04 Simplified method for removing free protein during preparation of protein-polysaccharide conjugates and vaccines using restricted-access media

Publications (2)

Publication Number Publication Date
JP2002502830A JP2002502830A (ja) 2002-01-29
JP2002502830A5 true JP2002502830A5 (enExample) 2006-03-30

Family

ID=22115824

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000530236A Withdrawn JP2002502830A (ja) 1998-02-05 1999-02-04 タンパク質−多糖コンジュゲートおよびワクチンの製造中に遊離タンパク質を除去するための、接近が制限された媒介材料を用いる簡素化された方法

Country Status (8)

Country Link
US (1) US6284250B1 (enExample)
EP (1) EP1053021B1 (enExample)
JP (1) JP2002502830A (enExample)
AT (1) ATE421339T1 (enExample)
AU (1) AU763349B2 (enExample)
CA (1) CA2320470A1 (enExample)
DE (1) DE69940338D1 (enExample)
WO (1) WO1999039739A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248334B1 (en) * 1997-01-08 2001-06-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
FR2806304B1 (fr) * 2000-03-17 2002-05-10 Aventis Pasteur Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie
WO2005072778A2 (en) * 2004-01-29 2005-08-11 Biosynexus, Inc. Use of amino-oxy functional groups in the preparation of vaccines conjugates
GB0409745D0 (en) * 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
GB0713880D0 (en) * 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
US8207298B2 (en) * 2008-05-01 2012-06-26 Archemix Corp. Methods of separating biopolymer conjugated molecules from unconjugated molecules
US8647621B2 (en) 2009-07-27 2014-02-11 Fina Biosolutions, Llc Method of producing protein-carbohydrate vaccines reduced in free carbohydrate
KR101635795B1 (ko) 2009-12-17 2016-07-04 피나 바이오솔루션스, 엘엘씨 다당류/단백질 접합체 백신의 제조에 있어서 시안화제인 1-시아노벤조트리아졸 (1-cbt)을 통한 다당류의 활성화
EP2560738B8 (en) 2010-04-23 2019-09-25 Serum Institute of India Private Limited Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels
BR112015005937A2 (pt) 2012-09-17 2017-07-04 Grace W R & Co meios e dispositivos cromatográficos
EP2999709A4 (en) 2013-05-20 2016-12-07 Shantha Biotechnics Private Ltd PURIFICATION OF PROTEIN-POLYSACCHARIDE CONJUGATES
CN104324708B (zh) * 2014-11-05 2016-08-24 华玉叶 一种亲水色谱介质的制备方法
JP6882193B2 (ja) * 2015-04-28 2021-06-02 バイオロジカル イー リミテッド 微生物莢膜多糖類からタンパク質および他の不純物を分離するための方法
CN114544841B (zh) * 2020-11-24 2024-09-03 武汉博沃生物科技有限公司 一种采用高效液相色谱法测定肺炎球菌多糖-蛋白结合疫苗中dmap残留量的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057685A (en) 1972-02-02 1977-11-08 Abbott Laboratories Chemically modified endotoxin immunizing agent
US4923978A (en) 1987-12-28 1990-05-08 E. I. Du Pont De Nemours & Company Process for purifying nucleic acids
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
US5277813A (en) 1988-06-17 1994-01-11 S.A.C. Corporation Shielded stationary phases
US5106966A (en) 1989-07-10 1992-04-21 University Of Kansas Use of gel polymer for dna extraction with organic solvents
US5153312A (en) 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
US5278284A (en) * 1992-05-14 1994-01-11 Miller Brewing Company Protein purification method
JP4163251B2 (ja) * 1992-09-24 2008-10-08 ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド グループｂストレプトコッカス・タイプ▲ｉｉ▼およびタイプ▲ｖ▼多糖−蛋白質接合ワクチン
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
ATE254475T1 (de) * 1993-09-22 2003-12-15 Jackson H M Found Military Med Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten
EP0814833B1 (en) * 1995-03-22 2003-05-28 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents
WO1996040242A1 (en) * 1995-06-07 1996-12-19 Smithkline Beecham Biologicals S.A. Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein
AUPN694895A0 (en) * 1995-12-01 1996-01-04 Macquarie Research Limited Desalting and purification of oligosaccharides and their derivatives

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