JP2002501534A5 - - Google Patents

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Publication number
JP2002501534A5
JP2002501534A5 JP1999500802A JP50080299A JP2002501534A5 JP 2002501534 A5 JP2002501534 A5 JP 2002501534A5 JP 1999500802 A JP1999500802 A JP 1999500802A JP 50080299 A JP50080299 A JP 50080299A JP 2002501534 A5 JP2002501534 A5 JP 2002501534A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1999500802A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002501534A (ja
JP4393594B2 (ja
Filing date
Publication date
Priority claimed from US08/865,666 external-priority patent/US6096881A/en
Application filed filed Critical
Publication of JP2002501534A publication Critical patent/JP2002501534A/ja
Publication of JP2002501534A5 publication Critical patent/JP2002501534A5/ja
Application granted granted Critical
Publication of JP4393594B2 publication Critical patent/JP4393594B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP50080299A 1997-05-30 1998-05-26 オリゴヌクレオチド合成用新規硫黄転移試薬 Expired - Lifetime JP4393594B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/865,666 1997-05-30
US08/865,666 US6096881A (en) 1997-05-30 1997-05-30 Sulfur transfer reagents for oligonucleotide synthesis
PCT/US1998/010653 WO1998054198A1 (en) 1997-05-30 1998-05-26 Novel sulfur transfer reagents for oligonucleotide synthesis

Publications (3)

Publication Number Publication Date
JP2002501534A JP2002501534A (ja) 2002-01-15
JP2002501534A5 true JP2002501534A5 (https=) 2005-12-08
JP4393594B2 JP4393594B2 (ja) 2010-01-06

Family

ID=25345990

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50080299A Expired - Lifetime JP4393594B2 (ja) 1997-05-30 1998-05-26 オリゴヌクレオチド合成用新規硫黄転移試薬

Country Status (9)

Country Link
US (1) US6096881A (https=)
EP (1) EP0986571B1 (https=)
JP (1) JP4393594B2 (https=)
AT (1) ATE271065T1 (https=)
AU (1) AU7597498A (https=)
CA (1) CA2291688C (https=)
DE (1) DE69825051T2 (https=)
ES (1) ES2226135T3 (https=)
WO (1) WO1998054198A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0992506B1 (en) * 1998-10-08 2003-08-06 Novartis AG Process for the sulfurisation of phosphorus-containing compounds
US7098325B2 (en) * 1998-10-08 2006-08-29 Pierre Martin Process for the sulfurization of a phosphorus-containing compound
GB0004889D0 (en) 2000-03-01 2000-04-19 Avecia Ltd Synthesis of oligonucleotides
US6768005B2 (en) * 2000-12-20 2004-07-27 Avecia Limited Process
WO2002046205A2 (en) * 2000-12-05 2002-06-13 Avecia Limited Process for the preparation of phosphorothionate oligonucleotides
AR036122A1 (es) * 2001-07-03 2004-08-11 Avecia Biotechnology Inc Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita
JP4825375B2 (ja) * 2001-08-28 2011-11-30 株式会社 資生堂 ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
WO2005097817A2 (en) * 2004-04-05 2005-10-20 Alnylam Pharmaceuticals, Inc. Process and reagents for oligonucleotide synthesis and purification
CN104086516B (zh) * 2014-07-18 2016-01-06 成都樵枫科技发展有限公司 R-(+)-硫代四氢呋喃-2-甲酸的合成方法
CN110199023A (zh) 2016-12-28 2019-09-03 第一三共株式会社 阿尔波特氏综合症治疗药
WO2019111791A1 (ja) * 2017-12-07 2019-06-13 第一三共株式会社 ジストロフィン遺伝子のイントロンリテンションを解消するアンチセンスオリゴヌクレオチド
CN111511915A (zh) 2018-03-09 2020-08-07 第一三共株式会社 糖原病Ia型治疗药
US20210207136A1 (en) 2018-06-13 2021-07-08 Daiichi Sankyo Company, Limited Myocardial dysfunction therapeutic agent
CA3140438A1 (en) 2019-06-05 2020-12-10 Masatora Fukuda Stable target-editing guide rna having chemically modified nucleic acid introduced thereinto
EP3995153A4 (en) 2019-06-26 2023-11-22 KNC Laboratories Co., Ltd. Nucleic acid drug suppressing production of myostatin gene mrna
BR112021024764A2 (pt) 2019-07-12 2022-04-19 Daiichi Sankyo Co Ltd Oligonucleotídeo antissenso capaz de alterar o splicing de pré-mrna de dux4
WO2021049504A1 (ja) 2019-09-10 2021-03-18 第一三共株式会社 肝臓送達用GalNAc-オリゴヌクレオチドコンジュゲートおよび製造方法
IL292286A (en) 2019-10-18 2022-06-01 Daiichi Sankyo Co Ltd Production method for bicyclic phosphoramidite
EP4119167A4 (en) 2020-03-11 2025-08-06 Biocomber Co Ltd SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR INDUCING FRAME SHIFT-1 AND COMPOSITION
JP7722666B2 (ja) 2020-07-28 2025-08-13 神戸天然物化学株式会社 アンギオテンシン変換酵素2遺伝子のエクソンのスキッピングを誘導するアンチセンス核酸
EP4261284A4 (en) 2020-12-08 2025-07-16 Univ Fukuoka STABLE TARGET EDITING GUIDE RNA INTO WHICH A CHEMICALLY MODIFIED NUCLEIC ACID HAS BEEN INTRODUCED
US20240229036A9 (en) 2021-02-26 2024-07-11 Knc Laboratories Co., Ltd. Nucleic acid medicine expressing splicing variant of myostatin
JPWO2023176863A1 (https=) 2022-03-16 2023-09-21
KR20240161967A (ko) 2022-03-16 2024-11-13 다이이찌 산쿄 가부시키가이샤 트랜스페린 수용체 2 의 발현을 억제하는 siRNA
TW202523839A (zh) 2023-08-25 2025-06-16 學校法人福岡大學 導入有磷酸部修飾之穩定型標靶編輯引導rna

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753908A (en) * 1971-08-30 1973-08-21 Chevron Res Oxidation inhibited lubricating oil compositions with extreme pressure properties
DE4320157A1 (de) * 1993-06-18 1994-12-22 Bayer Ag Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica

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